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| 1 | Review on supermolecules as chemical drugs显示文摘Supramolecular medicinal chemistry field has been a quite rapidly developing,increasingly active and newly rising interdiscipline which is the new expansion of supramolecular chemistry in pharmaceu-tical sciences,and is gradually becoming a relatively independent scientific area. Supramolecular drugs could be defined as medicinal supermolecules formed by two or more molecules through non-covalent bonds. So far a lot of supermolecules as chemical drugs have been widely used in clinics. Supermolecules as chemical drugs,i.e. supramolecular chemical drugs or supramolecular drugs,which might have the excellences of lower cost,shorter period,higher potential as clinical drugs for their successful research and development,may possess higher bioavailability,better biocompatibility and drug-targeting,fewer multidrug-resistances,lower toxicity,less adverse effect,and better curative effects as well as safety,and therefore exhibit wide potential application. These overwhelming advan-tages have drawn enormous special attention. This paper gives the definition of supramolecular drugs,proposes the concept of supramolecular chemical drugs,and systematically reviews the recent ad-vances in the research and development of supermolecules,including organic and inorganic complex ones as chemical drugs in the area of antitumor,anti-inflammatory,analgesic,antimalarial,antibacterial,antifungal,antivirus,anti-epileptic,cardiovascular agents and magnetic resonance imaging agents and so on. The perspectives of the foreseeable future and potential application of supramolecules as chemical drugs are also presented. | ZHOU ChengHe GAN LinLing ZHANG YiYi ZHANG FeiFei WANG GuangZhou JIN Lei GENG RongXia | 2009 | Science China Chemistry2009，52，4： | 17 |
| 2 | Adaptive subsequence adjustment with evolutionary asymmetric path-relinking for TDRSS scheduling显示文摘Due to the limited transmission resources for data relay in the tracking and data relay satellite system(TDRSS), there are many job requirements in busy days which will be discarded in the conventional job scheduling model. Therefore, the improvement of scheduling efficiency in the TDRSS can not only help to increase the resource utilities, but also to reduce the scheduling failure ratio.A model of nonhomogeneous parallel machines scheduling problems with time window(NPM-TW) is firstly built up for the TDRSS,considering the distinct features of the variable preparation time and the nonhomogeneous transmission rates for different types of antennas on each tracking and data relay satellite(TDRS). Then,an adaptive subsequence adjustment(ASA) framework with evolutionary asymmetric path-relinking(Ev APR) is proposed to solve this problem, in which an asymmetric progressive crossover operation is involved to overcome the local optima by the conventional job inserting methods. The numerical results show that, compared with the classical greedy randomized adaptive search procedure(GRASP) algorithm, the scheduling failure ratio of jobs can be reduced over 11% on average by the proposed ASA with EvAPR. | Peng Lin Linling Kuang Xiang Chen Jian Yan Jianhua Lu Xiaojuan Wang | 2014 | Journal of Systems Engineering and Electronics2014，25，5： | 12 |
| 3 | Enhanced desorption of PCB and trace metal elements (Pb and Cu) from contaminated soils by saponin and EDDS mixed solution显示文摘 | Menghua Cao Yuan Hu Qian Sun Linling Wang Jing Chen Xiaohua Lu | 2013 | Environmental Pollution2013，，： | 2 |
| 4 | Distribution of perfluorinated compounds in surface water from Hanjiang River in Wuhan, China显示文摘 | Beibei Wang Menghua Cao Hudi Zhu Jing Chen Linling Wang Guanghong Liu Xiaoman Gu Xiaohua Lu | 2013 | Chemosphere2013，，： | 2 |
