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| 1 | Cost effectiveness of a manual based coping strategy programme in promoting the mental health of family carers of people with dementia (the START (STrAtegies for RelaTives) study): a pragmatic randomised controlled trial显示文摘 | Martin Knapp Derek King Renee Romeo Barbara Schehl Julie Barber Mark Griffin Penny Rapaport Debbie Livingston Cath Mummery Zuzana Walker Juanita Hoe Elizabeth L Sampson Claudia Cooper Gill Livingston | 2013 | BMJ (oct )2013，，252： | 1 |
| 2 | Intensity modulated radiation therapy with simultaneous integrated boost based dose escalation on neoadjuvant chemoradiation therapy for locally advanced distal esophageal adenocarcinoma显示文摘AIM:To evaluate impact of radiation therapy dose escalation through intensity modulated radiation therapy with simultaneous integrated boost(IMRT-SIB).METHODS:We retrospectively reviewed the patients who underwent four-dimensional-based IMRT-SIBbased neoadjuvant chemoradiation protocol.During the concurrent chemoradiation therapy,radiation therapy was through IMRT-SIB delivered in 28 consecutive daily fractions with total radiation doses of 56 Gy to tumor and 5040 Gy dose-painted to clinical tumor volume,with a regimen at the discretion of the treating medical oncologist.This was followed by surgical tumor resection.We analyzed pathological completion response(p CR) rates its relationship with overall survival and event-freesurvival.RESULTS:Seventeen patients underwent dose escalation with the IMRT-SIB protocol between 2007 and 2014 and their records were available for analysis.Among the IMRT-SIB-treated patients,the toxicity appeared mild,the most common side effects were grade 1-3 esophagitis(46%) and pneumonitis(11.7%).There were no cardiac events.The Ro resection rate was 94%(n = 16),the p CR rate was 47%(n = 8),and the postoperative morbidity was zero.There was one mediastinal failure found,one patient had local failure at the anastomosis site,and the majority of failures were distant in the lung or bone.The 3-year diseasefree survival and overall survival rates were 41%(n = 7) and 53%(n = 9),respectively.CONCLUSION:The dose escalation through IMRT-SIB in the chemoradiation regimen seems responsible for down-staging the distal esophageal with well-tolerated complications. | Ming Zeng Fernando N Aguila Taral Patel Mark Knapp XueQiang Zhu XiLin Chen Phillip D Price | 2016 | World Journal of Gastrointestinal Oncology2016，8，5： | 1 |
| 3 | Interleukin-10 promoter polymorphisms and the outcome of hepatitis C virus infection显示文摘 | Susanne Knapp Branwen J. W. Hennig Angela J. Frodsham Lyna Zhang Simon Hellier Mark Wright Rob Goldin Adrian V. S. Hill Howard C. Thomas Mark R. Thursz | 2003 | Immunogenetics2003，，6： | 1 |
| 4 | Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP显示文摘 | Min Lu Hilde Breyssens Victoria Salter Shan Zhong Ying Hu Caroline Baer Indrika Ratnayaka Alex Sullivan Nicholas R. Brown Jane Endicott Stefan Knapp Benedikt M. Kessler Mark R. Middleton Christian Siebold E. Yvonne Jones Elena V. Sviderskaya Jonathan Cebo | 2013 | Cancer Cell2013，，5： | 1 |
| 5 | Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation显示文摘 | Pascal Furet Vito Guagnano Robin A. Fairhurst Patricia Imbach-Weese Ian Bruce Mark Knapp Christine Fritsch Francesca Blasco Joachim Blanz Reiner Aichholz Jacques Hamon Doriano Fabbro Giorgio Caravatti | 2013 | Bioorganic & Medicinal Chemistry Letters2013，，13： | 1 |
| 6 | Home -based versus hospital-based care for serious mental illness: Controlled cost - effectiveness study over four years显示文摘 | Knapp M Marks I Wolstenholme J | 1998 | Br J Psychiatry1998，172，： | 1 |
| 7 | Home-basedversus hospital-based care for serious mental illness:con-trolled cost-effectiveness study over four years显示文摘 | Knapp M Marks I Wolstenholme J | 1998 | Br J Psy-chiatry1998，172，： | 1 |
| 8 | A Polymorphism in IL28B Distinguishes Exposed, Uninfected Individuals From Spontaneous Resolvers of HCV Infection显示文摘 | Susanne Knapp Usama Warshow K.M. Alexander Ho Doha Hegazy Ann–Margaret Little Andrew Fowell Graeme Alexander Mark Thursz Matthew Cramp Salim I. Khakoo | 2011 | Gastroenterology2011，，1： | 1 |
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