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| 1 | Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration显示文摘Accumulating evidence indicates an association between the circadian clock and the aging process.However,it remains elusive whether the deregulation of circadian clock proteins underlies stem cell aging and whether they are targetable for the alleviation of aging-associated syndromes.Here,we identified a transcription factor-independent role of CLOCK,a core component of the molecular circadian clock machinery,in counteracting human mesenchymal stem cell(hMSC)decay.CLOCK expression was decreased during hMSC aging.In addition,CLOCK deficiency accelerated hMSC senescence,whereas the overexpression of CLOCK,even as a transcriptionally inactive form,rejuvenated physiologically and pathologically aged hMSCs.Mechanistic studies revealed that CLOCK formed complexes with nuclear lamina proteins and KAP1,thus maintaining heterochromatin architecture and stabilizing repetitive genomic sequences.Finally,gene therapy with lentiviral vectors encoding CLOCK promoted cartilage regeneration and attenuated age-related articular degeneration in mice.These findings demonstrate a noncanonical role of CLOCK in stabilizing heterochromatin,promoting tissue regeneration,and mitigating aging-associated chronic diseases. | Chuqian Liang Zunpeng Liu Moshi Song Wei Li Zeming Wu Zehua Wang Qiaoran Wang Si Wang Kaowen Yan Liang Sun Tomoaki Hishida Yanning Cai Juan Carlos lzpisua Belmonte Pedro Guillen Piu Chan Qi Zhou Weiqi Zhang Jing Qu Guang-Hui Liu | 2021 | Cell Research2021，31，2： | 8 |
| 2 | Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors显示文摘功能的网膜的颜料上皮(RPE ) 的产生具有到再生药的地的大治疗学的兴趣并且可以为网膜的退化疾病提供可能的痊愈,包括年龄相关的有斑点的退化(AMD ) 。尽管 RPE 房间能从胚胎的干细胞被生产或导致了 pluripotent 干细胞,决定系的抄写因素驾驶的直接房间 reprogramming 提供一条立即的线路给他们的产生。由监视人的 RPE 特定的 Best1::GFP 记者,我们报导进 RPE 系使用的人的成纤维细胞的变换定义抄写因素的集合。我们发现 Best1::GFP 积极房间形成了殖民地并且展出了早阶段 RPE 房间的词法、分子的特征。而且,他们能在 Retinoic 酸(RA ) 和表明小径的声音的刺猬(嘘) 的激活之上获得色素沉着。我们的学习不仅建立了一个理想的平台调查调整 RPE 房间命运决心的 transcriptional 网络,而且提供了其他的策略产生为疾病建模,屏蔽的药,和网膜的退化的房间治疗补充 pluripotent 干细胞的使用的功能的 RPE 房间。 | Kejing Zhang Guang-Hui Liu Fei Yi Nuria Montserrat Tomoaki Hishida Concepcion Rodriguez Esteban Juan Carlos Izpisua Belmonte] | 2014 | Protein & Cell2014，5，1： | 6 |
| 3 | On Turbulent Contribution to Frictional Drag in Wall-Bounded Turbulent Flow显示文摘我们为对摩擦医生的狂暴的贡献建议一个简单模型反对一围住墙狂暴怎么基于狂暴的爆炸事件的典型参数。它在水和流动在实验由粒子 imagevelocimetry 调查了的拖减少表面活化剂答案上被验证。对皮肤磨擦因素的狂暴的贡献与空间频率的产品线性地成正比,狂暴的爆炸的强度从墙发源,这被获得。 | 李凤臣 KAWAGUCHI Yasuo HISHIDA Koichi OSHIMA Marie | 2006 | Chinese Physics Letters2006，23，5： | 3 |
| 4 | Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions显示文摘Gastric cancer is the most common malignancy of the gastrointestinal tract in East Asian populations and the second most frequent cause of cancer-related mortality in the world. While previous studies have investigated the genetic factors involved in gastric carcinogenesis, there still exist relatively few studies that have investigated the genetic traits associated with the risk of gastric precancerous conditions. In this paper we will review the biology and genetic polymorphisms involved in the genesis of gastric precancerous conditions reported to date and discuss the future