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| 1 | Hepatocellular carcinoma: current management and recent advances显示文摘BACKGROUND: Hepatocellular carcinoma (HCC) is a major health problem worldwide. It is the fifth most common cancer in the world, and the third most common cause of cancer-related death. Without specific treatment, the prognosis is very poor. The goal of management is 'cancer control' - a reduction in its incidence and mortality as well as an improvement in the quality of life of patients with HCC and their families. This article aims to review the current management of HCC and its recent advances. DATA SOURCES: A MEDLINE database search was performed to identify relevant article using the keyworks 'hepatocellular carcinoma', 'hepatectomy', 'liver transplantation', and 'local ablative therapy'. Additional papers and book chapters were identified by a manual search of the references from the key articles. RESULTS: Liver resection and liver transplantation remain the options that give the best chance of a cure. Recent evidence suggests that local ablative therapy may offer comparable survival results in patients with small HCC, and preserved liver function. Transarterial chemoembolization (TACE) is the most promising palliative modality for unresectable HCC, but other techniques, such as transarterial radioembolization (TARE), and local ablative therapy, have also shown comparable results. CONCLUSIONS: Early diagnosis of HCC remains a key goal in improving the prognosis of patients. During the last two decades, operative mortality and surgical outcome of liver resection and liver transplantation for HCC have improved. Progress also has been made in multi-modality therapy which can increase the chance of survival and improve the quality of life for patients with advanced HCC. | Wan-Yee Lau Eric C. H. Lai | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，3： | 100 |
| 2 | Climatology and Interannual Variability of the Southeast Asian Summer Monsoon显示文摘ClimatologyandInterannualVariabilityoftheSoutheastAsianSummerMonsoonK.-M.LauLaboratoryforAtmospheres,Code913,NASA-GoddardSpac... | K. M. Lau Song Yang | 1997 | Advances in Atmospheric Sciences1997，14，2： | 123 |
| 3 | Glypican-3和CD34免疫组化染色在肝细胞癌与良性肝细胞性病变鉴别诊断中的价值显示文摘 | Coston W M P Loera S Lau S K 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，3： | 31 |
| 4 | Protein induced by vitamin K absence or antagonist-Ⅱ versus alpha-fetoprotein in the diagnosis of hepatocellular carcinoma: A systematic review with meta-analysis显示文摘Background: As a promising biomarker of hepatocellular carcinoma(HCC), protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ) has been studied extensively. However, its diagnostic capability varies across HCC studies. This study aimed to compare the performance of PIVKA-Ⅱ with alpha-fetoprotein(AFP) in the diagnosis of HCC. Data sources: A systematic literature search was conducted to identify the studies from MEDLINE, Embase and Cochrane Library Databases, which were published up to December 20, 2017 to compare the diagnostic capability of PIVKA-Ⅱ and AFP for HCC. The data were pooled using random effects model. Pooled sensitivity and specificity were calculated. Summary receiver operating characteristic curve(ROC) was employed to evaluate the diagnostic accuracy of each marker. Results: Thirty-one studies were included. The pooled sensitivity(95% CI) of PIVKA-Ⅱ and AFP was 0.66(0.65–0.68) and 0.66(0.65–0.67), respectively in diagnosis of HCC; and the corresponding pooled specificity(95% CI) was 0.89(0.88–0.90) and 0.84(0.83–0.85), respectively. The area under the ROC curve(AUC) of