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| 1 | 小乳腺癌:应用冷头射频专用系统对活体行经皮超声引导下射频消融治疗显示文摘目的评估新研制的人体乳腺癌射频(RF)消融系统在活体内对人小乳腺癌的治疗效果,包括诱导完全坏死、重复性消融病灶大小和形状及美容效果。方法该研究获得机构伦理委员会批准,病人签署知情同意书。34例经活检证实为侵袭性小导管癌(≤2cm)的绝经后女性[平均年龄(53+5)岁,范同:49-62岁]为研究对象。RF能量通过一个25mm可调温的15G单极冷针电极传输。根据乳腺摄影确定的乳腺类型将病例分为3组.明确凝固区的体积和形状以及消融时间。将组织病理学表现与术后3.0T对比增强MR检查结果进行比较, | G. Manenti F. Bolacchi T. Perretta E. Cossu C.A. Pistolese O.C.Buonomo 郑梅竹(译) 葛夕洪(校) | 2009 | 国际医学放射学杂志2009，32，4： | 10 |
| 2 | Recent achievements on underwater optical wireless communication [Invited]显示文摘The growing number of underwater activities is giving momentum to the development of new technologies, such as buoys, remotely operated vehicles, and autonomous underwater vehicles. The data collected by these vehicles need to be transmitted to a high-speed central unit. Clearly, wired solutions are not suitable, since they strongly impact the mobility. In this scenario, a promising solution is offered by underwater optical wireless communication(UOWC) technology, which can achieve both high-speed and wireless operation. Here, we provide a comprehensive survey on the challenges, the experimental realizations, and the state of the art in UOWC researches. | Giulio Cossu | 2019 | Chinese Optics Letters2019，17，10： | 4 |
| 3 | Successful outcome after combined chemotherapeutic and surgical management in a case of esophageal cancer with breast and brain relapse显示文摘Esophageal cancer (EC) is a highly lethal disease. Approximately 50% of patients present with metastatic EC and most patients with localized EC will have local recurrence or develop metastases, despite potentially curative local therapy. The most common sites of distant recurrence are represented by lung, liver and bone while brain and breast metastases are rare. Usually patients with advanced disease are not treated aggressively and their median survival is six months. We report a woman patient who developed breast and brain metastases after curative surgery. We treated her with a highly aggressive chemotherapeutic and surgical combination resulting in a complete remission of the disease even after 11-year follow-up. We think that in super selected patients with more than one metastasis, when functional status is good and metastases are technically resectable, a surgical excision may be considered as a salvage option and chemotherapy should be delivered to allow a systemic control. | Davide Adriano Santeufemia Gianfranca Piredda Giovanni Maria Fadda Paolo Cossu Rocca Salvatore Costantino Giovanni Sanna Maria Giuseppa Sarobba Maria Antonietta Pinna Carlo Putzu Antonio Farris | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 4 | Dealing with robot-assisted surgery for rectal cancer:current status and perspectives显示文摘The laparoscopic approach for treatment of rectal cancer has been proven feasible and oncologically safe, and is able to offer better short-term outcomes than traditional open procedures, mainly in terms of reduced length of hospital stay and time to return to working activity. In spite of this, the laparoscopic technique is usually practised only in high-volume experienced centres, mainly because it requires a prolonged and demanding learning curve. It has been estimated that over 50 operations are required for an experienced colorectal surgeon to achieve proficiency with this technique. Robotic surgery enables the surgeon to perform minimally invasive operations with better vision and more intuitive and precise control of the operating instruments, thus promising to overcome some