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| 1 | 自发性脑出血治疗指南美国心脏协会/美国卒中协会对医疗卫生专业人员发布的指南显示文摘目的本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法通过Medline进行规范的文献检索,利用证据表合并资料。撰写委员会成员通过远程电信会议讨论根据资料得出的推荐意见。采用美国心脏协会卒中委员会的证据分级方案对推荐意见进行分级。由6位同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南的草案进行发表前审阅。预期本指南在3年内完全更新。结果本文为脑出血患者的医疗诊治提供了循证指南。重点包括诊断、止血、血压管理、院内管理和护理、预防内科合并症、外科治疗、转归预测、康复、预防复发以及将来需要考虑的问题。结论脑出血是一种严重的疾病,早期积极救治可影响其转归。本指南为脑出血患者的目标导向治疗提供了一个框架。 | Lewis B. Morgenstem J. Claude Hemphill Ⅲ Craig Anderson Kyra Becker Joseph P. Broderick E. Sander Connolly Jr Steven M. Greenberg James N. Huang R. Loch Macdonald Steven R. Messe Pamela H. Mitchell Magdy Selim Rafael J. Tamargo 王玉洁(译) 王健(译) 刘相玉(译) 谢丽丽(译) | 2010 | 国际脑血管病杂志2010，，8： | 259 |
| 2 | Spatial organization of bacterial flora in normal and inflamed intestine: A fluorescence in situ hybridization study in mice显示文摘AIM: To studythe role of intestinal flora in inflammatory bowel disease (IBD).METHODS: The spatial organization of intestinal flora was investigated in normal mice and in two models of murine colitis using fluorescence in situ hybridization.RESULTS: The murine small intestine was nearly bacteriafree. The normal colonic flora was organized in three distinct compartments (crypt, interlaced, and fecal), each with different bacterial compositions. Crypt bacteria were present in the cecum and proximal colon. The fecal compartment was composed of homogeneously mixed bacterial groups that directly contacted the colonic wall in the cecum but were separated from the proximal colonic wall by a dense interlaced layer. Beginning in the middle colon, a mucus gap of growing thickness physically separated all intestinal bacteria from contact with the epithelium. Colonic inflammation was accompanied with a depletion of bacteria within the fecal compartment, a reduced surface area in which feces had direct contact with the colonic wall, increased thickness and spread of the mucus gap, and massive increases of bacterial concentrations in the crypt and interlaced compartments. Adhesive and infiltrative bacteria were observed in inflamed colon only, with dominant Bacteroides species.CONCLUSION: The proximal and distal colons are functionally different organs with respect to the intestinal flora, representing a bioreactor and a Segregation device.The highly organized structure of the colonic flora, its specific arrangement in different colonic segments, and its specialized response to inflammatory stimuli indicate that the intestinal flora is an innate part of host immunity that is under complex control. | Alexander Swidsinski Vera Loening-Baucke Herbert Lochs Laura P.Hale | 2005 | World Journal of Gastroenterology2005，11，8： | 27 |
| 3 | Increased secretion of pro-inflammatory cytokines by circulating polymorphonuclear neutrophills and regulation by interleukin 10 during intestinal inflammation显示文摘Increasedsecretionofproinflammatorycytokinesbycirculatingpolymorphonuclearneutrophilsandregulationbyinterleukin10duringintes... | S Nikolaus 1, J Bauditz 1, P Gionchetti 2, C Witt 3, H Lochs 1 and S Schreiber 1 1Charité University Hospital, 4th Medical Department, Humboldt University, Berlin, Germany 2Clinica Media I, Policlinico S. Orsola, University of Bolog | 1998 | World Journal of Gastroenterology1998，4，3： | 17 |
| 4 | Malnutrition affects quality of life in gastroenterology patients显示文摘瞄准:与良性的胃肠的疾病调查在在病人的生命的营养不良和质量之间的协会。方法:200 个病人(养育的 104 井并且 96 营养不良) 根据主观全球评价,人体测量的大小和简历被估计电的阻抗分析。生命的质量与短形式的一般健康调查的验证医药结果学习 36 条款(SF 36 ) 被决定。肌肉功能手工被估计掌握力量和山峰流动。结果:身体集体索引,身体细胞群,手臂肌肉区域和手握力法力量在营养不良的病人是显著地更低的。当时,生命的质量通常更低与标准价值相比。七从生活规模的八质量(排除身体疼痛) 显著地在营养不良的病人被减少。把病人与肝肝硬化和煽动性的肠疾病(IBD ) 作比较,有经历的 IBD 的病人显著地在感觉降低价值身体疼痛,社会工作和心理健康。营养不良的肝 cirrhotics 在更多的规模承受了减小(六从八) 比营养不良的 IBD,病人们做了(四从八) 。结论:生命的质量在良性的胃肠的疾病通常是低的并且进一步在作为营养不良被分类的病人被减少。看来,肝肝硬化病人比 IBD 病人做经历生命的高质量,但是营养不良的影响似乎比在 IBD 在肝肝硬化更大。 | Kristina Norman Henriette Kirchner Herbert Lochs Matthias Pirlich | 2006 | World Journal of Gastroenterology2006，12，21： | 10 |