PIVKA-Ⅱ and AFP was 0.856(0.817–0.895) and 0.770(0.728–0.811), respectively. Subgroup analysis showed that PIVKA-Ⅱ was superior to AFP in terms of the AUC for both small HCC( < 3 cm) [0.863(0.825–0.901) vs 0.717(0.658–0.776)] and large HCC( ≥ 3 cm) [0.854(0.811–0.897) vs 0.729(0.682–0.776)]; for American [0.926(0.897–0.955) vs 0.698(0.594–0.662)], European [0.772(0.743–0.801) vs 0.628(0.594–0.662)], Asian [0.838(0.812–0.864) vs 0.785(0.764–0.806)] and African [0.812(0.794–0.840) vs 0.721(0.675–0.767)] HCC patients; and for HBV-related [0.909(0.866–0.951) vs 0.714(0.673–0.755)] and mixed-etiology [0.847(0.821–0.873) vs 0.794(0.772–0.816)] HCC. Conclusion: This meta-analysis indicates that PIVKA-Ⅱ is better than AFP in terms of the accuracy for diagnosing HCC, regardless of tumor size, patient ethnic group, or HCC etiology. | Hao Xing Yi-Jie Zheng Jun Han Han Zhang Zhen-Li Li Wan-Yee Lau Feng Shen Tian Yang | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，6： | 34 |
| 5 | 冬虫夏草对巨噬细胞免疫活性的增强作用显示文摘目的:检测冬虫夏草对巨噬细胞免疫活性的影响,探讨其滋补强身作用机理。方法:采用不同浓度虫草水提液与J774巨噬细胞一起作细胞培养,观察细胞吞噬活性的变异情况。结果:细胞吞噬活性明显增强。在药物浓度100μg·ml-1到3000μg·ml-1范围内都有显著增强效果(P<0.05)。分别增强1.27倍到2.58倍,峰值在500μg·ml-1。结论:增强机体免疫功能,可能在虫草的滋补强身作用机制中起重要作用。 | 贾泰元 Benjamin HS Lau | 1997 | 中国药学杂志1997，32，3： | 30 |
| 6 | Methods of vascular control technique during liver resection:a comprehensive review显示文摘BACKGROUND:Significant hemorrhage together with blood transfusion increases postoperative morbidity and mortality of hepatic resection.Hepatic vascular occlusion is effective in minimizing bleeding during hepatic parenchymal transection.This article aimed to review the current role and status of various techniques of hepatic vascular occlusion during hepatic resection.DATA SOURCES:The relevant manuscripts were identified by searching MEDLINE,and PubMed for articles published between January 1980 and April 2010 using the keywords ' vascular control','vascular clamping','vascular exclusion' and 'hepatectomy'.Additional papers were identified by a manual search of the references from the key articles.RESULTS:One randomized controlled trial(RCT) and 5 RCTs showed intermittent Pringle maneuver and ischemic preconditioning followed by continuous Pringle maneuver were superior to continuous Pringle maneuver alone,respectively.Two RCTs compared the outcomes of hepatectomy with and without intermittent Pringle maneuver.One showed Pringle maneuver to be beneficial,while the other failed to show any benefit.One RCT showed that ischemic preconditioning had significantly less blood loss than using intermittent Pringle maneuver.Four RCTs evaluated the use of hemihepatic vascular occlusion.One RCT showed it had significantly less blood loss than Pringle maneuver,while the other 3 showed no significant difference.Only 1 RCT showed it had significantly less liver ischemic injury.No RCT had been carried out to assess segmental vascular occlusion.Two RCTs compared the outcomes of total hepatic vascular exclusion(THVE) and Pringle maneuver.One RCT showed THVE resulted in similar blood loss,but a higher postoperative complication.The other RCT showed less blood loss using THVE but the postoperative complication rate was similar.Both studies showed similar degree of liver ischemic injury.Only one RCT showed that selective hepatic vascular exclusion(SHVE) had less blood loss and liver ischemic injury than Pringle maneuver.CONCLUSION:Due to the great variations in these studies,it is difficult to draw a definitive conclusion on the best technique of hepatic vascular control. | Wan-Yee Lau Eric C.H.Lai Stephanie H.Y.Lau | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，5： | 27 |
