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| 1 | Physiology of natriuretic peptides: The volume overload hypothesis revisited显示文摘The discovery of the natriuretic peptide system in the early 1980s aroused great interest among clinical cardiologists. The heart was not a mechanical pump alone, but also an endocrine organ that had powerful effects on blood circulation. Natriuretic peptides caused both natriuresis and diuresis, and they responded to a volume overload which caused either stretch or pressure on the heart. As a result, the findings led to the conclusion that the human body had a hormone with effects similar to those of a drug which treats high blood pressure. Later, it became evident that the volume contraction was fortified by extrarenal plasma shift. Here, a hypothesis is presented in which the role of natriuretic peptides is to regulate oxygen transport as the volume contraction leads to hemoconcentration with an increased oxygen-carrying capacity. Wall stress, either chemical or mechanical, changes the oxygen gradient of the myocardium and affects the diffusion of oxygen within a myocyte. In support of this hypothesis, hypoxia-response elements have been found in both the atrial natriuretic peptide and the brain natriuretic peptide genes. | Olli Arjamaa | 2014 | World Journal of Cardiology2014，6，1： | 8 |
| 2 | 水资源开发:恶性与良性循环显示文摘可持续发展是一个代际概念。没有长远的构想可持续发展是不能实现的,没有专门知识和解决方案及行动也是不能实现的。科学世界正在目睹着强烈的专门化和分化的趋势;相反,对政策制定的挑战则在于整体性、跨学科性和广泛性。从一个狭隘的立场看问题,许多事情呈现'线性',具有直接的、单向的因果联系。然而,实际上它们由许多反馈和循环构成了复杂的相互联系网络。在认识这种相互联系时,必须有远大的目光。全世界大部分地区面临着不断增加的水资源开发的挑战。除了当前的任务,还应该鼓励部门专业人员将他们的专门技术和专业知识从分化的、高度专业化的方向向全面的、多学科的方向拓展。 | Olli Varis 鲁春霞 | 1999 | AMBIO-人类环境杂志1999，28，7： | 7 |
| 3 | 人p100蛋白:可增强STAT6基因转录活性的新因子显示文摘目的 :建立可稳定表达人类p10 0蛋白的细胞株 ,研究细胞内p10 0蛋白参与STAT6介导的基因转录调控的机制。方法 :利用免疫共沉淀法检测蛋白与蛋白间结合 ,荧光素酶法测定STAT6基因转录活性。结果 :p10 0既可与STAT6结合 ,亦可与RNA多聚酶Ⅱ结合 ,并能增强STAT6介导的基因转录活性。结论 :p10 0蛋白是STAT6共激活因子 ,可桥连STAT6和基本转录调控元件 ,促进STAT6介导的基因转录活性。 | 杨洁 姚智 郁春艳 Olli Silvennoinen | 2004 | 中国免疫学杂志2004，20，11： | 6 |
| 4 | 高温环境中训练和比赛的共识性建议显示文摘高温环境中运动会引起体温调节和其它生理压力,继而可导致耐力运动能力的损害。本共识性声明的目的是提供最新的建议以使热环境中体育活动时的运动能力最优化。可用于降低热应激压力和优化运动能力的最重要干预方式是热习服,其应包括1~2周以上反复的运动—高温环境暴露。此外,运动员应在正常水合状态下开始比赛和训练,并将运动中的脱水最小化。随着商用降温系统(如降温背心)的发展,在高温环境中训练或比赛前,运动员可以采取降温策略来促进热的散发或提高蓄热能力。而且,赛事组织者应该设计大面积的遮阳区域,并提供降温和补水设施,按照最小化运动员的健康风险来安排赛事,尤其是在大众参与的赛事中及一年之中炎热天气开始之初。以最近的2008年奥运会和2014年国际足联世界杯为例,当比赛在高温环境中举行时,赛事主管机构应考虑在比赛中或比赛之间允许额外的(或更长的)恢复期以提供补水和降温的时机。 | Sébastien Racinais Juan-Manuel Alonso Aaron J.Coutts Andreas D.Flouris Olivier Girard José González -Alonso Christophe Hausswirth Ollie Jay Jason K.W.Lee Nigel Mitchell George P.Nassis Lars Nybo Babette M.Pluim Bart Roelands Michael N.Sawka Jonathan Wingo Julien D.Périard. 徐金成 高璨 赵杰修 | 2016 | 中国运动医学杂志2016，35，2： | 4 |
| 5 | Photocatalytic reduction of CO2 with H2O over modified TiO2 nanofibers: Understanding the reduction pathway显示文摘Nanosized 金属(磅或 Pd ) 装饰了 TiO 2 nanofibers (NF ) 被一个湿受精方法综合。CdSe 量点(QD ) 然后被抛锚到装饰金属的 TiO 2 NF 上。这些催化剂的 photocatalytic 表演在 UV-B 光下面为公司 2 的激活和减小被测试。煤气的色析法的分析作为主要产品显示了甲醇,蚁的酸,和甲基甲酸盐的形成。当 CdSe QD 不在时,装饰 Pd 的 TiO 2 NF 被发现为甲醇生产与装饰磅的 TiO 2 NF 相比展出提高的性能。面对 CdSe,然而,装饰磅的 TiO 2 NF 为甲醇展出了更高的选择,典型地生产 90 ppmg 1 祴愠潠 { 琠敨朠潲瑷 ? 楤敲瑣潩 ? 景琠敨渠湡牯摯 ? 桷捩 ? 獩爠畯桧祬 ??? S 吗?? | Anjana Sarkar Eduardo Gracia-Espino Thomas Wagberg Andrey Shchukarev Melinda Mohl Anne-Riikka Rautio Olli Pitkanen Tiva Sharifi Krisztian Kordas Jyri-Pekka Mikkola | 2016 | Nano Research2016，9，7： | 4 |
