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| 1 | Role of ion channels in gastrointestinal cancer显示文摘In their seminal papers Hanahan and Weinberg described oncogenic processes a normal cell undergoes to be transformed into a cancer cell.The functions of ion channels in the gastrointestinal(GI)tract influence a variety of cellular processes,many of which overlap with these hallmarks of cancer.In this review we focus on the roles of the calcium(Ca^2+),sodium(Na^+),potassium(K^+),chloride(Cl^-)and zinc(Zn^2+)transporters in GI cancer,with a special emphasis on the roles of the KCNQ1 K+channel and CFTR Cl-channel in colorectal cancer(CRC).Ca^2+is a ubiquitous second messenger,serving as a signaling molecule for a variety of cellular processes such as control of the cell cycle,apoptosis,and migration.Various members of the TRP superfamily,including TRPM8,TRPM7,TRPM6 and TRPM2,have been implicated in GI cancers,especially through overexpression in pancreatic adenocarcinomas and down-regulation in colon cancer.Voltage-gated sodium channels(VGSCs)are classically associated with the initiation and conduction of action potentials in electrically excitable cells such as neurons and muscle cells.The VGSC NaV1.5 is abundantly expressed in human colorectal CRC cell lines as well as being highly expressed in primary CRC samples.Studies have demonstrated that conductance through NaV1.5 contributes significantly to CRC cell invasiveness and cancer progression.Zn2+transporters of the ZIP/SLC39A and ZnT/SLC30A families are dysregulated in all major GI organ cancers,in particular,ZIP4 up-regulation in pancreatic cancer(PC).More than 70 K+channel genes,clustered in four families,are found expressed in the GI tract,where they regulate a range of cellular processes,including gastrin secretion in the stomach and anion secretion and fluid balance in the intestinal tract.Several distinct types of K+channels are found dysregulated in the GI tract.Notable are hERG1 upregulation in PC,gastric cancer(GC)and CRC,leading to enhanced cancer angiogenesis and invasion,and KCNQ1 down-regulation in CRC,where KCNQ1 expression is associated with enhanced disease-free survival in stage II,III,and IV disease.Cl-channels are critical for a range of cellular and tissue processes in the GI tract,especially fluid balance in the colon.Most notable is CFTR,whose deficiency leads to mucus blockage,microbial dysbiosis and inflammation in the intestinal tract.CFTR is a tumor suppressor in several GI cancers.Cystic fibrosis patients are at a significant risk for CRC and low levels of CFTR expression are associated with poor overall disease-free survival in sporadic CRC.Two other classes of chloride channels that are dysregulated in GI cancers are the chloride intracellular channels(CLIC1,3&4)and the chloride channel accessory proteins(CLCA1,2,4).CLIC1&4 are upregulated in PC,GC,gallbladder cancer,and CRC,while the CLCA proteins have been reported to be down-regulated in CRC.In summary,it is clear,from the diverse influences of ion channels,that their aberrant expression and/or activity can contribute to malignant transformation and tumor progression.Further,because ion channels are often localized to the plasma membrane and subject to multiple layers of regulation,they represent promising clinical targets for therapeutic intervention including the repurposing of current drugs. | Kyle J Anderson Robert T Cormier Patricia M Scott | 2019 | World Journal of Gastroenterology2019，25，38： | 19 |
| 2 | Airborne fine particulate matter induced pulmonary inflammation as well as oxidative stress in neonate rats显示文摘背景在空中的好微粒物质(下午) 能导致可以不利地影响人的健康的肺的发炎,但是关于它出生不满一月的婴儿老鼠上的效果的很少的报告是可得到的。这研究试图在出生不满一月的婴儿 rats.Methods 在航线上观察好下午的潜在的影响和毒性象氧化剂产品一样的肺的发炎, cytotoxicity,组织病理学说,和抗氧化剂被估计在 intratracheal 灌输以后的 24 个小时连续地罚款首相 3 天。好下午的 Cytotoxicity 在与发达重要肺的发炎由 neutrophiland 巨噬细胞渗入描绘了的高剂量罚款下午一起对待的 Hep-2 cells.Results 老鼠被测量。煽动性的过程在肺与 TNF- 和 prooxidant/antioxidant 不平衡的提高的水平有关。在人的上皮的房间执行的 Cytotoxicity 研究显示那位高剂量罚款首相显著地减少了学习表明了的房间 viability.Conclusion 罚款首相的尖锐暴露导致了航线发炎以及在航线上皮房间上除了它的直接有毒的效果增加了氧化应力。 | DING Li-ren WANG Kai Baher Fahmy SHEN Hua-hao Cormier Stephania | 2010 | Chinese Medical Journal2010，，20： | 4 |
| 3 | Environmental reporting management: a continental European perspective显示文摘 | Denis Cormier Michel Magnan | 2003 | Journal of Accounting and Public Policy2003，，1： | 3 |
