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| 1 | 急性肾损伤诊断与分类专家共识显示文摘近几十来.临床和基础的研究工作者们针对急性肾功能衰竭(ARF)进行了广泛的研究,尽管我们在该疾病的生理和发病机制方面都取得了长足的进步,但如何将这些知识用于临床,改进ARF患者预后方面的工作却做得十分有限。ARF是由多种病因导致、可发生在各种临床情况之下(儿童或成人、门诊或住院、ICU或非ICU患者)的一种复杂的肾功能紊乱,其临床表现既可以是血肌酐水平的轻微升高,也可以是无尿性肾功能衰竭。 | RL Mehta JA Kellum S Shah B Molitoris C Ronco D Warnock A Levin 王欣 | 2006 | 中华肾脏病杂志2006，22，11： | 348 |
| 2 | 不同起始细胞数量对旋链角毛藻和中肋骨条藻种群竞争的影响显示文摘分析了起始细胞数对中肋骨条藻(Skeletonema costatum)和旋链角毛藻(Chaetoceros curvisetus)种群增长的影响。结果表明,单种培养的情况下,不同起始细胞数量对中肋骨条藻和旋链角毛藻种群细胞数有显著的影响,随起始细胞数的增加种群细胞数有增加的趋势。按不同接种比例进行混合培养,两种藻生长均受到抑制,而且中肋骨条藻降低的程度远大于旋链角毛藻。经计算,旋链角毛藻的种间竞争能力明显强于中肋骨条藻,抑制能力是中肋骨条藻抑制能力的11倍。 | 茅华 许海 刘兆普 MEHTA S K | 2008 | 海洋环境科学2008，27，5： | 14 |
| 3 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 4 | 血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂的使用与2019冠状病毒疾病检测阳性之间的关系显示文摘血管紧张素转换酶抑制剂(angiotensin-converting enzyme inhibitor,ACEI)和血管紧张素受体拮抗剂(angiotensin receptor blocker,ARB)在2019新型冠状病毒疾病(coronavirus disease 2019,COVID-19)全球大流行背景下的作用备受争议。此类药物是治疗一些慢性病的必须药物,有建议停止使用这些药物. | Mehta N KalraA Nowacki AS Anjewierden S Han Z Bhat p Rubio AEC Jacob M Procop GW Harrington S Milinovich A Svensson LG Jehi L Young JB Chung MK 周卫(译) 叶鹏(校) | 2020 | 中华高血压杂志2020，28，5： | 9 |
| 5 | Male infertility microsurgical training显示文摘Microsurgical 训练为专攻男不孕的泌尿科医师和临床的 andrologists 是必要的。在男不孕 microsurgery 的成功重重地依赖于外科医生的 microsurgical 技巧。提高 microsurgical 技巧的基于实验室的实践改进外科医生的信心,并且减少应力和操作时间,有益于病人和外科医生。这评论为设置一个 microsurgical 实验室开发并且提高合成的使用的 microsurgical 技巧和动物模型提供指南。新兴的技术的角色例如机器帮助 microsurgery,也被讨论。 | Akanksha Mehta Philip S Li | 2013 | Asian Journal of Andrology2013，15，1： | 8 |
| 6 | Anti-tumor activity of thalidomide in refractory multiple myeloma显示文摘 | Singhal S Mehta J Desikan R | | 0，，： | 8 |
| 7 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study显示文摘 | Shamir R Mehta Salim Yusuf Ron JG Peters Michel E Bertrand Basil S Lewis Madhu K Natarajan Klas Malmberg Hans-Jürgen Rupprecht Feng Zhao Susan Chrolavicius Ingrid Copland Keith AA Fox | 2001 | The Lancet . 2001 (9281)2001，，9281： | 4 |
| 8 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention:the PCI-CURE study显示文摘 | Mehta SR Yusuf S Peters RJ | | The Lancet0，，： | 3 |
| 9 | Recurrence of lymphangioleiomyomatosis: Nine years after a bilateral lung transplantation显示文摘Lymphangioleiomyomatosis(LAM) is a rare, slowly progressive lethal lung disease primary afflicting young women. LAM is characterized by proliferation of abnormal smooth muscle cells that target the lungs, causing cystic destruction and eventual respiratory failure leading to death. Recent ten year mortality due to end stage LAM has been reported to be approximately 10%-20%, but may vary. The decline in lung function in LAM is gradual, occurring at a rate of about 3% to 15% per year but can vary from patient to patient. But recently therapy with mammalian target of rapamycin(m TOR) inhibitors such as sirolimus has shown promising results in the stabilization of lung function and reduction of chylous effusions in LAM. Lung transplantation is a viable option for patients who continue to have decline in lung function despite m TOR therapy. Unique issues that may occur post-transplant in a recipient with LAM include development of chylous effusion and a risk of recurrence. We describe a case of LAM recurrence in a bilateral lung transplant recipient who developed histological findings of LAM nine years after transplantation. | Khawaja S Zaki Zahra Aryan Atul C Mehta Olufemi Akindipe Marie Budev | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 10 | Expression of genes that control core fucosylation in hepatocellular carcinoma: Systematic review显示文摘BACKGROUND Changes in N-linked glycosylation have been observed in the circulation of individuals with hepatocellular carcinoma. In particular, an elevation in the level of core fucosylation has been observed. However, the mechanisms through which core fucose is increased are not well understood. We hypothesized that a review of the literature and related bioinformatic review regarding six genes known to be involved in