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| 1 | Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1显示文摘AIM: To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS: The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed using a specialized ultrasound-based probe. Twelve type-1 diabetic patients with autonomic neuropathy and severe gastrointestinal symptoms and 12 healthy controls were studied. The geometry and biomechanical parameters (strain, tension/stress, and stiffness) were assessed. RESULTS: The diabetic patients had increased frequency of distension-induced contractions (6.0 ± 0.6 vs 3.3 ± 0.5, P < 0.001). This increased reactivity was correlated with the duration of the disease (P = 0.009). Impaired coordination of the contractile activity in diabetic patients was demonstrated as imbalance between the time required to evoke the first contraction at the distension site and proximal to it (1.5 ± 0.6 vs 0.5 ± 0.1, P = 0.03). The esophageal wall and especially the mucosa-submucosa layer had increased thickness in the patients (P < 0.001), and the longitudinal and radial compressive stretch was less in diabetics (P <0.001). The esophageal and duodenal wall stiffness and circumferential deformation induced by the distensions were not affected in the patients (all P > 0.14). CONCLUSION: The impaired contractile activity with an imbalance in the distension-induced contractions likely reflects neuronal abnormalities due to autonomic neuropathy. However, structural changes and remodeling of the gastrointestinal tract are also evident and may add to the neuronal changes. This may contribute to the pathophysiology of diabetic gut dysfunction and impact on future management of diabetic patients with gastrointestinal symptoms. | Jens BrΦndum FrΦkjΦr SΦren Due Andersen Niels EjskjΦr Peter Funch-Jensen AsbjΦrn Mohr Drewes Hans Gregersen | 2007 | World Journal of Gastroenterology2007，13，36： | 8 |
| 2 | Nonbismuth Quadruple (Concomitant) Therapy: Empirical and Tailored Efficacy versus Standard Triple Therapy for Clarithromycin‐Susceptible Helicobacter pylori and versus Sequential Therapy for Clarithromycin‐Resistant Strains显示文摘 | Javier Molina‐Infante Carmen Pazos‐Pacheco Gema Vinagre‐Rodriguez Belen Perez‐Gallardo Carmen Due?as‐Sadornil Moisés Hernandez‐Alonso Guadalupe Gonzalez‐Garcia Jose M. Mateos‐Rodriguez Miguel Fernandez‐Bermejo Javier P. Gisbert | 2012 | Helicobacter2012，，4： | 4 |
| 3 | WTO合作框架下的越南农产品市场显示文摘对于越南这样一个农业人口占70%,农业占GDP70%的国家来说,加入世界贸易组织无疑是柄双刃剑,机遇与挑战并存。 | 裴佑东 Bui Huu Due 任可 | 2009 | 中国市场2009，，4： | 2 |
| 4 | Towards a unified paradigm for sequence‐based identification of fungi显示文摘 | Urmas K?ljalg R. Henrik Nilsson Kessy Abarenkov Leho Tedersoo Andy F. S. Taylor Mohammad Bahram Scott T. Bates Thomas D. Bruns Johan Bengtsson‐Palme Tony M. Callaghan Brian Douglas Tiia Drenkhan Ursula Eberhardt Margarita Due?as Tine Grebenc Gareth W. Gri | 2013 | Mol Ecol2013，，21： | 2 |
| 5 | 不同基因型和营养对山羊生长性能、胴体品质及肉质的影响(英文)显示文摘【目的】探讨不同基因型和营养物质在改善老挝山羊的生长性能、胴体特征和肉质中的效果。【方法】采用2×2双因素试验,以本地山羊品种Lat为对照,对Lat与越南BachThao公山羊的杂交F(1BT×L)进行比较。从每个基因型中选择30头7月龄的成长公山羊并分成两组,其中一组采用传统饲喂方法即自由放牧,另一组采用改良饲喂方法,即放牧并任意采食木薯渣和矿物砖。试验期间测量山羊平均日增重(ADG),在后期每组选择3只山羊宰杀并测定胴体特性(胴体组成和初分切肉)、肉质(剪切力、肉色、pH、滴水损失率和蒸煮损失率)。【结果】杂交山羊F1的平均日增重(60.02g/头)明显高于本地山羊(38.45g/头),增幅为56.09%;饲喂补充木薯渣和矿物砖的山羊平均日增重(55.45g/头)则显著高于未添加对照组(43.02g/头),增幅为28.89%。杂交繁育和饲喂补充物对山羊胴体品质如屠宰率、前肢百分率、后肢百分率及胸肌率没有显著影响,但杂交F1山羊的脖子极显著大于本地山羊,而其腰腹部切口极显著小于本地山羊。在两种不同饲喂管理条件下,Lat和杂交F1山羊的肉质特性没有显著差异。【结论】老挝本地山羊Lat与BachThao公山羊杂交及在饲料中补充木薯渣和矿物砖,可提高山羊肉产量且对其肉质无任何负作用。 | NGUYEN Xuan Trach BOUNMY Phiovankham DO Due Luc | 2011 | 南方农业学报2011，42，7： | 2 |