| 5 | Video-Assisted Thoracoscopic Surgery (VATS) for Patients with Solitary Fibrous Tumors of the Pleura显示文摘 | Jun Liu Chengjie Cai Daoyuan Wang Hanzhang Chen Linling Cheng Wenlong Shao Shuben Li Yubao Guan Yingying Gu Jianxing He | 2010 | Journal of Thoracic Oncology2010，，2： | 2 |
| 6 | Adsorptive removal of chloramphenicol from wastewater by NaOH modified bamboo charcoal显示文摘 | Ye Fan Bin Wang Songhu Yuan Xiaohui Wu Jing Chen Linling Wang | 2010 | Bioresource Technology2010，，19： | 2 |
| 7 | Development of Specific SSR Molecular Marker of 'Huangzhou Radish' Based on Purity Identification显示文摘As an excellent local crop variety of Huanggang,'Huangzhou radish' has been widely promoted and its market influence is increasing day by day.Recently,the purity of 'Huangzhou radish' has declined deeply,so it is urgent to improve and strengthen the purity and viability of 'Huangzhou radish' including bad phenomena such as degeneration of varieties after self-pollination.At present,there was no SSR molecular marker can be used for genetic diversity identification of 'Huangzhou radish'.SSR molecular marker can provide a favorable tool to study 'Huangzhou radish'.In this study,'Xiakang','Hongbao'and 'Huangzhou radish' were used as experimental materials,100 SSR primers were screened,and 25 pairs of SSR primers were selected.Finally,two pairs of primers were selected for identification of the purity of 'Huangzhou radish' by non-denatured polyacrylamide gel electrophoresis (PAGE).The results showed that R-102 and R-112 primer pairs could amplify the special bands for 'Huangzhou radish' from above three kinds of radishes.These two pairs of primers could be developed as SSR markers to identify the specificity and purity of 'Huangzhou radish'.Furthermore,this study provides convenient conditions for promoting the economic and social value of 'Huangzhou radish'. | Pingan WANG Jinlan YAO Qiuyu ZENGCHEN Linling WANG Jingcai LI Yuanping FANG Shisheng LI | 2019 | Agricultural Biotechnology2019，8，5： | 2 |
| 8 | Statistical analysis and combination forecasting of environmental efficiency and its influential factors since China entered the WTO: 2002–2010–2012显示文摘 | Malin Song Linling Zhang Qingxian An Zeya Wang Zhen Li | 2012 | Journal of Cleaner Production2012，，： | 1 |
| 9 | Oxidation of hexachlorobenzene by the direct Fenton and EF-Feox method显示文摘 | Xie Qingjie Lu Na Wang Linling | 2005 | Fresenius Environmental Bulletin2005，14，10： | 1 |
| 10 | Expression patterns of an isoflavone reductase-like gene and its possible roles in secondary metabolism in Ginkgo biloba显示文摘 | Cheng Hua Li Linling Xu Feng Wang Yan Yuan Honghui Wu Conghua Wang Shaobing Liao Zhiqin Hua Juan Wang Yuping Cheng Shuiyuan Cao Fuliang | 2013 | Plant Cell Reports2013，，5： | 1 |
| 11 | Surfactant mediated HCB dechlorination in contaminated soils and sediments by micro and nanoscale Cu/Fe Particles显示文摘 | Songhu Yuan Zhonghua Zheng Xiang-Zhou Meng Jing Chen Linling Wang | 2010 | Geoderma2010，，1： | 1 |
| 12 | Preparation of sil- ver-modified TiO2 via microwave-assisted method and its photocatalytic activity for toluene degradation 显示文摘 | Li Xiaobin Wang Linling Lu Xiaohua | 2010 | Journal of Hazardous Materials2010，177，： | 1 |
| 13 | Systematic Effects of Bubble Volume on the Surface Tension Measured by Pendant Bubble Profiles显示文摘 | Wang W J Linl W | 1996 | Colliods Surfaces A1996，114，： | 1 |
| 14 | Ultrasonic-assisted water extraction and solvent bar microextraction followed by gas chromatography–ion trap mass spectrometry for determination of chlorobenzenes in soil samples显示文摘 | Li Wang Linling Wang Jing Chen Wenjun Du Guoliang Fan Xiaohua Lu | 2012 | Journal of Chromatography A2012，，： | 1 |
| 15 | Characterization of novel mixed-mode protein adsorbents fabricated from benzoyl-modified polyethyleneimine-grafted Sepharose显示文摘 | Na Liu Ziyuan Wang Xiaoguang (Margaret) Liu Linling Yu Yan Sun | 2014 | Journal of Chromatography A2014，，： | 1 |