of the technical difficulties associated with standard laparoscopy. It has high-definition threedimensional vision, it translates the surgeon's hand movements into precise movements of the instruments inside the patient, the camera is held and moved by the first surgeon, and a fourth robotic arm is available as a fixed retractor. The aim of this review is to summarise the current data on clinical and oncologic outcomes of robot-assisted surgery in rectal cancer, focusing on short- and long-term results, and providing original data from the authors' centre. | Roberto Biffi Fabrizio Luca Paolo Pietro Bianchi Sabina Cenciarelli Wanda Petz Igor Monsellato Manuela Valvo Maria Laura Cossu Tiago Leal Ghezzi Kassem Shmaissany | 2016 | World Journal of Gastroenterology2016，22，2： | 3 |
| 5 | Incidence and treatment of mediastinal leakage after esophagectomy:Insights from the multicenter study on mediastinal leaks显示文摘BACKGROUND Mediastinal leakage(ML) is one of the most feared complications of esophagectomy. A standard strategy for its diagnosis and treatment has beendifficult to establish because of the great variability in their incidence and mortality rates reported in the existing series.AIM To assess the incidence, predictive factors, treatment, and associated mortality rate of mediastinal leakage using the standardized definition of mediastinal leaks recently proposed by the Esophagectomy Complications Consensus Group(ECCG).METHODS Seven Italian surgical centers(five high-volume, two low-volume) affiliated with the Italian Society for the Study of Esophageal Diseases designed and implemented a retrospective study including all esophagectomies(n = 501) with intrathoracic esophagogastric anastomosis performed from 2014 to 2017.Anastomotic MLs were defined according to the classification recently proposed by the ECCG.RESULTS Fifty-nine cases of ML were recorded, yielding an overall incidence of 11.8%(95%CI: 9.1%-14.9%). The surgical approach significantly influenced the occurrence of ML: the proportion of leakage was 10.5% and 9% after open and hybrid esophagectomy(HE), respectively, and doubled(20%) after totally minimally invasive esophagectomy(TMIE)(P = 0.016). No other predictive factors were found. The 30-and 90-d overall mortality rates were 1.4% and 3.2%,respectively; the 30-and 90-d leak-related mortality rates were 5.1% and 10.2%,respectively; the 90-d mortality rates for TMIE and HE were 5.9% and 1.8%,respectively. Endoscopy was the first-line treatment in 49% of ML cases, with the need for retreatment in 17.2% of cases. Surgery was needed in 44.1% of ML cases.Endoscopic treatment had the lowest mortality rate(6.9%). Removal of the gastric tube with stoma formation was necessary in 8(13.6%) cases.CONCLUSION The incidence of ML after esophagectomy was high mainly in the TMIE group.However, the general and specific(leak-related) mortality rates were low. Early treatment(surgical or endoscopic) of severe leaks is mandatory to limit related mortality. | Uberto Fumagalli Gian Luca Baiocchi ANDrea Celotti Paolo Parise ANDrea Cossu Luigi Bonavina Daniele Bernardi Giovanni de Manzoni Jacopo Weindelmayer Giuseppe Verlato Stefano Santi Giovanni Pallabazzer Nazario Portolani Maurizio Degiuli Rossella Reddavid Stefano de Pascale | 2019 | World Journal of Gastroenterology2019，25，3： | 3 |
