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| 1 | Network Pharmacology-based Approaches Capture Essence of Chinese Herbal Medicines显示文摘Traditional Chinese Medicine(TCM), a crucial component of the current medical system, has been extensively used in clinical practice due to its valuable therapeutic efficacy, and its potentials as an important source of new pharmacophores. TCM is characterized by holistic theory, which emphasizes maintaining the balance of the patient's whole body using herbal formulae(fangji in Chinese) composed of mixtures of herbs with multiple bioactive ingredients. Because of the complex nature of these formulae, it is necessary to develop systematic methods to identify their bioactive ingredients and to clarify their mechanisms of action. With the rapid progress in bioinformatics, systems biology, and polypharmacology, 'network pharmacology', which shifts the 'one target, one drug' paradigm to the 'network target, multi-component' strategy, has attracted the attention because it can not only reveal the underlying complex interactions between a herbal formula and cellular proteins but detect the influence of their interactions on the function and behavior of the system. Growing evidence shows that the network pharmacology strategy can be a powerful approach to modern research on TCM. The present paper focuses on the basis of network pharmacology and the recent progress in its methodology, illustrates its utility in screening bioactive ingredients and elucidating the mechanisms of action of TCM herbal formulae, analyzes its limitations and problems, and discusses its development direction and application prospects. | Yan-qiong Zhang Xia Mao Qiu-yan Guo Na Lin Shao Li | 2016 | Chinese Herbal Medicines2016，8，2： | 87 |
| 2 | Interaction between the gut microbiome and mucosal immune system显示文摘The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is caused by the imbalance between the commensal and pathogenic microbiomes. The commensal microbiome regulates the maturation of the mucosal immune system, while the pathogenic microbiome causes immunity dysfunction, resulting in disease development.The gut mucosal immune system, which consists of lymph nodes, lamina propria and epithelial cells, constitutes a protective barrier for the integrity of the intestinal tract. The composition of the gut microbiota is under the surveillance of the normal mucosal immune system. Inflammation, which is caused by abnormal immune responses,influences the balance of the gut microbiome, resulting in intestinal diseases. In this review, we briefly outlined the interaction between the gut microbiota and the immune system and provided a reference for future studies. | Na Shi Na Li Xinwang Duan Haitao Niu | 2017 | Military Medical Research2017，4，3： | 65 |
| 3 | Exercise as a prescription for patients with various diseases显示文摘A growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy.Because each sport has its own set of characteristics and physiological complications that tend to occur during exercise training,the effects and underlying mechanisms of exercise remain unclear.Thus,the first step in probing the effects of exercise on different diseases is the selection of an optimal exercise protocol.This review summarizes the latest exercise prescription treatments for 26 different diseases:musculoskeletal system diseases(low back pain,tendon injury,osteoporosis,osteoarthritis,and hip fracture),metabolic system diseases(obesity,type 2 diabetes,type 1 diabetes,and