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| 1 | Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer显示文摘因为高发生和高死亡,肺癌症是在中国的最致命的癌症之一。Cyclooxygenase-2 (COX-2 ) 和容器 endothelial 生长因素 C (VEGF-C ) 被发现在恶意的肿瘤的 lymphangiogenesis 起一个重要作用。在这研究,我们调查了淋巴的 microvessel 密度(LMVD ) 是否与在非小的房间肺癌症(NSCLC ) 的预后有关是 COX-2 和 VEGF-C 的病人,和表情以便在 NSCLC lymphangiogenesis 决定 COX-2 和 VEGF-C 的可能的角色。嵌入的织物 NSCLC 取样的 65 修理福尔马林的石蜡被染色的 immunohistochemical 为 COX-2 和 VEGF-C 评估。估计肿瘤 lymphangiogenesis, LMVD 被 immunohistochemical 染色 VEGFR-3 polyclonal 决定抗体。在 COX-2 和 VEGF-C 表示, LMVD,和 clinicopathologic 参数之中的关系被分析。在 65 件样品之中,高 LMVD 显著地与淋巴节点转移和差的幸存被联系。Multivariate 幸存分析证明那 LMVD 价值和淋巴节点转移是独立预示的因素。COX-2 和 VEGF-C 的表示水平比邻近的纸巾的那些显著地高。在 NSCLC 的 COX-2 和 VEGF-C 表情显著地与淋巴节点转移,然而并非与耐心的性,年龄,肿瘤尺寸,或肿瘤相关,节点,转移分类舞台。COX-2- 或 VEGF-C-positive 肿瘤的吝啬的 LMVD 价值比 COX-2- 或 VEGF-C-negative 肿瘤的高。重要关联在 COX-2 和 VEGF-C 的表情之间被发现。这研究建议 LMVD 可以是为 NSCLC 病人的重要预示的因素之一。VEGF-C 可能在 COX-2 lymphangiogenic 小径起一个重要作用。COX-2 和 VEGF-C 可以由刺激 lymphangiogenesis 在肿瘤前进起一个重要作用。lymphangiogenesis, COX-2,或 VEGF-C 活动的抑制可以在 NSCLC 的控制有一个重要治疗学的好处。 | Xufeng Guo Yongbing Chen Zhonghua Xu Zhonghen Xu Yongyue Qian Xueyan Yu | 2009 | Acta Biochimica et Biophysica Sinica2009，41，3： | 34 |
| 2 | Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors显示文摘Multipotent 神经干细胞为房间治疗保持大诺言。到导致的 pluripotent 干细胞以及成熟神经原的成纤维细胞的 reprogramming 建议可能性没有首先建立 pluripotency,把一个严重地区分的体的房间变换成一个 multipotent 状态。这里,我们证明房间从中层导出的那 Sertoli 能直接被变换成拥有神经干细胞性质的一个 multipotent 状态。导致的神经干细胞(iNSCs ) 表示多重 NSC 特定的标记,展出类似于正常 NSC 的全球基因表示侧面,并且能够自强并且区分功能的神经原进神经胶质并且 electrophysiologically。为酷氨酸 hydroxylase (TH ) 积极的导出 iNSC 的神经原污点, γ -aminobutyric 酸,和胆碱 acetyltransferase。另外, iNSCs 能熬过并且产生跟随移植进有牙齿的回转的触处。iNSCs 的产生可以为疾病建模和再生药有重要含意。 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Libin Wang Wei Li Haijiang Zhang Xiao-Yang Zhao Lei Liu Ziwei Wang Changlong Guo Hua-Jun Wu Zhonghua Liu Liu Wang Shigang He Xiu-Jie Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，1： | 31 |
| 3 | How many sutures in the southern Central Asian Orogenic Belt:Insights from East Xinjiang-West Gansu(NW China)?显示文摘How ophiolitic mèlanges can be defined as sutures is controversial with regard to accretionary orogenesis and continental growth.The Chinese Altay,East junggar,Tianshan,and Beishan belts of the southern Central Asian Orogenic Belt(CAOB) in Northwest China,offer a special natural laboratory to resolve this puzzle.In the Chinese Altay,the Erqis unit consists of ophiolitic melanges and coherent assemblages,forming a Paleozoic accretionary complex.At least two ophiolitic melanges(Armantai,and Kelameili) in East Junggar,characterized by imbricated ophiolitic melanges,Nb-enriched basalts,adakitic rocks and volcanic rocks,belong to a Devonian-Carboniferous intra-oceanic island arc with some Paleozoic ophiolites,superimposed by Permian arc volcanism.In the Tianshan,ophiolitic melanges like Kanggurtag,North Tianshan,and South Tianshan occur as part of some Paleozoic accretionary complexes related to amalgamation of arc terranes.In the Beishan there are also several ophiolitic melanges,including the Hongshishan,Xingxingxia-Shibangjing,Hongliuhe-Xichangjing,and Liuyuan ophiolitic units.Most ophiolitic melanges in the study area are characterized by ultramafic,mafic and other components,which are juxtaposed,or even emplaced as lenses and knockers in a matrix of some coherent units.The tectonic settings of various components are different,and some adjacent units in the same melange show contrasting different tectonic settings.The formation ages of these various components are in a wide spectrum,varying from Neoproterozoic to Permian.Therefore we cannot assume that these ophiolitic melanges always form in linear sutures as a result of the closure of specific oceans.Often the ophiolitic components formed either as the substrate of intra-oceanic arcs,or were accreted as lenses or knockers in subduction-accretion complexes.Using published age and paleogeographic constraints,we propose the presence of (1) a major early Paleozoic tectonic boundary that separates the Chinese Altay-East Junggar multiple subduction systems of the southern Siberian active margin from those of the northern Tarim;and (2) a major Permian suture zone that separates the Tianshan-Beishan from the northern active margin of the Tarim Craton.These new observations and interpretations have broad implications for the architecture and crustal growth of central Asia and other ancient orogens as well. | Wenjiao Xiao Chunming Han Wei Liu Bo Wan Ji'en Zhang Songjian Ao Zhiyong Zhang Dongfang Song Zhonghua Tian Jun Luo | 2014 | Geoscience Frontiers2014，5，4： | 31 |
