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| 1 | Changing trends in management of gestational diabetes mellitus显示文摘Gestational diabetes mellitus(GDM)is on the rise globally.In view of the increasing prevalence of GDM and fetal and neonatal complications associated with it,there is a splurge of research in this field and management of GDM is undergoing a sea change.Trends are changing in prevention,screening,diagnosis,treatment and future follow up.There is emerging evidence regarding use of moderate exercise,probiotics and vitamin D in the prevention of GDM.Regarding treatment,newer insulin analogs like aspart,lispro and detemir are associated with better glycemic control than older insulins.Continuous glucose monitoring systems and continuous subcutaneous insulin systems may play a role in those who require higher doses of insulin for sugar control.Evidence exists that favors metformin as a safer alternative to insulin in view of good glycemic control and better perinatal outcomes.As the risk of developing GDM in subsequent pregnancies and also the risk of overt diabetes in later life is high,regular assessment of these women is required in future.Lifestyle interventions or metformin should be offered to women with a history of GDM who develop pre-diabetes.Further studies are required in the field of prevention of GDM for optimizing obstetric outcome. | Gunasekaran Kala Poomalar | 2015 | World Journal of Diabetes2015，6，2： | 32 |
| 2 | Community Responses to Mountain Tourism:A Case in Bhyundar Valley,Indian Himalaya显示文摘Tourism industry has become an important part of Indian economy,and tourism development has been,however,concentrated to a few areas. Accumulation of tourism activities has reached the critical stage in most of the tourism centers,which pose serious threats to the natural environment. The Bhyundar Valley of Nanda Devi Biosphere Reserve (NDBR) in Uttarakhand State of the Indian Himalaya is a burning example of such problems. Land use/cover changes,deforestation and accumulation of garbage are some of the negative impacts of unregulated tourism in the valley. Unsustainable activities of tourists and villagers in the valley make such problems very severe. To deal with the ongoing problems and ensure community involvement in tourism management and environmental conservation,the Biosphere Reserve Authority introduced ecotourism in the form of Eco Development Committees (EDCs) in the Bhyundar Valley. Study reveals that many problems associated with tourism have been minimized to some extent with the help of EDCs but few are still prevailing in valley. However,the existing attempts to conserve the valley from the negative effects of tourism are inadequate and modifications are needed in the current initiatives. | Ram Babu Singh Suraj Mal Chandra Prakash Kala | 2009 | Journal of Mountain Science2009，6，4： | 6 |
| 3 | Abnormal liver enzymes: A review for clinicians显示文摘Liver biochemical tests are some of the most commonly ordered routine tests in the inpatient and outpatient setting,especially with the automatization of testing in this technological era.These tests include aminotransferases,alkaline phosphatase,gamma-glutamyl transferase,bilirubin,albumin,prothrombin time and international normalized ratio(INR).Abnormal liver biochemical tests can be categorized based on the pattern and the magnitude of aminotransferases elevation.Generally,abnormalities in aminotransferases can be classified into a hepatocellular pattern or cholestatic pattern and can be further sub-classified based on the magnitude of aminotransferase elevation to mild[<5×upper limit of normal(ULN)],moderate(>5-<15×ULN)and severe(>15×ULN).Hepatocellular pattern causes include but are not limited to;non-alcoholic fatty liver disease/non-alcoholic steatohepatitis,alcohol use,chronic viral hepatitis,liver cirrhosis(variable),autoimmune hepatitis,hemochromatosis,Wilson’s disease,alpha-1 antitrypsin deficiency,celiac disease,medication-induced and ischemic hepatitis.Cholestatic pattern causes include but is not limited to;biliary pathology(obstruction,autoimmune),other conditions with hyperbilirubinemia(conjugated and unconjugated).It is crucial to interpret these commonly ordered tests accurately as appropriate further workup,treatment and referral can greatly benefit the patient due to prompt treatment which can improve the natural history of several of the diseases mentioned and possibly reduce the risk of progression to the liver cirrhosis. | M Ammar Kalas Luis Chavez Monica Leon Pahnwat Tonya Taweesedt Salim Surani | 2021 | World Journal of Hepatology2021，13，11： | 5 |
