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| 1 | Contrast-enhanced endoscopic ultrasound in discrimination between focal pancreatitis and pancreatic cancer显示文摘瞄准:作为基于微容器的灌注特征把发炎区分开来与胰腺的癌的一个方法评估提高对比的 endosonography。方法:在有怀疑的慢性胰炎的 86 个病人(变老:62+/-12 年;性别:f/m 38/48 ) ,胰腺的损害被常规内视镜的 B 模式,力量 Doppler 超声和提高对比的力量模式检验(日立 EUB 525, SonoVue, 2.4 mL, Bracco ) 用为恶意的损害的下列标准:用常规力量 Doppler 的没有可检测的 vascularisation 在用 SonoVue 提高对比的技术和没有可检测的静脉的容器里面的短距离上的动脉的容器的扫描、不规则的外观损害。如果所有标准是可检测的,恶意的损害被假定[内视镜的超声(EUS ) 指导了的标准答案好针渴望细胞学,操作] 。没有瘤形成的慢性胰炎的标准在 SonoVue 的注射前被定义为没有可检测的 vascularisation,在在 SonoVue 的注射和动脉、静脉的容器的察觉以后的至少 20 公里的距离上的容器的常规外观。结果:常规 EUS 的敏感和特性为胰腺的癌症分别地是 73.2% 和 83.3% 。与恶意的胰腺的损害和特性在 56 个病人中的 51 个增加到 91.1% 的提高对比的 EUS 的敏感与长期的煽动性的胰腺的疾病在 30 个病人中的 28 个增加了到 93.3% 。结论:提高对比的内视镜的超声改进在慢性胰炎和胰腺的癌之间的区别。 | Michael Hocke Ewald Schulze Peter Gottschalk Theodor Topalidis Christoph F Dietrich | 2006 | World Journal of Gastroenterology2006，12，2： | 43 |
| 2 | 麦芽糖、NAA及ABA对华北落叶松体细胞胚成熟及生根的影响显示文摘研究了麦芽糖、NAA、ABA对华北落叶松体细胞胚发生及体细胞胚根发生和再生完整植株的影响。结果表明 :在胚性愈伤组织继代、增殖过程中 ,以 0 5mg·L- 1 的NAA代替 2 ,4 -D后 ,有利于体细胞胚的成熟和根发生。在ABA 16mg·L- 1 时 ,产生的华北落叶松体细胞胚 ,能够再生良好植株 ,ABA大于 2 0mg·L- 1 时对体细胞胚根的发育不利。在含 3%麦芽糖、4 %PEG4 0 0 0活性炭 1g·L- 1 的成熟培养基上 ,华北落叶松每克愈伤组织子叶胚达 10 6 7个 ,生根率达 5 7 89% ;显著地提高了成熟体细胞胚及其根的质量。 | 齐力旺 韩一凡 韩素英 王建华 Dietrich Ewald | 2004 | 林业科学2004，40，1： | 38 |
| 3 | 华北落叶松体细胞胚胎发生及遗传转化实验系统的建立(简报)显示文摘华北落叶松(Larix principis-Rupprechtii)是我国北方中高山地区重要的针叶速生用材树种,进行其体细胞胚胎发生和植株再生的研究,在针叶树无性快速繁殖及基因工程育种上有其特殊的用途,既可为针叶树无性系林业提供产业化途径,也可作为目的基因遗传转化实验系统。针叶树的基因转化相对较难,再生更属不易,Lelu等报道过杂种落叶松与欧洲落叶松体细胞胚胎发生方面的研究;而我国尚未见有落叶松体细胞胚胎发生的研究报道。 | 齐力旺 韩一凡 李玲 Dietrich Ewald 韩素英 | 2000 | 实验生物学报2000，33，4： | 33 |
| 4 | 加拿大一枝黄花在中国的潜在入侵区预测(英文)显示文摘加拿大一枝黄花Solidago canadensis是原产于北美的菊科Asteraceae多年生草本植物, 上世纪30年代引入我国, 现广泛分布于我国东部地区的部分省市, 并已成为该区域的农业和环境杂草。为了预测加拿大一枝黄花在我国的潜在分布区, 本研究采用相同气候方法对其进行了估测。我们用加拿大一枝黄花的原产地——美国的气候参数作为参照, 将其与我国各地气象站的气候数据进行匹配。结果表明, 加拿大一枝黄花在我国的潜在分布区的纬度跨度为25°–50°, 所以其潜在的入侵区将远大于目前的实际分布区, 甚至东北的部分地区也将适宜于该物种的生长。据此, 我们建议相关管理部门应加强该物种的监测工作, 以防其进一步向目前入侵区以外的周边地区蔓延。 | 陆建忠 翁恩生 吴晓雯 Ewald WEBER 赵斌 李博 | 2007 | 植物分类学报2007，45，5： | 27 |
| 5 | 落叶松不同类型胚性和非胚性愈伤组织的生理生化差异显示文摘以华北落叶松继代、增殖培养的不同类型的胚性及非胚性愈伤组织为材料 ,测定其氨基酸、糖类、酚酸、激素以及离子的含量 ,结果表明 :氨基酸含量的差异十分明显 ,质地硬的非胚性愈伤组织中 18种游离氨基酸含量为胚性愈伤组织的 2倍以上 ,经ABA处理后 ,胚性愈伤组织中多糖及邻苯二酚含量急剧升高 ;三糖含量与不同基因型密切相关 ;乙烯释放量在非胚性愈伤组织中高于胚性愈伤组织 ;金属离子CO+ + 的含量 ,胚性愈伤组织是非胚性愈伤组织的 12倍 ,胚性愈伤组织中铵态氮 (NH+4)与硝态氮 (NO-3)的比值是非胚性愈伤组织中的 10倍以上 ;实验结果为进一步探讨针叶树体细胞胚胎发生的生理生化机理提供依据。 | 齐力旺 李玲 韩一凡 韩素英 Dietrich Ewald | 2001 | 林业科学2001，37，3： | 26 |
| 6 | Diagnosis and treatment of diabetes mellitus in chronic pancreatitis显示文摘Diabetes secondary to pancreatic diseases is commonly referred to as pancreatogenic diabetes or type 3c diabetes mellitus.It is a clinically relevant condition with a prevalence of 5%-10%among all diabetic subjects in Western populations.In nearly 80%of all type 3c diabetes mellitus cases,chronic pancreatitis seems to be the underlying disease.The prevalence and clinical importance of diabetes secondary to chronic pancreatitis has certainly been underestimated and underappreciated so far.In contrast to the management of type 1 or type2 diabetes mellitus,the endocrinopathy in type 3c is very complex.The course of the disease is complicated by additional present comorbidities such as maldigestion and concomitant qualitative malnutrition.General awareness that patients with known and/or clinically overt chronic pancreatitis will develop type 3c diabetes mellitus(up to 90%of all cases)is rather good.However,in a patient first presenting with diabetes mellitus,chronic pancreatitis as a potential causative condition is seldom considered.Thus many patients are misdiagnosed.The failure to correctly diagnose type 3 diabetes mellitus leads to a failure to implement an appropriate medical therapy.In patients with type 3c diabetes mellitus treating exocrine pancreatic insufficiency,preventing or treating a lack of fat-soluble vitamins(especially vitamin D)and restoring impaired fat hydrolysis and incretin secretion are key-features of medical therapy. | Nils Ewald Philip D Hardt | 2013 | World Journal of Gastroenterology2013，19，42： | 23 |
