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| 1 | Review of the diagnosis,classification and management of autoimmune pancreatitis显示文摘Autoimmune pancreatitis(AIP)is a rare form of chronic pancreatitis,with as yet undetermined incidence and prevalence in the general population.Our understanding of it continues to evolve.In the last few years,2separate subtypes have been identified:type 1 AIP has been recognised as the pancreatic manifestation of a multiorgan disease,named immunoglobulin G4(IgG4)-related disease while type 2 AIP is a pancreas specific disorder not associated with IgG4.International criteria for the diagnosis of AIP have been defined:the HISORt criteria from the Mayo clinic,the Japan consensus criteria and,most recently,the international association of pancreatology'International Consensus Diagnostic Criteria'.Despite this,in clinical practice it can still be very difficult to confirm the diagnosis and differenti-ate AIP from a pancreatic cancer.There are no large studies into the long-term prognosis and management of relapses of AIP,and there is even less information at present regarding the Type 2 AIP subtype.Further studies are necessary to clarify the pathogenesis,treatment and long-term outcomes of this disease.Critically for clinicians,making the correct diagnosis and differentiating the disease from pancreatic cancer is of the utmost importance and the greatest challenge. | Derek A O'Reilly Deep J Malde Trish Duncan Madhu Rao Rafik Filobbos | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，2： | 14 |
| 2 | Investigation of hepatoprotective activity of Cyathea gigantea(Wall.ex.Hook.)leaves against paracetamol-induced hepatotoxicity in rats显示文摘Objective:To investigate the hepatoprotective activity of methanolic leaf extract of Cyathea gigantea(C.gigantea)against paracetamol induced liver damage in rats.Methods:The hepatoprotective activity for plant extract was investigated for paracetamol induced hepatoxicity in rats.Wislar albino rats of either sex were divided into five groups of 6 animals each and are given orally the following treatment for seven days.The normal control group was given 1%Na.CMC 1mL/kg bw,p.o.Paracetamol at dose of 1g/kg bw,p.o.was given as toxic dose for inducing hepatoloxicity.Silymarin(50mg/kg.p.o.) was given as reference standard.Two doses of C. gigantea extract i.e.,100 mg/kg.p.o.and 200 mg/kg,p.o.were tested for hepatoprotective activity. The treatment was given for seven days and after 24 h of last treatment blood was collected from retro-orbital plexus and analysed for various serum parameters like serum glutamic-oxaloacetic transaminase(SGOT),serum glutamic pyruvic transaminase(SGPT),alkaline phosphatase(ALP),total bilirubin(TB)and total protein(TP)in different groups.Results:The paracetamol intoxication lead to histological and biochemical deteriorations.The treatment with methanolic leaf extract of C.gigantea reduced the elevated levels of SCOT,SGPT,ALP,TB and also reversed the hepatic damage towards normal which further supports the hepatoprotective activity of leaf extract of C.gigantea.Conclusions:The methanolic extract of leaves of C.gigantea at doses of 100 mg/kg bw and 200 mg/kg bw have significant effect on liver of paracetamol induced hepatotoxicity model in rats. | P Madhu Kiran A Vijaya Raju B Ganga Rao | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 7 |
| 3 | Hidden Markov Models Incorporating Fuzzy Measures and Integrals for Protein Sequence Identification and Alignment显示文摘Profile hidden Markov models (HMMs) based on classical HMMs have been widely applied for protein sequence identification. The formulation of the forward and backward variables in profile HMMs is made under statistical independence as-sumption of the probability theory. We propose a fuzzy profile HMM to overcome the limitations of that assumption and to achieve an improved alignment for protein sequences belonging to a given family. The proposed model fuzzifies the forward and backward variables by incorporating Sugeno fuzzy measures and Choquet inte-grals, thus further extends the generalized HMM. Based on the fuzzified forward and backward variables, we propose a fuzzy Baum-Welch parameter estimation al-gorithm for profiles. The strong correlations and the sequence preference involved in the protein structures make this fuzzy architecture based model as a suitable candidate for building profiles of a given family, since the fuzzy set can handle uncertainties better than classical methods. | Niranjan P. Bidargaddi Madhu Chetty Joarder Kamruzzaman | 2008 | Genomics, Proteomics & Bioinformatics2008，6，2： | 6 |
