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| 1 | Characterizing the optimal operation of photocatalytic degradation of BDE-209 by nano-sized TiO_2显示文摘Brominated flame retardants have been widely used in industry.There is a rapid growing public concern for their availabilities in the environment.Advanced oxidation process(AOP) is a promising and efficient technology which may be used to remove emerging chemicals such as brominated flame retardants.This study aims at investigating optimal operational conditions for the removal of BDE-209 using nano-scaled titanium(IV) oxide.The residual PBDE congeners after photocatalytical degradation of BDE-209 by TiO 2 were analysed by gas chromatography-mass spectrometry(GC-MS).It was found that the degradability of BDE-209 by TiO 2 was attributed to its photocatalytic activity but not the small size of the particles.The half-life of removing BDE-209 by TiO 2 was 3.05 days under visible light.Tetra-and penta-BDEs were the major degraded products of BDE-209.Optimum conditions for photocatalytical degradation of BDE-209 was found to be at pH 12(93% ± 1%),5,10,20 mg/L(93.0% ± 1.70%,91.6% ± 3.21%,91.9% ± 0.952%,respectively),respectively of humic acid and in the form of anatase/rutile TiO 2(82% ± 3%).Hence,the efficiency of removing BDE-209 can be maximized while being cost effective at the said operating conditions. | Ka Lai Chow Yu Bon Man Jin Shu Zheng Yan Liang Nora Fung Yee Tam Ming Hung Wong | 2012 | Journal of Environmental Sciences2012，24，9： | 8 |
| 2 | Profiles and removal efficiency of polycyclic aromatic hydrocarbons by two different types of sewage treatment plants in Hong Kong显示文摘Sewage discharge could be a major source of polycyclic aromatic hydrocarbons(PAHs) in the coastal waters. Stonecutters Island and Shatin Sewage Treatment Works(SCISTW and STSTW)in Hong Kong, adopted chemically enhanced primary treatment and biological treatment,respectively. This study aimed at(1) determining the removal efficiencies of PAHs,(2) comparing the capabilities in removing PAHs, and(3) characterizing the profile of each individual PAHs, in the two sewage treatment plants(STPs). Quantification of 16 PAHs was conducted by a Gas Chromatography. The concentrations of total PAHs decreased gradually along the treatment processes(from 301 ± 255 and 307 ± 217 ng/L to 14.9 ± 12.1 and 63.3 ± 54.1 ng/L in STSTW and SCISTW, respectively). It was noted that STSTW was more capable in removing total PAHs than SCISTW with average total removal efficiency 94.4% ± 4.12% vs. 79.2% ± 7.48%(p < 0.05). The removal of PAHs was probably due to sorption in particular matter, confirmed by the higher distribution coefficient of individual and total PAHs in solid samples(dewatered sludge contained92.5% and 74.7% of total PAHs in SCISTW and STSTW, respectively) than liquid samples(final effluent-total contained 7.53% and 25.3% of total PAHs in STSTW and SCISTW, respectively).Despite the impressive capability of STSTW and SCISTW in removing PAHs, there was still a considerable amount of total PAHs(1.85 and 39.3 kg/year, respectively for the two STPs) being discharged into Hong Kong coastal waters, which would be an environmental concern. | Yu Bon Man Ka Lai Chow Zhang Cheng Wing Yin Mo Yung Hau Chan James Chung Wah Lam Frankie Tat Kwong Lau Wing Cheong Fung Ming Hung Wong | 2017 | Journal of Environmental Sciences2017，29，3： | 5 |