| 7 | 应用311-A最优回归设计研究ABA、PEG4000及AgNO_3对落叶松体细胞胚发生数量的影响显示文摘采用三因素多项式回归 311 A最优设计方法对影响落叶松体细胞胚发生数量的ABA、PEG40 0 0和AgNO3的用量进行了研究 ,建立了华北落叶松正常体细胞胚发生数量与ABA、PEG40 0 0和AgNO3 的数学模型 ,分析了落叶松体细胞胚发生数量试验因子的主效应和互作效应 ,优选了落叶松体细胞胚发生数量最佳结果的最佳技术组合方案为ABA18 9138mg/L ,PEG40 0 0 88 80 0 7g/L与AgNO310 .75 13mg/L时 ,最佳体细胞胚数量应为 10 7 5 2 78个子叶胚 /g .callus。实验结果表明 :该方法是针叶树体细胞胚胎发生过程中 ,主要激素种类与浓度配比、处理组合 ,科学、合理的培养基优化途径。 | 齐力旺 韩一凡 李玲 Dietrich Ewald 韩素英 | 2001 | 生物工程学报2001，17，1： | 23 |
| 8 | Associating liver partition and portal vein ligation for staged hepatectomy: From technical evolution to oncological benefit显示文摘Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS) is a novel approach in liver surgery that allows for extensive resection of liver parenchyma by inducing a rapid hypertrophy of the future remnant liver. However,recent reports indicate that not all patients eligible for ALPPS will benefit from this procedure. Therefore,careful patient selection will be necessary to fully exploit possible benefits of ALPPS. Here,we provide a comprehensive overview of the technical evolution of ALPPS with a special emphasis on safety and oncologic efficacy. Furthermore,we review the contemporary literature regarding indication and benefits,but also limitations of ALPPS. | Jun Li Florian Ewald Amit Gulati Bjon Nashan | 2016 | World Journal of Gastrointestinal Surgery2016，8，2： | 9 |
| 9 | Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model显示文摘AIM: To compare different preconditioning strategies to protect the liver from ischemia/reperfusion injury focusing on the expression of pro- and anti-apoptotic proteins. Interventions comprised different modes of ischemic preconditioning (IP) as well as pharmacologic pretreatment by α-lipoic acid (LA). METHODS: Several groups of rats were compared: sham operated animals, non-pretreated animals (nt), animals receiving IP (10 min of ischemia by clamping of the portal triad and 10 min of reperfusion) prior to sustained ischemia, animals receiving selective ischemic preconditioning (IPsel, 10 min of ischemia by selective clamping of the ischemic lobe and 10 min of reperfusion) prior to sustained ichemia, and animals receiving 500 μmol α-LA injected i.v. 15 min prior to the induction of 90 min of selective ischemia. RESULTS: Cellular damage was decreased only in the LA group. TUNEL-positive hepatocytes as well as necrotic hepatocyte injury were also decreased only by LA (19 ± 2 vs 10 ± 1, P < 0.05 and 29 ± 5 vs 12 ± 1, P < 0.05). Whereas caspase 3- activities in liver tissue were unchanged, caspase 9- activity in liver tissue was decreased only by LA pretreatment (3.1 ± 0.3 vs 1.8 ± 0.2, P < 0.05). Survival rate as the endpoint of liver function was increased after IP and LA pretreatment but not after IPsel. Levels of lipid peroxidation (LPO) in liver tissue were decreased in the IP as well as in the LA group compared to the nt group. Determination of pro- and anti-apoptotic proteins showed a shift towardsanti-apoptotic proteins by LA. In contrast, both our IP strategies failed to influence apototic cell