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| 1 | Effects of glutamine supplementation on gut barrier,glutathione content and acute phase response in malnourished rats during inflammatory shock显示文摘AIM: To evaluate the effect of glutamine on intestinal mucosa integrity,glutathione stores and acute phase response in protein-depleted rats during an inflammatory shock. METHODS: Plasma acute phase proteins (APP),jejunal APP mRNA levels,liver and jejunal glutathione concentrations were measured before and one,three and seven days after turpentine injection in 4 groups of control,protein-restricted,protein-restricted rats supplemented with glutamine or protein powder. Bacterial translocation in mesenteric lymph nodes and intestinal morphology were also assessed. RESULTS: Protein deprivation and turpentine injection significantly reduced jejunal villus height,and crypt depths. Mucosal glutathione concentration significantly decreased in protein-restricted rats. Before turpentine oil,glutamine supplementation restored villus heights and glutathione concentration (3.24 ± 1.05 vs 1.72 ± 0.46 μmol/g tissue,P < 0.05) in the jejunum,whereas in the liver glutathione remained low. Glutamine markedly increased jejunal α1-acid glycoprotein mRNA level after turpentine oil but did not affect its plasma concentration. Bacterial translocation in protein-restricted rats was not prevented by glutamine or protein powder supplementation. CONCLUSION: Glutamine restored gut glutathione stores and villus heights in malnourished rats but had no preventive effect on bacterial translocation in our model. | Liliana Belmonte Mose Co■ffier Florence Le Pessot Olga Miralles-Barrachina Martine Hiron Antony Leplingard Jean-Franois Lemeland Bernadette Hecketsweiler Maryvonne Daveau Philippe Ducrotté Pierre Déchelotte | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 2 | Helicobacter pylori as a risk factor for central serous chorioretinopathy:Literature review显示文摘Helicobacter pylori(H. pylori), a Gram-negative bacterium, is one of the most frequent causes of gastrointestinal infections worldwide. It has been associated as a pathogen for the human body with many systemic diseases, including different eye diseases. We will focus on a specific eye disease called idiopathic central serous chorioretinopathy(ICSCR). This disease is characterized by a serous detachment of the neurosensory retina in the macular region, which affects the vision to different degrees. Currently, the pathophysiology of ICSCR is not clear and there is no effective treatment. However, several potential risk factors have been elucidated. One of the factors that has more frequently been associated with ICSCR is stress. As H. pylori was identified as a possible etiological factor for occlusive arterial diseases in young people who were particularly stressed, it was thought that H. pylori might also be present in ICSCR. Therefore, some physicians started to test its presence in patents with ICSCR. If H. pylori happened to be associated with ICSCR, the treatment of gastrointestinal infection could also improve visual symptoms and help to remediate this eye disease. Although H. pylori is highly prevalent in the general population, a true cor-relation seems to exist. We present a review on the relationship between ICSCR and H. pylori. | Aránzazu Mateo-Montoya Martine Mauget-Fa se | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 3 |
| 3 | Cognitive function in the sleep apnea/hypopnea syndrome (SAHS) 显示文摘 | Engleman HM Kingshott RN Martin SE | 2000 | Sleep2000，23，4： | 1 |
| 4 | Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer显示文摘 | Ludwig JA Szakacs G Martin SE | 2006 | Cancer Res2006，66，9： | 1 |
| 5 | Extension ofmurine life span by overexpression of catalase targeted tomitochondria显示文摘 | Schriner SE Linford NJ Martin GM | 2005 | Science2005，308，： | 1 |
| 6 | General anesthesia and elderly surgical patients显示文摘 | Hazen SE Larsen PD Martin JLH | 1997 | Aorn Journal1997，，04： | 1 |
| 7 | Control of vertigo after intratympanic corticoid therapy for unilateral Meniere ' s disease: a comparison of weekly versus daily fixed protocols 显示文摘 | Martin SE Zschaeck C Gonzalez M | 2013 | Otol Neuro- tol2013，34，8： | 1 |
| 8 | Effect of CPAPtherapy on daytime function in patients with mild sleep apnoea/hypopnoea syndrome显示文摘 | Engleman HM Martin SE Deaiy U | 1997 | Thorax1997，52，2： | 1 |
| 9 | Enhanced therapeutic potential of adoptive immunotherapy by in vitro CD28/4-1BB costimulation of tumor-reactive T cells against a poorly immunogenic,major histocompatibility complex class Ⅰ-negative A9P melanoma显示文摘 | Strome SE Martin B Flies D | 2000 | J Immunotherapy2000，23，4： | 1 |
| 10 | Abnormal polarization and axon outgrowth in retinal ganglion cells lacking the POU domain transcription factor Brn-3b 显示文摘 | Wang SW Gan L Martin SE | 2000 | Mol Cell Neurosci2000，16，： | 1 |
| 11 | The role of presenilin and its interacting proteins in the biogenesis of Alzheimer' s beta amyloid 显示文摘 | Verdile G Gandy SE Martins RN | 2007 | Neurochem Res2007，32，4： | 1 |
| 12 | Galectin -3 messenger RNA and proteins are expressed in benign thyroid tumors 显示文摘 | Martins L Matsuo SE Ebina KN | 2002 | J Clin Endocrinol Metab2002，87，10： | 1 |
| 13 | Extension of murine life span by overexpression of catalase targeted to mitochondria 显示文摘 | Schriner SE Linford NJ Martin GM | 2005 | Science2005，308，5730： | 1 |
| 14 | Serum levels of TCDD and dioxin-like chemicals in rhesus monkeys chronically exposed to dioxin:correlation of increased serum PCB levels with endometriosis显示文摘 | Rier SE Turner WE Martin DC | 2001 | ToxicolSci2001，59，1： | 1 |
| 15 | Predictors of serological cure and Serofast State after treatment in HIV-negative persons with early syphilis显示文摘 | Se(n)a AC Wolff M Martin DH | 2011 | Clin Infect Dis2011，53，11： | 1 |
| 16 | Temperature and soil organic matter decomposition rates-synthesis of current knowledge and a way forward显示文摘 | Conant RT Ryan MG Agren GI Birge HE Davidson EA Eliasson PE Evans SE Frey SD Giardina CP Hopkins FM Hyvǒnen R Kirschbaum MUF Lavallee JM Leifeld J Parton WJ Megan Steinweg J Wallenstein MD Martin Wetterstedt JA Bradford MA | | 0，，： | 1 |
| 17 | Endometriosis in rhesus monkeys(Macaca mulatta)following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin显示文摘 | Martin DC Bowman RE | 1993 | Fundam Appl Toxicol1993，21，4： | 1 |
| 18 | Effect of general self-efficacy expectancies on performance attributions显示文摘 | Martin PR | 1994 | Psychol Rep1994，75，1： | 1 |
| 19 | Cognitive function in the sleep apnea/hypopnea syndrome (SAHS)显示文摘 | Engleman HM Kingshott RN Martin SE | 2000 | Sleep2000，23，14： | 1 |
| 20 | Altered lumbar spine structure biochemistry and biomechanical properties in a canine model of mucopolysaccharidosis type Ⅶ显示文摘 | Smith LJ Martin JT Szczesny SE | | 0，，5： | 1 |
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