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| 1 | Delayed gastric emptying is associated with pylorus-preserving but not classical Whipple pancreaticoduodenectomy:A review of the literature and critical reappraisal of the implicated pathomechanism显示文摘Pylorus-preserving pancreaticoduodenectomy (PPPD) is nowadays considered the treatment of choice for periampullary tumors, namely carcinoma of the head, neck, or uncinate process of the pancreas, the ampulla of Vater, distal common bile duct or carcinoma of the peri-Vaterian duodenum. Delayed gastric emptying (DGE) comprises one of the most troublesome complications of this procedure. A search of the literature using Pubmed/Medline was performed to identify clinical trials examining the incidence rate of DGE following standard Whipple pancreaticoduodenectomy (PD) vs PPPD. Additionally we performed a thorough in-depth analysis of the implicated pathomechanism underlying the occurrence of DGE after PPPD. In contrast to early studies, the majority of recently performed clinical trials demonstrated no significant association between the occurrence of DGE with either PD or PPPD. PD and PPPD procedures are equally effective operations regarding the postoperative occurrence of DGE. Further randomized trials are required to investigate the effi cacy of a recently reported (but not yet tested in large- scale studies) modifi cation, that is, PPPD with antecolic duodenojejunostomy. | Kosmas I Paraskevas Costas Avgerinos Costas Manes Dimitris Lytras Christos Dervenis | 2006 | World Journal of Gastroenterology2006，12，37： | 16 |
| 2 | Role of symptoms in diagnosis and outcome of gastric cancer显示文摘Gastric cancer is one of the most common cancers and the second most common cause of cancer deaths worldwide. Apart from Japan, where screening programmes have resulted in early diagnosis in asymptomatic patients, in most countries the diagnosis of gastric cancers is invariably made on account on dyspeptic and alarm symptoms, which may also be of prognostic significance when reported by the patient at diagnosis. However, their use as selection criteria for endoscopy seems to be inconsistent since alarm symptoms are not sufficiently sensitive to detect malignancies. In fact, the overall prevalence of these symptoms in dyspeptic patients is high, while the prevalence of gastro-intestinal cancer is very low. Moreover, symptoms of early stage cancer may be indistinguishable from those of benign dyspepsia, while the presence of alarm symptoms may imply an advanced and often inoperable disease. The features of dyspeptic and alarm symptoms may reflect the pathology of the tumour and be of prognostic value in suggesting site, stage and aggressiveness of cancer. Alarm symptoms in gastric cancer are independently related to survival and an increased number, as well as specific alarm symptoms, are closely correlated to the risk of death.Dysphagia, weight loss and a palpable abdominal mass appear to be major independent prognostic factors in gastric cancer, while gastro-intestinal bleeding, vomiting and also duration of symptoms, do not seem to have a relevant prognostic impact on survival in gastric cancer. | Giovanni Maconi Gianpiero Manes Gabriele Bianchi Porro | 2008 | World Journal of Gastroenterology2008，14，8： | 11 |