| 4 | Antioxidant activity and identification of bioactive compounds from leaves of Anthocephalus cadamba by ultra-performance liquid chromatography/electrospray ionization quadrupole time of flight mass spectrometry显示文摘Objective:To evaluate the antioxidant potential of different extract/fractions of Anthocephalus cadamba(A.cadamba)(Roxb.) Miq.(Rubiaceae) and study the tentative identification of their active constituents.Methods:The extract/fractions were screened for antioxidant activity using various in vitro assays viz.DPPH assay,ABTS assay,superoxide anion radical scavenging assay, reducing power assay and plasmid DNA nicking assay.Total phenolic content of extract/fractions was determined by colorimetric method.An ultra-performance LC-electrospray-quadrupoletime of flight mass spectrometry method was used to analyse the active constituents of extract/ fractions of A.cadamba.Results:The ethyl acetate fraction was found to be most active fraction in all the assays as compared to other extract/fractions.The IC50 value of ethyl acetate fraction (ETAC fraction) was 21.24μg/mL,1.12μg/mL,9.68μg/mL and S7.81μg/mL in DPPH assay, ABTS assay,reducing power assay and superoxide scavenging assay respectively.All the extract/ fractions also showed the potential to protect the plasmid DNA(pBR322) against the attack of hydroxyl radicals generated by Fenton’s reagent.The bioactive compounds were identified by UPLC-ESI-QTOF-MS,by comparing the mass andλmax with literature values.Conclusions:The potential of the extract/fractions to scavenge different free radicals in different systems indicated that they may be useful therapeutic agents for treating radical-related pathologic damage. | Madhu Chandel Upendra Sharma Neeraj Kumar Bikram Singh Satwinderjeet Kaur | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 6 |
| 5 | Low velocity impact studies of E-glass/epoxy composite laminates at different thicknesses and temperatures显示文摘Low velocity impact experiments were carried out on E-glass/epoxy composite laminates having varying thicknesses at sub zero and elevated temperatures using hemi spherical steel impactor of 16 mm diameter with impact energies in the rage of 50-150 J.The performance of the laminates was assessed in terms of energy absorption,maximum displacement,peak force and failure behaviour.Results indicated that the effect of temperature on energy absorption of the laminate is negligible although the laminates are embrittling at sub zero temperatures.However it has influence on failure behaviour and displacement.Peak force has increased linearly with increase in laminate thickness from 5 to 10 mm.However it got reduced by 25% when temperature was increased from-20℃ to 100℃,Based on experimental results,laminate perforation energies were predicted using curve fitting equations.Statistical analysis was carried out using Taguchi method to identify the global effects of various parameters on laminate performance and confirmed that the laminate thickness has significant influence as compared to temperature,for the studied range. | T.Sreekantha Reddy P.Rama Subba Reddy Vemuri Madhu | 2019 | Defence Technology(防务技术)2019，15，6： | 5 |
| 6 | 氧化铝对铁矿石烧结质量和生产率的影响(英文)显示文摘烧结矿是现代高炉生产的主要含铁原料。合理控制入炉烧结矿的理化性能与冶金性能对高炉生产和稳定操作是很必要的。铁矿粉是烧结矿的主要原料,其化学成分和烧结料层内的热量条件在烧结过程中起着重要的作用。化学成分等参数也决定着烧结矿矿相结构和质量。由于含氧化铝原料的低反应性及其液相的高粘性,因此在人们的预料中高铝矿石对烧结矿结构组成的影响并不好。烧结混合料中的氧化铝在同化过程中需要消耗大量热量,延迟烧结过程。在确保高炉渣的流动性方面,氧化铝也需要消耗较大热量。不论是烧结还是高炉的生产实绩均表明,氧化铝是有害的。一般而言,高含铁量与低脉石的印度矿与其他矿石的不同特点就是氧化铝含量高。由于高品味铁矿石的消耗殆尽,使用可利用的烧结原料成为生产必需。因此,必须要掌握氧化铝的作用及其对烧结矿质量和生产过程的影响。实验室完成了不同氧化铝含量水平(2.00%~5.46%)的实验,可从中了解氧化铝在烧结矿矿物学、生产率、物理性能和冶金性能方面的影响。随着烧结矿中氧化铝含量的增加,残存赤铁矿、复合铁酸钙(SFCA)和孔隙率增加,而磁铁矿和硅酸盐比例下降。烧结生产率和烧结矿转鼓强度(TI)随着氧化铝含量上升而下降,反映烧结矿冶金性能的诸如低温还原粉化率(RDI)和还原率(RI)提高。 | T Umadevi S Prakash U K Bandopadhyay P C Mahapatra M Prabhu Madhu Ranjan | 2010 | 世界钢铁2010，，1： | 4 |