| 4 | Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis显示文摘Helicobacter pylori(H.pylori)is an infectious agent influencing as much as 50%of the world’s population.It is the causative agent for several diseases,most especially gastric and duodenal peptic ulcer,gastric adenocarcinoma and mucosaassociated lymphoid tissue lymphoma of the stomach.A number of other,extragastric manifestations also are associated with H.pylori infection.These include neurological disorders,such as Alzheimer’s disease,demyelinating multiple sclerosis and Parkinson’s disease.There is also evidence for a relationship between H.pylori infection and such dermatological diseases as psoriasis and rosacea as well as a connection with infection and open-angle glaucoma.Generally little is known about the relationship between H.pylori infection and diseases of the pancreas.Most evidence about H.pylori and its potential role in the development of pancreatic diseases concerns pancreatic adenocarcinoma and autoimmune forms of chronic pancreatitis.There is data(albeit not fully consistent)indicating modestly increased pancreatic cancer risk in H.pylori-positive patients.The pathogenetic mechanism of this increase is not yet fully elucidated,but several theories have been proposed.Reduction of antral Dcells in H.pylori-positive patients causes a suppression of somatostatin secretion that,in turn,stimulates increased secretin secretion.That stimulates pancreatic growth and thus increases the risk of carcinogenesis.Alternatively,H.pylori,as a part of microbiome dysbiosis and the so-called oncobiome,is proven to be associated with pancreatic adenocarcinoma development via the promotion of cellular proliferation.The role of H.pylori in the inflammation characteristic of autoimmune pancreatitis seems to be explained by a mechanism of molecular mimicry among several proteins(mostly enzymes)of H.pylori and pancreatic tissue.Patients with autoimmune pancreatitis often show positivity for antibodies against H.pylori proteins.H.pylori,as a part of microbiome dysbiosis,also is viewed as a potential trigger of autoimmune inflammation of the pancreas.It is precisely these relationships(and associated equivocal conclusions)that constitute a center of attention among pancreatologists,immunologists and pathologists.In order to obtain clear and valid results,more studies on sufficiently large cohorts of patients are needed.The topic is itself sufficiently significant to draw the interest of clinicians and inspire further systematic research.Next-generation sequencing could play an important role in investigating the microbiome as a potential diagnostic and prognostic biomarker for pancreatic cancer. | Lumir Kunovsky Petr Dite Petr Jabandziev Jiri Dolina Jitka Vaculova Martin Blaho Martina Bojkova Jana Dvorackova Magdalena Uvirova Zdenek Kala Jan Trna | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 5 |
| 5 | Predicting the impact of climate change on the distribution of two threatened Himalayan medicinal plants of Liliaceae in Nepal显示文摘Predicting the potential distribution of medicinal plants in response to climate change is essential for their conservation and management. Contributing to the management program, this study aimed to predict the distribution of two threatened medicinal plants, Fritillaria cirrhosa and Lilium nepalense. The location of focal species gathered from herbarium specimen housed in different herbaria and online databases were geo-referenced and checked for spatial autocorrelation. The predictive environmental variables were selected, and MaxE nt software was used to model the current and future distributions of focal species. Four Representative Concentration Pathway(RCP) trajectories of the BCC-CSM1.1 model were used as the future(2050) projection layer. The MaxEnt modelling delineated the potential distribution of F. cirrhosa and L. nepalense. The current suitability is projected towards Central and Eastern Hilly/Mountainous regions. Both species gainmaximum suitability in RCP 4.5 which decline towards other trajectories for L. nepalense. Overall, both the focal species shift towards the north-west, losing their potential habitat in hilly and lower mountainous regions by 2050 across all trajectories. Our results highlight the impact of future climate change on two threatened and valuable species. The results can be further useful to initiate farming of these medicinally and economically important species based on climatically suitable zone and for designing a germplasm conservation strategy. | RANA Santosh Kumar RANA Hum Kala GHIMIRE Suresh Kulllar SHRESTHA Krishna Kumar RANJITKAR Sailesh | 2017 | Journal of Mountain Science2017，14，3： | 5 |
