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| 1 | Non-alcoholic fatty liver disease:An expanded review显示文摘Non-alcoholic fatty liver disease(NAFLD) encompasses the simple steatosis to more progressive steatosis with associated hepatitis, fibrosis, cirrhosis, and in some cases hepatocellular carcinoma. NAFLD is a growing epidemic, not only in the United States, but worldwide in part due to obesity and insulin resistance leading to liver accumulation of triglycerides and free fatty acids. Numerous risk factors for the development of NAFLD have been espoused with most having some form of metabolic derangement or insulin resistance at the core of its pathophysiology. NAFLD patients are at increased risk of liver-related as well as cardiovascular mortality, and NAFLD is rapidly becoming the leading indication for liver transplantation. Liver biopsy remains the gold standard for definitive diagnosis, but the development of noninvasive advanced imaging, biochemical and genetic tests will no doubt provide future clinicians with a great deal of information and opportunity for enhanced understanding of the pathogenesis and targeted treatment. As it currently stands several medications/supplements are being used in the treatment of NAFLD; however, none seem to be the 'magic bullet' in curtailing this growing problem yet. In this review we summarized the current knowledge of NAFLD epidemiology, risk factors, diagnosis, pathogenesis, pathologic changes, natural history, and treatment in order to aid in further understanding this disease and better managing NAFLD patients. | Mark Benedict Xuchen Zhang | 2017 | World Journal of Hepatology2017，9，16： | 54 |
| 2 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 3 | Review: Improving our knowledge of male mosquito biology in relation to genetic control programmes显示文摘 | Rosemary Susan Lees Bart Knols Romeo Bellini Mark Q. Benedict Ambicadutt Bheecarry Hervé Christophe Bossin Dave D. Chadee Jacques Charlwood Roch K. Dabiré Luc Djogbenou Alexander Egyir-Yawson René Gato Louis Clément Gouagna Mo’awia Mukhtar Hassan Shakil A | 2013 | Acta Tropica2013，，： | 2 |
| 4 | Bench to bedside review:inhaled nitric oxide therapy in adults显示文摘 | Benedict CC* Mark JD Timothy WE | 2009 | Critical Care2009，13，4： | 1 |
| 5 | Survival outcomes in liver transplantation for hepatocellular carcinoma, comparing impact of hepatitis C versus other etiology of cirrhosis显示文摘 | Adel Bozorgzadeh Mark Orloff Peter Abt Georgios Tsoulfas Durald Younan Randeep Kashyap Ashok Jain Parvez Mantry Benedict Maliakkal Alok Khorana Seymour Schwartz | 2007 | Liver Transpl2007，，6： | 1 |
| 6 | Interval colorectal carcinoma:An unsolved debate显示文摘Colorectal carcinoma(CRC), as the third most common new cancer diagnosis, poses a significant health risk to the population. Interval CRCs are those that appear after a negative screening test or examination. The development of interval CRCs has been shown to be multifactorial: location of exam-academic institution versus community hospital, experience of the endoscopist, quality of the procedure, age of the patient, flat versus polypoid neoplasia, genetics, hereditary gastrointestinal neoplasia, and most significantly missed or incompletely excised lesions. The rate of interval CRCs has decreased in the last decade, which has been ascribed to an increased understanding of interval disease and technological advances in the screening of high risk individuals. In this article, we aim to review the literature with regard to the multifactorial nature of interval CRCs and provide the most recent developments regarding this important gastrointestinal entity. | Mark Benedict Antonio Galvao Neto Xuchen Zhang | 2015 | World Journal of Gastroenterology2015，21，45： | 1 |
| 7 | Outcome after discontinuation of infliximab in patients with inflammatory bowel disease in clinical remission: an observational Danish single center study显示文摘 | Casper Steenholdt Akbar Molazahi Mark Andrew Ainsworth J?rn Brynskov Ole ?stergaard Thomsen Jakob Benedict Seidelin | 2012 | Scandinavian Journal of Gastroenterology2012，，5： | 1 |
| 8 | Agrarian Transformations in China and Vietnam 显示文摘 | BENEDICT J TRIA KERKVLIET MARK SELDEN | 1998 | The China Journal1998，，40： | 1 |
| 9 | Limited resection for non–small cell lung cancer: observed local control with implantation of I-125 brachytherapy seeds显示文摘 | Winnie Lee Benedict D.T Daly Thomas A DiPetrillo Donna M Morelli Andrew C Neuschatz Jody Morr Mark J Rivard | 2003 | The Annals of Thoracic Surgery2003，，1： | 1 |
| 10 | Living Donor and Deceased Donor Liver Transplantation for Autoimmune and Cholestatic Liver Diseases—An Analysis of the UNOS Database显示文摘 | Randeep Kashyap Saman Safadjou Rui Chen Parvez Mantry Rajeev Sharma Vrishali Patil Manoj Maloo Charlotte Ryan Carlos Marroquin Christopher Barry Gopal Ramaraju Benedict Maliakkal Mark Orloff | 2010 | Journal of Gastrointestinal Surgery2010，，9： | 1 |
| 11 | Quantitative genetic analysis of biomass and wood chemistry of Populus under different nitrogen levels显示文摘 | Evandro Novaes Luis Osorio Derek R. Drost Brianna L. Miles Carolina R. D. Boaventura‐Novaes Catherine Benedict Christopher Dervinis Qibin Yu Robert Sykes Mark Davis Timothy A. Martin Gary F. Peter Matias Kirst | 2009 | New Phytologist2009，，4： | 1 |
| 12 | Green Infrastructure Plan Evaluation Frameworks 显示文摘 | Leigh Anne McDonald William L Allen Mark A Benedict | 2005 | Journal of Conservation Planning2005，，1： | 1 |
| 13 | Limited resection for non–small cell lung cancer: observed local control with implantation of I-125 brachytherapy seeds显示文摘 | Winnie Lee Benedict D.T Daly Thomas A DiPetrillo Donna M Morelli Andrew C Neuschatz Jody Morr Mark J Rivard | 2003 | The Annals of Thoracic Surgery2003，，1： | 1 |
| 14 | Clinical application of intensity-modulated radiotherapy for locally advanced cervical cancer显示文摘 | Brian D. Kavanagh Tracey E. Schefter Qiuwen Wu Shidong Tong Francis Newman Mark Arnfield Stanley H. Benedict Steve McCourt Radhe Mohan | 2002 | Seminars in Radiation Oncology2002，，： | 1 |
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