death. CONCLUSION: IP, consisting of 10 min of ischemia and 10 min of reperfusion, protects only partly against ischemia/reperfusion injury of the liver prior to 90 min of selective ischemia. IPsel did not influence ischemic tolerance of the liver. LA improved tolerance to ischemia, possibly by downregulation of pro-apoptotic Bax. | Friedrich Duenschede Kirsten Erbes Nina Riegler Patrick Ewald Achim Kircher Stefanie Westermann Arno Schad Imke Miesmer Simon Albrecht-Schck Ines Gockel Alexandra K Kiemer Theodor Junginger | 2007 | World Journal of Gastroenterology2007，13，27： | 8 |
| 10 | 落叶松胚性愈伤组织诱导培养基中激素的311-A最优回归设计筛选显示文摘采用 311- A最优回归设计 ,对落叶松胚性细胞诱导中激素种类与浓度优化筛选 ,建立胚性愈伤组织量依 2 ,4 - D、BA、KT的多项式回归方程。分析了试验因子的主效应和互作效应 ,借助此方程获得了 3因子的最佳配比组合以及最佳胚性愈伤组织发生量。 2 ,4 - D为 1.2 9mg· L-1、BA为0 .39mg· L-1和 KT为 0 .58mg· L-1时 ,落叶松胚性愈伤组织的诱导量可达到 13.9317mg·个 -1(外植体 )。结果表明 ,这是一种简便、实用。 | 齐力旺 李玲 韩一凡 韩素英 Dietrich Ewald | 2001 | 林业科学研究2001，14，3： | 8 |
| 11 | 法庭说话人识别新范式实证研究显示文摘目的通过对一起法庭说话人识别案例的实证研究,表明法庭语音证据评价新范式的核心内容及其在司法实践中的具体应用。新范式通过相关数据、定量测量和统计建模计算似然比,量化评价证据价值,并在反映该案实际条件下进行系统的有效性和可靠性验证。方法该案中,检材语音来源于两名嫌疑人之一。采集二人的样本语音,每人5段录音。提取每段录音的美尔频率倒谱系数(MFCC),使用典型线性判别函数进行降维和失配补偿。结果分别使用单变量t分布和正则化逻辑回归方法计算似然比,并对两种方法进行交叉验证。前者似然比在数百到数万之间,后者似然比在数百之内,方向都始终正确。正则化逻辑回归基于训练数据较少的考虑,得到的证据强度更为保守。结论似然比框架可以用于法庭语音证据的评价,其结果也可以在反映案件实际条件下进行验证。 | 张翠玲 Geoffrey Stewart Morrison Ewald Enzinger | 2018 | 中国人民公安大学学报(自然科学版)2018，24，3： | 6 |
| 12 | Endoscopic sphincterotomy in patients with stenosis of ampulla of Vater:Three-year follow-up of exocrine pancreatic function and clinical symptoms显示文摘AIM: To investigate retrospectively the long-term effect of endoscopic sphincterotomy (ES) including exocrine pancreatic function in patients with stenosis of ampulla of Vater. METHODS: After diagnostic endoscopic retrograde cholangiopancreatography (ERCP) and ES because of stenosis of the ampulla of Vater (SOD Type Ⅰ), follow-up examinations were performed in 60 patients (mean follow-up time 37.7 mo). Patients were asked about clini-cal signs and symptoms at present and before interven-tion using a standard questionnaire. Before and after ES exocrine pancreatic function was assessed by determina-tion of immunoreactive fecal elastase 1. Serum enzymes indicating cholestasis as well as serum lipase and amy-lase were measured. RESULTS: Eighty percent of patients reported an im-provement in their general condition after ES. The fecal elastase 1 concentrations (FEC) in all patients increased significantly after ES. This effect was even more marked in patients with pathologically low concentrations (< 200 μg/g) of fecal elastase prior to ES. The levels of serum lipase and amylase as well as serum alcaline phosphatase (AP) and gamma-glutamyltranspeptidase (GGT) decreased signifi-cantly after ES. CONCLUSION: The results of this study demonstrate that patients with stenosis of the ampulla of Vater can be successfully treated with endoscopic sphincterotomy. The positive effect is not only indicated by sustained improvement of clinical symptoms and cholestasis but also by improvement of exocrine pancreatic function. | Nils Ewald Axel Michael Marzeion Reinhard Georg Bretzel Hans Ulrich Kloer Philip Daniel Hardt | 2007 | World Journal of Gastroenterology2007，13，6： | 5 |