| 7 | Approaches for Optimal Planning of Energy Storage Units in Distribution Network and Their Impacts on System Resiliency显示文摘In the recent decade,a significant increase in the penetration level of renewable energy sources(RESs)into the distribution grid is evident due to the world’s shift towards clean energy and to increase the reliability or inboard manner resiliency of electrical distribution system.RES based microgrids are the most favorable option available,especially to enhance resiliency.However,the integration of RES over the distribution grid would hamper the grid stability due to its stochastic nature under normal conditions.During extreme weather conditions,RES behavior is completely uncertain.Hence there is a need to eliminate the adverse effects caused by the RES and make the distribution grid more reliable and stable under normal and resilient conditions.To address these issues,many researchers proposed several methods to place energy storage units(ESUs)and microgrids(RES integrated),which can support critical loads at an optimal location in the distribution system during normal and extreme conditions,respectively.The aim of this article is to consolidate and review the research towards various approaches to formulate the problem(optimal location,allocation,and operation of ESU and microgrids to face regular and extreme weather condition)and tools to solve it for enhanced system flexibility and resiliency.Based on the review,a generalized methodology has been designed to adapt the inputs and address both conditions.At the end of the review,future aspects for ESU to strengthen resistance and resiliency of its own are presented,which can be helpful to further improve the reliability and resiliency of the distribution system. | Balaji Venkateswaran V Devender K.Saini Madhu Sharma | 2020 | CSEE Journal of Power and Energy Systems2020，6，4： | 4 |
| 8 | Growth performance, and enteric and manure greenhouse gas emissions from Murrah calves fed diets with different forage to concentrate ratios显示文摘The present study investigated the effects of different dietary forage to concentrate ratios on animal performance, and enteric and manure greenhouse gas emissions in growing calves.Fifteen male Murrah calves(153.5 ± 18.17 kg; 6 to 12 months) were randomly assigned to 3 dietary treatments and fed corn fodder, wheat straw and concentrate in 3 different proportions: 20:60:20(C20); 20:40:40(C40) and 10:30:60(C60), for a period of 120 days.Increasing dietary concentrate proportion had no significant(P > 0.05) effect on dry matter intake(DMI) but increased crude protein(CP) and total digestible nutrient intake(P < 0.05).Average daily gain and feed conversion efficiency were significantly higher(P < 0.05)for C60 compared with C20 and for C40, these did not differ with C20 and C60(P > 0.05).The apparent digestibility of dry matter, organic matter and CP were higher(P < 0.05), but acid detergent fiber digestibility was lower(P < 0.05) for C60 compared with C20 whereas, ether extract and neutral detergent fiber digestibilities were not affected(P > 0.05).Daily methane(CH_4) emission(g/d), CH_4 energy loss(MJ/d) and CH_4 yield(CH_4 g/kg organic matter intake [OMI], CH_4 g/kg digestible OMI, and CH_4% of metabolizable energy intake) were significantly higher for C20 compared with C60(P < 0.05).Methane yield as g/kg DMI although lower for C60 compared with C20 but the difference was not significant(P > 0.05).Manure CH_4(g/kg DMI) and nitrous oxide(N_2O mg/kg nitrogen) emissions were not affected(P > 0.05), but N_2O emission on mg/kg DM basis was significantly higher(P < 0.05) from the manure of calves fed C60 than that for C20.Thus, increasing dietary concentrate proportion improved animal performance, and reduced enteric CH_4 emission(g/day) without any significant effect on manure N_2O(mg/kg nitrogen) and CH_4 emissions. | Vinu M.Nampoothiri Madhu Mohini Bilal A.Malla Goutam Mondal Sujata PANDita | 2018 | Animal Nutrition2018，，2： | 4 |
