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| 1 | Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma显示文摘We elucidated the anti-inflammatory mechanisms of IL-38 in allergic asthma.Human bronchial epithelial cells and eosinophils were cocultured upon stimulation with the viral RLR ligand poly(I:C)/LyoVec or infection-related cytokine TNF-αto induce expression of cytokines/chemokines/adhesion molecules.House dust mite(HDM)-induced allergic asthma and humanized allergic asthma NOD/SCID murine models were established to assess anti-inflammatory mechanisms in vivo.IL-38 significantly inhibited induced proinflammatory IL-6,IL-1β,CCL5,and CXCL10 production,and antiviral interferon-βand intercellular adhesion molecule-1 expression in the coculture system.Mass cytometry and RNA-sequencing analysis revealed that IL-38 could antagonize the activation of the intracellular STAT1,STAT3,p38 MAPK,ERK1/2,and NF-κB pathways,and upregulate the expression of the host defense-related gene POU2AF1 and anti-allergic response gene RGS13.Intraperitoneal injection of IL-38 into HDM-induced allergic asthma mice could ameliorate airway hyperreactivity by decreasing the accumulation of eosinophils in the lungs and inhibiting the expression of the Th2-related cytokines IL-4,IL-5,and IL-13 in the bronchoalveolar lavage fluid(BALF)and lung homogenates.Histological examination indicated lung inflammation was alleviated by reductions in cell infiltration and goblet cell hyperplasia,together with reduced Th2,Th17,and innate lymphoid type 2 cell numbers but increased proportions of regulatory T cells in the lungs,spleen,and lymph nodes.IL-38 administration suppressed airway hyperreactivity and asthma-related IL-4 and IL-5 expression in humanized mice,together with significantly decreased CCR3^(+) eosinophil numbers in the BALF and lungs,and a reduced percentage of human CD4^(+)CRTH2^(+)Th2 cells in the lungs and mediastinal lymph nodes.Together,our results demonstrated the anti-inflammatory mechanisms of IL-38 and provided a basis for the development of a regulatory cytokine-based treatment for allergic asthma. | Xiaoyu Sun Tianheng Hou Edwin Cheung Tiffany Nga-Teng Iu Victor Wai-Hou Tam Ida Miu-Ting Chu Miranda Sin-Man Tsang Paul Kay-Sheung Chan Christopher Wai-Kei Lam Chun-Kwok Wong | 2020 | Cellular & Molecular Immunology2020，17，6： | 22 |
| 2 | 带有自适应参数辨识的IPMSM MTPA控制显示文摘内置式永磁同步电机的工作点可能随着参数变化而偏离理想的最大转矩电流比(MTPA)轨迹,因而导致系统不能获得最优转矩-电流特性。针对这一问题,提出了一种在线识别定子交轴电感、转子磁链的模型参考自适应(MRAS)参数辨识方法。该方法在分析辨识模型欠秩问题和评估MTPA轨迹随参数变化偏离程度的基础上,推导了MRAS辨识模型,采用Popov超稳定性理论设计了满秩辨识器及其增益矩阵,并利用参数辨识结果计算定子电流工作点,以达到实时更新和跟踪MTPA轨迹的目的。仿真与实验结果验证了所设计方法的可行性和有效性,该方法显著提高了内置式永磁同步电机MTPA控制系统的转矩-电流特性。 | 金宁治 周凯 Herbert Ho-Ching IU | 2020 | 电机与控制学报2020，24，7： | 15 |
| 3 | Recovery of valuable metals from a low-grade nickel ore using an ammonium sulfate roasting-leaching process显示文摘Metal leaching from a low-grade nickel ore was investigated using an ammonium sulfate roasting-water leaching process.The nickel ore was mixed with ammonium sulfate,followed by roasting and finally leaching with water.During the process the effects of the amount of ammonium sulfate,roasting temperature,and roasting time on the leaching recovery of metal elements were analyzed.The optimum technological parameters were determined as follows:ammonium sulfate/ore ratio,0.8 g/g;roasting temperature,400°C;and roasting time,2 h.Under the optimum condition the leaching recoveries of Ni,Cu,Fe,and Mg were 83.48%,76.24%,56.43%,and 62.15%,respectively.Furthermore,the dissolution kinetics of Ni and Mg from the nickel ore was studied.The apparent activation energies for the leaching reaction of Ni and Mg were 18.782 and 10.038 kJ·mol-1,which were consistent with the values of diffusion control reactions.Therefore,the results demonstrated that the leaching recoveries of Ni and Mg were controlled by diffusion. | Xin-wei L iu Ya-li Feng Hao-ran L i Zhi-chao Yang Zhen-lei Cai | 2012 | International Journal of Minerals,Metallurgy and Materials2012，19，5： | 14 |
