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| 1 | Role of symptoms in diagnosis and outcome of gastric cancer显示文摘Gastric cancer is one of the most common cancers and the second most common cause of cancer deaths worldwide. Apart from Japan, where screening programmes have resulted in early diagnosis in asymptomatic patients, in most countries the diagnosis of gastric cancers is invariably made on account on dyspeptic and alarm symptoms, which may also be of prognostic significance when reported by the patient at diagnosis. However, their use as selection criteria for endoscopy seems to be inconsistent since alarm symptoms are not sufficiently sensitive to detect malignancies. In fact, the overall prevalence of these symptoms in dyspeptic patients is high, while the prevalence of gastro-intestinal cancer is very low. Moreover, symptoms of early stage cancer may be indistinguishable from those of benign dyspepsia, while the presence of alarm symptoms may imply an advanced and often inoperable disease. The features of dyspeptic and alarm symptoms may reflect the pathology of the tumour and be of prognostic value in suggesting site, stage and aggressiveness of cancer. Alarm symptoms in gastric cancer are independently related to survival and an increased number, as well as specific alarm symptoms, are closely correlated to the risk of death.Dysphagia, weight loss and a palpable abdominal mass appear to be major independent prognostic factors in gastric cancer, while gastro-intestinal bleeding, vomiting and also duration of symptoms, do not seem to have a relevant prognostic impact on survival in gastric cancer. | Giovanni Maconi Gianpiero Manes Gabriele Bianchi Porro | 2008 | World Journal of Gastroenterology2008，14，8： | 11 |
| 2 | Pre-illness changes in dietary habits and diet as a risk factor for inflammatory bowel disease: A case-control study显示文摘AIM: To evaluate whether symptoms of inflammatory bowel disease (IBD), before diagnosis modify dietary habits, and to investigate the pre-illness diet in patients with recent IBD in comparison with an age-matched healthy control group. METHODS: Overall, 83 new cases of IBD (41 ulcerative colitis, 42 Crohn's disease) and 160 healthy controls were studied. Portions per week of 34 foods and beverages before onset of symptoms were recorded using a validated questionnaire. Duration of symptoms before IBD diagnosis, presence of specific symptoms and their impact on subjective changes in usual dietary habits were also recorded. The association between diet and IBD was investigated by multiple logistic regression and dietary patterns were assessed by factor analysis. RESULTS: Changes in dietary habits, due to the presence of symptoms, were reported by 38.6% of patients and were not significantly related to specific symptoms, rather to long duration of symptoms, only in Crohn's disease patients. In IBD patients who did not change dietary habits, moderate and high consumption of margarine (OR = 11.8 and OR = 21.37) was associated with ulcerative colitis, whilst high consumption of red meat (OR = 7.8) and high intake of cheese were associated with Crohn's disease. CONCLUSION: More than one third of IBD patients change dietary habits before diagnosis. Margarine, red meat and cheese increase the risk of ulcerative colitis and Crohn's disease. | Giovanni Maconi Sandro Ardizzone Claudia Cucino Cristina Bezzio Antonio Giampiero Russo Gabriele Bianchi Porro | 2010 | World Journal of Gastroenterology2010，16，34： | 10 |
| 3 | How to perform gastrointestinal ultrasound: anatomy and normal findings显示文摘Gastrointestinal ultrasound is a practical, safe, cheap and reproducible diagnostic tool in inflammatorybowel disease gaining global prominence amongst clinicians. Understanding the embryological processes of the intestinal tract assists in the interpretation of abnormal sonographic findings. In general terms, the examination principally comprises interrogation of the colon, mesentery and small intestine using both lowfrequency and high-frequency probes. Interpretation of findings on GIUS includes assessment of bowel wall thickness, symmetry of this thickness, evidence of transmural changes, assessment of vascularity using Doppler imaging and assessment of other specific features including lymph nodes, mesentery and luminal motility. In addition to B-mode imaging, transperineal ultrasonography, elastography and contrast-enhanced ultrasonography are useful adjuncts. This supplement expands upon these features in more depth. | Nathan S S Atkinson Robert V Bryant Yi Dong Christian Maaser Torsten Kucharzik Giovanni Maconi Anil K Asthana Michael Blaivas Adrian Goudie Odd Helge Gilja Dieter Nuernberg Dagmar Schreiber-Dietrich Christoph F Dietrich | 2017 | World Journal of Gastroenterology2017，23，38： | 5 |
