|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Biosynthesis and biochemical properties of the hepatitis C virus core protein显示文摘 | Santolini E Migliaccio G La Monica N | 1994 | J Virol1994，68，： | 1 |
| 2 | Hepatitis C virus core protein impairs in vitro priming of specific T cell responses by dendritic cells and hepatocytes显示文摘 | Zimmermann M Flechsig C La Monica N | 2008 | J Hepatol2008，48，1： | 1 |
| 3 | Baculovirus vectors elicit antigen-specific immune responses in mice显示文摘 | FACCIABENE A AURISICCHIO L LA MONICA N | 2004 | J Virol2004，78，16： | 1 |
| 4 | Regulated and liver-specific tamarin alpha interferon gene delivery by a helper-dependent adenoviral vector 显示文摘 | Aurisicchio L De Tomassi A La Monica N | 2005 | J Virol2005，79，11： | 1 |
| 5 | Hepatitis C virus core protein impairs in vitro priming of specific T cell responses by dendritic cells and hepatocytes显示文摘 | Zimmermann M Fiechsig C La Monica N | 2008 | J Hepatol2008，48，1： | 1 |
| 6 | In vivo gene transfer in mouse skeletal muscle mediated by baculovirus vectors显示文摘 | Pieroni L Maione D La Monica N | 2001 | Hum Gene Ther2001，12，： | 1 |
| 7 | In vivo gene transfer in mouse skeletal muscle mediated by baculovirus vectors显示文摘 | Pieroni L Maione D La Monica N | 2001 | Hum Gene Ther2001，12，8： | 1 |
| 8 | Biosynthesis and biochemical properties of the hepatitis C virus core protein显示文摘 | Santolini E Migliaccio G La Monica N | 1994 | J Virol1994，68，6： | 1 |
| 9 | Biosynthesis and Biochemical Properties of Hepatits C Virus Core Protein 显示文摘 | Santolini E Migliaccio G La Monica N | 1994 | J Virol1994，68，： | 1 |
| 10 | Localization of extensive deletions in the structural genes of two neurotropic variants of murine coronavirus JHM显示文摘 | la Monica N Banner LR Morris VL | 1991 | Virology1991，182，2： | 1 |
| 11 | In vivo gene transfer in mouse skeletal muscle mediated by baculovirus vectors显示文摘 | PIERONI L MAIONE D La Monica N | 2001 | Hum Gene Ther2001，12，： | 1 |
| 12 | In vivo gene transfer in mouse skeletal muscle mediated by baculovirus vectors 显示文摘 | Pieroni L Maione D La Monica N | 2001 | Hum Gene Ther2001，12，8： | 1 |
| 13 | In vivo gene transfer in mouseskeletal muscle mediated by baculovirus vectors 显示文摘 | Pieroni L Maione D La Monica N | 2001 | Hum Gene Ther2001，12，8： | 1 |
| 14 | In vivo gene transfer in mouse skeletal muscle mediated by baculovirus vectors显示文摘 | Pieroni L Malone D La Monica N | 2001 | Hum Gene Ther2001，12，8： | 1 |
| 15 | Regulated and liver-specific tamarin alpha interferon gene delivery by a helper-dependent adenoviral vector显示文摘 | Aurisicchio L De Tomassi A La Monica N | 2005 | J Virol2005，79，11： | 1 |
| 16 | Hepatitis C virus core protein impairs in vitro priming of specific T cell responses by dendritic cells and hepatocytes显示文摘 | Zimmermann M Flechsig C La Monica N Tripodi M Adler G Dikopoulos N | 2008 | J Hepatol2008，48，1： | 1 |
| 17 | Biosynthesis and biochemical properties of the hepatitis C virus core protein显示文摘 | Migliaccio G La Monica N | 1994 | J VIROL1994，68，： | 1 |
| 18 | In vivo gene transfer in mouse skeletal mediated by baculovirus vectors显示文摘 | Pieroni L Malone D La Monica N | 2001 | Hum Gene Ther2001，12，8： | 1 |
| 19 | Efficient and regulated erythropoetin production by naked DNA injection and muscle electroporation 显示文摘 | Rizzuto G Cappelletfi M Maione D Savino R Lazzaro D Costa P Mathiesen I Cortese R Ciliberto G Laufer R La Monica N Fattori E | 1999 | Prec Natl hcad Sci USA1999，96，： | 1 |
| 20 | Insulin:A connection between pancreaticβcells and the hypothalamus显示文摘Insulin is a hormone secreted by pancreaticβcells.The concentration of glucose in circulation is proportional to the secretion of insulin by these cells.In target cells,insulin binds to its receptors and activates phosphatidylinositol-3-kinase/protein kinase B,inducing different mechanisms depending on the cell type.In the liver it activates the synthesis of glycogen,in adipose tissue and muscle it allows the capture of glucose,and in the hypothalamus,it regulates thermogenesis and appetite.Defects in insulin function[insulin resistance(IR)]are related to the development of neurodegenerative diseases in obese people.Furthermore,in obesity and diabetes,its role as an anorexigenic hormone in the hypothalamus is diminished during IR.Therefore,hyperphagia prevails,which aggravates hyperglycemia and IR further,becoming a vicious circle in which the patient cannot regulate their need to eat.Uncontrolled calorie intake induces an increase in reactive oxygen species,overcoming cellular antioxidant defenses(oxidative stress).Reactive oxygen species activate stress-sensitive kinases,such as c-Jun Nterminal kinase and p38 mitogen-activated protein kinase,that induce phosphorylation in serine residues in the insulin receptor,which blocks the insulin signaling pathway,continuing the mechanism of IR.The brain and pancreas are organs mainly affected by oxidative stress.The use of drugs that regulate food intake and improve glucose metabolism is the conventional therapy to improve the quality of life of these patients.Currently,the use of antioxidants that regulate oxidative stress has given good results because they reduce oxidative stress and inflammatory processes,and they also have fewer side effects than synthetic drugs. | Brenda De la Cruz Concepción Yaccil Adilene Flores Cortez Martha Isela Barragán Bonilla Juan Miguel Mendoza Bello Monica Espinoza Rojo | 2023 | World Journal of Diabetes2023，14，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员