nonalcoholic fatty liver disease),cardio-cerebral vascular system diseases(coronary artery disease,stroke,and chronic heart failure),nervous system diseases(Parkinson’s disease,Huntington’s disease,Alzheimer’s disease,depression,and anxiety disorders),respiratory system diseases(chronic obstructive pulmonary disease,interstitial lung disease,and after lung transplantation),urinary system diseases(chronic kidney disease and after kidney transplantation),and cancers(breast cancer,colon cancer,prostate cancer,and lung cancer).Each exercise prescription is displayed in a corresponding table.The recommended type,intensity,and frequency of exercise prescriptions are summarized,and the effects of exercise therapy on the prevention and rehabilitation of different diseases are discussed. | Xin Luan Xiangyang Tian Haixin Zhang Rui Huang Na Li Peijie Chen Ru Wang | 2019 | Journal of Sport and Health Science2019，8，5： | 61 |
| 4 | An Exploratory Analysis of Vegetation Strategies to Reduce Shallow Landslide Activity on Loess Hillslopes, Northeast Qinghai-Tibet Plateau, China显示文摘Heavy summer rainfall induces significant soil erosion and shallow landslide activity on the loess hillslopes of the Xining Basin at the northeast margin of the Qinghai-Tibet Plateau. This study examines the mechanical effects of five native shrubs that can be used to reduce shallow landslide activity. We measured single root tensile resistance and shear resistance, root anatomical structure and direct shear and triaxial shear for soil without roots and five root- soil composite systems. Results show that Atriplex canescens (Pursh) Nutt. possessed the strongest roots, followed by Caragana korshinskii Kom., Zygophyllum xanthoxylon (Bunge) Maxim., Nitraria tangutorum Bobr. and Lycium chinense Mill. Single root strength and shear resistance relationships with root diameter are characterized by power or exponential relations, consistent with the Mohr- Coulomb law. Root mechanical strength reflects their anatomical structure, especially the percentage of phloem and xylem cells, and the degree and speed of periderm lignifications. The cohesion force of root- soil composite systems is notably higher than that of soil without roots, with increasing amplitudes of cohesion force for A. canescens, C. korshinskii, Z. xanthoxylon, N. tangutorum and L. chinense of 75.9%, 75.1%, 36.2%, 24.6% and 17.0 % respectively. When subjected to shear forces, the soil without root samples show much greater lateral deformation thanthe root-soil composite systems, reflecting the restraining effects of roots. Findings from this paper indicate that efforts to reduce shallow landslides in this region by enhancing root reinforcement will be achieved most effectively using A. canescens and C. korshinskii. | HU Xia-song BRIERLEY Gary ZHU Hai-li LI Guo-rong FU Jiang-tao MAO Xiao-qing YU Qin-qin QIAO Na | 2013 | Journal of Mountain Science2013，10，4： | 41 |
| 5 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 6 | Improved Base Editor for Efficiently Inducing Genetic Variations in Rice with CRISPR/Cas9- Guided Hyperactive hAID Mutant显示文摘 | Bin Ren Fang Yan Yongjie Kuang Na Li Dawei Zhang Xueping Zhou Honghui Lin Huanbin Zhou | 2018 | Molecular Plant2018，11，4： | 46 |
