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| 1 | 新型非接触变压器的磁路模型及其优化显示文摘在非接触电能传输系统中,变压器的耦合系数直接关系到系统的变换效率。为提高非接触变压器的耦合系数,同时减小其体积、质量,给出改进的变压器磁芯结构及绕组排列方法,并结合电磁场仿真结果,提出新型非接触变压器的磁路模型。根据耦合程度不同,将总磁通分为无耦合、部分耦合和全耦合3部分。基于变压器磁路模型和该磁通分类方法,给出各部分磁阻和变压器耦合系数的量化计算方法,并进一步给出变压器优化设计方法,提出边沿扩展平面U型磁芯结构。采用优化后的变压器结构,设计了35~60V输入、60W输出的非接触变换器。变压器耦合系数的计算结果和测试结果一致,证明了所提磁路模型及耦合系数计算方法的正确性。与采用PlanarE64磁芯相比,在10mm气隙条件下,变压器耦合系数可从0.53提高到0.6,磁芯质量从122g减小到60g,最高变换效率提高了约2.5%。 | 张巍 陈乾宏 S.C.Wong Michael Tse 曹玲玲 | 2010 | 中国电机工程学报2010，30，27： | 31 |
| 2 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 3 | Hepatitis B virus genotype has no impact on hepatitis B e antigen seroconversion after lamivudine treatment显示文摘AIM: To investigate the association of hepatitis B virus (HBV) genotype and HBeAg seroconversion after nucleotide analogue treatment.METHODS: Chronic hepatitis B patients receiving lamivudine followed up for at least 6 months post-treatment were studied. Consecutive treatment-naive patients who were prospectively followed up in the clinic for at least 18 months were studied as controls. HBeAg seroconversion was defined as loss of HBeAg, appearance of anti-HBe and normalization of alanine aminotransferase for at least 6 months.RESULTS: Thirty-five patients on lamivudine and 96 control patients followed up for 39 (18-49) months were studied.Lamivudine was given for 12 (10-18) months, and patients were followed up for 15 (6-34) months after drug cessation.Genotype B and C HBV were found in 43 and 88 patients and HBeAg seroconversion occurred in 12 (28 %) and 16(18 %) patients, respectively (P=0.30). There was no difference in HBeAg seroconversion between patients infected by genotype B and C HBV in the control (35 % vs 21%, P=0.25) and lamivudine-treated (14 % vs 10 %,P=1.00) groups.CONCLUSION: HBeAg seroconversion after treatment by lamivudine was not influenced by the HBV genotype. | Henry Lik-Yuen Chan May-Ling Wong Alex Yui Hui Angel Mei-Ling Chim Ada Mei-Ling Tse Lawrence Cheung-Tsui Hung Francis Ka-Leung Chan Joseph Jao-Yiu Sung | 2003 | World Journal of Gastroenterology2003，9，12： | 21 |
| 4 | 不同左心室射血分数老年充血性心力衰竭患者药物治疗的临床研究显示文摘目的探讨充血性心力衰竭(心衰)患者的临床特征和药物治疗情况以及不同左心室射血分数(LVEF)心衰患者的并发症与药物治疗情况。方法连续调查2001年1月—2002年1月香港大学玛丽医院收住60岁以上的老年充血性心衰患者,符合ICD9CM诊断标准,并用弗明翰研究标准确诊,共计1074例次,收集入院时及入院3d内的超声心动图、心电图、X线胸片等检查结果以及患者出院时转归、出院带药情况。结果1女性充血性心衰患者几乎为男性患者的2倍,年龄≥65岁者占95.5%,≥80岁者占50.6%,按美国纽约心脏协会(NYHA)心功能分级,和级占70.2%,521例(占48.5%)入院治疗1次。2充血性心衰的主要并发症为糖尿病和高血压。3399例次行超声心动图检查者中,208例次(占52.1%)LVEF<0.50,191例次(占47.9%)LVEF≥0.50的患者更倾向于女性,年龄≥80岁,而冠心病及糖尿病较少发生,心房颤动84例次(占44.0%)占多数(P<0.05)。糖尿病、完全性左束支传导阻滞及心肌梗死病史常伴随LVEF<0.50的患者(P<0.05)。4大部分患者均接受利尿剂治疗,LVEF<0.50的患者中使用血管紧张素转换酶抑制剂(ACEI)131例次(占63.0%),地高辛47例次(占22.6%),β受体阻滞剂25例次(占12.0%),钙阻滞剂29例次(占13.9%),而LVEF≥0.50的患者分别有119例次(62.3%)、67例次(35.1%)、18例次(占9.4%)和35例次(占18.3%)使用上述药物,地高辛多用在LVEF≥0.50的患者(P<0.05)。结论1LVEF<0.50与≥0.50的充血性心衰患者单从临床症状和体征上较难区别,目前强调对每个心衰患者尽可能进行早期超声心动图检查,这是区别两类心衰的重要手段。2ACEI、β受体阻滞剂的使用与治疗指南还有一定距离。3尽早地区分LVEF<0.50与≥0.50充血性心衰患者将有利于抗心衰治疗。 | 詹红 Tse Hung-fat 曹晶茗 Lau Cpu-pak | 2006 | 中国危重病急救医学2006，18，4： | 20 |