| 4 | Glucose intolerance and diabetes mellitus in ulcerative colitis: Pathogenetic and therapeutic implications显示文摘Diabetes mellitus is one of the most frequent co-morbidities of ulcerative colitis patients.The epidemiological association of these diseases suggested a genetic sharing and has challenged gene identification.Diabetes co-morbidity in ulcerative colitis has also relevant clinical and therapeutic implications,with potential clinical impact on the follow up and outcome of patients.These diseases share specific complications,such as neuropathy,hepatic steatosis,osteoporosis and venous thrombosis.It is still unknown whether the coexistence of these diseases may increase their occurrence.Diabetes and hyperglycaemia represent relevant risk factors for postoperative complications and pouch failure in ulcerative colitis.Medical treatment of ulcerative colitis in patients with diabetes mellitus may be particularly challenging.Corticosteroids are the treatment of choice of active ulcerative colitis.Their use may be associated with the onset of glucose intolerance and diabetes,with difficult control of glucose levels andwith complications in diabetic patients.Epidemiologic and genetic evidences about diabetes co-morbidity in ulcerative colitis patients and shared complications and treatment of patients with these diseases have been discussed in the present review. | Giovanni Maconi Federica Furfaro Roberta Sciurti Cristina Bezzio Sandro Ardizzone Roberto de Franchis | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 5 | Mucosal Healing Predicts Late Outcomes After the First Course of Corticosteroids for Newly Diagnosed Ulcerative Colitis显示文摘 | Sandro Ardizzone Andrea Cassinotti Piergiorgio Duca Cristina Mazzali Chiara Penati Gianpiero Manes Riccardo Marmo Alessandro Massari Paola Molteni Giovanni Maconi Gabriele Bianchi Porro | 2011 | Clinical Gastroenterology and Hepatology2011，，6： | 2 |
| 6 | Randomized controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis显示文摘 | Ardizzone S Maconi G Russo A | 2006 | Gut2006，55，4： | 1 |
| 7 | Contrast radiology, computed tomography and ultrasonography in detecting internal fistulas and intra-abdominal abscesses in Crohn's disease: a prospective comparative study显示文摘 | Maconi G Sampietro GM Parente F | 2003 | Am J Gastroenterol2003，98，： | 1 |
| 8 | Reference limits and behaviour of serum transferrinreceptor in children 6 - 10 years of age显示文摘 | Danise M Maconi G Morelli | 2008 | lntemational Journal of Laboratory Hematology2008，30，： | 1 |
| 9 | Prevalence and clinical features of heterotopic gastyic mucosa in the upper oesophagus显示文摘 | Maconi G Pace F Vago L | 2000 | Eur J Gastroenterol Hepatol2000，12，： | 1 |
| 10 | Cervia 11 Working Group Report 2006: guidelines on diagnosis and treatment of Helicobacter pylori infection in Italy显示文摘 | Caselli M Zullo A Maconi G | 2007 | Dig Liver Dis2007，39，8： | 1 |
| 11 | Contrast radiology,computed tomography and ultrasonography in detecting internal fistulas and intraabdominal abbcesses in Crohn's disease:a prospective comparative study显示文摘 | Sampietro GM Parente F | 2003 | Am J Gastroenterol2003，98，7： | 1 |
| 12 | Management of Helicobacter pylori infection: gastroenterological and surgical perspectives显示文摘 | Maconi G Kurihara H Taschieri A Met | 1999 | J Chemother1999，11，6： | 1 |
| 13 | Gastric cancer in young patients with no alarm symptoms:focus on delay in diagnosis,stage of neoplasm and survival显示文摘 | MACONI G KURIHARA H PANIZZO V | 2003 | Scand J Gastroenterol2003，38，12： | 1 |
| 14 | Cervia II working group report 2006:guidelines on diagnosis and treatment of Helicobacter priori infection in Italy显示文摘 | Caselli M Zullo A Maconi G | | 0，，08： | 1 |
| 15 | Prevalence and clinical features of heterotopic gastric mucosa in the upper oesophagus (inlet patch)显示文摘 | Maconi G Pace F Vago L | | 0，，07： | 1 |
| 16 | CARD15 gene variants and risk of reoperation in Crohn's disease patients 显示文摘 | Maconi G Colombo E Sampietro GM | 2009 | Am J Gastroenterol2009，104，10： | 1 |
| 17 | Effect of Helicobacter pylori eradication on gastric histology, serum gastrin and pepsinogen I levels, and gastric emptying in patients with gastric ulcer显示文摘 | Maconi G Lazzaroni M Sangaletti O | | 0，，： | 1 |
| 18 | Randomised controlled trial of azathioprine and 5-aminosalieylic acid for treatment of steroid dependent ulcerative colitis 显示文摘 | Ardizzone S Maconi G Russo A | 2006 | Gut2006，55，1： | 1 |
| 19 | Erythrocyte and reticulocyte indices in iron deficiency in chronic kidney disease:comparison of two methods显示文摘 | Maconi M Cavalca L Danise P | 2009 | Scand J Clin Lab Invest2009，69，3： | 1 |
| 20 | Transperineal Perineal Ultrasound Versus Magnetic Resonance Imaging In the Assessment of Perianal Crohn?s Disease显示文摘 | Giovanni Maconi Massimo Tonolini Michela Monteleone Cristina Bezzio Federica Furfaro Chiara Villa Alessando Campari Alessandra Dell?Era Gianluca Sampietro Sandro Ardizzone Roberto de Franchis | 2013 | Inflammatory Bowel Diseases2013，，： | 1 |
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