| 7 | Tapetum Degeneration Retardation is Critical for Aliphatic Metabolism and Gene Regulation during Rice Pollen Development显示文摘作为在 flowering 植物的一个复杂的墙系统,花粉外部墙主要包含脂肪族的 sporopollenin;然而,为综合的机制在花粉期间,开发仍然是不太好的这些油脂的先锋理解。这里,我们在米饭花粉开发期间在脂肪族的新陈代谢和它的规章的角色在米饭表示 tapetum TDR (Tapetum 退化延迟) 的功能上报导基因。电子显微镜学(TEM ) 和扫描电子显微镜学(SEM ) 分析的传播的观察建议那花粉墙形成显著地在 tdr 异种被改变。花药的脂肪族的作文的内容极大地在测试的 GCMS (煤气的 chromatographymass spectrometry ) 揭示的 tdr 异种被改变,特别地在丰满的酸,主要白酒,链烷和链烯积累的更少,和有到在 tdr 的 C35 的从 C29 的碳长度的第二等的白酒的反常增加。Microarray 数据表明通常认为地涉及类脂化合物运输和新陈代谢的一组基因显著地在 tdr 异种被改变,显示在花粉墙的形成的 TDR 的关键角色。另外,大量基因(236 在起来调整的 total154 并且 82 下面调整) 展出了之间的统计上重要的表现差别野类型并且 tdr。除了它在支持 tapetum PCD 的函数, TDR 可能在米饭花粉开发期间在几基本生物进程起关键规章的作用。 | Da-Sheng Zhang Wan-Qi Liang Zheng Yuan Na Li Jing Shi Jue Wang Yu-Min Liu Wen-Juan Yu Da-Bing Zhang | 2008 | Molecular Plant2008，1，4： | 38 |
| 8 | CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells显示文摘 | Xiaojuan Liu Yongping Zhang Chen Cheng Albert W Cheng Xingying Zhang Na Li Changqing Xia Xiaofei Wei Xiang Liu Haoyi Wang | 2017 | Cell Research2017，27，1： | 40 |
| 9 | Developing the Science Product Algorithm Testbed for Chinese Next-Generation Geostationary Meteorological Satellites:Fengyun-4 Series显示文摘Fengyun-4A(FY-4A), the first of the Chinese next-generation geostationary meteorological satellites, launched in2016, offers several advances over the FY-2: more spectral bands, faster imaging, and infrared hyperspectral measurements. To support the major objective of developing the prototypes of FY-4 science algorithms, two science product algorithm testbeds for imagers and sounders have been developed by the scientists in the FY-4 Algorithm Working Group(AWG). Both testbeds, written in FORTRAN and C programming languages for Linux or UNIX systems, have been tested successfully by using Intel/g compilers. Some important FY-4 science products, including cloud mask, cloud properties, and temperature profiles, have been retrieved successfully through using a proxy imager, Himawari-8/Advanced Himawari Imager(AHI), and sounder data, obtained from the Atmospheric Infra Red Sounder, thus demonstrating their robustness. In addition, in early 2016, the FY-4 AWG was developed based on the imager testbed—a near real-time processing system for Himawari-8/AHI data for use by Chinese weather forecasters.Consequently, robust and flexible science product algorithm testbeds have provided essential and productive tools for popularizing FY-4 data and developing substantial improvements in FY-4 products. | Min MIN Chunqiang WU Chuan LI Hui LIU Na XU Xiao WU Lin CHEN Fu WANG Fenglin SUN Danyu QIN Xi WANG Bo LI Zhaojun ZHENG Guangzhen CAO Lixin DONG | 2017 | Journal of Meteorological Research2017，31，4： | 35 |
| 10 | Vision,Requirements and Network Architecture of 6G Mobile Network beyond 2030显示文摘With the 5th Generation(5G)Mobile network being rolled out gradually in 2019,the research for the next generation mobile network has been started and targeted for 2030.To pave the way for the development of the 6th Generation(6G)mobile network,the vision and requirements should be identified first for the potential key technology identification and comprehensive system design.This article first identifies the vision of the society development towards 2030 and the new application scenarios for mobile communication,and then the key performance requirements are derived from the service and application perspective.Taken into account the convergence of information technology,communication technology and big data technology,a logical mobile network architecture is proposed to resolve the lessons from 5G network design.To compromise among the cost,capability and flexibility of the network,the features of the 6G mobile network are proposed based on the latest progress and applications of the relevant fields,namely,on-demand fulfillment,lite network,soft network,native AI and native security.Ultimately,the intent of this article is to serve as a basis for stimulating more promising research on 6G. | Guangyi Liu Yuhong Huang Na Li Jing Dong Jing Jin Qixing Wang Nan Li | 2020 | China Communications2020，17，9： | 37 |