the attachment of core fucosylation, the synthesis of the fucosylation substrate guanosine diphosphate(GDP)-fucose, or the transport of the substrate into the Golgi might offer mechanistic insight into the regulation of core fucose levels.AIM To survey the literature to capture the involvement of genes regulating core Nlinked fucosylation in hepatocellular carcinoma METHODS The PubMed biomedical literature database was searched for the association of hepatocellular carcinoma and each of the core fucose-related genes and their protein products. We also queried The Cancer Genome Atlas Liver hepatocellular carcinoma(LIHC) dataset for genetic, epigenetic and gene expression changes for the set of six genes using the tools at cBioportal.RESULTS A total of 27 citations involving one or more of the core fucosylation-related genes(FPGT, FUK, FUT8, GMDS, SLC35 C1, TSTA3) and hepatocellular carcinoma were identified. The same set of gene symbols was used to query the371 patients with liver cancer in the LIHC dataset to identify the frequency of m RNA over or under expression, as well as non-synonymous mutations, copy number variation and methylation level. Although all six genes trended to moresamples displaying over expression relative to under-expression, it was noted that a number of tumor samples had undergone amplification of the genes of the de novo synthesis pathway, GMDS(27 samples) and TSTA3(78 samples). In contrast, the other four genes had undergone amplification in 2 or fewer samples.CONCLUSION Amplification of genes involved in the de novo pathway for generation of GDPfucose, GMDS and TSTA3, likely contributes to the elevated core fucose observed in hepatocellular carcinoma. | Pamela A Norton Anand S Mehta | 2019 | World Journal of Gastroenterology2019，25，23： | 3 |
| 11 | MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3显示文摘 | Joglekar MV Parekh VS Mehta s | | 0，，2： | 2 |
| 12 | Early and late effects of clopidogrel in patients with acute coronary syndromes显示文摘 | YUSUF S MEHTA S R ZHAO F | 2003 | Circulation2003，107，7： | 2 |
| 13 | Cardiac papillary fibroelastoma:The need for a timely diagnosis显示文摘Cardiac papillary fibroelastomas(CPFs) are the second most common primary cardiac tumors and the most common cardiac valvular tumors. Although they are histologically benign and usually asymptomatic, CPFs can lead to serious and life-threatening complications like myocardial infarction, stroke, pulmonary embolus, cardiac arrest etc. CPFs represent a rare entity in clinical medicine and literature regarding their management is limited. We report two cases which illustrate such complications arising from undiagnosed CPFs on the aortic valve. We further stress on the importance of identifying CPFs early so that they can be managed appropriately based on recommendations from the available literature. | Srikanth Yandrapalli Bella Mehta Pratik Mondal Tanush Gupta Pallavi Khattar John Fallon Randy Goldberg Sachin Sule Wilbert S Aronow | 2017 | World Journal of Clinical Cases2017，5，1： | 2 |
| 14 | Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation显示文摘 | Yusuf S Zhao F Mehta SR | | New England Journal of Medicine0，，： | 2 |
| 15 | Antitumor activity of thalidomide in refractory multiple myeloma显示文摘 | Singhal S Mehta J Desikan R | 1999 | N Engl J Med1999，341，21： | 1 |
| 16 | Noninvasive ventilation 显示文摘 | Mehta S Hill NS | 2001 | Am J respir Crit Care Med2001，163，： | 1 |
| 17 | Spectrum of acute renal failure in the intensive care unit : The PICARD experience 显示文摘 | Mehta RL Pascual MT Somko S | 2004 | Kidney lnt2004，66，4： | 1 |
| 18 | Marked anti-tumor effect from anti-angiogenesis therapy with thalidomide in high risk refractory multiple myeloma显示文摘 | Mehta J Eddiemon P | 1998 | Blood1998，92，1： | 1 |
| 19 | Noninvasive Ventilation显示文摘 | Mehta S Hill N S | 2001 | Am J Re2spir Crit Care Med2001，163，： | 1 |
| 20 | Detection and delineation of P and T waves in 12-lead electrocardiograms显示文摘 | MEHTA S LINGAYAT N SANGHVI S | 2009 | Expert Systems2009，26，： | 1 |
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