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| 1 | The complexities underlying age-related macular degeneration: could amyloid beta play an important role?显示文摘Age-related macular degeneration(AMD) causes irreversible loss of central vision for which there is no effective treatment. Incipient pathology is thought to occur in the retina for many years before AMD manifests from midlife onwards to affect a large proportion of the elderly. Although genetic as well as non-genetic/environmental risks are recognized, its complex aetiology makes it difficult to identify susceptibility, or indeed what type of AMD develops or how quickly it progresses in different individuals. Here we summarize the literature describing how the Alzheimer's-linked amyloid beta(Aβ) group of misfolding proteins accumulate in the retina. The discovery of this key driver of Alzheimer's disease in the senescent retina was unexpected and surprising, enabling an altogether different perspective of AMD. We argue that Aβ fundamentally differs from other substances which accumulate in the ageing retina, and discuss our latest findings from a mouse model in which physiological amounts of Aβ were subretinally-injected to recapitulate salient features of early AMD within a short period. Our discoveries as well as those of others suggest the pattern of Aβ accumulation and pathology in donor aged/AMD tissues are closely reproduced in mice, including late-stage AMD phenotypes, which makes them highly attractive to study dynamic aspects of Aβ-mediated retinopathy. Furthermore, we discuss our findings revealing how Aβ behaves at single-cell resolution, and consider the long-term implications for neuroretinal function. We propose Aβ as a key element in switching to a diseased retinal phenotype, which is now being used as a biomarker for latestage AMD. | Savannah A. Lynn Eloise Keeling Rosie Munday Gagandeep Gabha Helen Griffiths Andrew J.Lotery J.Arjuna Ratnayaka | 2017 | Neural Regeneration Research2017，12，4： | 6 |
| 2 | ASPP2 Binds Par-3 and Controls the Polarity and Proliferation of Neural Progenitors during CNS Development显示文摘 | Roberta Sottocornola Christophe Royer Virginie Vives Luca Tordella Shan Zhong Yihua Wang Indrika Ratnayaka Mark Shipman Amanda Cheung Carles Gaston-Massuet Patrizia Ferretti Zoltán Molnár Xin Lu | 2010 | Developmental Cell2010，，1： | 1 |
| 3 | Pea starch: composition, structure and properties- a review 显示文摘 | Ratnayaka W S Hooever R Warkentin T | 2002 | Starch/Starke2002，54，： | 1 |
| 4 | Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP显示文摘 | Min Lu Hilde Breyssens Victoria Salter Shan Zhong Ying Hu Caroline Baer Indrika Ratnayaka Alex Sullivan Nicholas R. Brown Jane Endicott Stefan Knapp Benedikt M. Kessler Mark R. Middleton Christian Siebold E. Yvonne Jones Elena V. Sviderskaya Jonathan Cebo | 2013 | Cancer Cell2013，，5： | 1 |
| 5 | Unexpected intracetlular localization of the AMD-associated cystatin C varinant 显示文摘 | Paraoan L Ratnayaka A Spiller DG | 2004 | Traffic2004，5，11： | 1 |
| 6 | Unexpected intracellular localization of the AMD-associated Cystatin C variant显示文摘 | Paraoan L Ratnayaka A Spiller DG | 2004 | Traffic2004，1，5： | 1 |
| 7 | Role ol macrophagesin acetaminophen ( paracetamol) -induced hepatotoxicity显示文摘 | Goldin R D Ratnayaka ID Breach CS | 1996 | J Pathol1996，179，4： | 1 |
| 8 | Pea starch: composition, structure and properties-a review显示文摘 | RATNAYAKA W S HOOEVER R WARKENTIN T | 2002 | Starch/Starke2002，54，： | 1 |
| 9 | Inhibitor of apoptosis-stirnulating protein of p53 (iASPP) prevents senescence and is required for epi?thelial stratification显示文摘 | Notari M Hu Y Koch S Lu Mv Ratnayaka I Zhong S | 2011 | Proc Natl Acad Sci USA2011，108，16： | 1 |
| 10 | Characterization and assessment of antifungal activity of chemically modified berberine显示文摘 | ABEYTUNGA D T U PATHIRATNE B N P RATNAYAKA W M S R | 2011 | Journal of the National Science Foundation of Sri Lanka2011，28，3： | 1 |
| 11 | Effect of parboiling on the formation of resistant starch ,digestibility and functional properties of rice flour from different varieties grown in Sri Lanka显示文摘 | GUNARATNE A KAO W RATNAYAKA J | 2013 | J Sci Food Agric2013，93，11： | 1 |