| 4 | Molecular fossils and oil-source rock correlations in Tarim Basin, NW China显示文摘The distribution of 'molecular fossils' (bio-markers) of steroid compounds in extracts from some spe-cific geologic age in the Tarim Basin have been analyzed andare used as the fingerprints for the oil-source rock correla-tion. Having been affected by maturation, migration, phasefractionation and biodegradation, not any molecular fossilsrelated to source and environment can be used as the finger-prints for oil-source rock correlation. Some special bio-markers widely existed in the extracts from Cambrian andOrdovician rocks in the Tarim Basin and showed obviousdifference in each stratum, including dinosteranes (C30),4-methyl-24-ethyl-cholestanes (C30) and their aromatizedsteroids, C24-norcholestanes and C28 steranes originated fromdinoflagellates and diatom. Few oils such as the heavy oildrilled in the Cambrian reservoir from Tadong 2 well (TD2)correlated well with the extracts from the Cambrian. Theamazing similarity of the relative contents of these com-pounds between the marine oils produced in Tazhong andTabei uplifts and the extracts from the Upper Ordoviciansuggests that the Middle-Upper Ordovician is the very likelymain source for the marine oils. | ZHANG Shuichang LIANG Digang LI Maowen XIAO Zhongyao HE Zhonghua | 2002 | Chinese Science Bulletin2002，47，S1： | 25 |
| 5 | Genome analysis of Taraxacum kok-saghyz Rodin provides new insights into rubber biosynthesis显示文摘The Russian dandelion Taraxacum kok-saghyz Rodin(TKS), a member of the Composite family and a potential alternative source of natural rubber(NR) and inulin, is an ideal model system for studying rubber biosynthesis. Here we present the draft genome of TKS, the first assembled NR-producing weed plant. The draft TKS genome assembly has a length of 1.29 Gb, containing 46 731 predicted protein-coding genes and68.56% repeats, in which the LTR-RT elements predominantly contribute to the genome enlargement. We analyzed the heterozygous regions/genes, suggesting its possible involvement in inbreeding depression.Through comparative studies between rubber-producing and non-rubber-producing plants, we found that enzymes of the mevalonate(MVA) pathway and rubber elongation might be critical for rubber biosynthesis, and several key isoforms have been isolated and shown to be predominantly expressed in the latex, indicating their crucial functions in rubber biosynthesis. Moreover, for two important families in rubber elongation, the CPT/CPTL and REF/SRPP families, diverse evolutionary tracks have been revealed. These results provide valuable resources and new insights into the mechanism of NR biosynthesis,and facilitate the development of alternative NR-producing crops. | Tao Lin Xia Xu Jue Ruan Shizhong Liu Shigang Wu Xiujuan Shao Xiaobo Wang Lin Gan Bi Qin Yushuang Yang Zhukuan Cheng Suhua Yang Zhonghua Zhang Guosheng Xiong Sanwen Huang Hong Yu Jiayang Li | 2018 | National Science Review2018，5，1： | 22 |
| 6 | CO_2 Emissions Embodied in China's Foreign Trade:An Investigation from the Perspective of Global Vertical Specialization显示文摘In light of the growth in vertically specialized in global trade,the present paper uses input-output tables from the World Input-Output Database to construct an environmental multiregional input-output model to calculate the CO_2 emissions embodied in China's international trade during 1995-2009.The advantage of this model lies in its incorporation of the reexported CO_2emissions component embodied in trade and its ability to differentiate domesticsourcedCO_2 emissions from foreign-sourced CO_2 emissions in trade.The results show that carbon emissions embodied in both China's exports and imports increased significantly during 1995-2009.One important reason for this is that the re-exported carbon emissions embodied in China's imported intermediate inputs increased substantially during this period.Our research reveals that accelerating the transformation of trade pattern and upgrading processing trade should be emphasized in the formulation of policy to prompt CO_2 emissions abatement in China. | Yuhuan Zhao Zhonghua Zhang Song Wang Shaojun Wang | 2014 | China & World Economy2014，22，4： | 21 |