| 11 | Control of Grain Size and Weight by the OsMKKK10-OsM KK4-OsMAPK6 Signaling Pathway in Rice显示文摘谷物尺寸是在庄稼决定谷物产量的关键农学的特点之一。然而,在庄稼位于谷物尺寸控制下面的机制留下逃犯。这里,我们证明断然表明小径的 OsMKKK10-OsMKK4-OsMAPK6 在米饭调整谷物尺寸和重量。在米饭,当组成地活跃的 OsMKKK10 (CA-OsMKKK10 ) 的 overexpression 导致大、重的谷物,长圆锥花序,和高植物时, OsMKKK10 功能的损失导致小、轻的谷物,短圆锥花序,和半矮子植物。OsMKKK10 交往与并且 phosphorylates OsMKK4。我们识别了 OsMKK4 gain-of-function 异种(large11-1D )? 那生产大、重的谷物。OsMKK4 large11-1D 等位基因编码的 A227T 比 OsMKK4 举办更强壮的 kinase 活动。植物 overexpressing OsMKK4 (OsMKK4-DD ) 的一种组成地活跃的形式也生产大谷物。进一步生物化学、基因的分析表明 OsMKKK10, OsMKK4,和 OsMAPK6 在一条普通小径工作控制谷物尺寸。一起拿,我们的学习在米饭为谷物尺寸和重量的 OsMKKK10-OsMKK4-OsMAPK6 调停串联的控制建立一个重要基因、分子的框架。 | Ran Xu Penggen Duan Haiyue Yu Zhengkui Zhou Baolan Zhang Ruci Wang Jing Li Guozheng Zhang Shangshang Zhuang Jia Lyu Na Li Tuanyao Chai Zhixi Tian Shanguo Yao Yunhai Li | 2018 | Molecular Plant2018，11，6： | 33 |
| 12 | REE geochemistry of suspended sediments from the rivers around the Yellow Sea and provenance indicators显示文摘Rare earth element (REE) compositions of the suspended sediments from the rivers around the Yellow Sea were different in that Korean river sediments (Han, Keum and Yeongsan Rivers) yield stronger fractionations than Chinese river sediments (Changjiang, Huanghe and Yalujiang), shown by obvious enrichments of LREE (light rare earth element) relative to UCC (upper continental crust). Variations of source rock compositions in the drainage basins are responsible for the differences of REE compositions between the river sediments. REE fractionation parameters including (La/Yb)UCC and (Gd/Yb)UCC as well as the ratios of La/Sc and Th/Sc can be treated as proper proxies for identifying the Chinese river sediments from those Korean river matters, and furthermore, for studying the provenances and paleoenvironmental changes of the marginal seas of China. | YANG Shouye LI Congxian C. B. Lee T. K. Na | 2003 | Chinese Science Bulletin2003，48，11： | 30 |
| 13 | Facile Synthesis and Application of Ag-Chemically Converted Graphene Nanocomposite显示文摘An in situ chemical synthesis approach has been employed to prepare an Ag-chemically converted graphene (CCG) nanocomposite. The reduction of graphene oxide sheets was accompanied by generation of Ag nanoparticles. The structure and composition of the nanocomposites were confirmed by means of transmission electron microscopy (TEM), atomic force microscopy (AFM) and X-ray diffraction. TEM and AFM results suggest a homogeneous distribution of Ag nanoparticles (5-10 nm in size) on CCG sheets. The intensities of the Raman signals of CCG in such nanocomposites are greatly increased by the attached silver nanoparticles, i.e., there is surface-enhanced Raman scattering activity. In addition, it was found that the antibacterial activity of free Ag nanoparticles is retained in the nanocomposites, which suggests they can be used as graphene-based biomaterials. | Jianfeng Shen Min Shi Na Li Bo Yan Hongwei Ma Yizhe Hu Mingxin Ye | 2010 | Nano Research2010，3，5： | 29 |
