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| 1 | 师生互动的实证研究:中芬法澳四国中学数学课堂中的师生互动显示文摘师生互动是中学数学课堂中的关键教学行为。通过选取中国、芬兰、法国和澳大利亚四个国家中学数学课堂录像进行实证研究,探寻出中芬法澳课堂中师生互动模式的可能形态:整体态势上中国课堂中的师生互动较为静态,并表现出教师主导性;而芬法澳三国的师生互动更为动态。互动模式1:教师提问-学生回答是各国主导的师生互动模式,中国尤甚;中国的互动模式1与芬法澳迥异,主要表现在互动对象上;互动模式2:学生提问-教师回答在中国课堂几乎缺失;互动模式3:教师讲解-学生听讲是各国课堂知识传输的主要媒介,中国课堂中尤甚;互动模式4:学生做题-教师辅导中的教师辅导,在中国主要表现为全班集中讲解,体现出集体主义色彩,在芬法澳课堂中主要是个性化、针对性的小组或个别辅导;互动模式5:课堂管理在芬法澳课堂是重要的师生互动形式,中国课堂缺失。 | 于国文 曹一鸣 David Clarke Man Ching Esther Chan | 2019 | 全球教育展望2019，48，1： | 27 |
| 2 | Identification of Ca2+ signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres显示文摘The development of the CNS in vertebrate embryos involves the generation of different sub-types of neurons and glia in a complex but highly-ordered spatio-temporal manner. Zebrafish are commonly used for exploring the development, plasticity and regeneration of the CNS, and the recent development of reliable protocols for isolating and culturing neural stem/progenitor cells(NSCs/NPCs) from the brain of adult fish now enables the exploration of mechanisms underlying the induction/specification/differentiation of these cells. Here, we refined a protocol to generate proliferating and differentiating neurospheres from the entire brain of adult zebrafish. We demonstrated via RT-qPCR that some isoforms of ip3 r, ryr and stim are upregulated/downregulated significantly in differentiating neurospheres, and via immunolabelling that 1,4,5-inositol trisphosphate receptor(IP3 R) type-1 and ryanodine receptor(RyR) type-2 are differentially expressed in cells with neuron-or radial glial-like properties. Furthermore, ATP but not caffeine(IP3 R and RyR agonists, respectively), induced the generation of Ca^(2+) transients in cells exhibiting neuron-or glial-like morphology. These results indicate the differential expression of components of the Ca^(2+) -signaling toolkit in proliferating and differentiating cells. Thus, given the complexity of the intact vertebrate brain, neurospheres might be a useful system for exploring neurodegenerative disease diagnosis protocols and drug development using Ca^(2+) signaling as a read-out. | Man Kit Tse Ting Shing Hung Ching Man Chan Tiffany Wong Mike Dorothea Catherine Leclerc Marc Moreau Andrew L.Miller Sarah E.Webb | 2018 | Science China(Life Sciences)2018，61，11： | 4 |
| 3 | Entecavir Monotherapy Is Effective in Suppressing Hepatitis B Virus After Liver Transplantation显示文摘 | James Fung Cindy Cheung See–Ching Chan Man–Fung Yuen Kenneth S.H. Chok William Sharr Wing–Chiu Dai Albert C.Y. Chan Tan–To Cheung Simon Tsang Banny Lam Ching–Lung Lai Chung–Mau Lo | 2011 | Gastroenterology2011，，4： | 3 |
| 4 | The cell surface marker CD36 selectively identifies matured, mitochondria-rich hPSC-cardiomyocytes显示文摘Dear Editor,Human pluripotent stem cell(hPSC)-derived cardiomyocytes(CMs)are of significant translational value to in vitro studies of human cardiac development,drug and cardiotoxicity testing and cardiac disease modelling.Differentiation of hPSCs to CMs,however,yields mixed cultures of atrial-,ventricular-,and pacemaker-like cells as well as non-CMs in variable proportions.1 Strategies to enrich CMs from non-CMs and to generate ventricular versus atrial cells have been successful;however,enriched hPSC-CMs are developmentally immature and fail to recapitulate key functional traits that are fundamental to the(patho)physiology of adult CMs.1,2 Moreover,these strategies do not adequately address experimental variabilities caused by differences in the genomes and differentiation capabilities of diverse hPSC lines.One validated approach that overcomes issues of cell heterogeneity and experimental variability is immunophenotyping;however,accessible