| 3 | Outcome of nonerosive gastro-esophageal reflux disease patients with pathological acid exposure显示文摘AIM: To assess the management and outcome of nonerosive gastro-esophageal reflux disease (NERD) patients who were identified retrospectively, after a 5-year follow-up.METHODS: We included patients with gastro-esophageal reflux disease (GERD) symptoms who had a negative endoscopy result and pathological 24-h esophageal pH-monitoring while off therapy. We interviewed them after an average period of 5 years (range 3.5-7 years) by means of a structured questionnaire to assess presence of GERD symptoms, related therapy, updated en-doscopic data and other features. We assessed predictors of esophagitis development by means of univariate and multivariate statistical analysis.RESULTS: 260 patients (137 women) were included. Predominant GERD symptoms were heartburn andregurgitation in 103/260 (40%). 70% received a maintenance treatment, which was proton pump inhibitor (PPI) in 55% of cases. An average number of 1.5 symptomatic relapses per patient/year of follow-up were observed. A progression to erosive gastro-esophageal reflux disease (ERD) was found in 58/193 (30.0%) of patients undergoing repeat endoscopy; 72% of these were Los Angeles grade A-B. CONCLUSION: This study shows that progression to ERD occurs in about 5% of NERD cases per year, despite therapy. Only two factors consistently and independently influence progression: smoking and absence of PPI therapy. | Fabio Pace Stefano Pallotta Gianpiero Manes Annalisa de Leone Patrizia Zentilin Luigi Russo Vincenzo Savarino Matteo Neri Enzo Grossi Rosario Cuomo | 2009 | World Journal of Gastroenterology2009，15，45： | 8 |
| 4 | Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRα in human UCP1 expression显示文摘我们调查了胎儿的间充质的干细胞(fMSCs ) 的能力区分进棕色、白的 adipocytes 并且比较了很多标记基因和关键规章的因素的表示。我们证明关键 adipocyte 管理者和标记的表示在另外的人、鼠科的 adipocyte 模型在区别期间类似于那,包括 PPAR 纬 2 和 FABP4 的正式就职。尤其是,我们发现 preadipocyte 标记, Pref-1,当这个过程继续,显著地在区别然后衰落早被导致,当他们承诺 adipogenic 系,建议 fMSCs 首先获得 preadipocyte 特征,在他们进成熟 adipocytes 的区别以前。在 adipogenic 正式就职以后,某干细胞孤立区分了进类似于棕色的 adipocytes 和其它进白 adipocytes 的房间。一个的详细调查孤立证明新奇棕色的胖决定的因素 PRDM16 在区别前后两个都被表示。重要地,展出的这些房间提高了基础 UCP-1 表示,它依赖于孤儿的活动原子受体犯错伪,加亮一个新奇角色为犯错在人的棕色的脂肪的伪。因此 fMSCs 代表一在 vitro 有用为人的 adipogenesis 当模特儿,并且提供机会在对 adipocyte 系的承诺以前学习阶段。他们也提供无价的卓见进人的棕色的脂肪的特征。 | Daniel L Morganstein Pensee Wu Meritxell R Mane Nick M Fisk Roger White Malcolm G Parker | 2010 | Cell Research2010，20，4： | 5 |
| 5 | 除草剂在土壤—植物系统中的环境行为与毒性效应显示文摘介绍了除草剂在土壤—植物系统中的环境行为、生态毒性效应及与其他污染物的交互作用。认为除草剂的环境行为对其生态毒性具有重大的影响。大部分除草剂在土壤环境中被降解或流失。残余除草剂对植物的毒害表现在光合作用、生长发育和吸收上 ; | 黄河 熊治廷 刘杰 Abdraha mane Bah | 2002 | 湖北农学院学报2002，22，3： | 5 |
| 6 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 7 | Radical resection of pancreatic cancer显示文摘BACKGROUND: Pancreatic adenocarcinoma (PCa) is a disease with dismal prognosis, and the only possibility of cure, albeit small, is based on the combination of complete resection with negative histopathological margins (R0 resection) with adjuvant treatment. Therefore, a lot of effort has been made during the last decade to assess the role of extensive surgery in both local recurrence and survival of patients with PCa. DATA SOURCES: Medline search and manual cross- referencing were utilized to identify published evidence- based data for PCa surgery between 1973 and 2006, with emphasis to feasibility, efficacy, long-term survival, disease free survival, recurrence rates, pain relief and quality of life. RESULTS: Extended surgery is safe and feasible in high volume surgical centers with comparable short-term results. Organ preserving surgery is a main goal because of quality of life reasons and is performed whenever possible from the tumor extent. Concerning long-term survival major vein resection does not adversely affect outcome. To date, there are no changes in long-term survival attributed to the extended lymph node dissection. However, there is a benefit in locoregional control with fewer local recurrences and extended lymphadenectomy allows better staging for the disease. CONCLUSIONS: Extended PCa surgery is safe and feasible despite the inconclusive results in patient's survival benefit. In the future, appropriately powered randomized trials of standard vs. extended resections may show improved outcomes for PCa patients. | Alexander Koliopanos C Avgerinos Athanasios Farfaras C Manes Christos Dervenis | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，1： | 4 |
