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| 1 | Nutritional status and nutritional therapy in inflammatory bowel diseases显示文摘Underweight and specific nutrient deficiencies are frequent in adult patients with inflammatory bowel disease(IBD).In addition,a significant number of children with IBD,especially Crohn's disease(CD) have impaired linear growth.Nutrition has an important role in the management of IBD.In adults with CD,enteral nutrition(EN) is effective in inducing clinical remission of IBD,although it is less efficient than corticosteroids.Exclusive EN is an established primary therapy for pediatric CD.Limited data suggests that EN is as efficient as corticosteroids for induction of remission.Additional advantages of nutritional therapy are control of inflammation,mucosal healing,positive benefits to growth and overall nutritional status with minimal adverse effects.The available evidence suggests that supplementary EN may be effective also for maintenance of remission in CD.More studies are needed to confirm these findings.However,EN supplementation could be considered as an alternative or as an adjunct to maintenance drug therapy in CD.EN does not have a primary therapeutic role in ulcerative colitis.Specific compositions of enteral dietselemental diets or diets containing specific components-were not shown to have any advantage over standard polymeric diets and their place in the treatment of CD or UC need further evaluation.Recent theories suggest that diet may be implicated in the etiology of IBD,however there are no proven dietary approaches to reduce the risk of developing IBD. | Corina Hartman Rami Eliakim Raanan Shamir | 2009 | World Journal of Gastroenterology2009，15，21： | 44 |
| 2 | 欧洲儿童急性胃肠炎处理循证指南(2014年版)显示文摘1991年世界卫生组织(WHO)制订了第一版儿童急性腹泻病指南,2005年WHO和联合国儿童基金会(UNICEF)制订了第二版,我国专家在参照WHO指南的基础上,结合我国国情分别于1993年、2009年制订了中国儿童急性腹泻病的专家共识;WH0指南和我国共识对中国儿童急性腹泻病的规范诊治发挥了重要的作用,收到了良好的效果。时至今日,欧洲儿科胃肠病学、肝病学和营养协会及欧洲儿科感染病协会对2008年儿童急性胃肠炎循证指南进行更新,即“2014年版”。指南中腹泻病原、低渗口服补液盐溶液使用、营养管理和常规对症治疗与我国现行共识基本一致。另首次对儿童脱水评估和疾病严重程度评分进行量化并提出通过鼻胃管补液,这是我们可以借鉴的。重度脱水休克的治疗强调了可重复3次20ml/kg0.9%氯化钠溶液,与我国危重专业观点相一致。静脉补充液体成分与我国现行共识存在差异,与指南执笔者之一意大利学者AndreaLoVecehio进行交流,其认同我国现用液体组成。细菌感染所致腹泻使用抗生素的指征与我国现行共识相同,但在抗生素选择上存在差异,建议根据我国药典和药敏结果选择合适抗生素。由于我国社会经济、文化和医学发展等与欧洲存在差异,因此指南中的观点、方法等应结合中国特点进行应用。 | Alfredo Guarino Shai Ashkenazi Dominique Gendrel Andrea Lo Vecchio Raanan Shamir Hania Szajewska 方铁夫 耿岚岚 龚四堂 | 2015 | 中华儿科杂志2015，53，7： | 30 |
| 3 | 无线电传播简介:专用术语,室内传播和路径损耗计算及实例显示文摘通过对传播路径损耗的估算来预测无线通信系统在其工作环境下的性能;解释了自由空间传播损耗的计算;电磁波在介质中的发射和反射系数的理论计算是预测反射和发射系数的工具.下面的一些实例和模型是在2.4GHz工作频率时给出的. | Adi Shamir | 2002 | 今日电子2002，，z1： | 15 |
| 4 | Differential cryptanalysis of DES-like cryptosystems显示文摘 | Eli Biham Adi Shamir | 1991 | Journal of Cryptology1991，，1： | 10 |
| 5 | A method for obtaining digital signatures and public-key cryptosystems显示文摘 | R. L. Rivest A. Shamir L. Adleman | 1978 | Communications of the ACM1978，，2： | 8 |
| 6 | Capsule endoscopy in pediatric patients显示文摘Wireless capsule endoscope (WCE) for the investigation of the small bowel is an approved technique both in adults and children (more than 10 years old). The present review provides data on the indications, diagnostic yield, adverse events and limitations of the WCE technique in children and tries to predict the future of WCE usage in this population of patients. | Raanan Shamir Rami Eliakim | 2008 | World Journal of Gastroenterology2008，14，26： | 6 |
| 7 | How to share a secret显示文摘 | Adi Shamir | 1979 | Communications of the ACM1979，，11： | 6 |
| 8 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study显示文摘 | Shamir R Mehta Salim Yusuf Ron JG Peters Michel E Bertrand Basil S Lewis Madhu K Natarajan Klas Malmberg Hans-Jürgen Rupprecht Feng Zhao Susan Chrolavicius Ingrid Copland Keith AA Fox | 2001 | The Lancet . 2001 (9281)2001，，9281： | 4 |
