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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties显示文摘 | Monica Bostad Kristian Berg Anders H?gset Ellen Skarpen Harald Stenmark P?l K. Selbo | 2013 | Journal of Controlled Release2013，，3： | 4 |
| 3 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 4 | Drug screening of neuraprotee- tive agents on an organotypic - based model of' spinal cord exeitotoxic damage 显示文摘 | Monica S Guzman L Xavier N | 2009 | Restorative Neurol Neuros~:i2009，27，： | 1 |
| 5 | Viability and stability of biological control agents on cotton and snap bean seeds显示文摘 | Monica L E Elizabeth A D J William E B J | 2001 | Pest Manag sc2001，57，8： | 1 |
| 6 | Requirement for IGF-I in Epidermal Growth Factor-Mediated Cell Cycle Progression of Mammary Epithelial Cells显示文摘 | MALINDA A S MONICA M R AIMEE V L | 2002 | Endocrinology2002，143，5： | 1 |
| 7 | The Insulin-Like Growth Factors (IGFs) and IGF binding proteins in postnatal development of murine mammary glands显示文摘 | TERESA L W MONICA M R MALINDA A S | 2000 | Journal of Mammary Gland Biology and Neoplasia2000，5，1： | 1 |
| 8 | Stacking resistance to crown gall and nematodes in walnut rootstocks显示文摘 | Sriema L Walawage Monica T Britton Charles A Lesliel | 2013 | BMC Genomics2013，14，： | 1 |
| 9 | The Insulin-Like Growth Factors (IGF) and IGF type Ⅰ receptor during postnatal growth of the murine mammary gland: sites of messenger ribonucleic acid expression and potential functions显示文摘 | MONICA M R TERESA L W | 1999 | Endocrinology1999，140，1： | 1 |
| 10 | A diverse family of phenylalanine ammonia-lyase genes expressed in pine trees and cell cultures显示文摘 | Stefanie L B Monica L C Brian E E | 1998 | Plant Molecular Biology1998，37，1： | 1 |
| 11 | Pyrrolidine dithiocarbamate protects mice from lethal shock induced by LPS or TNF-α显示文摘 | Pilar L Sara MM Monica M | 1999 | Eur J Immuno1999，29，： | 1 |
| 12 | Evaluation of various extraction techniques for obtaining bioactive extracts from pine seeds显示文摘 | Ali L Monica S Rosa M | 2010 | Food and Bioproducts Pocessing2010，88，23： | 1 |
| 13 | Electrically, chemically, and photonically powered torsional and tensile actuation of hybrid carbon nanotube yam muscles显示文摘 | Marcio D L Li Na Monica Jung de Andrade | 2012 | Science2012，338，6116： | 1 |
| 14 | Pyrene degradation by yeasts and filamentous fungi显示文摘 | Cristina R M Monica L S Cecilia C M | 2002 | Environmental Pollution2002，117，： | 1 |
| 15 | Early functional outcomes and histological analysis after spinal cord compression injury in rats显示文摘 | NICOLAS L PASCAL K MONICA P | 2010 | J Neurosurg Spine2010，12，1： | 1 |
| 16 | Baculovirus vectors elicit antigen-specific immune responses in mice显示文摘 | FACCIABENE A AURISICCHIO L LA MONICA N | 2004 | J Virol2004，78，16： | 1 |
| 17 | Complete genome sequence of Riemerella anatipestifer type strain (ATCC 11845)显示文摘 | Konstantinos M Meqan L Monica M et a1 | 2011 | Stand Genomic Sci2011，4，2： | 1 |
| 18 | Viability and stability of biological control agents on cotton and snap bean seeds显示文摘 | Monica L E Elizabeth A D J William E B J | | 0，，8： | 1 |
| 19 | Use of Pharmacologic Interventions for Breast Cancer Risk Reduction: American Society of Clinical Oncology Clinical Practice Guideline显示文摘 | Kala Visvanathan Patricia Hurley Elissa Bantug Powel Brown Nananda F. Col Jack Cuzick Nancy E. Davidson Andrea DeCensi Carol Fabian Leslie Ford Judy Garber Maria Katapodi Barnett Kramer Monica Morrow Barbara Parker Carolyn Runowicz Victor G. Vogel James L | 2013 | Journal of Clinical Oncology2013，，23： | 1 |
| 20 | Newbinary polymorphisms reshape and increase resolution of thehuman Y chromosomal haplogroup tree显示文摘 | Tatiana M K Fernando L M Monica B M | 2008 | Genome Res2008，18，： | 1 |
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