| 5 | Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | Lewis B. Morgenstern J. Claude Hemphill Craig Anderson Kyra Becker Joseph P. Broderick E. Sander Connolly Steven M. Greenberg James N. Huang R. Loch Macdonald Steven R. Messé Pamela H. Mitchell Magdy Selim Rafael J. Tamargo | 2010 | Stroke2010，，9： | 10 |
| 6 | Osteogenic potential of human periosteum-derived progenitor cells in PLGA scaffold using allogeneic serum显示文摘The use of periosteum-derived progenitor cells (PCs) combined with bioresorbable materials is an attractive approach for tissue engineering. The aim of this study was to characterize the osteogenic differentiation of PC in 3-dimensional (3D) poly-lactic-co-glycolic acid (PLGA) fleeces cultured in medium containing allogeneic human serum. PCs were isolated and expanded in monolayer culture. Expanded cells of passage 3 were seeded into PLGA constructs and cultured in osteogenic me- dium for a maximum period of 28 d. Morphological, histological and cell viability analyses of three-dimensionally cultured PCs were performed to elucidate osseous synthesis and deposition of a calcified matrix. Furthermore, the mRNA expression of type I collagen, osteocalcin and osteonectin was semi-quantitively evaluated by real-time reverse transcriptase-polymerase chain reac- tion (RT-PCR). The fibrin gel immobilization technique provided homogeneous PCs distribution in 3D PLGA constructs. Live-dead staining indicated a high viability rate of PCs inside the PLGA scaffolds. Secreted nodules of neo-bone tissue formation and the presence of matrix mineralization were confirmed by positive von Kossa staining. The osteogenic differentiation of PCs was further demonstrated by the detection of type I collagen, osteocalcin and osteonectin gene expression. The results of this study support the concept that this tissue engineering method presents a promising method for creation of new bone in vivo. | ZHENG Yi-xiong RINGE Jochen LIANG Zhong LOCH Alexander CHEN Li SITTINGER Michael | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，10： | 8 |
| 7 | Angiogenesis and vascular malformations:Antiangiogenic drugs for treatment of gastrointestinal bleeding显示文摘Treatment of gastrointestinal bleeding in patients with angiodysplasias and Osler’s disease (hereditary hemorrhagic teleangiectasia) is clinically challenging. Frequently, vascular malformations occur as multiple disseminated lesions, making local treatment an unfavorable choice or impossible. After local therapy, lesions often recur at other sites of the intestine. However, as there are few therapeutic alternatives, repeated endoscopic coagulations or surgical resections are still performed to prevent recurrent bleeding. Hormonal therapy has been employed for more than 50 years but has recently been shown to be ineffective. Therefore, new therapeutic strategies are required. Understanding of the pathophysiology of angiogenesis and vascular malformations has recently substantially increased. Currently, multiple inhibitors of angiogenesis are under development for treatment of malignant diseases. Experimental and clinical data suggest that antiangiogenic substances, which were originally developed for treatment of malignant diseases, may also represent long-awaited specif ic drugs for the treatment of vascular malformations. However, antiangiogenics display significantly different actions and side-effects. Although antiangiogenics like thalidomide seem to inhibit gastrointestinal bleeding, other substances like bevacizumab can cause mucosal bleeding. Therefore differential and cautious evaluation of this therapeutic strategy is necessary. | Juergen Bauditz Herbert Lochs | 2007 | World Journal of Gastroenterology2007，13，45： | 6 |