| 9 | Soil Biota in the Arava Valley of Negev Desert,Israel显示文摘Soil microorganism biomass and respiration and the soil nematode community were observed in the hypersaline desert valley that is found between the Dead Sea and the Red Sea. The lowest point of the valley is approximately 400 m below sea level, and is the lowest point on earth. Soil samples (n = 72) were collected from the 0-10 and 10-20 cm soil layers at different altitudes (from -400 to +100 m) in the open spaces between plants during one of the most extreme xeric periods. Both soil microbial respiration and microbial biomass were found to be negatively dependent on soil moisture (SM) and organic matter (OM), and positively dependent on pH values. The physical-chemical characteristics of this hypersaline area were extremely unfavorable for the soil nematode communities, and the nematodes were entirely absent in the open area below sea level. The bacterivores were found to be the most resistant nematodes in this hyperarid region, with the Wilsonema being the most widespread genus. We suggest that nitrogen availability may play a crucial role in the below-ground soil interaction in this region, with bacterivore nematodes as indicators of nitrogen availability. | S. PEN-MOURATOV T. MYBLAT I. SHAMIR G. BARNESS Y. STEINBERGER | 2010 | Pedosphere2010，20，3： | 4 |
| 10 | Cardiovascular disease risk factor profiles in children with celiac disease on gluten-free diets显示文摘AIM:To describe the cardiovascular disease(CVD)risk factors in a population of children with celiac disease(CD)on a gluten-free diet(GFD).METHODS:This cross-sectional multicenter study was performed at Schneider Children’s Medical Center of Israel(Petach Tiqva,Israel),and San Paolo Hospital(Milan,Italy).We enrolled 114 CD children in serologic remission,who were on a GFD for at least one year.At enrollment,anthropometric measurements,blood lipids and glucose were assessed,and compared to values at diagnosis.The homeostasis model assessment-estimated insulin resistance was calculated as a measure of insulin resistance.RESULTS:Three or more concomitant CVD risk factors[body mass index,waist circumference,low density lipoprotein(LDL)cholesterol,triglycerides,blood pressure and insulin resistance]were identified in 14%of CD subjects on a GFD.The most common CVD risk factors were high fasting triglycerides(34.8%),elevated blood pressure(29.4%),and high concentrations of calculated LDL cholesterol(24.1%).On a GFD,four children(3.5%)had insulin resistance.Fasting insulin and HOMA-IR were significantly higher in the Italian cohort compared to the Israeli cohort(P<0.001).Children on a GFD had an increased prevalence of borderline LDL cholesterol(24%)when compared to values(10%)at diagnosis(P=0.090).Trends towards increases in overweight(from 8.8%to 11.5%)and obesity(from 5.3%to 8.8%)were seen on a GFD.CONCLUSION:This report of insulin resistance and CVD risk factors in celiac children highlights the importance of CVD screening,and the need for dietary counseling targeting CVD prevention. | Lorenzo Norsa Raanan Shamir Noam Zevit Elvira Verduci Corina Hartman Diana Ghisleni Enrica Riva Marcello Giovannini | 2013 | World Journal of Gastroenterology2013，19，34： | 3 |
| 11 | Minimally perturbing a gene regulatory network to avoid a disease phenotype: the glioma network as a test case显示文摘 | Karlebach G Shamir R. | 2010 | 中国神经肿瘤杂志2010，8，1： | 3 |
| 12 | Differential cryptanalysis of DES-like cryptosystem显示文摘 | Biham E and Shamir A | 1991 | Journal of Cryptology1991，4，1： | 2 |
| 13 | Differential cryptanalysis of DES-like cryptosystems显示文摘 | Eli Biham Adi Shamir | 1991 | Journal of Cryptology1991，，1： | 2 |
| 14 | Whipple’s pancreaticoduodenectomy at a resource-poor,low-volume center in Trinidad and Tobago显示文摘BACKGROUND Many authorities advocate for Whipple’s procedures to be performed in highvolume centers,but many patients in poor developing nations cannot access these centers.We sought to determine whether clinical outcomes were acceptable when Whipple’s procedures were performed in a low-volume,resource-poor setting in the West Indies.AIM To study outcomes of Whipple’s procedures in a pancreatic unit in the West Indies over an eight-year period from June 1,2013 to June 30,2021.METHODS This was a retrospective study of all patients undergoing Whipple’s procedures in a pancreatic unit in the West Indies over an eight-year period from June 1,2013 to June 30,2021.RESULTS This center performed an average of 11.25 procedures per annum.There were 72 patients in the final study population at a mean age of 60.2 years,with 52.7%having American Society of Anesthesiologists scores≥III and 54.1%with Eastern Cooperative Oncology Group scores≥2.Open Whipple’s procedures were performed in 70 patients and laparoscopic assisted procedures in 2.Portal vein resection/reconstruction was performed in 19(26.4%)patients.In patients undergoing open procedures there was 367±54.1 min mean operating time,1394±656.8 mL mean blood loss,5.24±7.22 d mean intensive care unit stay and 15.1±9.53 d hospitalization.Six(8.3%)patients experienced minor morbidity,10(14%)major morbidity and there were 4(5.5%)deaths.CONCLUSION This paper adds to the growing body of evidence that volume alone should not be used as a marker of quality for patients requiring Whipple’s procedures.Low volume centers in resource poor nations can achieve good short-term outcomes.This is largely due to the process of continuous,adaptive learning by the entire hospital. | Shamir O Cawich Dexter A Thomas Neil W Pearce Vijay Naraynsingh | 2022 | World Journal of Clinical Oncology2022，13，9： | 2 |