| 9 | Impact of the source and serial passaging of goat mesenchymal stem cells on osteogenic differentiation potential:implications for bone tissue engineering显示文摘Background: Adult mesenchymal stem cells(MSCs) can be conveniently sampled from bone marrow, peripheral blood, muscle, adipose and connective tissue, harvested from various species, including, rodents, dogs, cats, horses,sheep, goats and human beings. The MSCs isolated from adult tissues vary in their morphological and functional properties. These variations are further complicated when cells are expanded by passaging in culture. These differences and changes in MSCs must be considered prior to their application in the clinic or in a basic research study. Goats are commonly used as animal models for bone tissue engineering to test the potential of stem cells for bone regeneration. As a result, goat MSCs isolated from bone marrow or adipose tissue should be evaluated using in vitro assays, prior to their application in a tissue engineering project.Results: In this study, we compared the stem cell properties of MSCs isolated from goat bone marrow and adipose tissue. We used quantitative and qualitative assays with a focus on osteogenesis, including, colony forming unit, rate of cell proliferation, tri-lineage differentiation and expression profiling of key signal transduction proteins to compare MSCs from low and high passages. Primary cultures generated from each source displayed the stem cell characteristics,with variations in their osteogenic potentials. Most importantly, low passaged bone marrow MSCs displayed a significantly higher and superior osteogenic potential, and hence, will be the preferred choice for bone tissue engineering in future in vivo experiments. In the bone marrow MSCs, this process is potentially mediated by the p38 MAPK pathway. On the other hand, osteogenic differentiation in the adipose tissue MSCs may involve the p44/42 MAPK pathway.Conclusions: Based on these data, we can conclude that bone marrow and fat-derived MSCs undergo osteogenesis via two distinct signaling pathways. Even though the bone marrow MSCs are the preferred source for bone tissue engineering, the adipose tissue MSCs are an attractive alternative source and undergo osteo-differentiation differently from the bone marrow MSCs and hence, might require a cell-based enhancer/inducer to improve their osteogenic regenerative capacity. | Hoda Elkhenany Lisa Amelse Marc Caldwell Ramadan Abdelwahed Madhu Dhar | 2016 | Journal of Animal Science and Biotechnology2016，7，4： | 4 |
| 10 | Role of angiotensin converting enzyme and angiotensinogen gene polymorphisms in angiotensin converting enzyme inhibitor-mediated antiproteinuric action in type 2 diabetic nephropathy patients显示文摘AIM To investigate the role of genetic variants of angiotensin converting enzyme(ACE) and angiotensinogen(AGT) genes in the antiproteinuric efficacy of ACE inhibitor therapy in diabetic nephropathy(DN) patients.METHODS In the present study, 270 type 2 diabetes mellitus patients with nephropathy were enrolled and treated with ACE inhibitor(ramipril) and followed at 6 mo for renal function and albumin excretion by estimating serum creatinine, end stage renal disease, and albumin/creatinine ratio(ACR) in urine. Genotyping of ACE I/D and AGT M235 T polymorphisms were performed by using primer specific polymerase chain reaction(PCR) and PCR-RFLP techniques, respectively. RESULTS Forty-eight percent of DN patients(responders) benefited with respect to proteinuria from ACE inhibitor therapy at 6 mo follow-up. A significant reduction in ACR was observed after 6 mo treatment with ACE inhibitor irrespective of whether DN patients were micro-albuminuric(≥ 30 and < 300 mg/g creatinine) or macro-albuminuric(≥ 300 mg/g creatinine) at the time of enrollment. However, macro-albuminuric patients(55%) showed better response to therapy. A reduction in urinary ACR was found independent of genotypes of ACE I/D and AGT M235 T polymorphisms although macro-albuminuric patients having TT genotype showed statistically insignificant increased response(72%). CONCLUSION ACE inhibitor therapy reduced urinary ACR by ≥ 30% in 50% of DN patients and the response is independent of ACE I/D and AGT M235 T polymorphisms. | Neerja Aggarwal Pawan Kumar Kare Parul Varshney Om Prakash Kalra Sri Venkata Madhu Basu Dev Banerjee Anil Yadav Alpana Raizada Ashok Kumar Tripathi | 2017 | World Journal of Diabetes2017，8，3： | 4 |