| 8 | Innovative endoscopic enucleations of the prostate--Xie’s Prostate Enucleations显示文摘In the past 2 decades,endoscopic enucleation of the prostate has become a safe and effective surgical treatment for benign prostatic hyperplasia(BPH),with comparable outcomes to traditional surgeries.Transurethral vapor enucleation and resection of the prostate(TVERP),transurethral vapor enucleation of the prostate(TVEP),and ultrasound-navigated TVEP(US-TVEP)are new,innovative endoscopic enucleation procedures.These procedures are named Xie’s Prostate Enucleations(Xie’s Procedures for short).Current clinical data indicate that Xie’s Procedures are safe and effective treatment options for patients with BPH,especially for patients with larger prostates.Further prospective,randomized clinical trials compared with traditional transurethral resection of prostate(TURP)are still needed. | Liping Xie Xiao Wang Hong Chen Xiangyi Zheng Ben Liu Shiqi Li Yeqing Mao Qiqi Mao Song Wang Jiangfeng Li Tillmann Loch | 2018 | Asian Journal of Urology2018，5，1： | 6 |
| 9 | Introductory to the ESPEN Guidelines on Enteral Nutrition: Terminology, Definitions and General Topics显示文摘 | H. Lochs S.P. Allison R. Meier M. Pirlich J. Kondrup St. Schneider G. van den Berghe C. Pichard | 2006 | Clinical Nutrition2006，，2： | 3 |
| 10 | Comparison of machine learning models for gully erosion susceptibility mapping显示文摘Gully erosion is a disruptive phenomenon which extensively affects the Iranian territory,especially in the Northern provinces.A number of studies have been recently undertaken to study this process and to predict it over space and ultimately,in a broader national effort,to limit its negative effects on local communities.We focused on the Bastam watershed where 9.3%of its surface is currently affected by gullying.Machine learning algorithms are currently under the magnifying glass across the geomorphological community for their high predictive ability.However,unlike the bivariate statistical models,their structure does not provide intuitive and quantifiable measures of environmental preconditioning factors.To cope with such weakness,we interpret preconditioning causes on the basis of a bivariate approach namely,Index of Entropy.And,we performed the susceptibility mapping procedure by testing three extensions of a decision tree model namely,Alternating Decision Tree(ADTree),Naive-Bayes tree(NBTree),and Logistic Model Tree(LMT).We dichotomized the gully information over space into gully presence/absence conditions,which we further explored in their calibration and validation stages.Being the presence/absence information and associated factors identical,the resulting differences are only due to the algorithmic structures of the three models we chose.Such differences are not significant in terms of performances;in fact,the three models produce outstanding predictive AUC measures(ADTree=0.922;NBTree=0.939;LMT=0.944).However,the associated mapping results depict very different patterns where only the LMT is associated with reasonable susceptibility patterns.This is a strong indication of what model combines best performance and mapping for any natural hazard-oriented application. | Alireza Arabameri Wei Chen Marco Loche Xia Zhao Yang Li Luigi Lombardo Artemi Cerda Biswajeet Pradhan Dieu Tien Bui | 2020 | Geoscience Frontiers2020，11，5： | 3 |
