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| 1 | Structure and function of ALG-2,a penta-EF-hand calcium-dependent adaptor protein显示文摘ALG-2(a gene product of PDCD6) is a 22-kD protein containing five serially repetitive EF-hand structures and belongs to the penta-EF-hand(PEF) family,including the subunits of typical calpains.ALG-2 is the most conserved protein among the PEF family members and its homologs are widely found in eukaryotes.X-ray crystal structures of various PEF proteins including ALG-2 have common features:presence of eightα-helices and dimer formation via paired EF5s that are positioned in anti-parallel orientation.ALG-2 forms a homodimer and a heterodimer with its closest paralog peflin.Like calmodulin,a well-known four-EF-hand protein,ALG-2 interacts with various proteins in a Ca2+-dependent fashion,but the binding motifs are completely different.With some exceptions,ALG-2-interacting proteins commonly contain Pro-rich regions,and ALG-2 recognizes at least two distinct Pro-containing motifs:PPYP(X) nYP(X,variable;n=4 in ALIX and PLSCR3) and PXPGF(represented by Sec31A) .A shorter alternatively spliced isoform,lacking two residues and designated ALG-2 GF122,does not bind ALIX but maintains binding capacity to Sec31A.X-ray crystal structural analyses have revealed that binding of calcium ions induces the configuration of the side chain of R125 so that it opens Pocket 1,which accepts PPYP,but Pocket 1 remains closed in the case of ALG-2 GF122.ALG-2 dimer has two ligand-binding sites,each in a monomer molecule,and appears to function as a Ca2+-dependent adaptor protein to either stabilize a preformed complex or to bridge two proteins on scaffolds in systems of the endosomal sorting complex required for transport(ESCRT) and ER-to-Golgi transport. | Masatoshi MAKI Hironori SUZUKI Hideki SHIBATA | 2011 | Science China(Life Sciences)2011，54，8： | 9 |
| 2 | Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss显示文摘Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors.Regulation of osteoclast differentiation is considered an effective therapeutic approach to the treatment of bone-lytic diseases.Periodontitis is an inflammatory disease characterized by extensive bone resorption. In this study, we investigated the effects of sodium fluoride(Na F) on osteoclastogenesis induced by Porphyromonas gingivalis, an important colonizer of the oral cavity that has been implicated in periodontitis. Na F strongly inhibited the P. gingivalis-induced alveolar bone loss. That effect was accompanied by decreased levels of cathepsin K, interleukin(IL)-1β, matrix metalloproteinase 9(MMP9), and tartrate-resistant acid phosphatase,which were up-regulated during P. gingivalis-induced osteoclastogenesis. Consistent with the in vivo anti-osteoclastogenic effect,Na F inhibited osteoclast formation caused by the differentiation factor RANKL(receptor activator of nuclear factor kB ligand)and macrophage colony-stimulating factor(M-CSF). The RANKL-stimulated induction of the transcription factor nuclear factor of activated T cells(NFAT) c1 was also abrogated by Na F. Taken together, our data demonstrate that Na F inhibits RANKL-induced osteoclastogenesis by reducing the induction of NFATc1, ultimately leading to the suppressed expression of cathepsin K and MMP9.The in vivo effect of Na F on the inhibition of P. gingivalis-induced osteoclastogenesis strengthens the potential usefulness of Na F for treating periodontal diseases. | Ujjal K Bhawal Hye-Jin Lee Kazumune Arikawa Michiharu Shimosaka Masatoshi Suzuki Toshizo Toyama Takenori Sato Ryota Kawamata Chieko Taguchi Nobushiro Hamada Ikuo Nasu Hirohisa Arakawa Koh Shibutani | 2015 | International Journal of Oral Science2015，7，4： | 3 |
| 3 | Nuclear survivin expression predicts poorer prognosis in glioblastoma显示文摘 | Katsuyuki Shirai Yoshiyuki Suzuki Kuniyuki Oka Shin-ei Noda Hiroyuki Katoh Yoshihiko Suzuki Jun Itoh Hideaki Itoh Shogo Ishiuchi Hideyuki Sakurai Masatoshi Hasegawa Takashi Nakano | 2009 | Journal of Neuro - Oncology2009，，3： | 1 |
| 4 | Measles infection in pregnancy 显示文摘 | Makiko Egashira Chiba Masatoshi Saito Nobuaki Suzuki | 2003 | J infect2003，47，1： | 1 |
| 5 | Quantitative analyses of GDNF and neurotrophins during postnatal development in rat skeletal muscles 显示文摘 | Masatoshi Nagano Hidenori Suzuki | 2003 | Neuroscience Research2003，45，： | 1 |