| 5 | 开关功率变换器中的间歇现象——理论分析显示文摘鉴于间歇分谐波与间歇混沌的产生可以从电路耦合滤波的角度进行合理的解释 ,则可以此为基础 ,用参数域上的分叉来映射时间域上的分叉 ,从而使得可以用一般的特征值分析方法 (针对参数分叉 )来实现变换器中间歇现象的分析 (针对时间分叉 ) ,特征值、分叉图及最大Lyapunov指数均表明得到的研究结果与仿真及实验是完全一致的 。 | 周宇飞 陈军宁 Chi K Tse 丘水生 柯导明 时龙兴 孙伟锋 | 2004 | 电子学报2004，32，2： | 19 |
| 6 | Ion Channels in Mesenchymal Stem Cells from Rat Bone Marrow显示文摘 | Li GR Deng XL Sun H Chung SS Tse HF Lau CP | 2006 | 中国生物学文摘2006，20，5： | 18 |
| 7 | 考虑采购资金约束的物流服务能力采购决策显示文摘以物流服务供应链为研究对象,研究集成商期初时期对服务能力批发量和期权预订量的决策、需求即将发生时期对期权执行量的决策以及需求确定时期对现货采购量的决策,构建在无采购资金约束条件下集成商的采购决策模型,求得服务集成商3个时期的采购决策。然后引入采购资金约束,分析存在采购资金约束情况下集成商各个时期的采购策略,并对比有无采购资金约束条件集成商采购策略的不同,分析采购资金约束对集成商采购策略的影响。最后,通过数据分析对研究结论进行说明和验证. | 赵海峰 何青 Edison TSE | 2017 | 管理科学学报2017，20，5： | 13 |
| 8 | 基于恒流源补偿网络的电磁感应式非接触能量传输的LED驱动电路显示文摘电磁感应式非接触能量传输(inductive power transfer,IPT)的半导体发光二极管(light-emitting diode,LED)照明系统具有便利、灵活、安全等优点。为提高IPT的传输效率,IPT松耦合变压器两边需引入补偿网络。补偿后的IPT变换器输出特性十分复杂,其输出电压或电流与变压器参数、补偿结构和参数、开关频率和负载均有关。而LED负载的等效阻抗易随温度变化,松耦合变压器的磁场并不均匀,难以设计,这些问题使得IPT LED驱动器难以直接输出LED需要的驱动电流。针对此问题,该文提出一种基于恒流源补偿网络的IPT LED驱动电路,恒流源补偿网络使得IPT输出恒流,解耦电流与负载阻抗的关系,通过提出的变压器参数和补偿参数设计方法,采用定频占空比控制,可直接输出LED所需的电流,避免使用后级变换器,避免频率控制带来的频率分叉问题。该文还提出在给定变压器尺寸、气隙、负载范围、效率下的IPT系统综合设计方案。最后,搭建了一台20 W的IPT LED驱动电路,实验结果证明所提出的补偿网络可以准确实现与负载无关的恒流输出,避免无功环流,实现较高的传输效率。 | 韩洪豆 曲小慧 WONG Siuchung TSE Chikong | 2015 | 中国电机工程学报2015，35，20： | 11 |
| 9 | 基于可调增益恒流源补偿网络的磁场耦合无线电能传输LED驱动电路显示文摘对于磁场耦合无线电能传输(WPT)系统,由于松耦合变压器漏感较大,补偿技术是实现其能量高效传输的关键。在半导体(LED)照明应用中,WPT LED驱动电路应直接输出LED所需的驱动电流,还应避免无功功率环流,减小器件应力,实现功率器件软开关。针对现有补偿网络的输出电流增益依赖变压器参数,而松耦合变压器存在设计受限的缺点,本文采用二端口网络理论,提出一族恒流源补偿网络,通过调节补偿参数灵活调节输出电流增益,增加变压器设计自由度。最后采用同一电路结构和变压器,分别实现了0.5A、1A和1.5A输出的WPT LED驱动电路,实验结果验证了理论分析的正确性。此外,还对所提出的可调增益补偿网络的特性进行了详细分析。 | 景妍妍 曲小慧 韩洪豆 Wong SiuChung Tse ChiKong | 2016 | 电工技术学报2016，31，A01： | 11 |
| 10 | 一种高光效可独立调光的LED均流电路显示文摘发光二极管(light-emitting diode,LED)的伏安特性易受温度影响,且个体间存在差异,当多条LED支路并联连接于同一电压源时,会出现不均流现象。电流大的LED支路老化加速,光效衰减,甚至过早熄灭,严重影响了LED照明的可靠性。针对此问题,提出一种最小导通电流幅值反馈控制的脉宽调制(pulse width modulation,PWM)均流电路,该电路在常见的PWM均流基础上,自动调整LED支路的供电电压,使得LED支路中存在至少一条支路的均流占空比为1,其他支路的占空比尽可能大,有效提高LED光源的发光效率。此外,在该均流电路上,可容易实现LED支路的独立调光,无需增加电路和成本。最后,以Buck变换器驱动3条LED支路为例,搭建实验样机。实验结果证明了所提出的均流电路可有效实现LED支路均流,提高LED发光效率,并具有独立调光功能。 | 曲小慧 唐亚鹏 WONG Siuchung TSE Chikong 章国宝 | 2014 | 中国电机工程学报2014，34，21： | 10 |