| 14 | Paeonol inhibits tumor growth in gastric cancer in vitro and in vivo显示文摘AIM:To investigate the anti-tumor effects of paeonol in gastric cancer cell proliferation and apoptosis in vitro and in vivo.METHODS:Murine gastric cancer cell line mouse forestomach carcinoma(MFC) or human gastric cancer cell line SGC-7901 was cultured in the presence or absence of paeonol.Cell proliferation was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay,and cell cycle and apoptosis by flow cytometry and TUNEL staining.Tumor growth after subcutaneous implantation of MFC cells in mice was monitored,and the effects of treatment with paeonol were determined.RESULTS:In vitro,paeonol caused dose-dependent inhibition on cell proliferation and induced apoptosis.Cell cycle analysis revealed a decreased proportion of cells in G0/G1 phase,with arrest at S.Paeonol treatment in gastric cancer cell line MFC and SGC-790 cells significantly reduced the expression of Bcl-2 and increased the expression of Bax in a concentration-related manner.Administration of paeonol to MFC tumor-bearing mice significantly lowered the tumor growth and caused tumor regression.CONCLUSION:Paeonol has signif icantly growth-inhibitory and apoptosis-inducing effects in gastric cancer cells both in vitro and in vivo. | Na Li Lu-Lu Fan Guo-Ping Sun Xin-An Wan Zhang-Gui Wang Qiang Wu Hua Wang | 2010 | World Journal of Gastroenterology2010，16，35： | 27 |
| 15 | A CRISPR/Cas9 toolkit for efficient targeted base editing to induce genetic variations in rice显示文摘Dear Editor,Gene-targeting technologies using sequence specific nucleases have been widely adopted to induce genetic modifications in both plant molecular biology research and crop improvement,of which generating targeted point mutation for gain-of-function phenotype is of great value.Although tremendous efforts have been made in developing geneinsertion or replacement approaches by | Bin Ren Fang Yan Yongjie Kuang Na Li Dawei Zhang Honghui Lin Huanbin Zhou | 2017 | Science China(Life Sciences)2017，60，5： | 28 |
| 16 | Severe Mycoplasma Pneumonia in Child with Bilateral Parapneumonic Effusion Successfully Treated with Integrated Chinese and Western Medicine: A Case Report显示文摘Mycoplasma pneumonia is a common communityacquired pneumonia(CAP)in Asia.Children suffering from M.pneumoniae tend to progress quickly and develop severe pneumonia with a poor prognosis.(1)Effective management of M.pneumoniae infections include macrolides,tetracyclines or fluoroquinolones, | ZENG Wen-ying LI Yan XU Zhi-lan XIE Xiao-lei XU Feng-qin RUI Na | 2018 | Chinese Journal of Integrative Medicine2018，24，9： | 27 |
| 17 | Effects of spironolactone on electrical and structural remodeling of atrium in congestive heart failure dogs显示文摘背景:Renin-angiotensin-aldosterone 系统被表明了与充血心力衰竭(CHF ) 并且在伊朗的银币纤维性颤动(AF ) 被联系。这研究调查了螺内酯的效果,一种醛固酮对手,在上在伊朗的银币,在 CHF 狗的电的改变和纤维变性导致了由长期快速的室的踱步。方法:21 条狗随机被划分成假冒操作组,控制组,和螺内酯组。在控制组和螺内酯组,狗是室的每分钟在 220 敲击踱步 6 个星期。另外,在 15 mg x kg 的螺内酯(-1) x d (-1) 1 个星期在快速的室的踱步前被给狗直到踱步停止了。经胸廓和 transoesophageal echocardiographic 考试被执行检测中庭的结构、功能的变化。Swan2 Ganz 漂浮导管被用来测量缝 adynamics 变化。房的的有效不应期(AERP ) , AERP 分散(AERPd ) , intra 中庭和内部中庭的传导时间(CT ) 和 intra 中庭传导速度(CV ) 是坚定的。AF 的 inducibility 和持续时间也在所有组被测量。最后,在伊朗的银币,纤维变性被确定,马森染色。结果:在狗是室的以后, AERP 没显著地变化踱步 6 个星期。然而,显著地增加的 AERPd, intra 中庭和内部中庭的 CT,和 CV 显然减少了,它否定地被相关到 at 伊朗的银币纤维变性(r =-0.74, P <
0.05 ) 。同时,左中庭被扩大,心脏的缝 adynamics 在在狗上踱步变得更坏。尽管螺内酯不能有效地影响心脏的缝 adynamics,它能显然在伊朗的银币喷射部分改进左(P <
0.05 ) 。螺内酯处理没改变 AERP 持续时间,但是这药戏剧性地减少 AERPd (P <
0.05 ) ,弄短的 intra 中庭和内部中庭的传导时间(P <
0.05 ) ,并且增加的中庭 CV。而且,螺内酯减少了 AF 的 inducibility 和持续时间(P <
0.05 ) ,以及在伊朗的银币,纤维变性(P< 0.01 ) 导致了由长期快速的室的踱步。结论:螺内酯在导致由的充血心力衰竭狗贡献 AF 预防长期快速的室的踱步,它在伊朗的银币纤维变性减小和缝 adynamics 的独立人士与有关。 | YANG Shu-sen HAN Wei ZHOU Hong-yan DONG Guo WANG Bai-chun HUO Hong WEI Na CAO Yong ZHOU Guo XIU Chun-hong LI Wei-min | 2008 | Chinese Medical Journal2008，，1： | 26 |