| 11 | Acclimatization of in Vitro-derived Dendrobium显示文摘The successful ex vitro establishment of Dendrobium plantlets raised in vitro determines the quality of the end product(cut flowers or potted plants) in commercial production for economic gain. When in vitro Dendrobium plantlets are transplanted from the culture room to greenhouse conditions, they may desiccate or wilt rapidly and can die as a result of changes in the environment, unless substantial precautions are taken to adapt plantlets to a new environment. The acclimatization of in vitro-grown Dendrobium plantlets to an ex vitro environment by gradually weaning them towards ambient relative humidity and light levels facilitates better survival of young and physiologically sensitive plantlets.Dendrobium plantlets raised in vitro must thus undergo a period of acclimatization or transitional development to correct anatomical abnormalities and to enhance their physiological performance to ensure survival under ex vitro conditions. The most common approach to improve the survival of Dendrobium plantlets upon transfer to an ex vitro environment is their gradual adaptation to that environment. Under such conditions, plants convert rapidly from a heterotrophic or photomixotrophic state to an autotrophic growth, develop a fully functional root system,and better control their stomatal and cuticular transpiration. Gradual adaptation is carried out in a greenhouse by decreasing relative humidity using fog or mist chambers and by increasing light intensity using shading techniques. This review details the acclimatization and ex vitro survival of Dendrobium plants produced in vitro. This advice is also useful for other orchids. | Jaime A.Teixeira da Silva Mohammad Musharof Hossain Madhu Sharma Judit Dobránszki Jean Carlos Cardoso ZENG Songjun | 2017 | Horticultural Plant Journal2017，3，3： | 4 |
| 12 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study显示文摘 | Shamir R Mehta Salim Yusuf Ron JG Peters Michel E Bertrand Basil S Lewis Madhu K Natarajan Klas Malmberg Hans-Jürgen Rupprecht Feng Zhao Susan Chrolavicius Ingrid Copland Keith AA Fox | 2001 | The Lancet . 2001 (9281)2001，，9281： | 4 |
| 13 | Non-alcoholic fatty liver and chronic kidney disease:Retrospect,introspect,and prospect显示文摘With the growing prevalence of obesity and diabetes in the United States and across the world,a rise in the overall incidence and prevalence of non-alcoholic fatty liver disease(NAFLD)is expected.The risk factors for NAFLD are also associated with the development of chronic kidney disease(CKD).We review the epidemiology,risk factors,genetics,implications of gut dysbiosis,and specific pathogenic mechanisms linking NAFLD to CKD.Mechanisms such as ectopic lipid accumulation,cellular signaling abnormalities,and the interplay between fructose consumption and uric acid accumulation have led to the emergence of potential therapeutic implications for this patient population.Transplant evaluation in the setting of both NAFLD and CKD is also reviewed.Potential strategies for surveillance and management include the monitoring of comorbidities,the use of non-invasive fibrosis scoring systems,and the measurement of laboratory markers.Lastly,we discuss the management of patients with NAFLD and CKD,from preventative measures to experimental interventions. | Rajiv Heda Masahiko Yazawa Michelle Shi Madhu Bhaskaran Fuad Zain Aloor Paul J Thuluvath Sanjaya K Satapathy | 2021 | World Journal of Gastroenterology2021，27，17： | 3 |
