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| 1 | Clinical End Points in Coronary Stent Trials: A Case for Standardized Definitions显示文摘 | Donald E. Cutlip Stephan Windecker Roxana Mehran Ashley Boam David J. Cohen Gerrit-Anne van Es P Gabriel Steg Marie-angèle Morel Laura Mauri Pascal Vranckx Eugene McFadden Alexandra Lansky Martial Hamon Mitchell W. Krucoff Patrick W. Serruys | 2007 | Circulation2007，，17： | 4 |
| 2 | Effect of dietary fiber and threonine content on intestinal barrier function in pigs challenged with either systemic E.coli lipopolysaccharide or enteric Salmonella Typhimurium显示文摘Background:The independent and interactive effects of dietary fiber(DF)and threonine(Thr)were investigated in growing pigs challenged with either systemic E.coli lipopolysaccharide(LPS)or enteric Salmonella Typhimurium(ST)to characterise their effect on intestinal barrier function.Results:In experiment 1,intestinal barrier function was assessed via oral lactulose and mannitol(L:M)gavage and fecal mucin analysis in pigs challenged with E.coli LPS and fed low fiber(LF)or high fiber(HF)diets with graded dietary Thr.Urinary lactulose recovery and L:M ratio increased(P<0.05)during the LPS inoculation period in LF fed pigs but not in HF fed pigs.Fecal mucin output was increased(P<0.05)in pigs fed HF compared to LF fed pigs.In experiment 2,RT-qPCR,ileal morphology,digesta volatile fatty acid(VFA)content,and fecal mucin output were measured in Salmonella Typhimurium challenged pigs,fed LF or HF diets with standard or supplemented dietary Thr.Salmonella inoculation increased(P<0.05)fecal mucin output compared to the unchallenged period.Supplemental Thr increased fecal mucin output in the HF-fed pigs(Fib×Thr;P<0.05).Feeding HF increased(P<0.05)VFA concentration in cecum and colon.No effect of either Thr or fiber on expression of gene markers was observed except a tendency(P=0.06)for increased MUC2 expression with the HF diet.Feeding HF increased goblet cell numbers(P<0.05).Conclusion:Dietary fiber appears to improve barrier function through increased mucin production capacity(i.e.,goblet cell numbers,MUC2 gene expression)and secretion(i.e.,fecal mucin output).The lack of effect of dietary Thr in Salmonella-challenged pigs provides further evidence that mucin secretion in the gut is conserved and,therefore,Thr may be limiting for growth under conditions of increased mucin production. | Michael O.Wellington Kimberley Hamonic Jack E.C.Krone John K.Htoo Andrew G.Van Kessel Daniel A.Columbus | 2020 | Journal of Animal Science and Biotechnology2020，11，3： | 3 |
| 3 | Interendoscopist variability in proximal colon polyp detection is twice higher for serrated polyps than adenomas显示文摘AIM To assess the interendoscopist variability in the detection of colorectal polyps according to their location and histological type.METHODS This study was a retrospective analysis of prospectively collected data from a regional colorectal cancer(CRC) screening program; 2979 complete colonoscopies from 18 endoscopists were included. Variability in performance between endoscopists for detection of at least one adenoma(A), one proximal adenoma(PA), one distal adenoma(DA), and one proximal serrated polyp(PSP) was assessed by using multilevel logistic regression models.RESULTS The observed detection rates among the 18 endoscopists ranged from 24.6% to 47.6%(mean = 35.7%) for A, from 19.1% to 39.0%(mean = 29.4%) for DA, from 6.0% to 22.9%(mean = 12.4%) for PA, and from 1.3% to 19.3%(mean = 6.9%) for PSP.After adjusting for patient-level variables(sex, age), the interendoscopist detection rates variability achieved a significant level for A, PA, and PSP but not for DA(P = 0.03, P = 0.02, P = 0.02 and P = 0.08, respectively). This