| 4 | An online maximum power point capturing technique for highefficiency power generation of solar photovoltaic systems显示文摘This paper proposes a novel high-efficiency generation technique for photovoltaic(PV) system,named maximum power point capturing(MPPC) technique. This is an aperiodic perturbation MPPC technique compared to the conventional periodic perturbation maximum power point tracking technique. Firstly, under a closed-loop circuit and an open-loop circuit,the complete I-V curves and P-V curves are defined. Secondly, the proposed MPPC technique is based on the complete I-V curves and a practical model of solar PV systems.The proposed method realizes that maximum power point(MPP) is captured online, and its control strategy is designed to set a steady operating area around MPP. The duty cycle keeps constant when the operating point is within the steady operating area, i.e., aperiodic perturbation, and when the operating point is outside the steady operating area, MPPC is triggered to capture a new MPP with an updated steady operating area. Simulation results demonstrate that no oscillations exist in steady-state;dynamic performances are improved;and only two perturbations are required to capture the new MPP. Using the proposed MPPC method,low voltage ride through and high voltage ride through can be prevented. | Lijun ZHANG Samson Shenglong YU Tyrone FERNANDO Herbert Ho-Ching IU Kit Po WONG | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，2： | 8 |
| 5 | Stability Analysis of PLL Influenced by Control Loops in Grid-connected Converters Under Fault Disturbance显示文摘When the power grid suffers from grid faults that cause phase disturbances,the grid-connected converter becomes destabilized by the interaction between the phase-locked loop(PLL)and the control loop.In this paper,the stability of the PLL affected by the control loop under transient grid faults is studied.First,the equivalent model of the PLL under the influence of the control loop is established.Then,different response processes of PLLs under the ground fault with various control parameters are qualitatively analyzed.Furthermore,a small-signal model is proposed to assess the stability of the PLL under different control loop parameters.The system poles can be calculated to show the physical origin of the instability.Finally,simulations of a three-phase 21-level modular multilevel converter(MMC)built in PSCAD and a down-scale experiment is performed to verify the parameter influence of the control loop on the PLL. | Yushuang Liu Meng Huang Xiaoming Zha Herbert Ho-Ching Iu | 2020 | CSEE Journal of Power and Energy Systems2020，6，2： | 6 |