| 16 | Determination of oxytetracycline, tetracycline and chloramphenicol antibiotics in animal feeds using subcritical water extraction and high performance liquid chromatography 显示文摘 | WANG Linling YANG Hai ZHANG Chunwei | 2008 | Analytica Chimca Acta2008，619，1： | 1 |
| 17 | Enhanced performance of flexible Zno nanowire based room-temperature oxygen sensors by piezotronic effect显示文摘 | Niu S HuY WenX Zhou Y ZhangF LinL WangS WangZ L | | 0，，27： | 1 |
| 18 | Determination of oxytetracycline, tetracycline and chlorampheni- col antibiotics in animal feeds using subcritical water extraction and high performance liquid chromatography 显示文摘 | WANG Linling YANG Hai ZHANG Chunwei | 2008 | Anal Chim Acta2008，619，1： | 1 |
| 19 | Characteristics of alveolar macrophages in bronchioalveolar lavage fluids from active tuberculosis patients identified by single-cell RNA sequencing显示文摘Tuberculosis(TB),is an infectious disease caused by Mycobacterium tuberculosis(M.tuberculosis),and presents with high morbidity and mortality.Alveolar macrophages play an important role in TB pathogenesis although there is heterogeneity and functional plasticity.This study aimed to show the characteristics of alveolar macrophages from bronchioalveolar lavage fluid(BALF)in active TB patients.Single-cell RNA sequencing(scRNA-seq)was performed on BALF cells from three patients with active TB and additional scRNA-seq data from three healthy adults were established as controls.Transcriptional profiles were analyzed and compared by differential gene expression and functional enrichment analysis.We applied pseudo-temporal trajectory analysis to investigate correlations and heterogeneity within alveolar macrophage subclusters.Alveolar macrophages from active TB patients at the single-cell resolution are described.We found that TB patients have higher cellular percentages in five macrophage subclusters.Alveolar macrophage subclusters with increased percentages were involved in inflammatory signaling pathways as well as the basic macrophage functions.The TB-increased alveolar macrophage subclusters might be derived from M1-like polarization state,before switching to an M2-like polarization state with the development of M.tuberculosis infection.Cell-cell communications of alveolar macrophages also increased and enhanced in active TB patients.Overall,our study demonstrated the characteristics of alveolar macrophages from BALF in active TB patients by using scRNA-seq. | Qianqian Chen Chunmei Hu Wei Lu Tianxing Hang Yan Shao Cheng Chen Yanli Wang Nan Li Linling Jin Wei Wu Hong Wang Xiaoning Zeng Weiping Xie | 2022 | The Journal of Biomedical Research2022，36，3： | 1 |
| 20 | Modeling and Simulation of Automatic Berthing based on Bow and Stern Thruster Assist for Unmanned Surface Vehicle显示文摘In order to solve the technical problems of autonomous berthing of the Unmanned Surface Vehicle(USV),this research has met the requirements of maneuverability berthing under different conditions by effectively using the bow and stern thrusters,which is a technological breakthrough in actual production and life.Based on the MMG model,the maneuverability mathematical model of the USV with bow and stern thruster was established.And the motion simulation of USV maneuvering was carried out through the numerical simulation calculation.Then the berthing plan was designed based on the maneuverability analysis of the USV low-speed motion,and the simulation of automatic berthing for USV was carried out.The research results of this paper can be of certain practical significance for the USV based on the support of the bow and stern thruster in the berthing.At the same time,it also provides a certain theoretical reference for the handling of the USV automatic berthing. | Gongxing Wu Xiaolong Zhao Linling Wang | 2021 | Journal of Marine Science2021，3，2： | 0 |
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