| 6 | Development of co-continuous structure in liquID crystalline polyester显示文摘 | Kenta Suzuki Hiromu Saito Masatoshi Tokita | 2005 | Polymer2005，46，19： | 1 |
| 7 | Nonacid nitration of benzenedicarboxylic and naphthalenecarboxylic acid esters显示文摘 | Nose Masatoshi Suzuki Hitomi Suzuki Hideo | 2001 | Journal of Organic Chemistry2001，66，12： | 1 |
| 8 | Scanning tunneling microscope with three-dimensional interferometer for surface roughness measurment显示文摘 | TORU Fuji MASATAKA Yamaguchi MASATOSHI Suzuki | 1995 | Rev Sci Instrumen1995，66，3： | 1 |
| 9 | New optically active imine dopants derived from (R)- (+)-1-(1-naphthyl)ethylamine: Relation between their large helical twisting power and internal rotation potential profiles显示文摘 | Kaoru Fukuda Hideyuki Suzuki Masatoshi Tokita | 2007 | Theochem2007，821，1： | 1 |
| 10 | Transcriptional induction of Smurf2 ubiquitin ligase by TGF-β显示文摘 | Naro Ohashi Tatsuo Yamamoto Chiharu Uchida Akashi Togawa Hirotaka Fukasawa Yoshihide Fujigaki Sayuri Suzuki Kyoko Kitagawa Takayuki Hattori Toshiaki Oda Hidetoshi Hayashi Akira Hishida Masatoshi Kitagawa | 2005 | FEBS Letters2005，，12： | 1 |
| 11 | 18 F-FDG uptake in primary gastric malignant lymphoma correlates with glucose transporter 1 expression and histologic malignant potential显示文摘 | Yuko Watanabe Hiroaki Suefuji Yasumitsu Hirose Hayato Kaida Gen Suzuki Jun Uozumi Etsuyo Ogo Mayumi Miura Konomi Takasu Kanoko Miyazaki Keita Nakahara Masatoshi Ishibashi Takashi Okamura Koichi Ohshima Naofumi Hayabuchi | 2013 | International Journal of Hematology2013，，1： | 1 |
| 12 | Ubiquitin-Dependent Degradation of Smad2 Is Increased in the Glomeruli of Rats with Anti-Thymocyte Serum Nephritis显示文摘 | Akashi Togawa Tatsuo Yamamoto Hiroyuki Suzuki Hirotaka Fukasawa Naro Ohashi Yoshihide Fujigaki Kyoko Kitagawa Takayuki Hattori Masatoshi Kitagawa Akira Hishida | 2003 | The American Journal of Pathology2003，，4： | 1 |
| 13 | Corrosion characteristics of reduced activation ferritic steel, JLF-1 (8.92Cr–2W) in molten salts Flibe and Flinak显示文摘 | Masatoshi Kondo Takuya Nagasaka Qi Xu Takeo Muroga Akio Sagara Nobuaki Noda Daisuke Ninomiya Masaru Nagura Akihiro Suzuki Takayuki Terai Naoki Fujii | 2009 | Fusion Engineering and Design2009，，7： | 1 |
| 14 | Corrosion characteristics of reduced activation ferritic steel, JLF-1 (8.92Cr–2W) in molten salts Flibe and Flinak显示文摘 | Masatoshi Kondo Takuya Nagasaka Qi Xu Takeo Muroga Akio Sagara Nobuaki Noda Daisuke Ninomiya Masaru Nagura Akihiro Suzuki Takayuki Terai Naoki Fujii | 2009 | Fusion Engineering and Design2009，，7： | 1 |
| 15 | Adenoendocrine cell carcinoma of the gallbladder clinically mimicking squamous cell carcinoma显示文摘 | Hiroya Taniguchi Junichi Sakagami Norihisa Suzuki Hirohito Hasegawa Misumi Shinoda Masatoshi Tosa Takehiko Baba Hiroaki Yasuda Keisho Kataoka Toshikazu Yoshikawa | 2009 | International Journal of Clinical Oncology2009，，2： | 1 |
| 16 | Transcriptional induction of Smurf2 ubiquitin ligase by TGF-β显示文摘 | Naro Ohashi Tatsuo Yamamoto Chiharu Uchida Akashi Togawa Hirotaka Fukasawa Yoshihide Fujigaki Sayuri Suzuki Kyoko Kitagawa Takayuki Hattori Toshiaki Oda Hidetoshi Hayashi Akira Hishida Masatoshi Kitagawa | 2005 | FEBS Letters2005，，12： | 1 |
| 17 | Phase separation structure in the polymer blend of fluorocarbon elastomers and hydrogenated nitrile rubber 显示文摘 | Kouser Hirano Ken Suzuki Kenji Nakano Masatoshi Tosaka | 2005 | Appl Polym Sci2005，95，： | 1 |
| 18 | Small cell neuroendocrine carcinoma of the ampulla of Vater with foci of squamous differentiation: a case report显示文摘 | Gen Sugawara Akihiro Yamaguchi Masatoshi Isogai Yoshio Watanabe Yuji Kaneoka Masahiko Suzuki | 2004 | Journal of Hepato-Biliary-Pancreatic Surgery2004，，1： | 1 |
| 19 | Preoperative localization of pancreatic insulinoma by super selective arterial stimulation with venous sampling显示文摘 | Satoru Morita Haruhiko Machida Ryohei Kuwatsuru Naoko Saito Kazufumi Suzuki Masatoshi Iihara Takao Obara Norio Mitsuhashi | 2007 | Abdominal Imaging2007，，1： | 1 |
| 20 | Characteristic Radiographic or Magnetic Resonance Images of Fresh Osteoporotic Vertebral Fractures Predicting Potential Risk for Nonunion: A Prospective Multicenter Study显示文摘 | Tadao Tsujio Hiroaki Nakamura Hidetomi Terai Masatoshi Hoshino Takashi Namikawa Akira Matsumura Minori Kato Akinobu Suzuki Kazushi Takayama Wakaba Fukushima Kyoko Kondo Yoshio Hirota Kunio Takaoka | 2011 | Spine2011，，15： | 1 |
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