| 15 | On a method for obtaining digital signatures and public key cryptosystem显示文摘 | Rivest R L Shamir A Adleman L | 1978 | Commun of ACM1978，21，2： | 2 |
| 16 | How to share a secret显示文摘 | Shamir A | 1979 | Communications of the ACM1979，22，11： | 2 |
| 17 | European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease显示文摘 | S. Husby S. Koletzko I.R. Korponay-Szabó M.L. Mearin A. Phillips R. Shamir R. Troncone K. Giersiepen D. Branski C. Catassi M. Lelgeman M. M?ki C. Ribes-Koninckx A. Ventura K.P. Zimmer | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，1： | 2 |
| 18 | Burden of celiac disease in the Mediterranean area显示文摘AIM: To estimate the burden of undiagnosed celiac disease (CD) in the Mediterranean area in terms of morbidity, mortality and health cost. METHODS: For statistics regarding the population of each country in the Mediterranean area, we accessed authoritative international sources (World Bank, World Health Organization and United Nations). The prevalence of CD was obtained for most countries from published reports. An overall prevalence rate of 1% cases/total population was finally estimated to represent the frequency of the disease in the area, since none of the available conf idence intervals of the reported rates significantly excluded this rate. The distribution of symptoms and complications was obtained from reliable reports in the same cohort. A standardized mortality rate of 1.8 was obtained from recent reports. Crude health cost was estimated for the years between symptoms and diagnosis for adults and children, and was standardized for purchasing power parity to account for the different economic prof iles amongst Mediterranean countries. RESULTS: In the next 10 years, the Mediterranean area will have about half a billion inhabitants, of which 120 million will be children. The projected number of CD diagnoses in 2020 is 5 million cases (1 million celiac children), with a relative increase of 11% compared to 2010. Based on the 2010 rate, there will be about 550 000 symptomatic adults and about 240 000 sick children: 85% of the symptomatic patients will suffer from gastrointestinal complaints, 40% are likely to have anemia, 30% will likely have osteopenia, 20% of children will have short stature, and 10% will have abnormal liver enzymes. The estimated standardized medical costs for symptomatic celiac patients during the delay between symptom onset and diagnosis (mean 6 years for adults, 2 years for children) will be about €4 billion (€387 million for children) over the next 10 years. A delay in diagnosis is expected to increase mortality: about 600 000 celiac patients will die in the next 10 years, with an excess of 44.4% vs age-and sexmatched controls. CONCLUSION: In the near future, the burden of CD will increase tremendously. Few Mediterranean countries are able to face this expanding epidemic alone. | Luigi Greco Laura Timpone Abdelhak Abkari Mona Abu-Zekry Thomas Attard Faouzi Bouguerrà Paskal Cullufi Aydan Kansu Dusanka Micetic-Turk Zrinjka Miak Eleftheria Roma Raanan Shamir Selma Terzic | 2011 | World Journal of Gastroenterology2011，17，45： | 2 |
| 19 | NOD2/CARD15 mutation analysis and genotype-phenotype correlation in Jewish pediatric patients compared with adults with Crohn’s disease显示文摘 | Batia Weiss Raanan Shamir Yoram Bujanover Mati Waterman Corina Hartman Akiva Fradkin Drora Berkowitz Ilana Weintraub Ram Eliakim Amir Karban | 2004 | The Journal of Pediatrics2004，，2： | 2 |
| 20 | European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease显示文摘 | S. Husby S. Koletzko I.R. Korponay-Szabó M.L. Mearin A. Phillips R. Shamir R. Troncone K. Giersiepen D. Branski C. Catassi M. Lelgeman M. M?ki C. Ribes-Koninckx A. Ventura K.P. Zimmer | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，1： | 2 |
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