| 6 | Clinical features and treatment outcomes of endogenous Klebsiella endophthalmitis:a 12-year review显示文摘AIM:To identify the clinical features and treatment outcomes of endogenous Klebsiella pneumoniae endophthalmitis and investigate prognostic factors of poor visual outcome.METHODS:The clinical records of all patients diagnosed with endogenous Klebsiella endophthalmitis between January 2007 to December 2018 in Prince of Wales Hospital,Hong Kong,China were retrospectively reviewed.Thorough ophthalmological examination findings were recorded in the case note,including visual acuity testing,slit-lamp examination,indirect ophthalmoscopy and B-scan ultrasonography if media opacity precluded fundus viewing.RESULTS:A total of 18 eyes in 14 patients were identified.Bilateral involvement was noted in 4 patients(28.6%).Hepatobiliary sepsis was the source in 9 patients(64.3%).Culture of intraocular fluid was positive in 5 out of 18 eyes(27.8%).Mortality was noted in 2 patients(14.3%).Mean final visual acuity was 20/1500.Six out of 16 eyes had total loss of sight(37.5%)and 3 eyes required evisceration(18.8%).Multivariate linear regression revealed poor presenting visual acuity(P=0.031)and lack of fundus view due to vitritis(P=0.02)as prognostic factors of poor visual outcome.CONCLUSION:Visual outcome of endogenous Klebsiella endophthalmitis is poor.Poor presenting visual acuity and lack of fundus view predict poor visual outcome.High index of suspicion for endophthalmitis is important in Klebsiella sepsis patients with complaints of ocular symptoms.Ophthalmological screening is recommended in noncommunicable patients with Klebsiella sepsis. | Chun Yue Mak Mary Ho Lawrence Pui-leung Iu Helena Pui-yee Sin Li Jia Chen Grace Lui Marten Erik Brelen Alvin Lerrmann Young | 2020 | International Journal of Ophthalmology(English edition)2020，13，12： | 5 |
| 7 | Sequential quadratic programming particle swarm optimization for wind power system operations considering emissions显示文摘In this paper,a computation framework for addressing combined economic and emission dispatch(CEED)problem with valve-point effects as well as stochastic wind power considering unit commitment(UC)using a hybrid approach connecting sequential quadratic programming(SQP)and particle swarm optimization(PSO)is proposed.The CEED problem aims to minimize the scheduling cost and greenhouse gases(GHGs)emission cost.Here the GHGs include carbon dioxide(CO_(2)),nitrogen dioxide(NO_(2)),and sulphur oxides(SO_(x)).A dispatch model including both thermal generators and wind farms is developed.The probability of stochastic wind power based on the Weibull distribution is included in the CEED model.The model is tested on a standard system involving six thermal units and two wind farms.A set of numerical case studies are reported.The performance of the hybrid computational method is validated by comparing with other solvers on the test system. | Yang ZHANG Fang YAO Herbert Ho-Ching IU Tyrone FERNANDO Kit Po WONG | 2013 | Journal of Modern Power Systems and Clean Energy2013，1，3： | 5 |
| 8 | Projection of the Zhujiang(Pearl) River Delta's potential submerged area due to sea level rise during the 21st century based on CMIP5 simulations显示文摘Projections of potential submerged area due to sea level rise are helpful for improving understanding of the influence of ongoing global warming on coastal areas. The Ensemble Empirical Mode Decomposition method is used to adaptively decompose the sea level time series in order to extract the secular trend component. Then the linear relationship between the global mean sea level(GMSL) change and the Zhujiang(Pearl) River Delta(PRD)sea level change is calculated: an increase of 1.0 m in the GMSL corresponds to a 1.3 m(uncertainty interval from1.25 to 1.46 m) increase in the PRD. Based on this relationship and the GMSL rise projected by the Coupled Model Intercomparison Project