| 7 | Isolation and characterization of bipotent liver progenitor cells from adult mouse显示文摘 | Li WL Su J Yao YC Tao XR Yan YB Yu HY Wang XM Li JX Yang YJ Lau JT HuYP | 2006 | 中国生物学文摘2006，20，5： | 26 |
| 8 | 微波消解-电感耦合等离子体质谱法测定丙烯腈-丁二烯-苯乙烯共聚物塑料中的铅、镉、汞、铬、砷显示文摘建立了微波消解技术-电感耦合等离子体质谱(ICP-MS)法同时测定丙烯腈-丁二烯-苯乙烯共聚物(ABS)塑料中的铅、镉、汞、铬、砷五种元素的方法。对仪器的参数设置、进样系统进行了优化,并对此类塑料样品中上述元素分析的前处理条件,如消解体系、消解温度、恒温时间以及酸用量等进行了优化。方法检出限为0.7~6.5ng·g-1;用加标回收的方法评价了该方法的准确性,加标回收率为89.8%~110.8%;样品测定相对标准偏差为2.8%~11.3%。该方法检出限低、精确度好、准确度高、简单快速、无需基体匹配。 | 王英锋 施燕支 张华 陈玉红 John Lau Steven Wilbur 李平 | 2008 | 光谱学与光谱分析2008，28，1： | 26 |
| 9 | Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma显示文摘Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver failure.Liver cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver cancers.Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management.Chronic infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for HCC.Due to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of HCC.Common mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral proteins.DNA integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV infection.The current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC. | Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel | 2020 | World Journal of Gastroenterology2020，26，38： | 25 |
| 10 | Optical cross-talk reduction in a quantumdot-based full-color micro-light-emitting-diode display by a lithographic-fabricated photoresist mold显示文摘In this study, a full-color emission red–green–blue(RGB) quantum-dot(QD)-based micro-light-emitting-diode(micro-LED) array with the reduced optical cross-talk effect by a photoresist mold has been demonstrated. The UV micro-LED array is used as an efficient excitation source for the QDs. The aerosol jet technique provides a narrow linewidth on the micrometer scale for a precise jet of QDs on the micro-LEDs. To reduce the optical cross-talk effect,a simple lithography method and photoresist are used to fabricate the mold, which consists of a window for QD jetting and a blocking wall for cross-talk reduction. The cross-talk effect of the well-confined QDs in the window is confirmed by a fluorescence microscope, which shows clear separation between QD pixels. A distributed Bragg reflector is covered on the micro-LED array and the QDs' jetted mold to further increase the reuse of UV light.The enhanced light emission of the QDs is 5%, 32%, and 23% for blue, green, and red QDs, respectively. | HUANG-YU LIN CHIN-WEI SHER DAN-HUA HSIEH XIN-YIN CHEN HUANG-MING PHILIP CHEN TENG-MING CHEN KEI-MAY LAU CHYONG-HUA CHEN CHIEN-CHUNG LIN HAO-CHUNG KUO | 2017 | Photonics Research2017，5，5： | 26 |
| 11 | The current role of neoadjuvant/adjuvant/chemoprevention therapy in partial hepatectomy for hepatocellular carcinoma:a systematic review显示文摘BACKGROUND:Following curative treatment for hepato-cellular carcinoma(HCC),50%-90% of postoperative death is due to recurrent disease.Intra-hepatic recurrence is frequently the only site of recurrence.Thus,any neoadjuvant or adjuvant therapy,which can decrease or delay the incidence of intra-hepatic recurrence,or any cancer chemoprevention which can prevent a new HCC from developing in the liver remnant,will improve the results of liver resection.This article systematically reviewed the current evidence of neoadjuvant,adjuvant, and chemoprevention in partial hepatectomy of HCC. DATA SOURCES:Studies were identified by searching MEDLINE and PubMed databases for articles from January 1990 to November 2008 using the keywords 'hepatocellular carcinoma','hepatectomy','adjuvant therapy','neoadjuvant