prospects of this field of study. The associations of gastric precancerous conditions with polymorphisms in the cytotoxin-associated gene A-related genes (e.g. PTPN11 G/A at intron 3, rs2301756), those in the genes involved in host immunity against Helico-bacter pylori (H. pylori) infection (e.g.TLR4 +3725G/C, rs11536889) or polymorphisms of the genes essential for the development/ differentiation of the gastric epithelial cells (e.g. RUNX3 T/A polymorphism at intron 3, rs760805) have been reported to date. Genetic epide-miological studies of the associations between H. pylori-induced gastric precancerous conditions and other gene polymorphisms in these pathways as well as polymor-phisms of the genes involved in other pathways like oxidative DNA damage repair pathways would provide useful evidence for the individualized prevention of these H. pylori-induced gastric precancerous conditions. | Asahi Hishida Keitaro Matsuo Yasuyuki Goto Nobuyuki Hamajima | 2010 | World Journal of Gastrointestinal Oncology2010，2，10： | 3 |
| 5 | Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis显示文摘 | Mitsuhiro Yokoyama Hideki Origasa Masunori Matsuzaki Yuji Matsuzawa Yasushi Saito Yuichi Ishikawa Shinichi Oikawa Jun Sasaki Hitoshi Hishida Hiroshige Itakura Toru Kita Akira Kitabatake Noriaki Nakaya Toshiie Sakata Kazuyuki Shimada Kunio Shirato | 2007 | The Lancet2007，，9567： | 2 |
| 6 | 多层螺旋CT计算心室容积的准确性及最佳层厚选择显示文摘目的(1)确定Simpson方法计算心室容积的最佳层厚;(2)评价多层螺旋CT计算心室容积的准确性。方法采用多层螺旋CT(东芝Aquilion)扫描系统对14个人的左室铸型和15个右室铸型进行扫描。分别以2.0、3.5、5.0、7.0及10.0mm层厚重建左、右心室短轴多平面重组(multiplanarreformattedimage,MPR)图像。采用标准Simpson法计算左、右心室铸型的容积。心室铸型的实际容积通过铸型排除水的容量来计算。结果各层厚计算的心室容积均高估相应心室的实际容积[左心室高估值介于(3.21±5.95)ml至(12.58±8.56)ml之间,右心室高估值介于(10.22±8.45)ml至(23.91±12.24)ml之间]。各层厚计算的心室容积均与相应的实际心室容积高度相关(左心室r值均>0.97,右心室r值均>0.95);心室容积的高估程度与选择的层厚呈显著正相关(左心室r=0.998,右心室r=0.996)。当层厚降至5mm时,计算的心室容积对实际容积的高估值与2mm层厚相比不再差异有统计学意义。结论采用多排Simpson法计算左、右心室容积时,5mm层厚是最有效率的层厚。MSCT可以准确计算左、右心室容积。 | 崔炜 Takeshi Kondo Hirofumi Anno 郭玉印 Takahisa Sato Masayoshi Sarai Hitoshi Shinozaki Satoshi Kakizawa Atsushi Sugiura Keita Oshima Kazuhiro Katada Hitoshi Hishida | 2005 | 中华放射学杂志2005，39，12： | 2 |
| 7 | Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction显示文摘In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases.However,it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state.Here,we describe a versatile in vivo gene knock-in methodology that enables the targeting of a broad range of mutations and cell types through the insertion of a minigene at an intron of the target gene locus using an intracellularly linearized single homology arm donor.As a proof-of-concept,we focused on a mouse model of prematureaging caused by a dominant point mutation,which is difficult to repair using existing in vivo genome-editing tools.Systemic treatment using our new method ameliorated aging-associated phenotypes and extended animal lifespan,thus highlighting the potential of this methodology for a broad range of in vivo genome-editing applications. | Keiichiro Suzuki Mako Yamamoto Reyna Hernandez-Benitez Zhe Li Christopher Wei Rupa Devi Soligalla Emi Aizawa Fumiyuki Hatanaka Masakazu Kurita Pradeep Reddy Alejandro Ocampo Tomoaki Hishida Masahiro Sakurai Amy NNemeth Estrella Nunez Delicado Josep MCampistol Pierre Magistretti Pedro Guillen Concepcion Rodriguez Esteban Jianhui Gong Yilin Yuan Ying Gu Guang-Hui Liu Carlos Lopez-Otin Jun Wu Kun Zhang Juan Carlos Izpisua Belmonte | 2019 | Cell Research2019，29，10： | 2 |
