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| 1 | 评估大气细颗粒物暴露引起的全球疾病负担的一个综合风险函数显示文摘[背景]评估由于环境空气中细颗粒物(PM2.5)长期暴露引起的疾病负担,需要了解相对风险度(RR)函数的图形和幅度。然而,在世界上很多观察到高PM2.5环境浓度的地方,都缺乏足够的直接证据确定死亡RR函数的图形。[目的]建立可用于全球PM2.5暴露范围内成人死因的RR函数:缺血性心脏病(IHD)、脑血管疾病(脑卒中)、慢性阻塞性肺病(COPD)和肺癌(LC)。建立急性下呼吸道感染(ALRI)发病的RR函数,用于估算〈5岁的儿童中死亡率和健康生活损失年数。[方法]通过整合现有的来自于环境空气污染(AAP)、二手烟草烟雾、家用固体烹饪用燃料和主动吸烟(AS)等研究的RR信息,拟合综合暴露-反应(IER)模型。采用颗粒物质的吸入剂量,通过转化AS暴露来估计全年PM2.5的暴露当量。在估算全球环境PM2.5浓度的基础上,得出各国的人群归因分数(PAFs)。[结果]与以往负担评估中使用的其他7种模型相比,IER模型是一种优越的RR预测方法。在不同国家中,归因于AAP暴露的PAF百分数各不相同,分别为:IHD,2~41;脑卒中,1~43;COPD,〈1~21;LC,〈1~25;ALRI,〈1~38。[结论]我们建立了一种以细颗粒物为基础的RR模型,它通过整合来自不同类型的燃烧所产生颗粒物排放的RR信息,涵盖全球范围的暴露。当获得新的RR信息时,可以对这个模型进行更新。 | Richard T.Burnett C.Arden Pope III Majid Ezzati Casey Olives Stephen S.Lim Sumi Mehta Hwashin H.Shin Gitanjali Singh Bryan Hubbell Michael Brauer H.Ross Anderson Kirk R.Smith John R.Balmes Nigel G.Bruce Haidong Kan Francine Laden Annette Prüss-Ustün Michelle C.Turner Susan M.Gapstur W.Ryan Diver Aaron Cohen 何蓉 张伊人 金泰廙 | 2014 | 环境与职业医学2014，31，11： | 80 |
| 2 | 血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂的使用与2019冠状病毒疾病检测阳性之间的关系显示文摘血管紧张素转换酶抑制剂(angiotensin-converting enzyme inhibitor,ACEI)和血管紧张素受体拮抗剂(angiotensin receptor blocker,ARB)在2019新型冠状病毒疾病(coronavirus disease 2019,COVID-19)全球大流行背景下的作用备受争议。此类药物是治疗一些慢性病的必须药物,有建议停止使用这些药物. | Mehta N KalraA Nowacki AS Anjewierden S Han Z Bhat p Rubio AEC Jacob M Procop GW Harrington S Milinovich A Svensson LG Jehi L Young JB Chung MK 周卫(译) 叶鹏(校) | 2020 | 中华高血压杂志2020，28，5： | 9 |
| 3 | Healthcare utilization and costs associated with gastroparesis显示文摘AIM To use a national database of United States hospitals to evaluate the incidence and costs of hospital admissions associated with gastroparesis.METHODS We analyzed the National Inpatient Sample Database(NIS)for all patients in whom gastroparesis(ICD-9 code:536.3)was the principal discharge diagnosis during the period,1997-2013.The NIS is the largest publicly available all-payer inpatient care database in the United States.It contains data from approximately eight million hospital stays each year.The statistical significance of the difference in the number of hospital discharges,length of stay and hospital costs over the study period was determined by regression analysis.RESULTS In 1997,there were 3978 admissions with a principal discharge diagnosis of gastroparesis as compared to16460 in 2013(P<0.01).The mean length of stay for gastroparesis decreased by 20%between 1997 and 2013from 6.4 d to 5.1 d(P<0.001).However,during this period the mean hospital charges increased significantly by 159%from$13350(after inflation adjustment)per patient in 1997 to$34585 per patient in 2013(P<0.001).The aggregate charges(i.e.,'national