therapy',and'regional therapy'. Additional papers and book chapters were identified by a manual search of the references from the key articles. RESULTS:Neoadjuvant transarterial chemoembolization or adjuvant regional transarterial chemotherapy± embolization+systemic chemotherapy did not add benefit. Both adjuvant transarterial radioembolization with 131 I-lipiodol and adjuvant systemic interferon showed promising results.However,there were only a limited number of such studies.CONCLUSIONS:Further randomized controlled studies need to be carried out.Currently,there is no consensus on a standard neoadjuvant/adjuvant/chemoprevention therapy in partial hepatectomy for HCC. | Wan-Yee Lau Eric C.H.Lai Stephanie H.Y.Lau | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，2： | 24 |
| 12 | 微波消解-电感耦合等离子体质谱(ICP-MS)法同时测定塑料中的铅、镉、汞、铬、砷显示文摘建立了微波消解-电感耦合等离子体质谱同时测定各种塑料中的铅、镉、汞、铬、砷等元素的方法.对仪器的参数设置、进样系统的选择、测试稳定性等方面进行了系统研究,并对塑料标准样品中上述元素分析的前处理条件如消解体系、酸用量、消解温度及时间等进行了优化.方法检出限为0.7—6.5 ng.g-1,加标回收率为89.8%—103.5%,相对标准偏差为0.8%—11.3%. | 陈玉红 张华 施燕支 王英锋 李平 John Lau Steven Wilbur 王海舟 | 2006 | 环境化学2006，25，4： | 24 |
| 13 | Input-occupancy-output models of the non-competitive type and their application - an examination of the China-US trade surplus显示文摘本文构建了一种能够反映中国加工贸易特点的非竞争(进口)型投入占用产出模型,提出了一个国家全部出口与分部门、分大类商品的单位出口对国内增加值和就业的拉动效应的计算方法,从数学上证明了出口总值等于出口商品所包含的完全国内增加值与完全进口额之和,并据此编制了2002年中美两国的非竞争(进口)型投入占用产出表,测算和分析了中美两国出口对各自国内增加值和就业的影响。 | Lawrence J. Lau Xikang Chen Cuihong Yang Leonard K. Cheng K. C. Fung Yun-Wing Sung Kunfu Zhu Jiansuo Pei Zhipeng Tang | 2010 | Social Sciences in China2010，31，1： | 24 |
| 14 | Laparoscopic liver resection under hemihepatic vascular inflow occlusion using the lowering of hilar plate approach显示文摘BACKGROUND: With advances in technology, laparoscopic liver resection is widely accepted. Laparoscopic liver resection under hemihepatic vascular inflow occlusion has advantages over the conventional total hepatic inflow occlusion using the Pringle's maneuver, especially in patients with cirrhosis.METHOD: From November 2011 to August 2012, eight consecutive patients underwent laparoscopic liver resection under hemihepatic vascular inflow occlusion using the lowering of hilar plate approach with biliary bougie assistance.RESULTS: The types of liver resection included right hepatectomy(n1), right posterior sectionectomy(n1), left hepatectomy and common bile duct exploration(n1), segment 4b resection(n1), left lateral sectionectomy(n2), and wedge resection(n2). Four patients underwent right and 4 left hemihepatic vascular inflow occlusion. Four patients had cirrhosis. The mean operation time was 176.3 minutes. The mean time taken to achieve hemihepatic vascular inflow occlusion was 24.3minutes. The mean duration of vascular inflow occlusion was54.5 minutes. The mean intraoperative blood loss was 361 mL.No patient required blood transfusion. Postoperatively, one patient developed bile leak which healed with conservative treatment. No postoperative liver failure and mortality occurred. The mean hospital stay of the patients was 7 days.CONCLUSION: Our technique of hemihepatic vascular inflow vascular occlusion using the lowering of hilar plate approachwas safe, and it improved laparoscopic liver resection by minimizing blood loss during liver parenchymal transection. | Ying-Jun Chen Zuo-Jun Zhen Huan-Wei Chen Eric CH Lai Fei-Wen Deng Qing-Han Li Wan Yee Lau | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，5： | 23 |