| 8 | Testing and numerical simulation of a medium strength rock material under unconfined compression loading显示文摘This study aims to numerically and experimentally investigate the response of a medium strength rock material under unconfined compression loading up to failure. The unconfined compressive strength(UCS) is one of the most important parameters in characterising rock material behaviour. Hence the UCS is crucial in understanding the failure mechanism of fractured rocks. An effective approach to determine the UCS and to investigate the behaviours of rock materials under unconfined compression is essential in the majority of research fields of rock mechanics. The experimental configuration for the unconfined compression test, suggested by the protocols of the ASTM standard, has some limitations which affect the accuracy in determination of the real UCS. Among several alternative configurations proposed, the Mogi's configuration seems to be the most appropriate one. Therefore, the ASTM and Mogi's configurations were used to perform the tests on a medium strength rock material, i.e. Pietra Serena sandstone. The results using two configurations were discussed in terms of the differences. The tests were also replicated in LSDYNA using a finite element method(FEM) coupled smooth particle hydrodynamics(SPH) technique.This technique is employed in this study due to its capabilities to cope with large deformation issues related to the rocks. An advanced material model, called the Karagozian and Case Concrete(KCC) model,is implemented in the numerical simulations. The KCC model consists of three independent fixed failure surfaces and it can consider the damage accumulation based on the current state of stress among these failure surfaces. An equation-of-state(EOS) is used in conjunction with KCC material model for decoupling the volumetric and deviatoric responses. The numerical and experimental results were finally compared with the focus on the stress-strain diagram and the failure patterns. The comparison shows that the numerical results are in good agreement with the experimental results. | Aria Mardalizad Riccardo Scazzosi Andrea Manes Marco Giglio | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，2： | 3 |
| 9 | Fuzzy Semi-continuity of fuzzy number-valued function显示文摘In this paper we discuss the conecept and property of fuzzy semi continuous function. | Magassy OUS MANE 吴从炘 | 2002 | Journal of Harbin Institute of Technology(New Series)2002，9，2： | 3 |
| 10 | Measuring the geometry of a developing scour hole in clear-water conditions using underwater sonar scanning显示文摘A novel scanning technique using a rotating-head sonar profiler attached to a slider mechanism is presented as a means to directly measure the complex erosion and deposition features of local scour holes developing in clear-water conditions around vertical cylinders mimicking bridge piers.Extensive validation shows that the method produces high-density elevation surfaces to within y1.5±2 mm accuracy in a quasi-non-invasive manner.This equates to 0.5±0.7%relative to the flow depth which sonar resolution is well known to scale with.Experimental data from three trials using different cylinder diameters indicate that monitoring of the entire scour hole over time(instead of only the maximum depth