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| 1 | Influence of Omeprazole on the Antiplatelet Action of Clopidogrel Associated With Aspirin显示文摘 | Martine Gilard Bertrand Arnaud Jean-Christophe Cornily Grégoire Le Gal Karine Lacut Geneviève Le Calvez Jacques Mansourati Dominique Mottier Jean-Fran?ois Abgrall Jacques Boschat | 2008 | Journal of the American College of Cardiology2008，，3： | 2 |
| 2 | Sclareol and linalyl acetate are produced by glandular trichomes through the MEP pathway显示文摘Sclareol,an antifungal specialized metabolite produced by clary sage,Salvia sclarea,is the starting plant natural molecule used for the hemisynthesis of the perfume ingredient ambroxide.Sclareol is mainly produced in clary sage flower calyces;however,the cellular localization of the sclareol biosynthesis remains unknown.To elucidate the site of sclareol biosynthesis,we analyzed its spatial distribution in the clary sage calyx epidermis using laser desorption/ionization mass spectrometry imaging(LDI–FTICR-MSI)and investigated the expression profile of sclareol biosynthesis genes in isolated glandular trichomes(GTs).We showed that sclareol specifically accumulates in GTs’gland cells in which sclareol biosynthesis genes are strongly expressed.We next isolated a glabrous beardless mutant and demonstrate that more than 90%of the sclareol is produced by the large capitate GTs.Feeding experiments,using 1-13 C-glucose,and specific enzyme inhibitors further revealed that the methylerythritol-phosphate(MEP)biosynthetic pathway is the main source of isopentenyl diphosphate(IPP)precursor used for the biosynthesis of sclareol.Our findings demonstrate that sclareol is an MEP-derived diterpene produced by large capitate GTs in clary sage emphasing the role of GTs as biofactories dedicated to the production of specialized metabolites. | Camille Chalvin Stephanie Drevensek Françoise Gilard Caroline Mauve Christel Chollet Halima Morin Edith Nicol Eva Heripre Lucie Kriegshauser Bertrand Gakiere Michel Dron Abdelhafid Bendahmane Adnane Boualem | 2021 | Horticulture Research2021，8，1： | 2 |
| 3 | Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin显示文摘 | Gilard M Amaud B Le Gal G | 2006 | American College of Cardiology2006，4，11： | 1 |
| 4 | Influence of omeprazol on the anpiplatelet action of clopi- dogrel associated to aspirin 显示文摘 | GILARD M ARNAUD B LEGAL G | 2006 | Thromb Haemost2006，4，： | 1 |
| 5 | Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA ( Omeprazole CLopidogrel Aspirin) study 显示文摘 | Gilard M Arnaud B Cornily JC | 2008 | J Am Coil Cardiol2008，51，3： | 1 |
| 6 | Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin : the ran- domized, double-blind OCLA (Omeprazole CLopidogrel Aspirin ) study显示文摘 | Gilard M Arnaud B Comily JG | 2008 | J Am Coll Cardiol2008，51，3： | 1 |
| 7 | Accuracy of multislice computed tomography in the preoperative assessment of coronary disease in patients with aortic valve stenosis显示文摘 | Gilard M Cornily JC Pennec PY | 2006 | J Am Coll Cardiol2006，47，： | 1 |
| 8 | Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized,double-blind OCLA (Omeprazole CLopidogrel Aspirin) study显示文摘 | Gilard M Arnaud B Cornily JC | 2008 | J Am Coil Cardiol2008，51，3： | 1 |
| 9 | lnfluente of omeprazol on the antiplatelet action of clopidogrel associated to aspirin 显示文摘 | Gilard M Arnaud B le Gal G | 2006 | J Thromb Haemost2006，4，： | 1 |
| 10 | Characterization ofcholine compounds with in vitro 1 H magnetic resonance spectrosco- py for the discrimination of primary brain tumors显示文摘 | Sabatier J Gilard V Malet MM | 1999 | Invest Radi-ol1999，34，： | 1 |
| 11 | Influence of omeprazole on the anti- platelet action of clopidogrel associated with aspirin: the randomized, doubleblind OCLA (Omeprazole CLopidogrel Aspirin) study 显示文摘 | Gilard M Arnaud B Cornfly JC | 2008 | J Am Coil Cardiol2008，51，： | 1 |
| 12 | Noninvasive assessment of left main coronary stent patency with 16-slice computed tomography 显示文摘 | Gilard M Cornily JC Rioufol G | 2005 | Am J Cardiol2005，95，1： | 1 |
| 13 | Characterization of Choline compounds with in vitro 1H magnetic resonance spectroscopy for the discrimination of primary brain tumors显示文摘 | Sabatier J Gilard V Malet-Mart ino M | 1999 | Invest Radiol1999，34，3： | 1 |
| 14 | Long-term left ventricular pacing:assessment and comparison with biventricular pacing in patients with severe congestive heart failure显示文摘 | Touiza A Etienne Y Gilard M | | 0，，： | 1 |
| 15 | Assessment of coronary artery stents by 16 slice computed tomography显示文摘 | Gilard M Cornily JC Pennec PY | 2006 | Heart2006，92，1： | 1 |
| 16 | Theoretical study of radiation effects on GaAs/A1GaAs and InGaAsP/InP quantum-well lasers显示文摘 | O Gilard | 2003 | Appl Phys2003，93，4： | 1 |
| 17 | Assessment of upgrading to biventricular pacing in patients with right ventricular pacing and congestive heart failure after atrioventricular junctional ablation for chronic atrial fibrillation显示文摘 | Fatemi M Gilard M | 2004 | Europace2004，6，5： | 1 |
| 18 | Assessment of coronary artery stents by 16 slice computed tomography显示文摘 | Gilard M Gornily JC Pennee PY et a1 | 2006 | Heart2006，92，： | 1 |
| 19 | Intravascular ultrasou-nd-guided balloon angioplasty compared with stent:immediate and 6-month results of the multicenter,randomized Balloon Equivalent to Stent Study (BEST)显示文摘 | Schiele F Meneveau N Gilard M | 2003 | Circulation2003，107，4： | 1 |
| 20 | Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) registry显示文摘 | SIMON T STEG PG GILARD M | 2011 | Circulation2011，123，5： | 1 |
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