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| 1 | The Immune System and the Role of Inflammation in Perinatal Depression显示文摘Major depression during pregnancy is a common psychiatric disorder that arises from a complex and multifactorial etiology. Psychosocial stress, sex, hormones, and genetic vulnerability increase the risk for triggering mood disorders. Microglia and toll-like receptor 4 play a crucial role in triggering wide and varied stress-induced responses mediated through activation of the inflammasome; this leads to the secretion of inflammatory cytokines, increased serotonin metabolism, and reduction of neurotransmitter availability along with hypothalamic–pituitary–adrenal axis hyperactivity. Dysregulation of this intricate neuroimmune communication network during pregnancy modifies the maternal milieu, enhancing the emergence of depressive symptoms and negative obstetric and neuropsychiatric outcomes. Although several studies have clearly demonstrated the role of the innate immune system in major depression, it is still unclear how the placenta, the brain, and the monoaminergic and neuroendocrine systems interact during perinatal depression. Thus, in the present review we describe the cellular and molecular interactions between these systems in major depression during pregnancy, proposing that the same stress-related mechanisms involved in the activation of the NLRP3 inflammasome in microglia and peripheral myeloid cells in depressed patients operate in a similar fashion in the neuroimmune placenta during perinatal depression. Thus, activation of Toll-like receptor 2 and 4 signaling and the NLRP3 inflammasome in placental immune cells may promote a shift of the Th1/Th2 bias towards a predominant Th1/Th17 inflammatory response, associated with increased secretion of pro-inflammatory cytokines, among other secreted autocrine and paracrine mediators, which play a crucial role in triggering and/or exacerbating depressive symptoms during pregnancy. | Philippe Leff-Gelman Ismael Mancilla-Herrera Monica Flores-Ramos Carlos Cruz-Fuentes Juan Pablo Reyes-Grajeda maría del pilar garcía-cuétara Marielle Danitza Bugnot-Perez David Ellioth Pulido-Ascencio | 2016 | Neuroscience Bulletin2016，32，4： | 17 |
| 2 | Epigenetic profiles of pre-diabetes transitioning to type 2 diabetes and nephropathy显示文摘AIM: To examine DNA methylation profiles in a longitudinal comparison of pre-diabetes mellitus(Pre-DM) subjects who transitioned to type 2 diabetes mellitus(T2DM).METHODS: We performed DNA methylation study in bisulphite converted DNA from Pre-DM(n = 11) at baseline and at their transition to T2 DM using Illumina Infinium Human Methylation27 Bead Chip, that enables the query of 27578 individual cytosines at Cp G loci throughout the genome, which are focused on the promoter regions of 14495 genes.RESULTS: There were 694 Cp G sites hypomethylated and 174 Cp G sites hypermethylated in progression from Pre-DM to T2 DM, representing putative genes involved in glucose and fructose metabolism, inflammation, oxidative and mitochondrial stress, and fatty acid metabolism. These results suggest that this high throughput platform is able to identify hundreds of prospective Cp G sites associated with diverse genes that may reflect differences in Pre-DM compared with T2 DM. In addition, there were Cp G hypomethylation changes associated with a number of genes that may be associated with development of complications of diabetes, such as nephropathy. These hypomethylation changes were observed in all of the subjects.CONCLUSION: These data suggest that some epigenomic changes that may be involved in the progression of diabetes and/or the development of complications may be apparent at the Pre-DM state or during the transition to diabetes. Hypomethylation of a number of genes related to kidney function may be an early marker for developing diabetic nephropathy. | Thomas A Vander Jagt Monica H Neugebauer Marilee Morgan Donald W Bowden Vallabh O Shah | 2015 | World Journal of Diabetes2015，6，9： | 5 |
