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| 1 | 曹雪涛院士科研团队论文荣膺中国百篇最具影响国际学术论文--长链非编码RNA1nc-DC通过STAT3调控人DC的分化和功能显示文摘树突状细胞(DC)是免疫系统中重要的抗原提呈细胞,其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物基因组能够转录产生大量的长链非编码RNA(long noncoding RNA,IncRNA),其在免疫系统中的功能还知之甚少。
曹雪涛院十科研团队王品副教授课题组采用了转录组芯片二代测序高通量筛选方法、RNA-pulldown、ChIP-seq等技术展开了对IncRNA在DC分化和功能中作用的研究,发现并鉴定了特异性高表达于DC的1ncRNA,命名为1nc-DC,其可通过抑制STAT3去磷酸化,从而促进DC分化和功能。该研究成果发表于Science杂志[2014,344(6181):310-313],并于2015年12月被评为“中国百篇最具影响国际学术论文”。 | wang p xue y han y lin l wu c xu s jiang z xu j liu q cao x | 2016 | 中国肿瘤生物治疗杂志2016，23，1： | 10 |
| 2 | Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels显示文摘 | Fu H Li W Lao Y Luo J Lee NT Kan KK Tsang HW Tsim KW Pang Y Li Z Chang DC Li M Han Y | 2006 | 中国生物学文摘2006，20，10： | 10 |
| 3 | 血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂的使用与2019冠状病毒疾病检测阳性之间的关系显示文摘血管紧张素转换酶抑制剂(angiotensin-converting enzyme inhibitor,ACEI)和血管紧张素受体拮抗剂(angiotensin receptor blocker,ARB)在2019新型冠状病毒疾病(coronavirus disease 2019,COVID-19)全球大流行背景下的作用备受争议。此类药物是治疗一些慢性病的必须药物,有建议停止使用这些药物. | Mehta N KalraA Nowacki AS Anjewierden S Han Z Bhat p Rubio AEC Jacob M Procop GW Harrington S Milinovich A Svensson LG Jehi L Young JB Chung MK 周卫(译) 叶鹏(校) | 2020 | 中华高血压杂志2020，28，5： | 9 |
| 4 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 5 | BOUNDARY ELEMENT APPROXIMATION OF STEKLOV EIGENVALUE PROBLEM FOR HELMHOLTZ EQUATION显示文摘Steklov eigenvalue problem of Helmholtz equation is considered in the present paper. Steklov eigenvalue problem is reduced to a new variational formula on the boundary of a given domain, in which the self-adjoint property of the original differential operator is kept and the calculating of hyper-singular integral is avoided. A numerical example showing the efficiency of this method and an optimal error estimate are given. | Tang, WJ Guan, Z Han, HD | 1998 | Journal of Computational Mathematics1998，16，2： | 5 |
| 6 | Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine显示文摘 | Xu Z Zheng H Law SL Dong So D Han Y Xue H | 2006 | 中国生物学文摘2006，20，10： | 3 |
| 7 | Identification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristics显示文摘 | Fang B Zheng C Liao L Han Q Sun Z Jiang X Zhao RC | 2006 | 中国生物学文摘2006，20，5： | 3 |
| 8 | Glycosaminoglycans enhance human leukemic cell growth in vitro显示文摘 | Maurer A M Han Z C Dhermy D | 1994 | Leuk Res1994，18，11： | 2 |
| 9 | Platelet-activating factor induces NF-kappa B activation through a G proteincoupled pathway显示文摘 | Kravchenko VV Pan Z Han J | 1995 | J Biol Chem1995，270，14： | 2 |
| 10 | 甜菜碱对肥育猪生长激素脉冲释放和血清代谢的影响显示文摘用添加含量为0和0.125%甜菜碱的日粮饲喂肥育猪,试验对杂交肥育猪日粮中甜菜碱对猪的生长性能、生长激素(GH)脉冲释放及血清代谢的影响进行研究。每试验组3个重复,每个重复8头猪(4头去势公猪,4头母猪),试验在饲喂后3h内每15min采集一次血液样本,测定生长激素脉冲释放。结果表明:添加甜菜碱组平均日增重增加5.45%(P〈0.05),而平均日采食量和饲料转化率则不受影响。 | Huang Q C Xu Z R Han X Y Li W F | 2007 | 饲料博览(技术版)2007，，7： | 2 |
| 11 | Engrafted bone marrow-derived flk-(1+) mesenchymal stem cells regenerate skin tissue显示文摘 | Deng W Han Q Liao L Li C Ge W Zhao Z You S Deng H Murad F Zhao RC | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 12 | 前列腺癌pT3亚型细分建议:精囊侵犯加前列腺腺外扩散比单独精囊侵犯的生化复发和淋巴结转移率更高显示文摘2020年美国前列腺癌发病率为21%,病死率为10%。术前血清PSA、预后分期肿瘤淋巴结转移、手术切缘状态和组织学分级[格里森评分和国际泌尿外科病理学会(ISUP)分组]被列为最高级别(Ⅰ类)证据。AJCC第8版TNM分期将前列腺癌pT3分为pT3a和pT3b,前者仅前列腺腺外扩散(EPE),后者为精囊侵犯(SVI)伴或不伴EPE。 | 方三高(摘译) 魏建国(审校) Rehman A El-Zaatari Z M Han S H | 2022 | 临床与实验病理学杂志2022，38，3： | 2 |
| 13 | Insights into human CD34(+) hematopoietic stem/progenitor cells through a systematically proteomic survey coupled with transcriptome显示文摘 | Liu F Lu J Fan HH Wang ZQ Cui SJ Zhang GA Chi M Zhang X Yang PY Chen Z Han ZG | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 14 | Controlling and synchronizing chaotic Genesio systemvia nonlinear feedback control显示文摘 | Chen M Han Z | 2003 | Chaos Solitons & Fractals2003，17，4： | 1 |
| 15 | Antioxidative or prooxidative effect of 4-hydroxyquinoline derivatives on free-radical-initiated hemolysis of erythrocytes is due to its distributive status 显示文摘 | Liu Z Q Han K Lin Y J | 2002 | Biochimica et Biophysica Acta2002，157，： | 1 |
| 16 | HLA 2DRB and 2DQB alle contribution to narcolep sy suscep tibility in Chinese patients with narcolep sy显示文摘 | Han F Chene Z Weih L | 2003 | Natl Med J Chinam2003，83，： | 1 |
| 17 | Postnatal development of interstitial cells of Cajal in mouse colon in response to Kit signal blockade with Imatinib(Glivec) 显示文摘 | Han J Zhou Y P Jiang Y Z | 2010 | Acta Histochem2010，112，3： | 1 |
| 18 | Initial-final mass relationship for stars of different metallicities 显示文摘 | MENG X CHEN X HAN Z | 2008 | Astron Astrophys2008，487，： | 1 |
| 19 | Effects of temperature and relative humidity on growth and enzyme production by Actinomucor elegans and Rhizopus oligosporus during sufu pehtze preparation显示文摘 | HAN B Z MA Y ROMBOUTS F M | 2003 | Fobd Chem2003，81，1： | 1 |
| 20 | The effect of temperature onthe interfacial tension between crude oil and gemini sur-factant solution显示文摘 | Ye Z Zhang F Han L | 2008 | Colloids and Surfaces A2008，322，： | 1 |
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