| 8 | αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model显示文摘Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular organisms.Their regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with age.During aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016). | Paloma Martinez-Redondo Isabel Guillen-Guillen Noah Davidsohn Chao Wang Javier Prieto Masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth Yuriko Hishida Concepcion Rodriguez Esteban Kensaku Shojima Ling Huang Maxim Shokhirev Estrella Nunez-Delicado Josep MCampistol Isabel Guillen-Vicente Elena Rodriguez-Inigo Juan Manuel Lopez-Alcorocho Marta Guillen-Vicente George Church Pradeep Reddy Pedro Guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua Belmonte | 2020 | Protein & Cell2020，11，3： | 2 |
| 9 | Flavonol eaffeoylglyco- sides as ct-glucosidase inhibitors from Spiraea cantoniensis flower显示文摘 | Yoshida K Hishida A lida O | 2008 | Agric Food Chem2008，56，12： | 1 |
| 10 | A randomized open-label comparative study of conventional therapy versus mizoribine on lay therapy in patients with steroid-resistant nephrotie syndrome (post marketing survey) 显示文摘 | Shibasaki T Koyama A Hishida A | 2004 | Clin Exp Nephrol2004，8，： | 1 |
| 11 | Determinants for the prognosis of acute renal disorders that developed during or after treatment with edaravone显示文摘 | Hishida A | 2009 | Clin Exp Nephrol2009，13，2： | 1 |
| 12 | Dynamin 3:a new candidate tumor suppressor gene in hepatocellular carcinoma detected by triple com-binationarray analysis显示文摘 | Inokawa Y Nomoto S Hishida M | 2013 | Onco Targets Ther2013，6，： | 1 |
| 13 | Problems in the current diagnostic standards of clinical N1 non-small cell lung cancer显示文摘 | v -- o - Hishida T Yoshida J Nishimura M | 2008 | Thorax2008，63，： | 1 |
| 14 | Regional lung perfu- sion and ventilation with radioisotopes in cervical cord-injured patients 显示文摘 | Hiraizumi Y Fujimaki E Hishida T | 1986 | Clin Nucl Med1986，11，5： | 1 |
| 15 | Antitumor activity exhibited by orally administered extract from fruit body of Grofola frondosa(maitake)显示文摘 | Hishida I Nanba H Kuroda H | 1987 | Chem Pharm Bull1987，36，： | 1 |
| 16 | Multiple sclerosing hemangio-mas with a 10 -year history 显示文摘 | Hishida T Yoshida J Nishimura M | 2005 | Jpn J Clin Oncol2005，35，1： | 1 |
| 17 | Fundamentals of rotating detonations显示文摘 | Hishida M Fujiwara T Wolanski P | 2009 | Shock Waves2009，19，1： | 1 |
| 18 | Constant strain rate testing of type 304 stainless steel in high temperature water-part Ⅱ:an investigation of the chloride effect on stress corrosion cracking显示文摘 | Hishida Mamoru Nakada Hiroshi | 1977 | Corrosion1977，33，11： | 1 |
| 19 | Smoking behavior and risk of Helicobacter pylori infection,gastric atrophy and gastric cancer in Japanese显示文摘 | Hishida A Matsuo K Goto Y | 2010 | Asian Pac J Cancer Prev2010，11，3： | 1 |
| 20 | Problems in the current diagn0stic standards of clinical N1 non-small cell lung cancer显示文摘 | Hishida T Yoshida J Nishimura M | 2008 | Thorax2008，63，6： | 1 |
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