| 11 | 心房颤动对慢性心力衰竭伴左室射血分数≥0.50患者预后的临床研究显示文摘目的探讨左室射血分数(LVEF)≥0.50的住院慢性心力衰竭(心衰)患者中心房颤动(房颤)的发生和分布类型,及房颤对此类心衰预后的影响。方法调查患者417例次,按LVEF〈0.50与≥0.50分为两组,根据患者入院前是否有房颤病史分为阵发性房颤、持续性房颤及入院后新发房颤。随后观察并记录严重恶性事件发生情况及因慢性心衰而再入院次数及每两次住院的间隔时间。结果LVEF〈0.50的慢性心衰更多见于男性,一年内心肌梗死的发病率较LVEF≥0.50者高[15.6%(34/218)比8.0%(16/199),P〈0.01],且房颤使得患者脑卒中发生率较不伴房颤者明显增高[24.3%(27/111)比8.4%(9/107),P〈0.053,急性冠脉综合征、心血管死亡事件例数及死亡数也高于不伴房颤者;在LVEF≥0.50的慢性心衰患者中新发房颤数量较LVEF〈0.50者明显增多(51比30,P〈0.05),房颤可见伴发在近2/3的患者中,且再入院次数较不伴房颤者增加[(2.78±1.79)次比(2.00±1.35)次,P〈0.013,前两次入院间隔时间亦较不伴房颤者缩短[(117±107)d比(154±130)d,P〈0.053。结论房颤更易发生在LVEF≥0.50的慢性心衰患者,导致更短的再入院间隔,强调治疗和管理这类房颤的重要性。 | 詹红 TSE Hung-fat 曹晶茗 LAU Cpu-pak | 2008 | 中国危重病急救医学2008，20，4： | 9 |
| 12 | 颅脑有限元模型演化规律及其生物力学研究进展显示文摘交通事故中头颈部损伤因其较高的致命性,已成为最严重的损伤类型。有限元模型在创伤性脑损伤生物力学机理研究中得到日益广泛应用。回顾头颈部有限元模型的生物力学研究历史和现状,并阐述车辆碰撞交通事故中人体颅脑典型交通伤演化规律和生物力学研究进展,探索头颈部损伤安全防护的方法,以期为车辆碰撞事故中人体颅脑损伤生物力学研究和相应的汽车安全防护装置研制提供理论依据。 | 羊玢 曹立波 陈宁 Tse Kwong Ming Lee Heow Pueh | 2014 | 医用生物力学2014，29，6： | 8 |
| 13 | Left atrial enlargement and non-paroxysmal atrial fibrillation as risk factors for left atrial thrombus/spontaneous Echo contrast in patients with atrial fibrillation and low CHA2DS2-VASc score显示文摘Objective To determine the risk factors for thromboembolism in lower risk patients with non-valvular atrial fibrillation(AF)and low CHA2DS2-VASc scores,which remain undefined.Methods We retrospectively analyzed the baseline clinical characteristics,routine laboratory parameters,and echocardiographic measurements of 705 patients(71.1%male;mean age:52.10±9.64 years)with low CHA2DS2-VASc score(0 or 1;1 point for female sex)out of 1346 consecutive patients with non-valvular AF who underwent transesophageal echocardiography(TEE)at Guangdong Cardiovascular Institute between January 2013 and December 2015.Results Patients with left atrial thrombus(LAT)or spontaneous echo contrast(SEC)on TEE(24/705,4%)showed a higher incidence rate of vascular disease(54.2%vs.32.9%,P=0.045)and non-paroxysmal AF(79.2%vs.29.4%,P<0.001),larger left atrial diameter(43.08±4.59 vs.36.02±5.53 mm,P<0.001),and lower left ventricular ejection fraction(58.23±8.82%vs.64.15±7.14%,P<0.001)than those without.Multivariate logistic regression analysis identified left atrial diameter[odds ratio(OR)=1.171,95%confidence interval(CI):1.084–1.265,P<0.001]and non-paroxysmal AF(OR=3.766,95%CI:1.282–11.061,P=0.016)as independent risk factors for LAT/SEC.In ROC curve analysis,a left atrial dimeter cutoff of 37.5 mm yielded 95.0%sensitivity and 62.7%specificity(AUC:0.847,P<0.0001,95%CI:0.793–0.914).Conclusion In patients with non-valvular AF with low CHA2DS2-VASc score,the presence of LAT or SEC was associated with left atrial enlargement,which had moderate predictive value,and non-paroxysmal AF. | Wei-Dong LIN Yu-Mei XUE Fang-Zhou LIU Xian-Hong FANG Xian-Zhang ZHAN Hong-Tao LIAO Gary Tse Shu-Lin WU | 2020 | Journal of Geriatric Cardiology2020，17，3： | 8 |