| 12 | The clinical spectrum of Sweet's syndrome (acute febrile neutrophilic dennatosis)-a report of eighteen cases 显示文摘 | Gunawardena DA Gunawardena KA Ratnayaka RM | 1975 | Br J Dermatol1975，92，4： | 1 |
| 13 | Topical amethocaine gel for pain relief of heel prick blood sampling:A randomised double blind controlled trial显示文摘 | Jain A Rutter N Ratnayaka M | 2001 | Arch Dis Child Fetal Neonatal Ed2001，84，1： | 1 |
| 14 | Yansatrial intrapellcardial tricuspid annuloplaty显示文摘 | Rgrs T Ratnayaka K Sonmez M | 2015 | JACC Cudiovasc lnterv2015，8，3： | 1 |
| 15 | Unexpected intracellular locallzafion of the AMD-associated cystatin C varinant显示文摘 | Paraoan L Ratnayaka A Spiller DG | 2004 | Traffic2004，5，11： | 1 |
| 16 | Role of macrophages in acetaminophen (paracetamol)-induced hepatotoxicity显示文摘 | Ratnayaka I D Breach C S | 1996 | J Pathol1996，179，： | 1 |
| 17 | Trafficking of os- teonectin by retinal pigment epithelial cells, Evidence for baso- lateral secretion显示文摘 | Ratnayaka A Paraoan L Nelson G 64 al | 2007 | Int J Biochem Cell Biol2007，39，1： | 1 |
| 18 | Serial block face scanning electron microscopy reveals novel organizational details of the retinal pigment epithelium显示文摘Advances in imaging have led to the development of several new types of microscopes such as serial block face scanning electron microscopy (SBF-SEM),lightsheet microscopy,as well as X-ray micro-computed tomography (micro-CT),which enables the study of samples in fundamentally different ways. | J.Arjuna Ratnayaka Eloise Keeling | 2022 | Neural Regeneration Research2022，17，3： | 0 |
| 19 | Challenges in studying geographic atrophy(GA) age-related macular degeneration: the potential of a new mouse model with GA-like features显示文摘Loss of central vision critical to everyday activities such as reading,face-recognition and driving due to damage in the central retina (the macula) is the leading cause of irreversible blindness amongst adults in the developed world.This condition,termed age-related macular degeneration (AMD),is a complex,chronic degenerative disease driven by a combination of genetic and lifestyle risk factors.Early signs of retinal changes in people as young as 30–40 years have been reported,although these individuals appear to be asymptomatic.However,by the age of 65,the disease is present in ~3% of individuals,which increases dramatically to affect 1/3 of individuals by the eighth decade of life.Early to intermediate AMD is estimated to affect ~150 million individuals globally,with another 10 million individuals suffering from end-stage,sight-threatening forms.These terminal stages are broadly grouped into dry (geographic atrophy,GA) or wet (choroidal neovascular,CNV) AMD (Sarks et al.,1988;Bird et al.,2014),with similar frequencies reported in patients.Recent advances in identifying genetic risk factors,including our discoveries in this field,indicate an initial shared pathology before progressing to aforementioned late-stage phenotypes.Currently,GA patients have no effective treatment,which may in part be due to the lack of good in vivo models for GA studies.Here,we summarize our new findings that describe an altogether new mouse model with GA-like features which shows progressive outer retinal pathology (Ibbett et al.,2019) that can be used to gain novel insights into GA and potentially as a tool for drug development. | J. Arjuna Ratnayaka Andrew J. Lotery | 2020 | Neural Regeneration Research2020，15，5： | 0 |
| 20 | Impaired lysosomes in the retinal pigment epithelium play a central role in the degeneration of the neuroretina显示文摘Lysosomes are highly dynamic, single membranebound compartments that are critical for maintaining cellular homeostasis. These organelles, which appear to vary between 200 nm–1 μm in diameter, originate from the maturation of endocytic vesicles and via the enrichment of newly synthesized lysosomal proteins in the trans-Golgi network. | Rebecca D.Miller J.Arjuna Ratnayaka | 2023 | Neural Regeneration Research2023，18，12： | 0 |
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