as is commonly done in laboratory experiments)can reveal important information about local scour evolution.In particular,results show that the scour-hole volume scales with the maximum scour depth cubed(VOL y3s)through three linear regimes.The transition to the third linear regime was found to represent a step change in the scour evolution process.Following the recent theoretical framework proposed by Manes and Brocchini(2015),this change,termed the crossover point,was interpreted as the point where the production of turbulent kinetic energy plateaus which corresponds to a stabilization in the erosive power of the horseshoe vortex.Scour development beyond the crossover point is characterised by a significant reduction in the rate of volumetric scour,relative to the steadily-increasing maximum scour depth.This overall reduction in volume-development is attributed to a balance between erosion from in-front of the pier and deposition around the sides using topography analysis.It is speculated that the existence of the crossover point may help to identify the characteristic length and time scales describing the evolution of local scour,which may be used for modeling purposes. | Ashley Rogers Costantino Manes Toru Tsuzaki | 2020 | International Journal of Sediment Research2020，35，1： | 3 |
| 11 | Statistical optics applied to high-power glass lasers显示文摘 | Manes K R Simmons W W | 1985 | J Opt Soc Am A1985，2，4： | 2 |
| 12 | Dicationic Ionic Liquid Mediated Synthesis of 5-Arylidine-2,4-thiazolidinediones显示文摘5-arylidine-2,4-thiazolidinediones 的有效合成用 dicationic 被开发了离子的液体同样绿的媒介和催化剂。这个方法与 2,4-thiazolidinedione 为芳基以及 heteryl 醛的冷凝作用表现了很好并且与优秀收益给了 5-arylidine-2,4-thiazolidinediones。 | Jawale Dhanaji V. Pratap Umesh R. Lingampalle Dinesh L. Mane Ramrao A. | 2011 | Chinese Journal of Chemistry2011，29，5： | 2 |
| 13 | Design and characterization of monolaurin loaded electrospun shellac nanofibers with antimicrobial activity显示文摘The aim of this study was to elucidate the optimized fabrication factors influencing the formation and properties of shellac(SHL) nanofibers loaded with an antimicrobial monolaurin(ML). The main and interaction effects of formulation and process parameters including SHL content(35%–40% w/w), ML content(1%–3% w/w), applied voltage(9–27 kV) and flow rate(0.4–1.2 ml/h) on the characteristic of nanofibers were investigated through a total of 19 experiments based on a full factorial design with three replicated center points. As a result, the SHL content was the major parameter affecting fiber diameter. Another response result revealed that the SHL content would be also the most significant negative impact on amount of beads. An increase in the concentration of SHL leaded to a reduction in the amount of beads. From the results of characterization study, it was proved that ML might be entrapped between the chains of SHL during the electrospinning process exhibiting an excellent encapsulation. According to the response surface area, small(?488 nm) and beadless(?0.48) fibers were obtained with the SHL and ML contents of 37.5% and 1.1% w/w respectively, at the applied voltage of 18 k V and the flow rate of 0.8 ml/h. In addition, the results of the kill-kinetic studies showed that SHL nanofibers loaded with ML exhibited an excellent antibacterial activity against Staphylococcus aureus, while Escherichia coli was less affected due to the hydrophilic structure of the its outer membrane. ML also exerted an antifun-gal activity by reducing the number of Candida albicans colonies. Based on their structural and antimicrobial properties, SHL nanofibers containing ML could be potentially used as a medicated dressing for wound treatment. | Nawindac Chinatangkul Chutima Limmatvapirat Jurairatb Nunthanid Manee Luangtana-Anan Pornsak Sriamornsak Sontaya Limmatvapirat | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，5： | 2 |