| 6 | Mitigating People-Park Conflicts on Resource Use through Ecotourism:A Case of the Nanda Devi Biosphere Reserve,Indian Himalaya显示文摘Ecotourism aims to deliver the philosophy of sustainable development through environmental conservation as well as socio-economic development.Areas with rich biodiversity and scenic beauty,like the Indian Himalayan region,have been one of the major destination centers for nature lovers from historical time.In view of conserving the rich biodiversity and natural heritage of the Himalayan region 92 protected areas have been set aside,of these Nanda Devi Biosphere Reserve(NDBR) is a well known world heritage site.Over a period of time establishing NDBR has invited conflicts between the local people and reserve authorities on the management approaches and utilization criteria of the natural resources,especially banning the traditional bio-resource collection rights of local community,expeditions,trekking,and other anthropogenic activities in the core zones.The present study aims to understand and analyze the various people-park conflicts,and also to suggest ways to mitigate such conflicts in view of biodiversity conservation and improvement of economic status of local people by promoting ecotourism.With this view the study further discusses the various aspects of ecotourism,its pros and cons,and the avenues of developing appropriate strategies for promotion of ecotourism in buffer zone areas of NDBR. | Chandra Prakash KALA Rakesh Kumar MAIKHURI | 2011 | Journal of Mountain Science2011，8，1： | 4 |
| 7 | Geoclimatic factors influence the population genetic connectivity of Incarvillea arguta(Bignoniaceae)in the Himalaya-Hengduan Mountains biodiversity hotspot显示文摘Geoclimatic factors related to the uplift of the Himalaya and the Quaternary climatic oscillations in fluence the population genetic connectivity in the Himalaya-Hengduan Mountains(HHM)biodiversity hotspot.Therefore,to explore the relative roles played by these two factors,we examined the population dynamics and dispersal corridors of Incarvillea arguta(Royle)Royle incorporating ensemble species distribution modelling(SDM).Thirty-seven populations were genotyped using plastid chloroplast DNA and low copy nuclear gene(ncpCS)sequences.Phylogeographic analysis was carried out to reveal the genetic structure and lineage differentiation.Ensemble SDMs were carried out for distributional change in the last glacial maximum,present,and future.Finally,the least cost path method was used to trace out possible dispersal corridors.The haplotypes were divided into four clades with strong geographical structure.The late Miocene origin of I.arguta in the western Himalaya ca.7.92 Ma indicates lineage diversification related to the uplift of the HHM.The variability in habitat connectivity revealed by SDM is due to change in suitability since the Pleistocene.A putative dispersal corridor was detected along the drainage systems and river valleys,with strong support in the eastern Hengduan Mountains group.Our results support the signature of geoclimatic influence on population genetic connectivity of I.arguta in the HHM.We proposed that the major drainage systems might have assisted the rapid dispersal of isolated riverine plant species I.arguta in the HHM.The population genetic connectivity,using the fine-tuned ensemble SDMs,enables scientists and policymakers to develop conservation strategies for the species gene pool in the HHM biodiversity hotspots. | Santosh Kumar Rana Dong Luo Hum Kala Rana Alexander Robert O'Neill Hang Sun | 2021 | Journal of Systematics and Evolution2021，59，1： | 3 |
| 8 | Ultrathin tunable terahertz absorber based on MEMS-driven metamaterial显示文摘The realization of high-performance tunable absorbers for terahertz frequencies is crucial for advancing applications such as single-pixel imaging and spectroscopy.Based on the strong position sensitivity of metamaterials’electromagnetic response,we combine meta-atoms that support strongly localized modes with suspended flat membranes that can be driven electrostatically.This design maximizes the tunability range for small mechanical displacements of the membranes.We employ a micro-electromechanical system technology and successfully fabricate the devices.Our prototype devices are among the best-performing tunable THz absorbers demonstrated to date,with an ultrathin device thickness(~1/50 of the working