| 6 | A systems biological approach to identify key transcription factors and their genomic neighborhoods in human sarcomas显示文摘Identification of genetic signatures is the main objective for many computational oncology studies. The signature usually consists of numerous genes that are differentially expressed between two clinically distinct groups of samples, such as tumor subtypes. Prospectively, many signatures have been found to generalize poorly to other datasets and, thus, have rarely been accepted into clinical use. Recognizing the limited success of traditionally generated signatures, we developed a systems biology-based framework for robust identification of key transcription factors and their genomic regulatory neighborhoods. Application of the framework to study the differences between gastrointestinal stromal tumor (GIST) and leiomyosarcoma (LMS) resulted in the identification of nine transcription factors (SRF, NKX2-5, CCDC6, LEF1, VDR, ZNF250, TRIM63, MAF, and MYC). Functional annotations of the obtained neighborhoods identified the biological processes which the key transcription factors regulate differently between the tumor types. Analyzing the differences in the expression patterns using our approach resulted in a more robust genetic signature and more biological insight into the diseases compared to a traditional genetic signature. | Antti Ylipaa Olli Yli-Harja Wei Zhang Matti Nykter | 2011 | Chinese Journal of Cancer2011，30，1： | 3 |
| 7 | Early Repolarization: Electrocardiographic Phenotypes Associated With Favorable Long-Term Outcome显示文摘 | Jani T. Tikkanen M. Juhani Junttila Olli Anttonen Aapo L. Aro Samuli Luttinen Tuomas Kerola Solomon J. Sager Harri A. Rissanen Robert J. Myerburg Antti Reunanen Heikki V. Huikuri | 2011 | Circulation2011，，23： | 3 |
| 8 | Destruction of water contaminants 显示文摘 | OLLIS D F PELIZZETTI E SERPONE N | 1991 | Environ Sci Technol1991，25，9： | 2 |
| 9 | The significance of intensity of stroke: a controlled trial显示文摘 | Juhani S Kalevi P Olli PH | 1985 | Stroke1985，16，： | 2 |
| 10 | Association of Early Repolarization and Sudden Cardiac Death During an Acute Coronary Event显示文摘 | Jani T. Tikkanen Viktor Wichmann M. Juhani Junttila Meri Rainio Eeva Hookana Olli-Pekka Lappi Marja-Leena Kortelainen Olli Anttonen Heikki V. Huikuri | 2012 | Circulation: Arrhythmia and Electrophysiology2012，，4： | 2 |
| 11 | Viral pneumonia显示文摘 | Olli Ruuskanen Elina Lahti Lance C Jennings David R Murdoch | 2011 | 2011 (9773)2011，，9773： | 2 |
| 12 | MicroRNA in Prostate, Bladder, and Kidney Cancer: A Systematic Review <ce:link locator='eulogo1'/>显示文摘 | James W.F. Catto Antonio Alcaraz Anders S. Bjartell Ralph De Vere White Christopher P. Evans Susanne Fussel Freddie C. Hamdy Olli Kallioniemi Lourdes Mengual Thorsten Schlomm Tapio Visakorpi | 2011 | European Urology2011，，5： | 2 |