bill') for gastroparesis increased exponentially by 1026%from$50456642±4662620 in 1997 to$568417666±22374060 in 2013(P<0.001).The percentage of national bill for gastroparesis discharges(national bill for gastroparesis/total national bill)has also increased over the last 16 years(0.0013%in 1997 vs 0.004%in2013).During the study period,women had a higher frequency of gastroparesis discharges when compared to men(1.39/10000 vs 0.9/10000 in 1997 and 5.8/10000vs 3/10000 in 2013).There was a 6-fold increase in the discharge diagnosis of gastroparesis amongst type 1 DM and 3.7-fold increase amongst type 2 DM patients over the study period(P<0.001).CONCLUSION The number of inpatient admissions for gastroparesis and associated costs have increased significantly over the last 16 years.Inpatient costs associated with gastroparesis contribute significantly to the national healthcare bill.Further research on cost-effective evaluation and management of gastroparesis is required. | Vaibhav Wadhwa Dhruv Mehta Yash Jobanputra Rocio Lopez Prashanthi N Thota Madhusudhan R Sanaka | 2017 | World Journal of Gastroenterology2017，23，24： | 3 |
| 4 | Eu(Ⅲ) Indirect Probe to Investigate Interaction of DOPA (3,4,Di-Hydroxyphenylalanine) and Dopamine (3,4-Dihydroxy Phenyl Ethyl Amine) Using Electrochemical Methods显示文摘Eu(Ⅲ) can be utilized as an indirect electrochemical probe to investigate the interaction of bio-molecules such as DOPA and Dopamine with Ca(Ⅱ) in vitro. The interaction of DOPA and Dopamine with Eu(Ⅲ)-Eu(Ⅱ) redox pair was investigated by electrochemical techniques. Both the neurotransmitters are structurally related and undergo interaction with Eu(Ⅲ). Eu(Ⅲ) coordinates with DOPA and Dopamine through five-member chelate rings via carboxylic oxygen and amino nitrogen. The electrode kinetic parameters viz, transfer coefficient (α_ na ), diffusion coefficient (D), forward heterogeneous rate constant (k^0_ fh ) were evaluated for Eu(Ⅲ)-DOPA/Eu(Ⅲ)-Dopamine. The results obtained were used to investigate the nature of interaction of Eu(Ⅲ) with multi-donor biomolecules. The possible mechanism was also proposed. [BT(4+1] | Prashant N Bhatt Trupti V Pathak Jignasu P Mehta G.Ramchandraiha | 2006 | Journal of Rare Earths2006，24，6： | 3 |
| 5 | KIinefeIter综合征的诊断:新型甲基化特异性实时定量PCR显示文摘本文研究目的为设计一种基于额外X染色体(X-ch)检测的分子检测方法用于Klinefelter综合征的诊断。从26名47,XXY男性,2名46,XY/47,XXY男性,22名46,XY男性和15名46,XX的女性的外周血标本中提取DNA,并进行脱氨基处理。甲基化特异性的定量多聚酶链反应(MS-qpPCR)以非甲基化和甲基化的X染色体非活化特异性转录基因(XIST-U和XIST-M)拷贝为模板。X染色体二倍体通过XIST基因甲基化状态来判定。46,XY/47,XXY男性的嵌合程度通过核型分析和原位荧光杂交(FISH)的结果比较来判定。数据分析应用Roche LightCycler software v.3.5.3,包括通过拟合点分析和溶解曲线分析决定交叉点(CPs)。所有对照组女性和Ks患者均检测到X染色体二倍体,而对照组男性只表达XIST-M。XIST-U和IXIST-M的交叉点范围分别是(29.5-32.5,SD0.8)和(29-31,SD0.6)。嵌合度的检测极限为1%。根据2名47,XXY/46,XY患者的XIST-U/)(IST-M比值分析,计算出的嵌合率(1.8%和17.8%)与FISH结果(2.3%和15%)相当。从DNA脱氨基到最终数据分析的间隔小于9小时。本文得出结论:MS-qpPCR是一种敏感、特异及快速的X染色体二体检测方法,可以用于KS的筛查和诊断,甚至在低嵌合水平的47,XXY/46,XY患者也适用。 | Akanksha Mehta Anna Mielnik Peter N Schlegel Darius A Paduch | 2014 | Asian Journal of Andrology2014，16，5： | 2 |