| 14 | Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity显示文摘In this study,three new germacranolide sesquiterpenes(1–3),together with six related known analogues(4–9)were isolated from the whole plant of Carpesium cernuum.Their structures were established by a combination of extensive NMR spectroscopic analysis,HR-ESIMS data,and ECD calculations.The anti-leukemia activities of all compounds towards three cell lines(HEL,KG-1a,and K562)were evaluated in vitro.Compounds 1–3 exhibited moderate cytotoxicity with IC50 values ranging from 1.59 to 5.47μmol·L^(−1).Mechanistic studies indicated that 2 induced apoptosis by decreasing anti-apoptotic protein Bcl-2 and activating the caspase family in K562 cells.These results suggest that compound 2 is a potential anti-leukemia agent. | YAN Chen LONG Qun ZHANG Yun-Dong BABU Gajendran KRISHNAPRIYA Madhu Varier QIU Jian-Fei SONG Jing-Rui RAO Qing YI Ping SUN Mao LI Yan-Mei | 2021 | Chinese Journal of Natural Medicines2021，19，7： | 3 |
| 15 | Human-carnivore conflict in China: a review of current approaches with recommendations for improved management显示文摘Human-wildlife conflict(HWC)is a conservation concern that increasingly threatens the continued existence of some of the world’s most endangered species.With an increase in human population,urban sprawl and subsequent encroachment on wild land,human and wildlife interaction has become inevitable.In the majority of cases,this interaction results in a negative outcome for humans,wildlife or both.In China,these key elements,along with a decrease in wild prey species,have resulted in the expansion of HWC encounters,and the need for alleviating this conflict has become a conservation priority.Loss of human life,livestock and/or crops is most often the catalysts that fuel HWC.Techniques to alleviate conflict around the world have included preventative measures and mitigation techniques,such as financial compensation and other incentive programs.Both types of measures have had variable success.We review the current status of human-carnivore conflict management in China,and,drawing lessons from around the globe,we make recommendations for improving conservation management in China.For example,an increase in law enforcement in nature reserves is vital to reducing human disturbance in prime carnivore habitat,thereby reducing conflict encounters.Also,modifications to current wildlife compensation programs,so that they are linked with preventative measures,will ensure that moral hazards are avoided.Furthermore,investigating the potential for a community self-financed insurance scheme to fund compensation and increasing efforts to restore wild prey populations will improve the outcome for wildlife conservation.Ultimately,HWC management in China will greatly benefit from an integrative approach. | Melissa PETTIGREW Yan XIE Aili KANG Madhu RAO John GOODRICH Tong LIU Joshua BERGER | 2012 | Integrative Zoology2012，7，2： | 3 |
| 16 | The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-lp transcription and processing in monocytes显示文摘 | Ankita Singh Vishal Singh Rajiv L. Tiwari Tulika Chandra Ashutosh Kumar Madhu Dikshit Manoj K. Barthwal | 2016 | Cellular & Molecular Immunology2016，13，6： | 3 |
| 17 | Suppression of monosodium urate crystal-induced inflammation by inhibiting TGF-β-activated kinase 1-dependent signaling:role of the ubiquitin proteasome system显示文摘Monosodium urate(MSU)crystals activate inflammatory pathways that overlap with interleukin-1β(IL-1β)signaling.However,the post-translational mechanisms involved and the role of signaling proteins in this activation are unknown.In the present study,we investigated the intracellular signaling mechanisms involved in MSU-induced activation of THP-1 macrophages and human nondiseased synovial fibroblasts(NLSFs)and the in vivo efficacy of an inhibitor of tumor grovArth factor-β(TGF-β)-activated kinase 1(TAK1),5Z-7-oxozeaenoI,in MSU-induced paw inflammation in C57BL76 mice.THP-1 macrophage activation with MSU crystals(25-200 ng/ml)resulted in the rapid and sustained phosphorylation of interleukin-1 receptor-activated kinase 1(IRAK1 Thr^(209))and TAK1(Thr^(184/187))and their association with the E3 ubiquitin ligase TRAF6.At the cellular level,MSU inhibited the deubiquitinases A20 and UCHL2 and increased 20s proteasomal activity,leading to a global