| 11 | The Latent Structure of Medically Unexplained Symptoms and Its Relation to Functional Somatic Syndromes显示文摘 | Michael Witth?ft Wolfgang Hiller Noelle Loch Fabian Jasper | 2013 | International Journal of Behavioral Medicine2013，，2： | 2 |
| 12 | Mucosal flora in inflammatory bowel disease显示文摘 | Alexander Swidsinski Axel Ladhoff Annelie Pernthaler Sonja Swidsinski Vera Loening-Baucke Marianne Ortner Jutta Weber Uwe Hoffmann Stefan Schreiber Manfred Dietel Herbert Lochs | 2002 | Gastroenterology2002，，1： | 2 |
| 13 | Weight gain in long-term survivors of kidney or liver transplantation—Another paradigm of sarcopenic obesity?显示文摘 | Tatjana Schütz Heike Hudjetz Anne-Eve Roske Cornelia Katzorke Georg Kreymann Klemens Budde Lutz Fritsche Hans-Hellmut Neumayer Herbert Lochs Mathias Plauth | 2012 | Nutrition2012，，4： | 2 |
| 14 | Prognostic impact of disease-related malnutrition显示文摘 | Kristina Norman Claude Pichard Herbert Lochs Matthias Pirlich | 2007 | Clinical Nutrition2007，，1： | 2 |
| 15 | Adoption of HPAI biosecurity measures: The Chinese broiler industry显示文摘Highly pathogenic avian influenza(HPAI) contamination via wild birds and rodents poses a threat to food security and safety.As chicken meat comprises an increasing proportion of diet in China,it is useful to determine whether broiler farmers are adopting wild bird and rodent controls to minimize the risk of HPAI impacts on food supply.Our study surveyed a cross sectional sample of 331 Chinese broiler farmers in six provinces.We find that only 47% of farmers(mainly farmers with large herds) adopted control measures against wild birds and rodents,while 14% adopted no measures.Farm size was the biggest driver of adoption followed by proportion of farm revenue derived from broiler production.However,southern farmers were at a far greater probability of non-adoption.We suggest that assistance in the form of education/training programs and subsidized traps or baiting controls across smaller producers could help raise of the adoption level toward more effective HPAI control. | HUANG Ze-ying Adam Loch Christopher Findlay WANG Ji-min | 2017 | Journal of Integrative Agriculture2017，16，1： | 2 |
| 16 | ESPEN Guidelines on Enteral Nutrition: Gastroenterology显示文摘 | H. Lochs C. Dejong F. Hammarqvist X. Hebuterne M. Leon-Sanz T. Schütz W. van Gemert A. van Gossum L. Valentini H. Lübke S. Bischoff N. Engelmann P. Thul | 2006 | Clinical Nutrition2006，，2： | 2 |
| 17 | Conventional therapy for Crohn's disease显示文摘Crohn 的疾病(CD ) 是未知原因的多因素的混乱。关于 CD 的病理生理学的突出的进步导致了创新治疗学的概念的开发。众多的控制试用在最后年在 CD 被执行了。然而,许多药没被规章的当局由于功效或严重副作用的缺乏同意了。因此,包括象 azathioprine 那样的 5-ASA,全身或热门的 corticosteroids,和抑制免疫力的药,著名的药仍然是 CD 治疗的支柱。重要地,象 infliximab 那样的生物制品出现了在象 fistulizing 或类固醇依赖者 CD 那样的有问题的背景有效。这评论被打算为 CD 的常规处理把实际指南给临床医生。当可得到时,我们专注于使随机化的、控制安慰剂的审判和元分析的结果,提供证据的最高的度。我们提供基于证据的处理算法每当时可能。然而,许多临床的状况没被控制临床的审判回答了,通过专家意见充满这些差距是重要的。我们希望这评论在 CD 的挑战性的处理为临床医生提供一个有用工具。 | Carsten Büning Herbert Lochs | 2006 | World Journal of Gastroenterology2006，12，30： | 2 |
| 18 | Reoperation and ercurrence of plemorphic adenoma of the parotid显示文摘 | Chevolier D Loche V Darras JA | 1996 | Ann Otolaryngol Chir Cervicofac1996，113，2： | 1 |
| 19 | The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life显示文摘 | Stefano Romeo Federica Sentinelli Valentina M Cambuli Michela Incani Tiziana Congiu Vanessa Matta Sabrina Pilia Isabel Huang-Doran Efisio Cossu Sandro Loche Marco G Baroni | 2010 | Journal of Hepatology2010，，2： | 1 |
| 20 | Problem-Solving Oscillations in Complex Engineering Projects显示文摘 | Mihm J Loch C Huchzermeier A | 2003 | Management Science2003，49，6： | 1 |
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