| 3 | Identification of Ca2+ signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres显示文摘The development of the CNS in vertebrate embryos involves the generation of different sub-types of neurons and glia in a complex but highly-ordered spatio-temporal manner. Zebrafish are commonly used for exploring the development, plasticity and regeneration of the CNS, and the recent development of reliable protocols for isolating and culturing neural stem/progenitor cells(NSCs/NPCs) from the brain of adult fish now enables the exploration of mechanisms underlying the induction/specification/differentiation of these cells. Here, we refined a protocol to generate proliferating and differentiating neurospheres from the entire brain of adult zebrafish. We demonstrated via RT-qPCR that some isoforms of ip3 r, ryr and stim are upregulated/downregulated significantly in differentiating neurospheres, and via immunolabelling that 1,4,5-inositol trisphosphate receptor(IP3 R) type-1 and ryanodine receptor(RyR) type-2 are differentially expressed in cells with neuron-or radial glial-like properties. Furthermore, ATP but not caffeine(IP3 R and RyR agonists, respectively), induced the generation of Ca^(2+) transients in cells exhibiting neuron-or glial-like morphology. These results indicate the differential expression of components of the Ca^(2+) -signaling toolkit in proliferating and differentiating cells. Thus, given the complexity of the intact vertebrate brain, neurospheres might be a useful system for exploring neurodegenerative disease diagnosis protocols and drug development using Ca^(2+) signaling as a read-out. | Man Kit Tse Ting Shing Hung Ching Man Chan Tiffany Wong Mike Dorothea Catherine Leclerc Marc Moreau Andrew L.Miller Sarah E.Webb | 2018 | Science China(Life Sciences)2018，61，11： | 4 |
| 4 | Establishing minimum clinically important difference values for the Patient-Reported Outcomes Measurement Information System Physical Function, hip disability and osteoarthritis outcome score for joint reconstruction, and knee injury and osteoarthritis out显示文摘AIM To establish minimum clinically important difference(MCID) for measurements in an orthopaedic patient population with joint disorders.METHODS Adult patients aged 18 years and older seeking care for joint conditions at an orthopaedic clinic took the Patient-Reported Outcomes Measurement Information System Physical Function(PROMIS~? PF) computerized adaptive test(CAT), hip disability and osteoarthritis outcome score for joint reconstruction(HOOS JR), and the knee injury and osteoarthritis outcome score for joint reconstruction(KOOS JR) from February 2014 to April 2017. MCIDs were calculated using anchorbased and distribution-based methods. Patient reports of meaningful change in function since their first clinic encounter were used as an anchor.RESULTS There were 2226 patients who participated with a mean age of 61.16(SD = 12.84) years, 41.6% male, and 89.7% Caucasian. Mean change ranged from 7.29 to 8.41 for the PROMIS~? PF CAT, from 14.81 to 19.68 for the HOOS JR, and from 14.51 to 18.85 for the KOOS JR. ROC cut-offs ranged from 1.97-8.18 for the PF CAT, 6.33-43.36 for the HOOS JR, and 2.21-8.16 for the KOOS JR. Distribution-based methods estimated MCID values ranging from 2.45 to 21.55 for the PROMIS~? PF CAT; from 3.90 to 43.61 for the HOOS JR, and from 3.98 to 40.67 for the KOOS JR. The median MCID value in the range was similar to the mean change score for each measure and was 7.9 for the PF CAT, 18.0 for the HOOS JR, and 15.1 for the KOOS JR.CONCLUSION This is the first comprehensive study providing a wide range of MCIDs for the PROMIS? PF, HOOS JR, and KOOS JR in orthopaedic patients with joint ailments. | Man Hung Jerry Bounsanga Maren W Voss Charles L Saltzman | 2018 | World Journal of Orthopedics2018，9，3： | 3 |
| 5 | HBsAg Seroclearance in Chronic Hepatitis B in Asian Patients: Replicative Level and Risk of Hepatocellular Carcinoma显示文摘 | Man–Fung Yuen Danny Ka–Ho Wong James Fung Philip Ip David But Ivan Hung Kevin Lau John Chi–Hang Yuen Ching–Lung Lai | 2008 | Gastroenterology2008，，4： | 2 |
| 6 | Accuracy of Risk Scores for Patients With Chronic Hepatitis B Receiving Entecavir Treatment显示文摘 | Grace Lai–Hung Wong Henry Lik–Yuen Chan Hoi–Yun Chan Pete Chi–Hang Tse Yee–Kit Tse Christy Wing–Hin Mak Stanley King–Yeung Lee Zoe Man–Yi Ip Andrew Ting–Ho Lam Henry Wing–Hang Iu Joyce May–Sum Leung Vincent Wai–Sun Wong | 2013 | Gastroenterology2013，，5： | 2 |
