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| 1 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 2 | Gut hormones, and short bowel syndrome: The enigmatic role of glucagon-like peptide-2 in the regulation of intestinal adaptation显示文摘Short bowel syndrome (SBS) refers to the malabsorption of nutrients, water, and essential vitamins as a result of disease or surgical removal of parts of the small intestine. The most common reasons for removing part of the small intestine are due to surgical intervention for the treatment of either Crohn's disease or necrotizing enterocolitis. Intestinal adaptation following resection may take weeks to months to be achieved, thus nutritional support requires a variety of therapeutic measures, which include parenterai nutrition. Improper nutrition management can leave the SBS patient malnourished and/or dehydrated, which can be life threatening. The development of therapeutic strategies that reduce both the complications and medical costs associated with SBS/long-term parenterai nutrition while enhancing the intestinal adaptive response would be valuable. Currently, therapeutic options available for the treatment of SBS are limited. There are many potential stimulators of intestinal adaptation including peptide hormones, growth factors, and neuronally-derived components. Glucagon-like peptide-2 (GLP-2) is one potential treatment for gastrointestinal disorders associated with insufficient mucosal function. A significant body of evidence demonstrates that GLP-2 is a trophic hormone that plays an important role in controlling intestinal adaptation. Recent data from clinical trials demonstrate that GLP-2 is safe, well-tolerated, and promotes intestinal growth in SBS patients. However, the mechanism of action and the localization of the glucagon-like peptide-2 receptor (GLP-2R) remains an enigma. This review summarizes the role of a number of mucosal-derived factors that might be involved with intestinal adaptation processes; however, this discussion primarily examines the physiology, mechanism of action, and utility of GLP-2 in the regulation of intestinal mucosal growth. | GR Martin PL Beck DL Sigalet | 2006 | World Journal of Gastroenterology2006，12，26： | 3 |
| 3 | Influence of Omeprazole on the Antiplatelet Action of Clopidogrel Associated With Aspirin显示文摘 | Martine Gilard Bertrand Arnaud Jean-Christophe Cornily Grégoire Le Gal Karine Lacut Geneviève Le Calvez Jacques Mansourati Dominique Mottier Jean-Fran?ois Abgrall Jacques Boschat | 2008 | Journal of the American College of Cardiology2008，，3： | 2 |
| 4 | Shot-noise limited, supercontinuum-based optical coherence tomography显示文摘We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography(SD-OCT)with an axial resolution of 5.9μm at a center wavelength of 1370 nm.Current supercontinuumbased SD-OCT systems cannot be operated in the shot-noise limited detection regime because of severe pulse-topulse relative intensity noise of the supercontinuum source.To overcome this disadvantage,we have developed a low-noise supercontinuum source based on an all-normal dispersion(ANDi)fiber,pumped by a femtosecond laser.The noise performance of our 90 MHz ANDi fiber-based supercontinuum source is compared to that of two commercial sources operating at 80 and 320 MHz repetition rate.We show that the low-noise of the ANDi fiber-based supercontinuum source improves the OCT images significantly in terms of both higher contrast,better sensitivity,and improved penetration.From SD-OCT imaging of skin,retina,and multilayer stacks we conclude that supercontinuumbased SD-OCT can enter the domain of shot-noise limited detection. | Shreesha Rao D.S. Mikkel Jensen Lars Grüner-Nielsen Jesper Toft Olsen Peter Heiduschka Björn Kemper Jürgen Schnekenburger Martin Glud Mette Mogensen Niels Møller Israelsen Ole Bang | 2021 | Light(Science & Applications)2021，10，7： | 2 |
| 5 | BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo显示文摘 | Coucouvanis E Martin GR | 1999 | Development1999，126，3： | 2 |
| 6 | Estimates of the Annual Net Carbon and Water Exchange of Forests: The EUROFLUX Methodology显示文摘 | M. Aubinet A. Grelle A. Ibrom ü. Rannik J. Moncrieff T. Foken A.S. Kowalski P.H. Martin P. Berbigier Ch. Bernhofer R. Clement J. Elbers A. Granier T. Grünwald K. Morgenstern K. Pilegaard C. Rebmann W. Snijders R. Valentini T. Vesala | 2000 | Advances in Ecological Research2000，，： | 1 |
| 7 | Laminin and other basement membrane components显示文摘 | Martin GR Timpl R | 1987 | Annu Rev Cell Biol1987，3，： | 1 |
| 8 | Isolation of a pluripotant cell line from early mouse embryos cultured in medium conditioned by terato carcinoma stem cell显示文摘 | Martin GR | 1981 | Proceeding of the National Academy of Science USA1981，78，76： | 1 |
| 9 | Endorsement of Health and Human Services recommendation for pulse oximetry screening for critical congenital heart disease显示文摘 | Mahle WT Martin GR Beekman RH | | 0，，01： | 1 |
| 10 | Screening for critical congenital heart dis- ease : advancing detection in the newborn 显示文摘 | Bradshaw EA Martin GR | 2012 | Curr Opin Pediatr2012，24，5： | 1 |
| 11 | Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis显示文摘 | Lu P Ewald AJ Martin GR | | 0，，01： | 1 |
| 12 | Marine ecoregions of the world:a bioregionalization of coastal and shelf areas显示文摘 | Spalding MD Fox HE Allen GR Davidson N Ferdafia ZA Finlayson M Halpern BS Jorge MA Lombana AL Lourie SA Martin KD Manus EC Molnar J Recchia CA Robertson J | | 0，，： | 1 |
| 13 | Airway and lung in sepsis显示文摘 | Martin GS Bernard GR | 2001 | Intensive Care Med2001，27，1： | 1 |
| 14 | Gastrointestinal inflammation : a central component of mucosal defense and repair 显示文摘 | Martin GR Wallace JL | 2006 | Exp Biol Med (Maywood)2006，231，： | 1 |
| 15 | Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocareinoma stem cells显示文摘 | Martin GR | 1981 | Proc Natl Acad Sci USA1981，78，12： | 1 |
| 16 | The oral yeast flora of 10-year-old schoolchildren显示文摘 | Martin MY and Wilkinson GR | 1983 | Sabouraudia1983，21，： | 1 |
| 17 | FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations 显示文摘 | Hebert J M Rosenquist T Gotz J and GR Martin | 1994 | Cell1994，78，6： | 1 |
| 18 | Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells显示文摘 | Martin GR | 1981 | Proc Natl Acad Sci USA1981，78，12： | 1 |
| 19 | Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells显示文摘 | Martin GR | 1981 | Proc Natl Acad Sci USA1981，78，12： | 1 |
| 20 | Use of buccal fat pad to repair intraoral defects, review of 30 cases 显示文摘 | Martin GR Naval L Coctas A | 1997 | Br J Oral Maxillofac Surg1997，35，2： | 1 |
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