| 6 | Contrast-enhanced ultrasound Liver Imaging Reporting and Data System:Lights and shadows in hepatocellular carcinoma and cholangiocellular carcinoma diagnosis显示文摘BACKGROUND Contrast-enhanced ultrasound(CEUS)is considered a secondary examination compared to computed tomography(CT)and magnetic resonance imaging(MRI)in the diagnosis of hepatocellular carcinoma(HCC),due to the risk of misdiagnosing intrahepatic cholangiocarcinoma(ICC).The introduction of CEUS Liver Imaging Reporting and Data System(CEUS LI-RADS)might overcome this limitation.Even though data from the literature seems promising,its reliability in real-life context has not been well-established yet.AIM To test the accuracy of CEUS LI-RADS for correctly diagnosing HCC and ICC in cirrhosis.METHODS CEUS LI-RADS class was retrospectively assigned to 511 nodules identified in 269 patients suffering from liver cirrhosis.The diagnostic standard for all nodules was either biopsy(102 nodules)or CT/MRI(409 nodules).Common diagnostic accuracy indexes such as sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)were assessed for the following associations:CEUS LR-5 and HCC;CEUS LR-4 and 5 merged class and HCC;CEUS LR-M and ICC;and CEUS LR-3 and malignancy.The frequency of malignant lesions in CEUS LR-3 subgroups with different CEUS patterns was also determined.Inter-rater agreement for CEUS LI-RADS class assignment and for major CEUS pattern identification was evaluated.RESULTS CEUS LR-5 predicted HCC with a 67.6%sensitivity,97.7%specificity,and 99.3%PPV(P<0.001).The merging of LR-4 and 5 offered an improved 93.9%sensitivity in HCC diagnosis with a 94.3%specificity and 98.8%PPV(P<0.001).CEUS LR-M predicted ICC with a 91.3%sensitivity,96.7%specificity,and 99.6%NPV(P<0.001).CEUS LR-3 predominantly included benign lesions(only 28.8%of malignancies).In this class,the hypo-hypo pattern showed a much higher rate of malignant lesions(73.3%)than the iso-iso pattern(2.6%).Inter-rater agreement between internal raters for CEUS-LR class assignment was almost perfect(n=511,k=0.94,P<0.001),while the agreement among raters from separate centres was substantial(n=50,k=0.67,P<0.001).Agreement was stronger for arterial phase hyperenhancement(internal k=0.86,P<2.7×10-214;external k=0.8,P<0.001)than washout(internal k=0.79,P<1.6×10-202;external k=0.71,P<0.001).CONCLUSION CEUS LI-RADS is effective but can be improved by merging LR-4 and 5 to diagnose HCC and by splitting LR-3 into two subgroups to differentiate iso-iso nodules from other patterns. | Gianpaolo Vidili Marco Arru Giuliana Solinas Diego Francesco Calvisi Pierluigi Meloni Assunta Sauchella Davide Turilli Claudio Fabio Antonio Cossu Giordano Madeddu Sergio Babudieri Maria Assunta Zocco Giovanni Iannetti Enza Di Lembo Alessandro Palmerio Delitala Roberto Manetti | 2022 | World Journal of Gastroenterology2022，28，27： | 3 |
| 7 | 立体定向融合影像技术在治疗脑动静脉畸形引发癫痫的定位作用显示文摘目的探讨立体定向结合脑血管造影与MRI影像融合在治疗脑动静脉畸形引发癫痫时对脑功能区、脑内病变和致痫灶空间范围的定位作用。方法对17例患者采用Talairach立体定向系统,绘制脑皮质表面血管图,并与三维MRI成像进行融合,标注脑功能区并设计术前深部电极放置部位和手术方案。结果17例患者获得了清晰的立体脑血管造影与MRI图像,涉及手术部位包括额叶8例、顶叶6例、颞叶2例和枕叶1例。手术完整切除动静脉畸形。术后随访1年,8例未见癫痫发作。结论该技术可以保证术前准确定位病灶,有利于术中判断脑沟回和功能区,避免损伤皮质功能区和血管。 | 赵国光 F Cardinale M Cossu G Lo Russo | 2005 | 中国脑血管病杂志2005，2，7： | 3 |