| 18 | Two mechanical methods for thromboembolism prophylaxis after gynaecological pelvic surgery: a prospective, randomised study显示文摘 | GAO Jie ZHANG Zhen-yu LI Zhan LIU Chong-dong ZHAN Yu-xin QIAO Bao-li SANG Cui-qin GUO Shu-li WANG Shu-zhen JIANG Ying ZHAO Na | 2012 | Chinese Medical Journal2012，，23： | 25 |
| 19 | Keyword Extraction Based on tf/idf for Chinese News Document显示文摘Keyword extraction is an important research topic of information retrieval. This paper gave the specification of key- words in Chinese news documents based on analyzing linguistic characteristics of news documents and then proposed a new key- word extraction method based on tf/idf with multi-strategies. The approach selected candidate keywords of uni-, bi-and tri-grams, and then defines the features according to their morphological characters and context information. Moreover, the paper proposed several strategies to amend the incomplete words gotten from the word segmentation and found unknown potential keywords in news documents. Experimental results show that our proposed method can significantly outperform the baseline method. We also applied it to retrospective event detection. Experimental results show that the accuracy and efficiency of news retrospective event detection can be significantly improved. | LI Juanzi FAN Qi'na ZHANG Kuo | 2007 | Wuhan University Journal of Natural Sciences2007，12，5： | 23 |
| 20 | Mineral chemistry and isotope geochemistry of pyrite from the Heilangou gold deposit, Jiaodong Peninsula, Eastern China显示文摘The Heilangou gold deposit is located in the northern QixiaePenglai gold belt, which is one amongst the three large gold belts in the eastern Shandong Province(Jiaodong Peninsula). The ore body has formed within the Guojialing granite. In this study, we report the mineral chemistry of pyrite, as well as the S, Pb,and HeO isotope data of the Heilangou gold deposit. The chemical composition of pyrite in the Heilangou gold deposit indicates that the associated gold deposit is a typical magmatic hydrothermal one. The geochemical signatures and crystal structure of pyrite show that the ore-forming materials have been derived from the crust. The S isotope data of the pyrites from Heilangou show an overall range from 5.5 to7.8& and an average of 6.7&. The S isotope data in this deposit are similar to those from the deposits in the Jiaodong gold belt. The Pb and S isotope variations are small in the Heilangou gold deposit. The206Pb/204Pb,207Pb/204Pb and208Pb/204Pb ratios are 17.4653-17.5958, 15.5105-15.5746 and 38.0749-38.4361, respectively. These data plot between the lower crust and the orogenic belt. The Pb isotope data in the Heilangou gold deposit are similar to those in the Linglong gold deposit. From the Qixia gold area(the Liukou and Majiayao gold deposits) to the MupingeRushan gold belt(Rushan gold deposit) to the ZhaoeYe gold belt(the Linglong, Sanshandao and Jiaojia gold deposits), the206Pb/204Pb ratios progressively increase. The DeO isotope data obtained from quartz separates suggest that the ore-forming fluid was similar to a mixture of magmatic and meteoric waters. These results suggest that the ore-forming elements were primarily from source fluids derived from the lower crust. | Yutong Yan Na Zhang Shengrong Li Yongsheng Li | 2014 | Geoscience Frontiers2014，5，2： | 22 |
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