| 6 | Asynchronous Interference Mitigation in Cooperative Base Station Systems显示文摘 | ZHANG Hong-yuan MEHTA N B MOLISCJ A F | 2008 | IEEE Transactions on Wireless Communications2008，7，1： | 1 |
| 7 | Noninvasive Ventilation显示文摘 | Mehta S Hill N S | 2001 | Am J Re2spir Crit Care Med2001，163，： | 1 |
| 8 | Detection and delineation of P and T waves in 12-lead electrocardiograms显示文摘 | MEHTA S LINGAYAT N SANGHVI S | 2009 | Expert Systems2009，26，： | 1 |
| 9 | Effects of organic compounds on the degradation of p-nitrophenol in lake and industrial wastewater by inoculated bacteria显示文摘 | Zaidi B R Mehta N K | 1995 | Biodesradation1995，6，： | 1 |
| 10 | Oligosaccharide side chains on human secretory IgA serve as receptors for ricin 显示文摘 | Mantis N J Farrant SA Mehta S | 2004 | J Immunol2004，172，11： | 1 |
| 11 | Use of endoscopic third ventriculostomy in hydrocephalus of tubercular origin显示文摘 | Bhagwati S Mehta N Shah S | 2010 | Childs Nerv Syst2010，26，12： | 1 |
| 12 | A possible biomecbanieal role of ocelusal cusp - fossa contact relationships显示文摘 | Wang M Mehta N | 2013 | J Oral Rehabil2013，40，1： | 1 |
| 13 | Nonalcoholic fatty liver disease: pathogenesis and the role of antioxidants显示文摘 | Mehta K Van Thiel DH Shah N | 2002 | Nutr Rev2002，60，9： | 1 |
| 14 | Peripartum cardiomyopathy: clinical and therpeutic aspects显示文摘 | MEHTA N J MEHAT R N KHAN I A | 2001 | Angiology2001，52，： | 1 |
| 15 | Noninvasive ventilation显示文摘 | MEHTA S HILL N S | 2001 | Am J Respir Crit Care Med2001，163，2： | 1 |
| 16 | Role of spectral studies in detection of antibacterial PHytoelements and PHytochemicals of Moringa oleifera显示文摘 | Mehta S Rai P K Rai N K | 2011 | Food BiopHysics2011，6，4： | 1 |
| 17 | Androgenetic alopecia: quality-of-life and associated lifestyle patterns显示文摘 | Sawant N Chikhalkar S Mehta V | 2010 | Int J Trichology2010，2，2： | 1 |
| 18 | Cardiac output estimation with a new Doppler device after off-pump coronary artery bypass surgery显示文摘 | Chand R Mehta Y Trehan N | 2006 | J Cardiothorac Vase Anesth2006，20，3： | 1 |
| 19 | Feeding-deterreney of oleanolic acid isolated from Panax quinquefolium against lepidopterans显示文摘 | Shukla Y N Tripathi A K Mehta V K | 1997 | Phytotherapy Research1997，11，8： | 1 |
| 20 | Nonalcoholic fatty liver disease: pathogenesis and the role ofantioxidant 显示文摘 | Mehta K van Thiel DH Shah N | 2002 | Nutr Rev2002，60，： | 1 |
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