| 8 | Predicting scour beneath subsea pipelines from existing small free span depths under steady currents显示文摘An equation was developed to predict current-induced scour beneath subsea pipelines in areas with small span depths,S.Current equations for scour prediction are only applicable to partially buried pipelines.The existence of small span depths(i.e.S/D<0.3)are of concern because the capacity for scour is higher at smaller span depths.Furthermore,it is impractical to perform rectification works,such as installing grout bags,under a pipeline with a small S/D.Full-scale two-dimensional computational fluid dynamics(CFD)simulations were performed using the Reynolds-averaged Navier-Stokes approach and the Shear stress transport k-ωturbulence model.To predict the occurrence of scour,the computed maximum bed shear stress beneath the pipe was converted to the dimensionless Shields parameter,and compared with the critical Shields parameter based on the mean sediment grain size.The numerical setup was verified,and a good agreement was found between model-scale CFD data and experimental data.Field data were obtained to determine the mean grain size,far field current velocity and to measure the span depths along the surveyed pipe length.A trend line equation was fitted to the full-scale CFD data,whereby the maximum Shields parameter beneath the pipe can be calculated based on the undisturbed Shields parameter and S/D. | Jun Y.Lee Jasmin McInerney Remo Cossu Zhi Q.Leong Alexander L.Forrest | 2017 | Journal of Ocean Engineering and Science2017，2，2： | 2 |
| 9 | Electroclinical, MRI and neuropathological study of 10 patients with nodular heterotopia, with surgical outcomes 显示文摘 | Tassi L Colombo N Cossu M | 2005 | Brain2005，128，2： | 1 |
| 10 | The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life显示文摘 | Stefano Romeo Federica Sentinelli Valentina M Cambuli Michela Incani Tiziana Congiu Vanessa Matta Sabrina Pilia Isabel Huang-Doran Efisio Cossu Sandro Loche Marco G Baroni | 2010 | Journal of Hepatology2010，，2： | 1 |
| 11 | Antioxidant en- zymes, glutathione and lipid peroxidation as relevant bio- markers of experimental or field exposure in the gills and the digestive gland of the eshwater bivalve Unio tu- midus 显示文摘 | Doyotte A Cossu C Jacquin M C | 1997 | Aquatic Toxicology1997，39，2： | 1 |
| 12 | Electrochemical treatment of landfill leachate: Oxidation at Ti/PbO2 and Ti/SnO2 anodes 显示文摘 | COSSU R | 1998 | Environ Sci and Technol1998，32，11： | 1 |
| 13 | Non-recurrent inferior laryngeal nerve : anatomy, frequency and surgical considerations 显示文摘 | Sparta C Cossu ML Fais E | 2004 | Minerva Chit2004，59，6： | 1 |
| 14 | Overexpression of h-prune in breast cancer is correlated with advanced disease status显示文摘 | Zollo M Andre A Cossu A | 2005 | Clin Cancer Res2005，11，1： | 1 |
| 15 | Endoscopic combined intrarenal surgery in Galdakao-modified supine Valdivia position : a new standard for percutaneous nephrolithotomy? 显示文摘 | Scoffone CM Cracco CM Cossu M | 2008 | Eur Urol2008，54，6： | 1 |
| 16 | Rectal endometrial stromal sarcoma arising in endometriosis显示文摘 | Luisanna Bosincu Giovannino Massarelli Paolo Cossu Rocca María A. Isaac Francisco F. Nogales | 2001 | Diseases of the Colon & Rectum2001，，： | 1 |
| 17 | Duodenal switch without gastric reseetiort: results and observations after 6 years显示文摘 | Cossu ML Noya G Tonolo GC | 2004 | Obes Surg2004，14，10： | 1 |
| 18 | Removal of tumours of the orbital apex via a postero-lateral orbitotomy显示文摘 | Carta F Siccardi D Cossu M | 1998 | J Neurosurg Sci1998，42，4： | 1 |
| 19 | Classic follicular dendritic reticulum cells tumor of the lymph node developing in a patient with a previous inflammatory pseudotumor-like proliferation显示文摘 | Cossu A Lissia A Dedola MF | 2005 | Hum Pathol2005，36，2： | 1 |
| 20 | A comparative study of K - nearest neighbour, support vector machine and multi - layer perceptron for thalassemia screening显示文摘 | Amendolia SR Cossu G Ganadu ML | 2003 | Chemometrics and Intelli- gent Laboratory Systems2003，69，12： | 1 |
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