| 7 | Targeted hepatitis C screening among ex‐injection drug users in the community显示文摘 | Vincent Wai‐Sun Wong Grace Lai‐Hung Wong Angel Mei‐Ling Chim Tsz‐Fai Cheng Shirley Wing‐Yan Cheung Carol Man‐Sze Lai Kylie Joan‐Yi Szeto Sharon Tsang Stephen Ho‐Chun Wu Kenneth Kar‐Lung Yan Alex Yui Hui Desmond Chi‐Him Yiu Brian Bing‐Ying Wu David Cheung | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 8 | Efficient approaches for materialized views selection in a data warehouse显示文摘 | Ming Chuan Hung Man Lin H uang Don Lin Yang Nien Lin H sueh | 2007 | Information Sciences2007，177，： | 1 |
| 9 | Entecavir treatment reduces hepatic events and deaths in chronic hepatitis B patients With liver cirrhosis显示文摘 | Grace Lai‐Hung Wong Henry Lik‐Yuen Chan Christy Wing‐Hin Mak Stanley King‐Yeung Lee Zoe Man‐Yi Ip Andrew Ting‐Ho Lam Henry Wing‐Hang Iu Joyce May‐Sum Leung Jennifer Wing‐Yan Lai Angeline Oi‐Shan Lo Hoi‐Yun Chan Vincent Wai‐Sun Wong | 2013 | Hepatology2013，，5： | 1 |
| 10 | A pilot controlled trial of a combination of dense cranial electroacupuncture stim- ulation and body acupuncture for post-stroke depression 显示文摘 | Man SC Hung BH Ng RM | 2014 | BMC Complement Altern Med2014，19，14： | 1 |
| 11 | Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis显示文摘 | Rui-Hong Wang Yin Zheng Hyun-Seok Kim Xiaoling Xu Liu Cao Tyler Lahusen Mi-Hye Lee Cuiying Xiao Athanassios Vassilopoulos Weiping Chen Kevin Gardner Yan-Gao Man Mien-Chie Hung Toren Finkel Chu-Xia Deng | 2008 | Molecular Cell2008，，1： | 1 |
| 12 | 基于多变量概率模型的钻井周期预测方法显示文摘鉴于现有的预测钻井周期的方法忽视了影响钻井周期的关键因素因而精确度有限,提出采用多变量概率法预测钻井周期,并采用实测数据进行了算例分析和验证。利用自适应核密度估计法建立了各主要钻井阶段与深度相关的钻井周期概率模型,结合蒙特卡洛模拟得出了一次完整钻井施工作业的总周期的概率分布。采用该方法对澳大利亚及亚洲地区192口井的钻井周期进行了预测。尽管现有数据记录不全,但经过统计分析发现,模型模拟结果与实测数据的匹配度很高。研究表明,在10%~90%的置信区间内,总钻井周期比无事故钻井周期延长至少4 d,至多12 d。采用该方法可以得到钻至一定深度的可能的施工周期,有利于评价整个钻井施工过程的风险,模拟数据还可以用于机器学习模型的训练。图10表2参34。 | LUU Quang Hung LAU Man Fai NG Sebastian P.H. TING Clement P.W. WEE Reuben THEN Patrick H.H. | 2021 | 石油勘探与开发2021，48，4： | 1 |
| 13 | Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia显示文摘 | Ming‐Wai Hung Gennadi M. Kravtsov Chi‐Fai Lau Angela Ming‐See Poon George L. Tipoe Man‐Lung Fung | 2013 | J Pineal Res2013，，3： | 1 |
| 14 | Second homes in the Chinese mainland under'one country, two systems':a cross-border perspective 显示文摘 | Eddie Chi Man Hui Ka Hung Yu | 2009 | Habitat International2009，33，1： | 1 |
| 15 | A comparative study on aqueous root extracts of Pueraria thomsonii and Pueraria lobata by antioxidant assay and HPLC fingerprint analysis显示文摘 | Ren - Wang Jiang Kit - Man Lau Hung - Ming Lam | 2005 | Journal of Ethnopharmacology2005，96，： | 1 |
| 16 | Monolithic device with dual capacitor and varistor functions 显示文摘 | HUNG C LING MAN F YAN WARREN W RHODES | 1989 | J Am Ceram Soc1989，72，7： | 1 |
| 17 | From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound显示文摘 | Ming Wai Hung Zai Jun Zhang Shang Li Benson Lei Shuai Yuan Guo Zhen Cui Pui Man Hoi Kelvin Chan Simon Ming Yuen Lee Karl Wah-Keung Tsim | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
| 18 | Reversal of Left Ventricular Remodeling by Synchronous Biventricular Pacing in Heart Failure显示文摘 | CHU‐PAK LAU CHEUK‐MAN YU ELAINE CHAU KATHRYN FAN HUNG‐FAT TSE KATHY LEE MAN‐OI TANG SIU‐HONG WAN TIN‐CHU LAW PUI‐YIN LEE YUI‐MING LAM MICHAEL R.S. HILL | 2000 | Pacing and Clinical Electrophysiology (P)2000，，11： | 1 |
| 19 | Heavy metals, islet function and diabetes development显示文摘 | Ya Wen Chen Ching Yao Yang Chun Fa Huang Dong Zong Hung Yuk Man Leung Shing Hwa Liu | 2009 | Islets2009，，3： | 1 |
| 20 | In vitro electrophysi- ological mechanisms for antiarrhythmic efficacy of resveratrol, a red wine antioxidant 显示文摘 | Wen - Pin Chen Ming - Jai Su Li - Man Hung | 2007 | European Journal of Pharmacology2007，554，： | 1 |
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