markers suitable for defining mature,live CMs are lacking.Although cell surface markers such as SIRPA(CD172a)and VCAM1(CD106)3,4 have been used to sort for hPSC-CMs,they do not distinguish between maturation states.Here,we report the identification of CD36 as a cell surface marker of maturation,which can be used to reduce experimental variability and improve drug screens. | Ellen Ngar-Yun Poon Xiao-ling Luo Sarah EWebb Bin Yan Rui Zhao Stanley Chun Ming Wu Yong Yang Peng Zhang Huajun Bai Jiaofang Shao Ching Man Chan Godfrey Chi-Fung Chan Suk Ying Tsang Rebekah LGundry Huang-Tian Yang Kenneth RBoheler | 2020 | Cell Research2020，30，7： | 1 |
| 5 | Entecavir Monotherapy Is Effective in Suppressing Hepatitis B Virus After Liver Transplantation显示文摘 | James Fung Cindy Cheung See–Ching Chan Man–Fung Yuen Kenneth S.H. Chok William Sharr Wing–Chiu Dai Albert C.Y. Chan Tan–To Cheung Simon Tsang Banny Lam Ching–Lung Lai Chung–Mau Lo | 2011 | Gastroenterology2011，，4： | 1 |
| 6 | Entecavir Monotherapy Is Effective in Suppressing Hepatitis B Virus After Liver Transplantation显示文摘 | James Fung Cindy Cheung See–Ching Chan Man–Fung Yuen Kenneth S.H. Chok William Sharr Wing–Chiu Dai Albert C.Y. Chan Tan–To Cheung Simon Tsang Banny Lam Ching–Lung Lai Chung–Mau Lo | 2011 | Gastroenterology2011，，4： | 1 |
| 7 | Pediatric liver transplantation in Hong Kong—a domain with scarce deceased donors显示文摘 | Kwong Leung Chan Sheung Tat Fan Chung Mau Lo William I. Wei Raymond Wai Man Ng Ho Yu Chung Kelvin Kwok Chai Ng See Ching Chan Kwok Wah Chan Wai Kuen Tso Nai Shun Tsoi Paul Kwong Hang Tam John Wong | 2009 | Journal of Pediatric Surgery2009，，12： | 1 |
| 8 | 现代精灵显示文摘2006夏天的发型趋势,i-chi hair的创意总监Angus及Cliff认为是一则则关于layer及cut的图象故事。一洗过往厚重的模样,从冬天集中在外边的层次,春夏则转而改玩内敛的层次,营造感觉轻松、富60-70年代的怀旧感觉。在这里,bob shape hair被重新赋于意义,加入了更多的层次以及色调变化,轻松的散乱感,宛如画家笔下跳脱的现代精灵。 | Ching Man Yuen Mondy Chan | 2006 | 潇洒2006，0，8： | 0 |
| 9 | Monday blues of deceased-donor liver transplantation显示文摘BACKGROUND:There is a constant and global shortage of deceased-donor organs for transplantation.Ways to identify areas for securing potential deceased-donor organs may improve the supply and hence benefit more patients in need of transplantation. METHODS:We looked into the disparity of the number of deceased-donor liver transplantation(DDLT)performed at our hospital on different days of the weeks from January 2000 to the end of December 2009(237 DDLTs).The number of DDLT performed on each day was compared with the other days of the week. RESULTS:It was apparent that there were fewer DDLTs on Mondays,as shown by the numbers of DDLT performed on different days of the week in an ascending order:Monday 18(7.6%),Sunday 30(12.7%),Thursday 34(14.3%),Friday 36(15.2%),Wednesday 38(16.0%),Tuesday 40(16.9%), and Saturday 41(17.3%).The difference reached statistical significance when Monday was compared with Tuesday (P=0.019),Wednesday(P=0.010),Friday(P=0.021),and Saturday(P=0.007).It was twice as unlikely a DDLT would be performed on Monday as compared with other days.Such a trend did not change even with an increase in the number of deceased-donor liver grafts in the last year.As consent to donation was obtained from the donor family the day before DDLT,fewer consents were thus obtained on Sundays.CONCLUSION:These findings suggested that deceased-donor organ donation activities were less active on Sundays and could be improved.This further raises the concern of possible wastage of potential cases of organ donation. | See Ching Chan Wing Chiu Dai Chung Mau Lo Banny Lam Yuen Man Kwan Wai Yi Ho Sheung Tat Fan | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，1： | 0 |
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