| 14 | Safety of cold polypectomy for < 10 mm polyps at colonoscopy: a prospective multicenter study显示文摘 | A. Repici C. Hassan E. Vitetta E. Ferrara G. Manes G. Gullotti A. Princiotta P. Dulbecco N. Gaffuri E. Bettoni N. Pagano G. Rando G. Strangio A. Carlino F. Romeo D. de Paula Pessoa Ferreira A. Zullo L. Ridola A. Malesci | 2012 | Endoscopy2012，，01： | 2 |
| 15 | Colorectal stenting as a bridge to surgery reduces morbidity and mortality in left-sided malignant obstruction: a predictive risk score-based comparative study显示文摘 | Vincenzo Cennamo Carmelo Luigiano Gianpiero Manes Rocco Maurizio Zagari Luca Ansaloni Carlo Fabbri Liza Ceroni Fausto Catena Antonio Daniele Pinna Lorenzo Fuccio Alessandro Mussetto Tino Casetti Federico Coccolini Nicola D’Imperio Franco Bazzoli | 2012 | Digestive and Liver Disease2012，，6： | 2 |
| 16 | Mucosal Healing Predicts Late Outcomes After the First Course of Corticosteroids for Newly Diagnosed Ulcerative Colitis显示文摘 | Sandro Ardizzone Andrea Cassinotti Piergiorgio Duca Cristina Mazzali Chiara Penati Gianpiero Manes Riccardo Marmo Alessandro Massari Paola Molteni Giovanni Maconi Gabriele Bianchi Porro | 2011 | Clinical Gastroenterology and Hepatology2011，，6： | 2 |
| 17 | 英国的研究:TORCH筛查中只有巨细胞病毒检测是有必要的显示文摘目的综述关于胎儿医学的TORCH测试的适应证和价值(弓形虫,风疹病毒,巨细胞病毒,疱疹病毒)。方法收集近10年中一个胎儿医学小组负责的所有产妇和胎儿的TORCH测试的分析报告。分析可能由先天性胎儿感染所引起的超声影像特征。研究孕妇及胎儿确诊感染后的围产结局。结果笔者对462位产妇进行了TORCH测试。也对其中的67例胎儿样本(羊水或胎儿血样)进行了检测。另外,检测了14例胎儿样本,但缺少其母亲的样本,从而使总样本数达到476例。其中,有11例产妇为巨细胞病毒感染(2.3%),10例胎儿巨细胞病毒感染,并没有发现其他病毒感染。检测的适应证包括超声发现胎儿肠管高回声、水肿、大脑脑室增宽、高回声病灶、羊水过少、羊水过多和胎儿宫内发育迟缓。其中可能与胎儿宫内感染相关的最常见表现为胎儿肠管高回声、腹水、心脏扩大症和羊水过少。没有病例与羊水过多相关,同时胎儿宫内发育迟缓和脑室增宽总是与其他特点相关。结论在英国,由于胎儿的详细检查结果就对产妇进行完整的TORCH检查通常是没有必要的。检测可仅限于巨细胞病毒,特别是因为其他感染性病原体,包括弓形体病,在英国都是罕见的。更多了解先天性感染的不同超声特点之间的相关性也很重要。 | Sherif A.Abdel-Fattah Abha Bhat Sebastian Manes Jose L.Bartha David Carrington 周文婷 | 2009 | 中国产前诊断杂志(电子版)2009，，2： | 2 |
| 18 | Adsorption and desorption phenomena on thermally annealed multi-walled carbon nanotubes by XANES study显示文摘The multi-walled carbon nanotubes(MWCNTs) studied in this work were synthesized by the catalytic chemical vapor deposition(CCVD) process, and were thermally annealed by the hot filament plasma enhanced(HF PE) method at 550℃ for two hours.The x-ray absorption near edge structure(XANES) technique was used to investigate the adsorption and desorption phenomena of the MWCNTs at normal and grazing incidence angles.The adsorbates were found to have different sensitivities to the thermal annealing.The geometry of the incident beam consistently gave information about the adsorption and desorption phenomena.In addition, the adsorption of non-intrinsic potassium quantitatively affected the intrinsic adsorbates and contributed to increase the conductivity of the MWCNTs.The desorption of potassium was almost 70% greater after the thermal annealing.The potassium non-intrinsic adsorbates are from a physisorption mechanism whereas the intrinsic adsorbates result from chemisorption. | Camile Rodolphe Tchenguem Kamto Bridinette Thiodjio Sendja Jeannot Mane Mane | 2019 | Chinese Physics B2019，28，9： | 2 |
| 19 | Improved glycaemic control with metformin - glibenclamide combined tablet therapy ( Glucovance@ ) in type 2 diabetic patients inadequately controlled on metformin 显示文摘 | Mane M Howlett H Lehert P | 2002 | Diabet Med2002，19，： | 1 |
| 20 | Chikungunya epidemic: global and Indian scenario 显示文摘 | Das S Kolher RP Mane BG | 2007 | J Commun Dis2007，39，1： | 1 |
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