| 4 | Thermal cycling creep properties of a directionally solidified superalloy DZ125显示文摘Aero-engine turbine blades may suffer overheating during service,which can result in severe microstructural and mechanical degradation within tens of seconds.In this study,the thermal cycling creep under(950℃/15 min+1100℃/1 min)-100 MPa was performed on a directionally solidified superalloy,DZ125.The effects of overheating and thermal cycling on the creep properties were evaluated in terms of creep behavior and microstructural evolution against isothermally crept specimens under 950℃/100 MPa,950℃/270 MPa,and 1100℃/100 MPa.The results indicated that the thermal cycling creep life was reduced dramatically compared to the isothermal creep under 950℃/100 MPa.The plastic creep deformation mainly occurred during the overheating stage during the thermal cycling creep.The thermal cycling creep curve exhibited three stages,similar to the 1100℃isothermal creep,but its minimum creep rate occurred at a lower creep strain.The overheating events caused severe microstructural degradation,such as substantial dissolution ofγ'phase,earlier formation of raftedγ'microstructure,widening of theγchannels,and instability of the interfacial dislocation networks.This microstructural degradation was the main reason for the dramatic decrease in thermal cycling creep life,as the thermal cycling promoted more dislocations to cut intoγ'phase and more cracks to initiate at grain boundaries,carbides,and residual eutectic pools.This study underlines the importance of evaluating the thermal cycling creep properties of superalloys to be used as turbine blades and provides insights into the effect of thermal cycling on directionally solidified superalloys for component design. | Wenrui An Satoshi Utada Xiaotong Guo Stoichko Antonov Weiwei Zheng Jonathan Cormier Qiang Feng | 2022 | Journal of Materials Science & Technology2022，，9： | 3 |
| 5 | Management of Hepatocellular Carcinoma显示文摘 | Janice N. Cormier K. Tyson Thomas Ravi S. Chari C. Wright Pinson | 2006 | Journal of Gastrointestinal Surgery2006，，5： | 2 |
| 6 | Characterization of H13 steel produced via electron beam melting显示文摘 | Cormier D Harrysson O West H | 2004 | Rapid Prototyping Journal2004，10，1： | 1 |
| 7 | Arterial disease of the lower limbs indiabetic patients显示文摘 | Cormier J Cormier F Fichelle J | 1995 | Rev Prat1995，45，1： | 1 |
| 8 | Role of interleukin-2 in the development and persistence of lymphocytic alveolitis in farmer's lung显示文摘 | Dakhama A Israel-Assayag E Cormier Y | 1998 | Eur Respir J1998，11，： | 1 |
| 9 | Numerical simulations of LNG vapor dispersion in brayton fire training field tests with ANSYS CFX显示文摘 | Qi R F Ng D Cormier B R | 2010 | Journal of Hazardous Materials2010，183，13： | 1 |
| 10 | Intraindividual variability of striatal (1) H-MRS brain metabolite measurements at 3 T显示文摘 | Soreni N Noseworthy MD Cormier T | 2006 | Magn Reson Imaging2006，24，： | 1 |
| 11 | Characterization of H13 Steel Produced via Electron Beam Melting显示文摘 | CormIer D Harry sson 0 West H | 2004 | Rapid Pmtotyping2004，10，： | 1 |
| 12 | Corporate Environmental Disclosure,Financial Markets and the Media:An International Perspective显示文摘 | Aerts W Cormier D Magnan M | 2008 | Ecological Economics2008，，64： | 1 |
| 13 | Molecular structure of RADA16-I designer self-assembling peptide nanofibers显示文摘 | Cormier AR Pang X Zimmerman MI | 2013 | ACS Nano2013，7，9： | 1 |
| 14 | Toward a formalization of affordance modeling for engineering design显示文摘 | CORMIER P OLEWNIK A LEWIS K | 2014 | Research in Engineering Design2014，25，3： | 1 |
| 15 | Evaluation of titanium implant components directly fabricated through electron beam melting technology显示文摘 | Harrysson O Cormier D | 2005 | Advanced Materials and Processes2005，163，7： | 1 |
| 16 | Intraindividual variability of striatal (1)H-MRS brain metabolite measurements at 3T显示文摘 | Soreni N Noseworthy MD Cormier T | 2006 | Magn Reson Imaging2006，24，2： | 1 |
| 17 | Absence of functional type 1 parathyroid hormone (PTH)/PTH - related protein receptors in humans is associated with abnormal breast development and tooth impaction 显示文摘 | WYSOLMERSKI J J CORMIER S PHILBRICK W M | 2001 | J Clin Endocrinol Metab2001，86，4： | 1 |
| 18 | Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis显示文摘 | Cormier RT Hong KH Halberg RB | | 0，，： | 1 |
| 19 | Transfemoral Aortic Valve Implantation显示文摘 | Kentaro Hayashida Thierry Lefèvre Bernard Chevalier Thomas Hovasse Mauro Romano Philippe Garot Darren Mylotte Jhonathan Uribe Arnaud Farge Patrick Donzeau-Gouge Erik Bouvier Bertrand Cormier Marie-Claude Morice | 2011 | JACC: Cardiovascular Interventions2011，，8： | 1 |
| 20 | Intra- industry Imitationin Corporate Environmental Reporting : An InternationalPerspective 显示文摘 | Aerts W Cormier D Magnan M | 2006 | Journal of Accounting & Public Policy2006，25，3： | 1 |
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