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| 1 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | 含酒精的肝炎的管理: 当前的概念显示文摘 Alcoholic hepatitis is a devastating form of acute liver injury seen in chronic alcohol abusers with significant morbidity and mortality.It is a multisystem disease that is precipitated by ingesting large quantities of alcohol with genetic and environmental factors playing a role.Prognostic criteria have been developed to predict disease severity and these criteria can serve as indicators to initiate medical therapy.Primary therapy remains abstinence and supportive care,as continued alcohol abuse is the most important risk factor for disease progression.The cornerstone of supportive care remains aggressive nutritional support,and although acute alcoholic hepatitis has been extensively studied,few specific medical therapies have been successful.Corticosteroids remain the most effective medical therapy available in improving short term survival in a select group of patients with alcoholic hepatitis;however,the long-term outcome of drug therapies is still not entirely clear and further clinical investigation is necessary.While liver transplantation for acute alcoholic hepatitis have demonstrated promising results,this practice remains controversial and has not been advocated universally,with most transplant centers requiring a prolonged period of abstinence before considering transplantation.Extracorporeal liver support devices,although still experimental,have been developed as a form of liver support to give additional time for liver regeneration.These have the potential for a significant therapeutic option in the future for this unfortunately dreadful disease. | Hetal A Karsan Samir Parekh | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 3 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 4 | Impact of gout on in-hospital outcomes of acute coronary syndrome-related hospitalizations and revascularizations: Insights from the national inpatient sample显示文摘BACKGROUND Previous studies have established a role of gout in predicting risk and prognosis of cardiovascular diseases. However, large-scale data on the impact of gout on inpatient outcomes of acute coronary syndrome (ACS)-related hospitalizations and post-revascularization is inadequate. AIM To evaluate the impact of gout on in-hospital outcomes of ACS hospitalizations, subsequent healthcare burden and predictors of post-revascularization inpatient mortality. METHODS We used the national inpatient sample (2010-2014) to identify the ACS and goutrelated hospitalizations, relevant comorbidities, revascularization and postrevascularization outcomes using the ICD-9 CM codes. A multivariable analysis was performed to evaluate the predictors of post-revascularization in-hospital mortality. RESULTS We identified 3144744 ACS-related hospitalizations, of which 105198 (3.35%) also had gout. The ACS-gout cohort were more often older white males with a higher prevalence of comorbidities. Coronary artery bypass grafting was required more often in the ACS-gout cohort. Post-revascularization complications including cardiac (3.2% vs 2.9%), respiratory (3.5% vs 2.9%), and hemorrhage (3.1% vs 2.7%) were higher whereas all-cause mortality was lower (2.2% vs 3.0%) in the ACSgout cohort (P < 0.001). An older age (OR 15.63, CI: 5.51-44.39), non-elective admissions (OR 2.00, CI: 1.44-2.79), lower household income (OR 1.44, CI: 1.17- 1.78), and comorbid conditions predicted higher mortality in ACS-gout cohort undergoing revascularization (P < 0.001). Odds of post-revascularization inhospital mortality were lower in Hispanics (OR 0.45, CI: 0.31-0.67) and Asians (OR 0.65, CI: 0.45-0.94) as compared to white (P < 0.001). However, postoperative complications significantly raised mortality odds. Mean length of stay, transfer to other facilities, and hospital charges were higher in the ACS-gout cohort. CONCLUSION Although gout was not independently associated with an increased risk of postrevascularization in-hospital mortality in ACS, it did increase postrevascularization complications. | Rupak Desai Tarang Parekh Hemant Goyal Hee Kong Fong Dipen Zalavadia Nanush Damarlapally Rajkumar Doshi Sejal Savani Gautam Kumar Rajesh Sachdeva | 2019 | World Journal of Cardiology2019，11，5： | 4 |
| 5 | 美洛昔康自纳米乳化颗粒的研制显示文摘美洛昔康(MLX)属于生物药剂学分类(BCS)Ⅱ类药物。为增加其溶解度和溶出速率、缩短起效时间,研制了载MLX的自纳米乳化颗粒(SNEGs)。 | Parekh VJ 王盈 | 2017 | 中国医药工业杂志2017，48，3： | 4 |
| 6 | Yoga and Qigong in the Psychological Prevention of Mental Health Disorders:A Conceptual Synthesis显示文摘学习建议探索为平衡整体的头脑身体并且因而的必要二部曲的药 therapies-qigong 和瑜伽为应力,无常,焦虑和消沉为一个答案提供的二种选择。质的研究方法被用来创造瑜伽和 qigong 的概念的合成。控制的一种增加的感觉是在这二种形式之间的接口,这被建议。qigong 和瑜伽的这概念的一致被认为是一选择,药品方法,为理想的生活的一张药方和人的本质存在的地面。而且,这本质被认为提高头脑鈥檚 自我规章过程并且阻止心理健康混乱。二其他的治疗能阻止象焦虑那样的心理健康混乱,消沉并且,最小化象应力和生活的差的质量那样的心理健康混乱。病人或顾客从这熔化装 benefifit,这被建议。关键词瑜伽 - qigong - 心理混乱 - | Paul Posadzki Sheetal Parekh Nel Glass | 2010 | Chinese Journal of Integrative Medicine2010，16，1： | 3 |
| 7 | 机器人辅助与腹腔镜子宫全切术对照研究显示文摘目的比较机器人辅助腹腔镜子宫全切术与腹腔镜子宫全切术用于良性疾病患者的手术结果。方法通过回顾病历审查机器人(41例)和与之匹配的腹腔镜(100例)患者行子宫全切术的手术结果,统计方法采用Fisher确切概率法及卡方检验。两组年龄(P=0.65)、体重指数(P=032)、妊娠次数(P=0.21)、既往盆腹腔手术(P=0.25)以及子宫大小(P=0.65)均相匹配。观察数据包括手术时间、术中出血量、并发症、术后住院时间。结果机器人组与腹腔镜组平均手术时间(82.51min、80.98min),平均出血量(55.05ml、73.25ml),术中并发症(0例、0例)术后并发症(2例、3例),住院天数超过2d(0例、0例),再住院及症状两组之间无显着差异。两组无1例转开腹手术。结论机器人组与腹腔镜组子宫全切术短期结果相似,长期结果并没有评估。机器人技术被成功地用于子宫切除术与腹腔镜组有相似的手术结果。 | 何晓琴 PAREKH MT | 2011 | 现代诊断与治疗2011，22，3： | 2 |
| 8 | MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3显示文摘 | Joglekar MV Parekh VS Mehta s | | 0，，2： | 2 |
| 9 | 机器人辅助腹腔镜子宫全切术41例报告显示文摘目的探讨机器人辅助腹腔镜子宫全切术的临床应用。方法全麻后取截石位,放置阴道环切环、子宫操纵器及阴道封堵球囊,准备数字电视摄像系统,确定一个内镜端口、2个器械端口及一个助手端口的位置并置入套管,自动操作仪器置于患者两腿间,对接自动操作仪器和内镜摄像臂,一侧端口安装双极电凝钳,一侧端口安装单极电剪。缝合时两侧端口均安装针持器。助手端口置入普通腔镜器械,由手术助手帮助暴露视野、吸引等协助动作。术者到控制台进行操作指挥机器臂完成手术。结果手术时间(82.5±9.5)m in,控制台操作时间(61.9±7.9)m in,对接时间(7.0±1.5)m in,出血量(55.0±12.8)m l。术中无并发症。术后并发症2例:1例血压高头晕给予对症治疗;1例术后第3天泌尿系感染,口服消炎药治愈。4例随访42 d无阴道流血及腹痛。结论机器人辅助腹腔镜子宫全切术方法安全可靠,并发症少,恢复快。 | 何晓琴 Mukesh Parekh | 2011 | 中国微创外科杂志2011，11，6： | 2 |