| 3 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 4 | An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair显示文摘The aim of this study was to evaluate injectable,in situ cross-linkable elastin-like recombinamers(ELRs)for osteochondral repair.Both the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal stromal cells(rMSCs)were tested for the regeneration of critical subchondral defects in 10 New Zealand rabbits.Thus,cylindrical osteochondral defects were filled with an aqueous solution of ELRs and the animals sacrificed at 4months for histological and gross evaluation of features of biomaterial performance,including integration,cellular infiltration,surrounding matrix quality and the new matrix in the defects.Although both approaches helped cartilage regeneration,the results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration,whereas the ELR-based hydrogel alone led to an excellent regeneration of hyaline cartilage.In conclusion,the ELR cross-linker solution can be easily delivered and forms a stable well-integrated hydrogel that supports infiltration and de novo matrix synthesis. | Filippo Cipriani Blanca Arino Palao Israel Gonzalez de Torre Aurelio Vega Castrillo Hector Jose Aguado Hernandez Matilde Alonso Rodrigo Angel Jose Alvarez Barcia Ana Sanchez Veronica Garcıa Diaz Monica Lopez Pena Jose Carlos Rodriguez-Cabello | 2019 | Regenerative Biomaterials2019，6，6： | 3 |
| 5 | Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma显示文摘AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters.METHODS:β-actin is a housekeeping gene,frequently used as loading control,but,differentially expresses in cancer.In gastric cancer,an overall increased expression ofβ-actin has been reported using tissue disruptive techniques.At present,no histological data is available to indicate its cell type-specific expression and distribution pattern.In the present study,we analyzedβ-actin expression and distribution in paired normal and tumor tissue samples of gastric adenocarcinoma patients using immunohistochemistry(IHC),a tissue non-disruptive technique as well as tissue disruptive techniques like reverse transcriptase-polymerase chain reaction(RT-PCR)and western blotting.Correlation ofβ-actin level with clinicopathological parameters was done using univariate analysis.RESULTS:The results of this study showed significant overexpression,at both mRNA and protein level in tumor tissues as confirmed by RT-PCR(1.47±0.13 vs2.36±0.16;P<0.001)and western blotting(1.92±0.26 vs 2.88±0.32;P<0.01).IHC revealed thatβ-actin expression is majorly distributed between epithelial and inflammatory cells of the tissues.Inflammatory cells showed a significantly higher expression compared to epithelial cells in normal(2.46±0.13 vs 5.92±0.23,P<0.001),as well as,in tumor tissues(2.79±0.24 vs6.71±0.14,P<0.001).Further,comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpressβ-actin in tumor tissues,however,significant difference was observed only in inflammatory cells(5.92±0.23vs 6.71±0.14,P<0.01).Moreover,combined expression in epithelial and inflammatory cells also showed significant increase(4.19±0.15 vs 4.75±0.14,P<0.05)in tumor tissues.In addition,univariate analysis showed a positive correlation ofβ-actin level of inflammatory cells with tumor grade(P<0.05)while epithelial cells exhibited negative correlation(P>0.05).CONCLUSION:In gastric cancer,β-actin showed an overall higher expression predominantly contributed by inflammatory or tumor infiltrating immune cells of the tissue microenvironment and correlates with tumor grade. | Shafqat A Khan Monica Tyagi Ajit K Sharma Savio G Barreto Bhawna Sirohi Mukta Ramadwar Shailesh V Shrikhande Sanjay Gupta | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 6 | Effects of obstructive sleep apnea and its treatment over the erectile function: a systematic review显示文摘可勃起的机能障碍(编辑) 与大量病原学被认为一个条件。