| 13 | Coactivator p100 protein enhances histone acetyltransferase activity of CBP显示文摘Human p100 protein consists of four repeated domains of staphylococcal nuclease (SN)-like domain, as well as a tudor (TD) domain thereafter. We have previously shown that the SN-like domain of p100 interacted with STAT6 and the large subunit of RNA pol II , resulting in the enhancement of STAT6-mediated gene transcriptional activation. Here, we show that SN-like domain also interacted with CREB binding protein (CBP) and directly enhanced the acetyl transferase activity of CBP on his tone. On the other hand, overexpression of CBP alone had no ability to significantly increase STAT6 dependent transcriptional activation, however, together with p100 protein, sufficiently enhanced the activation of transcription which was in line with the previous result that p100 protein bridged STAT6 with CBP. | JIE YANG HONG BAI Li JIE DONG JIE SHAO OLLI SILVENNOINEN ZHI YAO | 2006 | Journal of Microbiology and Immunology2006，4，1： | 2 |
| 14 | Cancer research in the era of next-generation sequencing and big data calls for intelligent modeling显示文摘We examine the role of big data and machine learning in cancer research.We describe an example in cancer research where gene-level data from The Cancer Genome Atlas(TCGA) consortium is interpreted using a pathway-level model.As the complexity of computational models increases,their sample requirements grow exponentially.This growth stems from the fact that the number of combinations of variables grows exponentially as the number of variables increases.Thus,a large sample size is needed.The number of variables in a computational model can be reduced by incorporating biological knowledge.One particularly successful way of doing this is by using available gene regulatory,signaling,metabolic,or context-specific pathway information.We conclude that the incorporation of existing biological knowledge is essential for the progress in using big data for cancer research. | Jari Yli-Hietanen Antti Ylipää Olli Yli-Harja | 2015 | Chinese Journal of Cancer2015，34，10： | 2 |
| 15 | 显示文摘 | Ollis DF | 1985 | Sci Technol1985，19，6： | 1 |
| 16 | Hormones and Breathing显示文摘 | Tarja Saaresranta Polo Olli | 2002 | Chest2002，122，6： | 1 |
| 17 | TiO2 photocatalyst deactivation by gas-phase oxidation of heteroatom organics显示文摘 | Jose Peral David F Ollis | 1997 | Journal of Molecular Cataysis A:Chemical1997，，115： | 1 |
| 18 | Benzene and toluene gas-phase photocatalytic degradation over H2O and HCl pretreated TiO2 by-products and mechanisms显示文摘 | Hennezel O Pichat P Ollis D F | 1998 | Photochem Photoboil Chem1998，118，： | 1 |
| 19 | Structure of TiO2 prepared by sol-gel显示文摘 | OLLIS D PELIZZETTI E SERPONEN | 1991 | Environ Sci Technol1991，25，9： | 1 |
| 20 | Probiotic lactobacilliin a semi-soft cheese survive in the simulated human gastrointestinaltract显示文摘 | MAKELAINEN H FORSSTEN S OLLI K | 2009 | International Dairy Journal2009，19，： | 1 |
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