| 10 | Investigation of anticancer potencies of newly generated Schiff base imidazolylphenylheterocyclic-2-ylmethylenethiazole-2-amines显示文摘A new series of multi-heterocyclic Schiff base was constructed starting from 4'-(imidazol-1-yl[56_TD$IF])-acetophenone which was converted to its 2-bromoethanone precursor which on cyclic condensation with thiourea yielded final thiazol-2-amine intermediate(3) to be reacted with substituted aldehydes to generate final imidazolylphenylheterocyclic-2-ylmethylenethiazole-2-amines(4a–4i). New Schiff base was investigated for their in vitro cytotoxic efficacies against a panel of three human cancer cell lines namely, MCF7(human breast cancer), HCT116(human colon cancer), and DU145(human prostate cancer) and one normal skin fibroblast(SF). Most of these synthetic derivatives shown important cytotoxic actions against individual carcinoma cell line collections, but weak actions against SF, which is as anticipated. Observations of SAR suggested that the difference in the characteristics of substituents attached to the Schiff base function leads to the interesting variations within pharmacological effects of resultant molecular systems. Structural analysis performed using FT-IR,~1H NMR,^(13)C NMR spectroscopy and CHN analysis for final potent anticancer Schiff base, which warrant further investigations. | Nikhil M. Parekh Bhupendra M. Mistry Muthuraman Pandurangan Surendra K. Shinde Rahul V. Patel | 2017 | Chinese Chemical Letters2017，28，3： | 2 |
| 11 | A generalized processor sharing approach to flow control in integrated services networks:The single-node case显示文摘 | Parekh A K Gallager R G | 1993 | IEEE/ACM Transactions on Networking1993，1，3： | 2 |
| 12 | Comparison of HIV type 1 incidence observed during longitudinal follow-up with incidence estimated by cross-sectional analysis using the BED capture enzyme immunoassay显示文摘 | McDougal JS Parekh BS Peterson ML | 2006 | AIDS Res Hum Retroviruses2006，22，10： | 1 |
| 13 | Complications of esophageal resection and reconstruction显示文摘 | Parekh K Iannettoni MD | 2007 | Semin Thorac Cardiovasc Surg2007，19，1： | 1 |
| 14 | Quantitative detection of increasing HIV type 1 antibodies after seroconversion:a simple assay for detecting recent HIV infectiong and estimating incidence显示文摘 | Parekh BS Kennedy MS Dobbs T | 2002 | AIDS Res Hum retroviruses2002，18，： | 1 |
| 15 | Modal verification of a destructive test of a damaged prestressed concrete beam显示文摘 | Allbright K Parekh K Miller R | 1994 | Experimental Mechanics1994，34，4： | 1 |
| 16 | Quantitative detection of increasing HIV type 1 antibodies after seroconversion : a sim- ple assay for detecting recent HIV infection and estimating inci- dence显示文摘 | Parekh BS Kennedy MS Dobbs T | 2002 | AIDS Res Hum Retroviruses2002，18，： | 1 |
| 17 | Multiple pulp stones and shortened roots of unknown etiology显示文摘 | Parekh S Kyriazidou A Bloch-Zupan A | 2006 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2006，101，6： | 1 |
| 18 | Strain history and TGF 11 induce urinary bladder wall smooth muscle remodeling and elastogenesis 显示文摘 | HEISE RL PAREKH A JOYCE EM | 2012 | Biomech Model Mechanobiol2012，11，13： | 1 |
| 19 | Acetate production from glucose by Clos tridium thermoaceticum显示文摘 | PAREKH SR CHERYAN M | 1990 | Process Biochem1990，25，： | 1 |
| 20 | A generalized processor sharing approach to flow control in integrated services networks:the single-node case显示文摘 | Parekh A K Gallager R G | 1993 | IEEE/ACM Transactions on Networking1993，1，3： | 1 |
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