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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 3 | Cell:癌基因“遗传平衡”或会影响患者对癌症疗法的反应显示文摘进行癌症疗法的选择越来越需要确定肿瘤细胞中是否含有一些特殊突变的癌基因会驱动癌细胞异常生长。并且确定是否癌细胞会对特殊药物耐受或敏感.近日来自加州大学旧金山分校的研究人员就通过研究发现。以常见的癌基因KRAs突变为例。患者对疗法的反应往往会随着肿瘤的不断进化而发生改变。相关研究刊登于国际杂志Cell上。 | Michael R. Burgess Eugene Hwang Rana Mroue Craig M. Bielski Anica M. Wandler Benjamin J. Huang Ari J. Firestone Amy Young Jennifer A. Lacap Lisa Crocker Saurabh Asthana Elizabeth M. Davis Jin Xu Keiko Akagi Michelle M. Le Beau Qing Li Benjamin Haley David Stokoe Deepak Sampath Barry S. Taylor Marie Evangelista Kevin Shannon | 2017 | 现代生物医学进展2017，17，18： | 2 |
| 4 | Boceprevir for Chronic HCV Genotype 1 Infection in Patients with Prior Treatment Failure to Peginterferon/Ribavirin, including Prior Null Response显示文摘 | John M. Vierling Mitchell Davis Steven Flamm Stuart C. Gordon Eric Lawitz Eric M. Yoshida Joseph Galati Velimir Luketic Jonathan McCone Ira Jacobson Patrick Marcellin Andrew J. Muir Fred Poordad Lisa D. Pedicone Janice Albrecht Clifford Brass Anita Y.M. H | 2013 | Journal of Hepatology2013，，： | 2 |
| 5 | A critical review of ohmic and rectifying contacts for silicon carbide 显示文摘 | Porter Lisa M Davis Robert F | 1995 | Materials Science and Engineering B1995，34，23： | 1 |
| 6 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 1 |
| 7 | Efficacy of a meal replacement diet plan compared to a food-based diet plan after a period of weight loss and weight maintenance:a randomized controlled trial显示文摘 | Lisa M Davis Chirstoper Coman Jessica Kiel | 2010 | Nutrition Journal2010，9，3： | 1 |
| 8 | PICC, the Music and Travel to the Port of Relaxation: The Effects of Music on Perceived Pain and Anxiety in Patients Receiving PICCs and Port-A-Caths显示文摘 | Caroline McDaniel A. Meaghan Burkett Michelle Cormier Julie Duvall Susan Davis Lisa Gabriel Ginger Elmore Nancy Mahaffey Marty Moran Annette Z. Silver Suzanne Burns Mark Conaway | 2009 | Journal of Radiology Nursing2009，，1： | 1 |
| 9 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 1 |
| 10 | Pathogenesis of Ebola Hemorrhagic Fever in Primate Models显示文摘 | Thomas W. Geisbert Howard A. Young Peter B. Jahrling Kelly J. Davis Tom Larsen Elliott Kagan Lisa E. Hensley | 2003 | The American Journal of Pathology2003，，6： | 1 |
| 11 | Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials显示文摘 | Jonathan Emberson Kennedy R Lees Patrick Lyden Lisa Blackwell Gregory Albers Erich Bluhmki Thomas Brott Geoff Cohen Stephen Davis Geoffrey Donnan James Grotta George Howard Markku Kaste Masatoshi Koga Ruediger von Kummer Maarten Lansberg Richard I Lindley | 2014 | The Lancet . 2014 (9958)2014，，： | 1 |
| 12 | Peanuts, peanut oil, and fat free peanut flour reduced cardiovascular disease risk factors and the development of atherosclerosis in syrian golden hamsters 显示文摘 | Amanda M Stephens Lisa L Dean Jack P Davis Jason A Osborne Timothy H Sanders | 2010 | Journal of Food Science2010，75，4： | 1 |
| 13 | Safety and Efficacy of the Use of Intravesical and Oral Pentosan Polysulfate Sodium for Interstitial Cystitis: A Randomized Double-Blind Clinical Trial显示文摘 | Edward L. Davis Samar R. El Khoudary Evelyn O. Talbott Josephine Davis Lisa J. Regan | 2008 | The Journal of Urology2008，，1： | 1 |
| 14 | Alterations in the functional capacity of albumin in patients with decompensated cirrhosis is associated with increased mortality显示文摘 | Rajiv Jalan Kerstin Schnurr Rajeshwar P. Mookerjee Sambit Sen Lisa Cheshire Stephen Hodges Vladimir Muravsky Roger Williams Gert Matthes Nathan A. Davies | 2009 | Hepatology2009，，2： | 1 |
| 15 | Arterial Stiffness in Chronic Inflammatory Diseases显示文摘 | Mary J. Roman Richard B. Devereux Joseph E. Schwartz Michael D. Lockshin Stephen A. Paget Adrienne Davis Mary K. Crow Lisa Sammaritano Daniel M. Levine Beth-Ann Shankar Elfi Moeller Jane E. Salmon | 2005 | Hypertension2005，，1： | 1 |
| 16 | An Ecologic Analysis of County-Level PM^sub 2.5^ Concentrations and Lung Cancer Incidence and Mortality显示文摘 | Vinikoor-Imler Lisa C Davis J Allen Luben Thomas J | 2011 | International Journal of Environmental Research and Public Health2011，，6： | 1 |
| 17 | Adolescent sexuality: Disentangling the effects of family structure and family context显示文摘 | Erin Calhoun Davis Lisa V Friel | 2001 | Journal of Marriage and Family Aug 2001 632001，3，： | 1 |
| 18 | A Critical Review of Ohmic and Rectifying Contacts for Silicon Carbide显示文摘 | Lisa M Porter Robert F Davis | 1995 | Materials Science and Engineering1995，，34： | 1 |
| 19 | Predictors of acute stroke mimics in 8,187 patients referred to a stroke service显示文摘 | José G. Merino Marie Luby Richard Benson Lisa A. Davis Amie W. Hsia Lawrence L. Latour John K. Lynch Steven Warach | 2013 | Journal of Stroke and Cerebrovascular Diseases2013，，： | 1 |
| 20 | Efficacy of a meal replacement diet plan compared to a food - based diet plan after a period of weight loss and weight maintenance : a randomized controlled trial 显示文摘 | Lisa M Davis Chirstoper Coman Jessica Kiel | 2010 | Nutrition Joumal2010，9，3： | 1 |
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