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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Supported iron(m)porphyrins pentalfluo-rophenylderivatives as catalysts in epoxidationreaction by H202: the role of the silica-support and sul-fonatophenyl residues in theactivation of the peroxidic bond显示文摘 | Vinhado FS Martins PR Masson AP | 2002 | J Mol Catal A Chem2002，188，2： | 1 |
| 3 | The role of thiamine deficiency in alcoholic brain disease显示文摘 | Martin PR Singleton CK Hiller Sturmhofel S | 2003 | Alcohol Res Health2003，27，2： | 1 |
| 4 | Anaesthesia for chronic spinal cord lesions 显示文摘 | Hambly PR Martin B | 1998 | Anaesth1998，53，： | 1 |
| 5 | Cloning of human transketolase cDNA and comparison of the nucleofide sequence of the coding region in Wemicke - Korsakoff and Non - Wemicke - Korsskoff individuals显示文摘 | McCool BA Plonk SG Martin PR | 1993 | J Biol Chem1993，268，2： | 1 |
| 6 | Oxidative metabolism of 5-o-caffeoylquinic acid (chlorogenic acid), a bioactive natural product, by metalloporphyrin and rat liver mitochondria显示文摘 | dos Santos MD Martins PR dos Santos PA | 2005 | Eur J Pharm Sci2005，26，1： | 1 |
| 7 | Melatonin fails to improve sleep or agitation in double-blind randomized placebo -controlled trial of institutionalized patients with Alzheimer disease显示文摘 | Gehrman PR Connor DJ Martin JL | 2009 | Am J Geriatr Psychiatry2009，17，2： | 1 |
| 8 | Effect of general self-efficacy expectancies on performance attributions显示文摘 | Martin PR | 1994 | Psychol Rep1994，75，1： | 1 |
| 9 | Multiple antibiotic resistance (mar) locus in Salmonella enterica serovar typhimurium DT104 显示文摘 | Luke PR Martin JW | 2001 | Appl Envir Microbiol2001，67，： | 1 |
| 10 | Evidence that blue-on cells are part of the third geniculocortical pathway in primates显示文摘 | Martin PR White AJ Goodchild AK | 1997 | Fur J Neurosci1997，9，7： | 1 |
| 11 | Environmental tobacco smoke (ETS):a market cigarette study显示文摘 | Martin P Heavner DL Nelson PR | 1997 | Environment International1997，23，1： | 1 |
| 12 | Modified Blalock Taussig shunt: a not-so-simple palliative procedure显示文摘 | Verena Dirks René Prê tre Walter Knirsch Emanuela R. Valsangiacomo Buechel Burkhardt Seifert Martin Schweiger Michael Hü bler Hitendu Dave | 2013 | European Journal of Cardio-Thoracic Surgery2013，，6： | 1 |
| 13 | Ventricular assist by cardiac cycle specific increases in intrathoracic pressure 显示文摘 | Pinsky PR Marquez J Martin D | 1987 | Chest1987，91，5： | 1 |
| 14 | identificatian of a plasmid-encoded gene from Haemophilus ducreyi which confers NAD independence显示文摘 | Martin PR Shea RJ Mulks MH | 2001 | J Bacterial2001，183，4： | 1 |
| 15 | The Tomato Transcription Factor Pti4Regulates Defense-Related Gene Expression via GCC Box and Non-GCC Box cis Elements显示文摘 | Chakravarthy S Tuori RP D'Ascenzo MD Fobert PR Despres C Martin GB | 2003 | Plant Cell2003，15，： | 1 |
| 16 | Behavioral management of head- ache triggers:avoidance of triggers is an inadequate strat egy显示文摘 | Martin PR MacLeod C | 2009 | Clin Psychol Rev2009，29，6： | 1 |
| 17 | Fostering patient safety com- petencies using multiple - patient simulation experiences显示文摘 | Ironside PM Jeffries PR Martin A | 2009 | Nurs Outlook2009，57，6： | 1 |
| 18 | Ab initio study of the molecules BC and B2C显示文摘 | Martin JML Taylor PR | 1994 | J Chem Phys1994，100，12： | 1 |
| 19 | Pulsed laser evaporation of boron/carbon pellets:Infrared spectra and quantum chemical structures and frequencies foe BC2显示文摘 | Martin JML Taylor PR Yustein JT | 1993 | J Chem Phys1993，99，： | 1 |
| 20 | Deep endometriosis:a consequence of infilt- ration or retraction or possible adenomyosis externa?显示文摘 | Koninckx PR Martin D | 1992 | Fertil Steril1992，58，5： | 1 |
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