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| 1 | Leucocyte apheresis in the treatment of paediatric ulcerative colitis显示文摘 | Tarja Ruuska Marja-Leena L? hdeaho Yelda Sutas Merja Ashorn Juhani Gr? nlund | 2007 | Scandinavian Journal of Gastroenterology2007，，11： | 1 |
| 2 | A Simplified Risk Score for Predicting Postoperative Nausea and Vomiting: Conclusions from Cross-validations between Two Centers显示文摘 | Christian C. Apfel Esa L??r? Merja Koivuranta Clemens-A. Greim Norbert Roewer | 1999 | Anesthesiology1999，，3： | 1 |
| 3 | A Simplified Risk Score for Predicting Postoperative Nausea and Vomiting: Conclusions from Cross-validations between Two Centers显示文摘 | Christian C. Apfel Esa L??r? Merja Koivuranta Clemens-A. Greim Norbert Roewer | 1999 | Anesthesiology1999，，3： | 1 |
| 4 | Recent advances in the malting and brewing industry显示文摘 | Matti L Auli H Anneli R Merja P | 1998 | J Biotech1998，65，： | 1 |
| 5 | Expression of two Trichoderma reesei endoglucanases in the yeast Saccharomyces cerevisiae 显示文摘 | Merja E Penttila M Andre L | 1987 | Yeast1987，3，3： | 1 |
| 6 | Expression of two Trichoderma reesei endoglucanases in the yeast Saccharomyces cerevisiae显示文摘 | MERJA E PENTTILA M ANDRE L | 1987 | Yeast1987，3，3： | 1 |
| 7 | Systematic Identification of MicroRNAs That Impact on Proliferation of Prostate Cancer Cells and Display Changed Expression in Tumor Tissue显示文摘 | Anna Aakula Pekka Kohonen Suvi-Katri Leivonen Rami M?kel? Petteri Hintsanen John Patrick Mpindi Elena Martens-Uzunova Tero Aittokallio Guido Jenster Merja Per?l? Olli Kallioniemi P?ivi ?stling | 2015 | European Urology2015，，： | 1 |
| 8 | Transesterification of trimethylolpropane and rapeseed oil methyl ester to environmentally acceptable lubricants显示文摘 | Esa Uosukainen Yu-Yen Linko Merja L?ms? Tommi Tervakangas Pekka Linko | 1998 | Journal of the American Oil Chemists’ Society1998，，11： | 1 |
| 9 | Correlation between serum inhibin B and other indicators of the ovarian function显示文摘 | Helean T Merja B Pekka L | 2001 | European Journal of Obstetrics and Gynecology and Reproductive Biology2001，94，1： | 1 |
| 10 | Construction of Owner-Manager Identity in Corporate Social Responsibility Discourse显示文摘 | Merja L | 2012 | Business Ethics: A Euro- pean Review2012，21，4： | 1 |
| 11 | Inducible nitric oxide synthase ex- pression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas显示文摘 | Merja V Katriina K Essi L | 2000 | Clinical Cancel' Research2000，6，6： | 1 |
| 12 | Effect of anaesthesia on contrast-enhanced ultrasound of the feline spleen显示文摘 | Merja R L Marja R R Outi M V | | 0，，： | 1 |
| 13 | Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas 显示文摘 | Merja V Katriina K Essi L | 2000 | Clinical Cancer Research2000，6，： | 1 |
| 14 | High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth显示文摘 | Suvi-Katri Leivonen Kristine Kleivi Sahlberg Rami M?kel? Eldri Undlien Due Olli Kallioniemi Anne-Lise B?rresen-Dale Merja Per?l? | 2014 | Molecular Oncology2014，，1： | 1 |
| 15 | Serum concentration of apolipoprotein A-I,apoprotein B,and lipoprotein (a) in a population sample显示文摘 | AILA L OILI I MERJA K | 1995 | Clin Chem1995，41，： | 1 |
| 16 | Mineralization and conversion of pentachlorophenol (PCP) in soil inoculated with the white-rot fungus Trametes versicolor显示文摘 | Maria T Merja L Pekka O | 1999 | Soil Biology and Biochemistry1999，31，： | 1 |
| 17 | ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific,brain-penetrating fusion protein显示文摘Background:Hijacking the transferrin receptor(TfR)is an effective strategy to transport amyloid-beta(Aβ)immuno-positron emission tomography(immunoPET)ligands across the blood-brain barrier(BBB).Such ligands are more sensitive and specific than small-molecule ligands at detecting Aβpathology in mouse models of Alzheimer’s disease(AD).This study aimed to determine if this strategy would be as sensitive in rats and to assess how TfR affinity affects BBB transport of bispecific immunoPET radioligands.Methods:Two affinity variants of the rat TfR antibody,OX26,were chemically conjugated to a F(ab′)2 fragment of the anti-Aβantibody,bapineuzumab(Bapi),to generate two bispecific fusion proteins:OX265-F(ab′)2-Bapi and OX2676-F(ab′)2-Bapi.Pharmacokinetic analyses were performed 4 h and 70 h post-injection of radioiodinated fusion proteins in wild-type(WT)rats.[124I]I-OX265-F(ab′)2-Bapi was administered to TgF344-AD and WT rats for in vivo PET imaging.Ex vivo distribution of injected[124I]I-OX265-F(ab′)2-Bapi and Aβpathology were assessed.Results:More[125I]I-OX265-F(ab′)2-Bapi was taken up into the brain 4 h post-administration than[124I]I-OX2676-F(ab′)2-Bapi.[124I]I-OX265-F(ab′)2-Bapi PET visualized Aβpathology with significantly higher signals in the TgF344-AD rats than in the WT littermates without Aβpathology.The PET signals significantly correlated with Aβlevels in AD animals.Conclusion:Affinity to TfR affects how efficiently a TfR-targeting bispecific fusion protein will cross the BBB,such that the higher-affinity bispecific fusion protein crossed the BBB more efficiently.Furthermore,bispecific immunoPET imaging of brain Aβpathology using TfR-mediated transport provides good imaging contrast between TgF344-AD and WT rats,suggesting that this immunoPET strategy has the potential to be translated to higher species. | Gillian Bonvicini Stina Syvänen Ken G.Andersson Merja Haaparanta-Solin Francisco López-Picón Dag Sehlin | 2022 | Translational Neurodegeneration2022，11，1： | 0 |
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