| 14 | Outcome of 1355 consecutive transabdominal chorionic villus samplings in 1351 patients显示文摘Background The true risk of choronic villus sampling (C VS) is poorly defined. The objective of this study was to review the clinical o utcome of transabdominal CVS performed in a university teaching unit, with an em phasis on the complication rate. Methods A comprehensive audit database was maintained for 1351 pregnant women, including 17 sets of twin pregnancies, who had a CVS. Details a nd outcome of all CVSs made in the unit between May 1996 and May 2004 were revie wed. All CVSs were performed by one of 5 operators using the identical techniqu es. Results All procedures were performed transabdominally. A tota l of 1355 CVSs were performed because there were 4 dichorionic twin pregnancies which required 2 punctures. The mean gestation at CVS was (11.8±0.7) weeks, and 97.3% of the procedures were performed between 11 and 13 completed weeks. The majority (96.2%) required only 1 puncture to achieve correct needle placeme nt. The procedure failed to obtain an adequate sample in 4 subjects (0.30%). A total of 1351 chromosomal studies were requested and there was 1 case (0.07%) of culture failure. The results of chromosomal studies were available within 1 4 days in 36.7% of the cases and within 21 days in 94.0%. Overall, 77 chromos omal abnormalities (5.7%) and 5 cases of thalassemia major were detected. Preg nancy outcome was unknown in only 13 singleton subjects (0.96%). In the remain ing 1355 fetuses, there were 76 pregnancy terminations (5.56%), 10 fetal losses with obvious obstetric causes (0.73%), and 21 potentially procedure-relat ed fetal losses (1.54%). In the last group, the majority had one or more co-e xisting obstetric complications. The background fetal loss rate for pregnancies at similar gestational age in the unit was about 0.8%. Therefore, the procedu re-related fetal loss rate was estimated to be at the maximum of 0.74%. Conclusions In experienced hands, first trimester transabdomina l CVS is an accurate and safe invasive prenatal diagnostic procedure. It should be one of the treatment options available to pregnant women who require prenata l genetic diagnosis. | LAU Tze Kin LEUNG Tak Yeung FUNG Tak Yuen Daljit S SAHOTA LEUNG Tse Ngong | 2005 | Chinese Medical Journal2005，，20： | 8 |
| 15 | Thiazolidinedione increases serum soluble receptor for advanced glycation end-products in type 2 diabetes显示文摘 | Tan, KCB Chow, WS Tso, AWK Xu, A Tse, HF Hoo, RLC Betteridge, DJ Lam, KSL | 2007 | 中国生物学文摘2007，21，11： | 7 |
| 16 | Serum Hepatitis B Surface Antigen Quantitation Can Reflect Hepatitis B Virus in the Liver and Predict Treatment Response显示文摘 | Henry Lik–Yuen Chan Vincent Wai–Sun Wong Ada Mei–Ling Tse Chi–Hang Tse Angel Mei–Ling Chim Hoi–Yun Chan Grace Lai–Hung Wong Joseph Jao–Yiu Sung | 2007 | Clinical Gastroenterology and Hepatology2007，，12： | 7 |