Phase 5 under three greenhouse gas emission scenarios(representative concentration pathways, or RCPs, from low to high emission scenarios RCP2.6, RCP4.5, and RCP8.5), the PRD sea level is calculated and projected for the period 2006–2100. By around the year 2050, the PRD sea level will rise 0.29(0.21 to 0.40) m under RCP2.6, 0.31(0.22 to 0.42) m under RCP4.5, and 0.34(0.25 to 0.46) m under RCP8.5, respectively.By 2100, it will rise 0.59(0.36 to 0.88) m, 0.71(0.47 to 1.02) m, and 1.0(0.68 to 1.41) m, respectively. In addition,considering the extreme value of relative sea level due to land subsidence(i.e., 0.20 m) and that obtained from intermonthly variability(i.e., 0.33 m), the PRD sea level will rise 1.94 m by the year 2100 under the RCP8.5scenario with the upper uncertainty level(i.e., 1.41 m). Accordingly, the potential submerged area is 8.57×103 km2 for the PRD, about 1.3 times its present area. | XIA Jiangjiang YAN Zhongwei ZHOU Wen FONG Soi Kun LEONG Ka Cheng TANG Iu Man CHANG S W LEONG W K JIN Shaofei | 2015 | Acta Oceanologica Sinica2015，34，9： | 3 |
| 9 | Accuracy of Risk Scores for Patients With Chronic Hepatitis B Receiving Entecavir Treatment显示文摘 | Grace Lai–Hung Wong Henry Lik–Yuen Chan Hoi–Yun Chan Pete Chi–Hang Tse Yee–Kit Tse Christy Wing–Hin Mak Stanley King–Yeung Lee Zoe Man–Yi Ip Andrew Ting–Ho Lam Henry Wing–Hang Iu Joyce May–Sum Leung Vincent Wai–Sun Wong | 2013 | Gastroenterology2013，，5： | 2 |
| 10 | 基于神经网络和光流场的嵌入式高速目标识别与跟踪(英文)显示文摘研究了面向嵌入式硬件平台的高速视频图像处理与高速目标跟踪算法。基于神经网络的光流场算法能有效减少程序对硬件系统的内存要求和运算要求,该算法能够比传统算法更加容易的应用于以DSP(数字信号处理)芯片为核心的嵌入式硬件平台中。首先设计了一个基于Hopfield神经网络控制器的自适应滤波器,以图像信噪比为控制指标,对需进行目标识别的视频图像进行图像预处理;然后,利用补偿模糊神经网络控制器对光流场计算方法进行优化,这是一种通过参数控制平滑度实现的平均速度的角度误差和标准角误差的CFNN(补偿模糊神经网络)控制器识别跟踪算法。微机仿真及嵌入式系统试验结果均表明:该算法能够在同等条件下显著提高目标辨别与跟踪能力,显示其具有较高的有效性和实用性。 | 苏金泷 HERBERT H C IU FERNANDO T | 2015 | 中国公路学报2015，28，11： | 2 |
| 11 | Visual function and quality of life among patients with glaucoma 显示文摘 | Parrish RK Gedde SJ Scott IU | 1997 | Arch Ophthalmol1997，115，19： | 1 |
| 12 | In vivo,in vitro, and moleculer aspects of interleukin - 8 and interleukin - 8 receptors显示文摘 | Hoch RC Schtaufstaetter IU Cochrane CG | 1996 | J Lab Clin Med1996，128，2： | 1 |
| 13 | Intravitreal bevacizumab (Avastin) injection associated with regression of retinal neovascularization caused by sickle cell retinopathy 显示文摘 | Siqueira RC Costa RA Scott IU | 2006 | Acta Ophthalmol Scand2006，84，6： | 1 |
| 14 | Control of chaos in a PWM current-mode H-bridge inverter using time-delayed feedback显示文摘 | Iu H H C Ronert B | 2003 | IEEE Transactions on Circuits and Systems2003，50，8： | 1 |
| 15 | Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation I' dendritic cell-mediated allergic inflammation 显示文摘 | 1 iu YJ | 2007 | J AllergyClin lmmuno12007，120，2： | 1 |
| 16 | Reminiscences of A Li- brarian 显示文摘 | Alfred K'aiming Ch'iu | 1965 | Harvard Journal of Asiatic Stud- ies1965，，25： | 1 |
| 17 | A dual-band antenna for WLAN applications 显示文摘 | I iu D Gaucher B Hildner T | 2005 | IEEE Ant Techn lnt Workshop2005，，： | 1 |
| 18 | Incidence of endophthalmitis after 20-gauge vs 23-gauge vs 25-gauge pars plana vitrectomy 显示文摘 | Scott IU Flynn HW Acar N | 2011 | Graefers Arch Clin Experim Ophthalm2011，249，： | 1 |
| 19 | Design of a memcapacitor emulator based on a memristor显示文摘 | Wang X Y Fitch A L Iu H H C | 2012 | Physics Letters A2012，376，： | 1 |
| 20 | Perforator for skin transplants 显示文摘 | Stepanov Iu I | 1980 | Khirurgiia (Mosk)1980，7，： | 1 |
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