heterogeneity, as measured by the variance partition coefficient, was approximately threefold higher for PA(6.6%) compared with A(2.1%), and twofold higher for PSP(12.3%) compared with PA.CONCLUSION These results demonstrate significant interendoscopist variability for proximal polyp particularly for serrated p o l y p s, b u t n o t f o r d i s t a l a d e n o m a d e t e c t i o n. These findings contribute to explain the decreased effectiveness of complete colonoscopies at preventing proximal CRCs and the need to carefully assess the proximal colon during scope procedure. | Jean-François Bretagne Stéphanie Hamonic Christine Piette Jean-François Viel Guillaume Bouguen | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 4 | Mechanisms and preven-tion of restenosis: from experimental models to clinical practice 显示文摘 | Bauters C Meurice T Hamon M | 1996 | Cardiovasc Res1996，31，6： | 1 |
| 5 | Root exudates of the hyperaccumulator Thlaspi caerulescens do not enhance metal mobili- zation 显示文摘 | ZHAO F J HAMON R E MCLAUGHL1N M J | 2001 | New Phytologist2001，151，3： | 1 |
| 6 | The human ATP-binding cassette (ABC) transporter super-family显示文摘 | Dean M Hamon Y Chimini G | 2001 | J Lipid Res2001，42，7： | 1 |
| 7 | Lability of Cd,Cu,and Zn in polluted soils treated with lime,beringite,and red mud and identification of a non-labile colloidal fraction of metals using isotopic techniques显示文摘 | LOMBI E HAMON R E MCGRATH S P | 2003 | Environmental Science and Technology2003，37，5： | 1 |
| 8 | Solution properties of graphite and graphene 显示文摘 | NIYOGI S BEKYAROVA E ITKIS M E MCWILLIAMS J L HAMON M A HADDON R C | 2006 | Journal of American Chemical Society2006，128，24： | 1 |
| 9 | Solution properties of singlewalled carbon nanotubes显示文摘 | Hamon Mark A | 1998 | Science1998，282，： | 1 |
| 10 | Biofilters: Flexible,reliable biological reactors显示文摘 | Pujol R Hamon M Kandel X | 1994 | Wat Sci Tech1994，29，1011： | 1 |
| 11 | Time to treat?ment does not influence overall survival in newly diag?nosed mantle-celllymphoma显示文摘 | Eve HE Furtado MV Hamon MD | 2009 | J Clin Oncol2009，27，32： | 1 |
| 12 | Induction of Serotonin Transporter by Hypoxia in Pulmonary Vascular Smooth Muscle Cells: Relationship With the Mitogenic Action of Serotonin显示文摘 | S. Eddahibi V. Fabre C. Boni M.P. Martres B. Raffestin M. Hamon S. Adnot | 1999 | Circulation Research1999，，3： | 1 |
| 13 | Could direct stenting reduce no-reflow in acute coronary syndromes? A randomized pilot study显示文摘 | Sabatier R Hamon M Zhao QM | 2002 | Am Heart J2002，143，： | 1 |
| 14 | Cadmium and zinc in plants and soil solution from contaminate soils 显示文摘 | LORENZ S E HAMON R E HOLM P E | 1997 | Plant and Soil1997，189，： | 1 |
| 15 | Biofihers : Flexible reliable biological reactors显示文摘 | Rujol R Hamon M Kandel X | 1994 | Water Sci Technol1994，20，1011： | 1 |
| 16 | Detection of autoantibodies against oxidized low density lipoproteins and IgG-bound low density lipoproteins in patients with coronary artery disease 显示文摘 | Boullier A Hamon M Wahers LE | 1995 | Clin Chim Acta1995，238，1： | 1 |
| 17 | A 1 100 build up resistor for the calibration of standard resistors显示文摘 | Hamon B V | 1954 | Journal of Scientific Instruments1954，31，1： | 1 |
| 18 | The human ATP-binding cassette ( ABC ) transporter superfamily 显示文摘 | Dean M Hamon Y Chimini G | 2001 | The Journal Lipid Research2001，427，： | 1 |
| 19 | Mechanism of thrombosis: physiopat hology role of_ thrombin and its inhibition by modem therapies 显示文摘 | Hamon M | 2006 | Arch MALCoe- ar Vaiss2006，99，3： | 1 |
| 20 | CYP2B6 SNPs are associated with methadone dose required for ef fective treatment of opioid addiction显示文摘 | Levran O Peles E Hamon S | 2013 | Addict Bi ol2013，18，4： | 1 |
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