decrease in K^(63)-linked ubiquitination and increase in K^(48)-linked ubiquitination in THP-1 macrophages.While MSU did not stimulate cytokine produaion in NLSFs,it significantly amplified IL-1β-induced IL-6,IL-8,and ENA-78/CXCL5 production.Docking studies and MD simulations followed by TAK1 in vitro kinase assays revealed that uric acid molecules are capable of arresting TAK1 in an active-state conformation,resulting in sustained TAK1 kinase activation.Importantly,MSU-induced proinflammatory cytokine production was completely inhibited by 5Z-7-oxozeaenol but not IRAK1/4 or TRAF6 inhibitors.Administration of 5Z-7-oxozeaenol(5 or 15 mg/kg;orally)significantly inhibited MSU-induced paw inflammation in C57BL/6 mice.Our study identifies a novel post-translational mechanism of TAK1 activation by MSU and suggests the therapeutic potential of TAK1 in regulating MSU-induced Inflammation. | Anil K.Singh Mahamudul Haque Kayla O'Sullivan Mukesh Chourasia Madhu M.Ouseph Salahuddin Ahmed | 2021 | Cellular & Molecular Immunology2021，18，1： | 2 |
| 18 | Atrial fibrillation ablation in patients with gastroesophageal reflux disease or irritable bowel syndrome—the heart to gut connection!显示文摘 | Yeruva Madhu Reddy Dhssraj Singh Darbhamulla Nagarajan Jayasree Pillarisetti Mazda Biria Hemant Boolani Martin Emert Vineela Chikkam Kay Ryschon James Vacek Sudha Bommana Donita Atkins Atul Verma Mojtaba Olyaee Buddhadeb Dawn Dhanunjaya Lakkireddy | 2013 | Journal of Interventional Cardiac Electrophysiology2013，，3： | 2 |
| 19 | The Value of Peritoneal Cytology as a Preoperative Predictor in Patients With Gastric Carcinoma Undergoing a Curative Resection显示文摘 | David Bentrem Andrew Wilton Madhu Mazumdar Murray Brennan Daniel Coit | 2005 | Annals of Surgical Oncology2005，，： | 2 |
| 20 | Comparative study of endoscopy vs.transjugular intrahepatic portosystemic shunt in the management of gastric variceal bleeding显示文摘Background and Aim:Gastric varices are associated with high mortality.There have been conflicting reports on whether endoscopic treatment with cyanoacrylate or the placement of a transjugular intrahepatic portosystemic shunt(TIPS)is more effective in the treatment of gastric varices.We compared the outcomes of patients treated with cyanoacrylate glue or TIPS for the management of acute gastric variceal bleeding.Methods:The study was designed as a retrospective cohort analysis of patients undergoing either TIPS or endoscopic treatment with cyanoacrylate for acute gastric variceal bleeding at our institution from 2001 to 2011.Primary compared to studied between the two treatment modalities were the short-term treatment outcomes,including re-bleeding within 30 days,length of hospital stay and in-hospital mortality.Kaplan-Meier survival analysis was performed to assess factors associated with in-hospital mortality.Results:A total of 169 patients were included in the analysis.The TIPS arm contained 140 patients and the cyanoacrylate arm contained 29 patients.There was no evidence to suggest any significant differences in demographics or disease severity.There were no differences between the TIPS arm and the cyanoacrylate armtwo groups in treatment outcomes including re-bleeding within 30 days(17.4%vs.17.2%;P=0.98),median length of stay in the hospital(4.5 days vs.6.0 days;P紏0.35)or in-hospital mortality(9.0%vs.11.1%;P=0.74).In-hospital mortality was evaluated for 149 patients and lower albumin(P=0.015),higher MELD score(P<0.001),higher CTP score(P=0.005)and bleeding(P=0.008)were all significantly associated with in-hospital death.Conclusion:These findings suggest that both treatments are equally effective.Cyanoacrylate offers a safe,effective alternative to TIPS for gastric varices,and physician may choose the best therapy for each patient,factoring in the availability of TIPS or cyanoacrylate,the individual patient’s presentation,and cost. | Gursimran Singh Kochhar Udayakumar Navaneethan Jason Hartman Jose Mari Parungao Rocio Lopez Ranjan Gupta Baljendra Kapoor Paresh Mehta Madhu Sanaka | 2015 | Gastroenterology Report2015，3，1： | 2 |
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