| 6 | Androgens and esophageal cancer: What do we know?显示文摘Significant disparities exist between genders for the development and progression of several gastrointestinal(GI) diseases including cancer. Differences in incidence between men vs women for colon, gastric and hepatocellular cancers suggest a role for steroid sex hormones in regulation of GI carcinogenesis. Involvement of intrinsic gender-linked mechanisms is also possible for esophageal adenocarcinoma as its incidence is disproportionally high among men. However, the cause of the observed gender differences and the potential role of androgens in esophageal carcinogenesis remains unclear, even though the cancer-promoting role of androgen receptors(AR) shown in other cancers such as prostate and bladder suggests this aspect warrants exploration. Several studies have demonstrated expression of ARs in esophageal cancer. However, only one study has suggested a potential link between AR signaling and outcome- poorer prognosis. Two groups have analyzed data from cohorts with prostate cancer and one of these found a decreased incidence of esophageal squamous and adenocarcinoma after androgen deprivation therapy. However, very limited information is available about the effects of androgen and AR-initiated signaling on esophageal cancer cell growth in vitro and in vivo. Possible mechanisms for androgens/AR involvement in the regulation of esophageal cancer growth are considered, and the potential use of AR as a prognostic factor and clinical target is highlighted, although insufficient evidence is available to support clinical trials of novel therapies. As esophageal adenocarcinoma is a gender linked cancer with a large male predominance further studies are warranted to clarify the role of androgens and ARs in shaping intracellular signaling and genomic responses in esophageal cancer. | Olga A Sukocheva Bin Li Steven L Due Damian J Hussey David I Watson | 2015 | World Journal of Gastroenterology2015，21，20： | 2 |
| 7 | Targeting Dexamethasone to Macrophages in a Porcine Endotoxemic Model显示文摘 | Asger Granfeldt Christine Lodberg Hvas Jonas Heilskov Graversen Peter Astrup Christensen Mikkel Due Petersen Gabriela Anton Pia Svendsen Christoffer S?lling Anders Etzerodt Else T?nnesen S?ren Kragh Moestrup Holger Jon M?ller | 2013 | Critical Care Medicine2013，，11： | 2 |
| 8 | Skin rejuvenation using intense pulsed light-a randomized controlled splitface trial with blinded response evaluation显示文摘 | Hedelund L Due E Bjerring P | 2006 | Arch Dermatol2006，142，： | 1 |
| 9 | Characterization of Ba- cillus pmbiotics available for human use显示文摘 | Due le H Hong H A Barbosa T M | 2004 | Appl Environ Micro- biol2004，70，4： | 1 |
| 10 | Feature extraction methods for character recognition显示文摘 | Olvind Due Trier Anil K Jain Torfinn Taxt | 1996 | A Survey Pattem Recognition1996，29，4： | 1 |
| 11 | Dividing wall column structuredesign using response surface methodology 显示文摘 | van Due Long N Lee M | 2012 | Computersand Chemical Engineering2012，37，10： | 1 |
| 12 | Mutations in the P53 gene and protein expression of P53, MDM2 and P21waf1/cip1 in primary cervical carcinomas with no or low human papillomavirus load显示文摘 | Helland A Karlsen F Due EU | 1998 | Br J Cancer1998，78，1： | 1 |
| 13 | The real costs of outsourcing显示文摘 | | 1992 | Information Systems Management1992，9，： | 1 |
| 14 | Teaching medi ca1student Sthe SUbjeCt iVe g 1 Oba 1 a s se s sment显示文摘 | Due rk sen DR | 2002 | Nut rition2002，18，4： | 1 |
| 15 | Volatile organic components migrating from plastic (HDPE, PEX and PVC) into drinking water 显示文摘 | Skjevrak I Due A Gjerstad KO | 2003 | Water Res2003，37，： | 1 |
| 16 | An improved method of surgical pathology testing for onychomycosis显示文摘 | Nazarian RM Due B Deshpande A | 2012 | J Am Acad Dermatol2012，66，4： | 1 |
| 17 | B-type natriuretie peptide and renal function in the diagnosis of heart failure : ananalysis from the Breathing Not Properly Multinational Study 显示文摘 | MeCullough PA Due P Omland T | 2003 | Am J Kidney Dis2003，41，3： | 1 |
| 18 | The use of bacterialspore formers as probiotics显示文摘 | Hong H A Due L H Cutting S M | 2005 | FEMS Microbiology Re-views2005，29，4： | 1 |
| 19 | Taxonomic revision of Aspergillus section Clavati based on molecular,morpholog-ical and physiological data显示文摘 | Varga J Due M Frisvad J C | 2007 | Studies in Mycology2007，59，： | 1 |
| 20 | Uterine Rupture Secondary to the Use a Cook Balloon as Tamponade显示文摘 | Dueas-Garcia OF Young CA Mikhail M | 2010 | J Minima Invas Gynecol2010，17，6： | 1 |
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