妨碍的睡觉呼吸暂停(OSA ) 症候群是为我们打算在在 OSA 和性缺陷之间的关系上总结当前的证据的编辑的更小的学习风险因素之一,集中于以提供给 OSA 病人的不同治疗的可勃起的功能的结果。系统的评论被进行,选择与 OSA 和编辑的生理学有关的文章,并且到在可勃起、性的功能的 OSA 症候群和他们的报导结果的治疗。在 OSA 组的编辑的更高的流行被出版了。然而,可勃起的功能上的这效果是否发生在 OSA 严厉的全部范围,仍然保持不清楚。几个假设被建议解释这个协会的生理学。为有编辑的 OSA 病人的治疗在大多数研究在性参数完成了有意义的改进的连续积极航线压力。需求上的 Phosphodiesterase 类型 5 禁止者(iPDE5 ) 作为为在病人的这亚群的编辑的治疗有用,与高满足率。为证实的 OSA 的外科的治疗用 mandible 的前进设备在治疗的性满足上在可勃起的功能,和效果上受益仍然是未定义的。 | Felix Campos-Juanatey Marcos Fernandez-Barriales Monica Gonzalez Jose A Portillo-Martin | 2017 | Asian Journal of Andrology2017，19，3： | 2 |
| 7 | Leptospirosis: a zoonotic disease of global importance显示文摘 | Ajay R Bharti Jarlath E Nally Jessica N Ricaldi Michael A Matthias Monica M Diaz Michael A Lovett Paul N Levett Robert H Gilman Michael R Willig Eduardo Gotuzzo Joseph M Vinetz | 2003 | The Lancet Infectious Diseases2003，，12： | 2 |
| 8 | Glutathione- S -transferase family of enzymes显示文摘 | Richard C Strange Monica A Spiteri Sudarshan Ramachandran Anthony A Fryer | 2001 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2001，，1： | 2 |
| 9 | Identification of an immunodominant CD4+ T cell epitope in the VP6 protein of rotavirus following intranasal immunization of BALB/C mice显示文摘 | Monica M M Mitali B Judy A B | 2007 | Virology2007，363，2： | 1 |
| 10 | Atorvastatin reduces NF-κB activation and chemokine expression in vascular smooth cells and mononuclear cells显示文摘 | Monica Qrtego Carmen Bustos Miguel A | 1999 | Atherosclerosis1999，147，： | 1 |
| 11 | Odometric Estimation for Automatic Train Protection and Control Systems 显示文摘 | MONICA M BENEDETTO A | 2011 | Vehi- cle System Dynamics2011，49，5： | 1 |
| 12 | Detecting chlorophyll Secchi disk depth and surfacee temperature in a sub-alpine lake using landsat irnagery显示文摘 | Claudia G Monica P Pietm A Paolo G Eugenio Z | 2001 | The Science of the Total Environment2001，268，： | 1 |
| 13 | Influence of malt browning de- gree on lipoxygenase activity显示文摘 | SOVRANO S BUIATTI S MONICA A | 2006 | Food Chem2006，，： | 1 |
| 14 | Phytate degradation by Bifidobacteriumon whole wheat fermentation显示文摘 | Mar í a Consuelo Palacios Monica Haros Yolanda Sanz | | 0，，05： | 1 |
| 15 | Viability and stability of biological control agents on cotton and snap bean seeds显示文摘 | Monica L E Elizabeth A D J William E B J | 2001 | Pest Manag sc2001，57，8： | 1 |
| 16 | Induction of CD69 activation molecule on human neutrophils by GM-CSF,IFN-γ,and IFN-α显示文摘 | FABIOLA A MONICA S ANNA M | 2002 | Cell Immunol2002，220，1： | 1 |
| 17 | Strategic development of third party logistics providers显示文摘 | Susanne H Monica A | 2003 | Industrial Marketing Management2003，32，2： | 1 |
| 18 | Requirement for IGF-I in Epidermal Growth Factor-Mediated Cell Cycle Progression of Mammary Epithelial Cells显示文摘 | MALINDA A S MONICA M R AIMEE V L | 2002 | Endocrinology2002，143，5： | 1 |
| 19 | Evaluation of nursing students' work technique after proficiency training in patient transfer methods during undergraduate education显示文摘 | Christina E Johnsson A Monica AK | 2006 | Nurse Education Today2006，，4： | 1 |
| 20 | Quantitative determi-nation of the macrolide antibiotic tulathromycin in plasma and bronchoalve-olar cells of foals using tandem mass spectrometry显示文摘 | EBERHARD S A JANINA S A MONICA V B | 2007 | Journal of Chroma-tography B2007，850，12： | 1 |
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