| 17 | 结肠镜检查病人疼痛程度和焦虑水平的调查研究显示文摘[目的]了解结肠镜检查病人的疼痛程度和焦虑水平。[方法]选择60例结肠镜检查病人,用视觉模拟评分法(VAS)和状态焦虑问卷(SAI)评估疼痛程度和焦虑水平。[结果]结肠镜检查病人检查中经历了中等程度的疼痛,检查前后焦虑水平比较有统计学意义(P<0.05)。[结论]医护人员应重视病人的主观感受,针对性地采取措施,控制结肠镜检查病人的疼痛及焦虑。 | 周会兰 蒋晓莲 Mimi My Tse | 2007 | 护理研究(中旬版)2007，21，2： | 7 |
| 18 | Metadiscourse in Academic Writing: A Reappraisal显示文摘 | Ken Hyland Polly Tse | 2004 | Applied Linguistics2004，，： | 6 |
| 19 | Chinese social media reaction to the MERS-CoV and avian influenza A(H7N9) outbreaks显示文摘Background:As internet and social media use have skyrocketed,epidemiologists have begun to use online data such as Google query data and Twitter trends to track the activity levels of influenza and other infectious diseases.In China,Weibo is an extremely popular microblogging site that is equivalent to Twitter.Capitalizing on the wealth of public opinion data contained in posts on Weibo,this study used Weibo as a measure of the Chinese people’s reactions to two different outbreaks:the 2012 Middle East Respiratory Syndrome Coronavirus(MERS-CoV)outbreak,and the 2013 outbreak of human infection of avian influenza A(H7N9)in China.Methods:Keyword searches were performed in Weibo data collected by The University of Hong Kong’s Weiboscope project.Baseline values were determined for each keyword and reaction values per million posts in the days after outbreak information was released to the public.Results:The results show that the Chinese people reacted significantly to both outbreaks online,where their social media reaction was two orders of magnitude stronger to the H7N9 influenza outbreak that happened in China than the MERS-CoV outbreak that was far away from China.Conclusions:These results demonstrate that social media could be a useful measure of public awareness and reaction to disease outbreak information released by health authorities. | Isaac Chun-Hai Fung King-Wa Fu Yuchen Ying Braydon Schaible Yi Hao Chung-Hong Chan Zion Tsz-Ho Tse | 2013 | Infectious Diseases of Poverty2013，2，1： | 6 |
| 20 | 循环内皮祖细胞与血管内皮功能在2型糖尿病和2型糖尿病合并冠心病患者中的相关性研究显示文摘目的对比研究2型糖尿病(T2DM)和T2DM合并稳定型冠心病(T2DM CAD)患者的循环内皮祖细胞(EPCs)与血管内皮功能的变化。方法测取88例健康对照组、73例T2DM和79例T2DM-CAD患者的内皮依赖性血管舒张功能(FMD),非内皮依赖性血管舒张功能(GTN)和循环EPCs水平。结果 T2DM和T2DM-CAD组的循环EPCs水平较健康对照组明显降低(P<0.001),T2DM组循环CD133+KDR+EPCs%与循环CD34+KDR+EPCs%高于T2DM-CAD组(分别为0.51 9%±0.288%vs 0.303%±0.357%,P=0.042和1.038%±1.252%vs 0.672%±0.220%,P=0.028)。T2DM和T2DM CAD组相比,肱动脉FMD没有显著性差异(6.62%±2.86%vs 6.13%±2.51%,P=0.335),然而,肱动脉GTN有显著性差异(16.80%±6.4 7%vs 13.26%±4.49%,P=0.017)。3组中CD34+KDR+EPCs%和CD133+KDR+EPCs%与肱动脉FMD有着较高的相关关系,多元回归分析循环CD133+KDR+EPCs%、CD34+KDR+EPCs%和HbA1c是肱动脉FMD的独立预测指标。结论高血糖状态可以减少循环EPCs的数量,减弱糖尿病患者的血管内皮细胞功能。与T2DM组相比,T2DM CAD组的循环EPCs水平和肱动脉GTN明显降低,血管平滑肌层受损程度更加严重。 | 李晓艳 岳文胜 Tse Hungfat 顾鹏 萧颂华 曹礼庭 陈艳 | 2012 | 中国超声医学杂志2012，28，10： | 6 |
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