| 13 | Soil temperature modifies effects of soil biota on plant growth显示文摘Aims Plants directly and indirectly interact with many abiotic and biotic soil components.Research so far mostly focused on direct,indi-vidual abiotic or biotic effects on plant growth,but only few studies tested the indirect effects of abiotic soil factors on plant growth.therefore,we investigated how abiotic soil conditions affect plant performance,via changes induced by soil biota.Methods In a full-factorial experiment,we grew the widespread grass Dactylis glomerata either with or without soil biota and investigated the impact of soil temperature,fertility and moisture on the soil biota effects on plant growth.We measured biomass production,root traits and colonization by arbuscular mycorrhizal fungi as well as microbial respiration.Important Findings We found significant interaction effects between abiotic soil con-ditions and soil biota on plant growth for fertility,but especially for soil temperature,as an increase of 10°c significantly changed the soil biota effects on plant growth from positive to neutral.However,if tested individually,an increase in soil temperature and fertility per se positively affected plant biomass production,whereas soil biota per se did not affect overall plant growth,but both influenced root architecture.By affecting soil microbial activ-ity and root architecture,soil temperature might influence both mutualistic and pathogenic interactions between plants and soil biota.Such soil temperature effects should be considered in soil feedback studies to ensure greater transferability of results from artificial and experimental conditions to natural environmental conditions. | Johannes Heinze Sabine Gensch Ewald Weber Jasmin Joshi | 2017 | Journal of Plant Ecology2017，10，5： | 3 |
| 14 | Pancreaticoduodenectomy: Secondary stenting of the celiac trunk after inefficient median arcuate ligament release and reoperation as an alternative to simultaneous hepatic artery reconstruction显示文摘In patients undergoing pancreaticoduodenectomy(PD),unrecognized hemodynamically significant celiac axis(CA) stenosis impairs hepatic arterial flow by suppressing the collateral pathways supplying arterial flow from the superior mesenteric artery and leads to serious hepatobiliary complications due to liver and biliary ischemia, with a high rate of mortality. CA stenosis is usually due to an extrinsic compression by a previously asymptomatic median arcuate ligament(MAL). MAL is diagnosed by computerized tomography in about 10% of the candidates for PD, but only half are found to be hemodynamically significant during the gastroduodenal artery clamping test with Doppler assessment, which is mandatory before any resection. MAL release is usually efficient to restore an adequate liver blood inflow and prevent ischemic complications. In cases of failure in MAL release, postponed PD with secondary stenting of the CA and reoperation for PD should be considered as an alternative to immediate hepatic artery re-construction, which involves the risk of postoperative thrombosis of the arterial reconstruction. We recently used this two-stage strategy in a patient undergoing surgery for pancreatic adenocarcinoma. | Théophile Guilbaud Jacques Ewald Olivier Turrini Jean Robert Delpero | 2017 | World Journal of Gastroenterology2017，23，5： | 3 |
| 15 | Utility based pricing and exercising of real options under geometric mean reversion and risk aversion toward idiosyncratic risk显示文摘 | Christian-Oliver Ewald Zhaojun Yang | | Mathematical Methods of Operations Research0，，： | 2 |