wavelength),absorption varying between 60%and 80%in the initial state when the membranes remain suspended,and fast switching speed(~27μs).The absorption is tuned by an applied voltage,with the most marked results achieved when the structure reaches the snap-down state.In this case,the resonance shifts by >200% of the linewidth(14% of the initial resonance frequency),and the absolute absorption modulation measured at the initial resonance can reach 65%.The demonstrated approach can be further optimized and extended to benefit numerous applications in THz technology. | Mingkai Liu Mohamad Susli Dilusha Silva Gino Putrino Hemendra Kala Shuting Fan Michael Cole Lorenzo Faraone Vincent P.Wallace Willie J.Padilla David A.Powell Ilya V.Shadrivov Mariusz Martyniuk | 2017 | Microsystems & Nanoengineering2017，3，1： | 2 |
| 9 | The Gravitational Force Quantum and its Value显示文摘 | Tomas Kala | 2015 | Journal of Physical Science and Application2015，5，4： | 2 |
| 10 | Distribution pattern and conservation of threatened medicinal and aromatic plants of Central Himalaya, India显示文摘A study was conducted to examine the distribution pattern of four rhizomatous medicinal and aromatic plant species (MAPs) viz., Angelica glauca, Pleurospermum angelicoides, Rheum emodi and Arne- bia benthamii in different forest stands in Central Himalaya. Results show that A. glauca and P. angelicoides had a higher (50%) frequency at Chipkoan, Garpak and Phagati forest, R. emodi had a higher (60%) frequency at Rishikund, Suki and Himtoli, and A. benthamii had a higher (70%) frequency at Suki and Khambdhar The densities of A. glauca (0.6 plants·m -2 ) and P. angelicoides (0.5 plants·m -2 ) were higher at Chipkoan and Garpak sites than at other micro-sites, while densities of R. emodi (0.8 plants·m -2 ) and A. benthamii (1.0 plants·m -2 ) were higher at Suki and Khambdhar sites. A. glauca had highest total basal covers (TBC) (1.2 cm 2 ·m -2 ) at Chipkoan, P. angelicoides had highest TBC (0.92 cm 2 ·m -2) at Lati kharak site, A. benthamii had the highest TBC (6.48 cm 2 ·m -2 ) atKhambdhar, and R. emodi had highest TBC (4.53 cm 2 ·m -2 ) at Rishikund. For the four studied species, A. glauca showed a contagious distribution, P. angelicoides and R. emodi showed the random and A. benthamii showed the regular type of distribution. | L. S. Kandari K.S. Rao R. K. Maikhuri G. Kharkwal K. Chauhan C.P. Kala | 2011 | Journal of Forestry Research2011，22，3： | 2 |
| 11 | Uric acid: role in cardiovascular disease and effects of losartan显示文摘 | Michael Alderman Kala J. V. Aiyer | 2004 | Current Medical Research and Opinion?2004，，3： | 2 |
| 12 | A biochemical perspective on the use of tandem mass spectrometry for newborn screening and clinical testing 显示文摘 | Chace DH Kalas TA | 2005 | Clin Biochem2005，38，4： | 1 |
| 13 | Pulse cyclophosphamide for steroid-resistant focal segmental glomerulosclerosis显示文摘 | Rennert WP Kala UK Jacobs D | 1999 | PediatrNephrol1999，13，： | 1 |
| 14 | Brachytherapy and percutaneous stenting in the treatment of cholangiocarcinoma: a prospective randomised study显示文摘 | VALEK V KYSELA P KALA Z | 2007 | Eur J Radiol2007，62，2： | 1 |
| 15 | Age-related treatment strategy and long-term outcome in acute myocardial infarction patients in the PCI era显示文摘 | Kala P Kanovsky J Rokyta R | 2012 | BMC Cardiovasc Disord2012，12，： | 1 |
| 16 | The required characteristics of ensiled crops used as a feedstock for biogas production: A review显示文摘 | Kalae P | 2011 | J Agrobiolog2011，28，2： | 1 |
| 17 | Synthesis and solution properties of new linean-dendric diblock copolymers 显示文摘 | Kala F P T | 1998 | Macromolecules1998，，31： | 1 |
| 18 | 显示文摘 | Kala R Gladis J M Rao T P | 2004 | Anal Chim Acta2004，518，： | 1 |
| 19 | Vascular complications of pancreatitis显示文摘More than 200000 hospital admissions happen per year for acute pancreatitis and more than 50000 for chronic pancreatitis in the United States of America.Necrotizing pancreatitis accounts for 20%-30%of the cases.One-quarter of the patients with pancreatitis develop vascular complications,which carries a high mortality.This mini-review will address these complications that can help primary care physicians and hospitalists in managing their patients effectively. | M Ammar Kalas Monica Leon Luis Omar Chavez Eduardo Canalizo Salim Surani | 2022 | World Journal of Clinical Cases2022，10，22： | 1 |
| 20 | Ion imprinted polymer based sensor for monitoring toxic uranium in environmental samples 显示文摘 | Metilda P Prasad K Kala R | 2007 | Analytica Chimica Acta2007，582，： | 1 |
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