| 15 | Repetitive transcranial magnetic stimulation for lower extremity motor function in patients with stroke:a systematic review and network meta-analysis显示文摘Transcranial magnetic stimulation,a type of noninvasive brain stimulation,has become an ancillary therapy for motor function rehabilitation.Most previous studies have focused on the effects of repetitive transcranial magnetic stimulation(rTMS)on motor function in stroke patients.There have been relatively few studies on the effects of different modalities of rTMS on lower extremity motor function and corticospinal excitability in patients with stroke.The MEDLINE,Embase,Cochrane Library,ISI Science Citation Index,Physiotherapy Evidence Database,China National Knowledge Infrastructure Library,and ClinicalTrials.gov databases were searched.Parallel or crossover randomized controlled trials that addressed the effectiveness of rTMS in patients with stroke,published from inception to November 28,2019,were included.Standard pairwise meta-analysis was conducted using R version 3.6.1 with the“meta”package.Bayesian network analysis using the Markov chain Monte Carlo algorithm was conducted to investigate the effectiveness of different rTMS protocol interventions.Network meta-analysis results of 18 randomized controlled trials regarding lower extremity motor function recovery revealed that low-frequency rTMS had better efficacy in promoting lower extremity motor function recovery than sham stimulation.Network meta-analysis results of five randomized controlled trials demonstrated that highfrequency rTMS led to higher amplitudes of motor evoked potentials than low-frequency rTMS or sham stimulation.These findings suggest that rTMS can improve motor function in patients with stroke,and that low-frequency rTMS mainly affects motor function,whereas high-frequency rTMS increases the amplitudes of motor evoked potentials.More highquality randomized controlled trials are needed to validate this conclusion.The work was registered in PROSPERO(registration No.CRD42020147055)on April 28,2020. | Yun-Juan Xie Yi Chen Hui-Xin Tan Qi-Fan Guo Benson Wui-Man Lau Qiang Gao | 2021 | Neural Regeneration Research2021，16，6： | 20 |
| 16 | 不同左心室射血分数老年充血性心力衰竭患者药物治疗的临床研究显示文摘目的探讨充血性心力衰竭(心衰)患者的临床特征和药物治疗情况以及不同左心室射血分数(LVEF)心衰患者的并发症与药物治疗情况。方法连续调查2001年1月—2002年1月香港大学玛丽医院收住60岁以上的老年充血性心衰患者,符合ICD9CM诊断标准,并用弗明翰研究标准确诊,共计1074例次,收集入院时及入院3d内的超声心动图、心电图、X线胸片等检查结果以及患者出院时转归、出院带药情况。结果1女性充血性心衰患者几乎为男性患者的2倍,年龄≥65岁者占95.5%,≥80岁者占50.6%,按美国纽约心脏协会(NYHA)心功能分级,和级占70.2%,521例(占48.5%)入院治疗1次。2充血性心衰的主要并发症为糖尿病和高血压。3399例次行超声心动图检查者中,208例次(占52.1%)LVEF<0.50,191例次(占47.9%)LVEF≥0.50的患者更倾向于女性,年龄≥80岁,而冠心病及糖尿病较少发生,心房颤动84例次(占44.0%)占多数(P<0.05)。糖尿病、完全性左束支传导阻滞及心肌梗死病史常伴随LVEF<0.50的患者(P<0.05)。4大部分患者均接受利尿剂治疗,LVEF<0.50的患者中使用血管紧张素转换酶抑制剂(ACEI)131例次(占63.0%),地高辛47例次(占22.6%),β受体阻滞剂25例次(占12.0%),钙阻滞剂29例次(占13.9%),而LVEF≥0.50的患者分别有119例次(62.3%)、67例次(35.1%)、18例次(占9.4%)和35例次(占18.3%)使用上述药物,地高辛多用在LVEF≥0.50的患者(P<0.05)。结论1LVEF<0.50与≥0.50的充血性心衰患者单从临床症状和体征上较难区别,目前强调对每个心衰患者尽可能进行早期超声心动图检查,这是区别两类心衰的重要手段。2ACEI、β受体阻滞剂的使用与治疗指南还有一定距离。3尽早地区分LVEF<0.50与≥0.50充血性心衰患者将有利于抗心衰治疗。 | 詹红 Tse Hung-fat 曹晶茗 Lau Cpu-pak | 2006 | 中国危重病急救医学2006，18，4： | 20 |
| 17 | Optimal central venous pressure during partial hepatectomy for hepatocellular carcinoma显示文摘BACKGROUND:Low central venous pressure(CVP) affects hemodynamic stability and tissue perfusion.This prospective study aimed to evaluate the optimal CVP during partial hepatectomy for hepatocellular carcinoma(HCC).METHODS:Ninety-seven patients who underwent partial hepatectomy for HCC had their CVP controlled at a level of 0 to 5 mmHg during hepatic parenchymal transection.The systolic blood pressure(SBP) was maintained,if possible,at 90 mmHg or higher.Hepatitis B surface antigen was positive in 90 patients(92.8%) and cirrhosis in 84 patients(86.6%).Pringle maneuver was used routinely in