| 16 | Using multispectral landsat and sentinel-2 satellite data to investigate vegetation change at Mount St. Helens since the great volcanic eruption in 1980显示文摘Long-term analyses of vegetation succession after catastrophic events are of high interest for an improved understanding of succession dynamics. However, in many studies such analyses were restricted to plot-based measurements. Contrarily, spatially continuous observations of succession dynamics over extended areas and timeperiods are sparse. Here, we applied a change vector analysis(CVA) to investigate vegetation succession dynamics at Mount St. Helens after the great volcanic eruption in 1980 using Landsat. We additionally applied a supervised random forest classification using Sentinel-2 data to map the currently prevailing vegetation types. Change vector analysis was performed with the normalized difference vegetation index(NDVI) and the urban index(UI) for three subsequent decades after the eruption as well as for the whole observation time between 1984 and 2016. The influence of topography on the current vegetation distribution was examined by comparing altitude, slope angles and aspect values of vegetation classes derived by the random forest classification. WilcoxRank-Sum test was applied to test for significant differences between topographic properties of the vegetation classes inside and outside of the areas affected by the eruption. For the full time period, a total area of 516 km2 was identified as re-vegetated, whereas the area and magnitude of re-growing vegetation decreased during the three decades and migrated closer to the volcanic crater. Vegetation losses were mainly observed in regions unaffected by the eruption and related mostly to timber harvesting. The vegetation type classification reached a high overall accuracy of approximately 90%. 36 years after the eruption, coniferous and deciduous trees have established at formerly devastated areas dominating with a proportion of 66%, whereas shrubs are more abundant in riparian zones. Sparse vegetation dominates at regions very close to the crater. Elevation was found to have a great influence on the reestablishment and distribution of the vegetation classes within the devastated areas showing in almost all cases significant differences in altitude distribution. Slope was less important for the different classes-only representing significantly higher values for meadows, whereas aspect seems to have no notable influence on the reestablishment of vegetation at Mount St. Helens. We conclude that major vegetation succession dynamics after catastrophic events can be assessed and characterized over large areas from freely available remote sensing data and hence contribute to an improved understanding of succession dynamics. | Katharina TELTSCHER Fabian Ewald FASSNACHT | 2018 | Journal of Mountain Science2018，15，9： | 2 |
| 17 | Diabetes mellitus secondary to pancreatic diseases (Type 3c) — Are we neglecting an important disease?显示文摘 | Nils Ewald Reinhard G. Bretzel | 2013 | European Journal of Internal Medicine2013，，3： | 2 |
| 18 | Current knowledge of hypertriglyceridemic pancreatitis显示文摘 | Pedro Valdivielso Alba Ramírez-Bueno Nils Ewald | 2014 | European Journal of Internal Medicine2014，，8： | 2 |
| 19 | Inflammation and Carotid Artery—Risk for Atherosclerosis Study (ICARAS)显示文摘 | Martin Schillinger Markus Exner Wolfgang Mlekusch Schila Sabeti Jasmin Amighi Robert Nikowitsch Ewald Timmel Bernhard Kickinger Christoph Minar Matthias Pones Wolfgang Lalouschek Helmut Rumpold Gerald Maurer Oswald Wagner Erich Minar | 2005 | Circulation2005，，17： | 2 |
| 20 | Origin of Polycyclic Aromatic Hydrocarbons (PAHs) in Coastal Marine Sediments: Case Studies in Cotonou (Benin) and Aquitaine (France) Areas显示文摘 | H.H Soclo Ph Garrigues M Ewald | 2000 | Marine Pollution Bulletin2000，，5： | 2 |
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