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| 1 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 2 | A rat model of bone cancer pain显示文摘 | S.J Medhurst K Walker M Bowes B.L Kidd M Glatt M Muller M Hattenberger J Vaxelaire T O’Reilly G Wotherspoon J Winter J Green L Urban | 2002 | Pain2002，，： | 2 |
| 3 | Three or more routes for leukocyte migration into the central nervous system显示文摘 | Kivisakk P Kidd G | 2003 | Nat Rev Immunol2003，3，7： | 1 |
| 4 | Raising Tibet显示文摘 | Harrison T M Copeland P Kidd W S | 1992 | Science1992，255，： | 1 |
| 5 | Sex Discrimination and Occupational Segregation in the Australian Labour market 显示文摘 | KIDD M | 1993 | The Economic Record1993，，： | 1 |
| 6 | Differentiating the impact of anatomic and non-anatomic liver resection on early recurrence in patients with Hepatocellnlar Carcinoma显示文摘 | Eltawil KM Kidd M Giovinazzo F | 2010 | World J Surg Oncol2010，8，： | 1 |
| 7 | The Talcum powder problem in surgery and its solution 显示文摘 | Seelig M G Verda D J Kidd F H | 1943 | Journal of American Medical Association1943，123，15： | 1 |
| 8 | Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy显示文摘 | Eltawil KM Gustafsson BI Kidd M | 2010 | J Clin Gastroenterol2010，44，10： | 1 |
| 9 | Trace ele- ment behaviour at the root-soil interface: Implications in phytoremediation显示文摘 | KIDD P BARCELO J BERNAL M P | 2009 | Eviron Exp Bot2009，67，： | 1 |
| 10 | Nutritional and osmoregulatory functions of betaine显示文摘 | Kidd M T Ferket P R Garlich J D | 1997 | World''s Pouh Science Journal1997，53，2： | 1 |
| 11 | Dietary apparent metabo lizable energy and amino acid density effects on growth and carcass traits of heavy broilers显示文摘 | Dozier W A Corzo A Kidd M T | 2007 | J ApplPoult Res2007，16，： | 1 |
| 12 | A 5-decade analysis of 13715 carcinoid tumors显示文摘 | Modlin IM Lye KD Kidd M | 2003 | Cancer2003，97，4： | 1 |
| 13 | Threonine and crude protein responses in broiler chicks显示文摘 | Kidd M T Gerard P D Heger J | 2001 | Animal Feed Science and Technology2001，94，： | 1 |
| 14 | Neuroendocrine tumors of the diffuse neuroendocrine system显示文摘 | Gustafsson BI Kidd M Modlin IM | 2008 | Curr Opin Oncol2008，20，1： | 1 |
| 15 | A 5-decade analysis of 13,715 carcinoid tumors 显示文摘 | Modlin IM Lye KD Kidd M | 2003 | Cancer2003，97，4： | 1 |
| 16 | Secondary caries显示文摘 | Kidd EA Toffenetti F M jor IA | 1992 | Int Dent J1992，42，3： | 1 |
| 17 | Carcinoid tumors of the stomach显示文摘 | Modlin IM Lye KD Kidd M | 2003 | Surg Oncol2003，12，2： | 1 |
| 18 | Dietary L-carnitine influences broiler thigh yield显示文摘 | KIDD M T GILBERT J CORZO A | 2009 | Asian-Australasian Journal of Animal Science2009，22，5： | 1 |
| 19 | Food-dependent exercise- induced anaphylaxis显示文摘 | Kidd J M Cohen S H Sosman A J | 1983 | Allergy Clin I mmunol1983，，71： | 1 |
| 20 | Comparisons of male and female broiler responses to dietary threonine from 42 to 56 days of age显示文摘 | Dozier W A Moran Jr E T Kidd M T | 2001 | J ApplPoult Res2001，10，： | 1 |
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