these patients with clamp/unclamp cycles of 15/5 minutes.The average clamp time was 21.4±8.0 minutes.These patients were divided into 5 groups based on the CVP:group A:0-1 mmHg;B:1.1-2 mmHg;C:2.1-3 mmHg;D:3.1-4 mmHg and E:4.1-5 mmHg.The blood loss per transection area during hepatic parenchymal transection and the arterial blood gas before and after liver transection were analyzed.RESULTS:With active fluid load,a constant SBP ≥90 mmHg which was considered as optimal was maintained in 18.6% in group A(95% CI:10.8%-26.3%);39.2% in group B(95% CI:29.5%-48.9%);72.2% in group C(95% CI:63.2%-81.1%);89.7% in group D(95% CI:83.6%-95.7%);and 100% in group E(95% CI:100%-100%).The blood loss per transection area during hepatic parenchymal transection decreased with a decrease in CVP.Compared to groups D and E,blood loss in groups A,B and C was significantly less(analysis of variance test,P<0.05).Compared with the baseline,the blood oxygenation decreased significantly when the CVP was reduced.Base excess and HCO 3-in groups A and B were significantly decreased compared with those in groups C,D and E(P<0.05).CONCLUSION:In consideration of blood loss,SBP,base excess and HCO 3-,a CVP of 2.1-3 mmHg was optimal in patients undergoing partial hepatectomy for HCC. | Cheng-Xin Lin Ya Guo Wan Yee Lau Guang-Ying Zhang Yi-Ting Huang Wen-Zheng He Eric CH Lai | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 19 |
| 18 | ^(18)F-FDG PET/CT显像在鼻咽癌分期与疗效监测中的临床应用价值显示文摘背景与目的:18F-脱氧葡萄糖(fluorine-18 fluorodeoxyglucose,18F-FDG)PET/CT显像可明显提高肺癌、食管癌等多种肿瘤的诊断、分期与疗效监测的准确性,有助于更准确地制定治疗方案。本研究探讨全身18F-FDG PET/CT显像在鼻咽癌首次分期、再分期及疗效监测中的临床应用价值。方法:回顾性分析澳大利亚Peter MacCallum肿瘤中心2002年2月至2005年12月43例鼻咽癌患者的18F-FDG PET/CT全身扫描报告,根据临床资料、病理结果及临床随访结果,计算18F-FDG PET/CT与传统影像学检查CT、MRI的准确性、特异性、灵敏度、阳性预测值与阴性预测值,并对结果进行比较和分析。结果:18F-FDG PET/CT诊断鼻咽癌总的准确率、敏感性、特异性、阳性预测值与阴性预测值分别为95.3%、100.0%、85.7%、93.8%、100.0%,传统影像学检查CT、MRI分别为65.5%、79.4%、64.7%、81.8%、57.9%。18F-FDGPET/CT诊断结果使2例首次分期、7例再分期患者治疗方案得到改变,并影响1例首次分期和3例再分期患者治疗方案的制定;在疗效监测组中,指导医生修改治疗方案共11例(其中5例为原则性的修改)。18F-FDG PET/CT检测到2例第二原发肿瘤,1例是甲状腺癌,1例是低度恶性胃癌。结论:18F-FDG PET/CT全身显像对鼻咽癌N、M分期与疗效监测的临床作用可能优于CT、MR检查。 | 王国慧 Eddie W. F. Lau Ramdave Shakher David S. Binns Annette Hogg Elizabeth Drummond Rodney J. Hicks | 2007 | 癌症2007，26，6： | 19 |
| 19 | Exogenous neural stem cell transplantation for cerebral ischemia显示文摘Cerebral ischemic injury is the main manifestation of stroke,and its incidence in stroke patients is 70–80%.Although ischemic stroke can be treated with tissue-type plasminogen activator,its time window of effectiveness is narrow.Therefore,the incidence of paralysis,hypoesthesia,aphasia,dysphagia,and cognitive impairment caused by cerebral ischemia is high.Nerve tissue regeneration can promote the recovery of the aforementioned dysfunction.Neural stem cells can participate in the reconstruction of the damaged nervous system and promote the recovery of nervous function during self-repair of damaged brain tissue.Neural stem cell transplantation for ischemic stroke has been a hot topic for more than 10 years.This review discusses the treatment of ischemic stroke with neural stem cells,as well as the mechanisms of their involvement in stroke treatment. | Ling-Yi Liao Benson Wui-Man Lau Dalinda Isabel Sánchez-Vidana Qiang Gao | 2019 | Neural Regeneration Research2019，14，7： | 19 |
| 20 | 延胡索酸水合酶缺陷型肾细胞癌32例临床病理和分子分析显示文摘延胡索酸水合酶缺陷型肾细胞癌属于罕见的、新近发现的与遗传性平滑肌瘤病和肾细胞癌综合征相关的肿瘤实体。延胡索酸水合酶缺陷型肾细胞癌可表现出多种临床和病理学表现,但通常表现为局部进展和转移性疾病,预后较差。作者通过延胡索酸水合酶免疫组化和(或)延胡索酸水合酶突变分析确定32例延胡索酸水合酶缺陷型肾细胞癌,并对其临床和病理特征进行回顾性分析。 | Lau H D Chan E Fan A C 魏建国(摘译) 方三高(审校) | 2020 | 临床与实验病理学杂志2020，36，3： | 19 |
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