| 7 | GRAIN INCOMPLETE FILLING 2 regulates grain filling and starch synthesis during rice caryopsis development显示文摘Rice grain filling determines grain weight,final yield and grain quality.Here,a rice defective grain filling mutant,gif2,was identified.Grains of gif2 showed a slower filling rate and a significant lower final grain weight and yield compared to wild-type.The starch content in gif2 was noticeably decreased and its physicochemical properties were also altered.Moreover,gif2 endosperm cells showed obvious defects in compound granule formation.Positional cloning identified GIF2 to encode an ADP-glucose pyrophosphorylase(AGP) large subunit,AGPL2;consequently,AGP enzyme activity in gif2 endosperms was remarkably decreased.GIF2 is mainly expressed in developing grains and the coded protein localizes in the cytosol.Yeast two hybrid assay showed that GIF2 interacted with AGP small subunits Os AGPS1,Os AGPS2a and Os AGPS2 b.Transcript levels for granule-bound starch synthase,starch synthase,starch branching enzyme and starch debranching enzyme were distinctly elevated in gif2 grains.In addition,the level of nucleotide diversity of the GIF2 locus was extremely low in both cultivated and wild rice.All of these results suggest that GIF2 plays important roles in the regulation of grain filling and starch biosynthesis during caryopsis development,and that it has been preserved during selection throughout domestication of modern rice. | Xiangjin Wei Guiai Jiao Haiyan Lin Zhonghua Sheng Gaoneng Shao Lihong Xie Shaoqing Tang Qingguo Xu Peisong Hu | 2017 | Journal of Integrative Plant Biology2017，59，2： | 20 |
| 8 | Multislice CT angiography in coronary artery disease: Technical developments, radiation dose and diagnostic value显示文摘Multislice computed tomography (CT) angiography has been increasingly used in the detection and diagnosis of coronary artery disease because of its rapid technical evolution from the early generation of 4-slice CT scanners to the latest models such as 64-slice, 256-slice and 320-slice CT scanners. Technical developments of multislice CT imaging enable improved diagnostic value in the detection of coronary artery disease, and this indicates that multislice CT can be used as a reliable lessinvasive alternative to invasive coronary angiography in selected patients. In addition, multislice CT angiography has played a significant role in the prediction of disease progression and cardiac events. Despite promising results reported in the literature, multislice CT has the disadvantage of having a high radiation dose which could contribute to the radiation-induced malignancy. A variety of strategies have been currently undertaken to reduce the radiation dose associated with multislice CT coronary angiography while in the meantime acquiring diagnostic images. In this article, the author will review the technical developments, radiation dose associated with multislice CT coronary angiography, and strategies to reduce radiation dose. The diagnostic and prognostic value of multislice CT angiography in coronary artery disease is briefly discussed, and future directions of multislice CT angiography in the diagnosis of coronary artery disease will also be highlighted. | Zhonghua Sun, Discipline of Medical Imaging, Department of Imaging and Applied Physics, Curtin University of Technology, Perth, Western Australia 6845, Australia | 2010 | World Journal of Cardiology2010，2，10： | 19 |
| 9 | Evolution characters of water exchange abilities between Dongting Lake and Yangtze River显示文摘在 19512010 在东廷·莱克和长江主流由使用相关控制的地调查水文学数据驻扎,在到从不同时间规模的三座峡水库( TGR )的操作的二水身体和他们的反应之间的水交换能力的进化字符基于他们的水力的关系被分析。结果如下被显示出。第一在 7 月 9 月期间,到东廷·莱克的三个插头的补充能力更强壮,并且在 1 月三月,到长江的东廷·莱克的补充能力更强壮。第二,在东廷·莱克和长江之间的水交换系数上有一个明显的内部十的波浪。在 19511958 和 19591968,到东廷·莱克的三个插头的补充能力更强壮,但是在 20032010,到长江的东廷·莱克的补充能力被加强了。第三,三个插头的喷洒部门能力变弱,并且来自三个插头的东廷·莱克的水在三座峡水库的操作以后在典型的年里或在 TGR 的不同派遣模式下面减少。而且,来自四条河的东廷·莱克的水拿主导的位置,它显然提高东廷·莱克的补充能力到长江。第四如果在盆的流量变化的效果没被考虑,交换能力和交换的进化人物在规模通常与在他们之间的水交换数量的变化被改变的不同时间在东廷·莱克和长江之间处理,尽管影响水的因素交换在他们之间的能力是很复杂的。在河湖水交换能力和河湖水交换之间有同轴的生长或衰落关系的这些表演总计。 | OU Chaomin LI Jingbao ZHOU Yongqiang CHENG Weiyan YANG Yan ZHAO Zhonghua | 2014 | Journal of Geographical Sciences2014，24，4： | 19 |
| 10 | The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism显示文摘在动物农业和药的抗菌素的 overuse 引起了一系列潜在的威胁到公共健康。Macleaya cordata 是从 Papaveraceae 家庭的药用的植物种,提供为抗菌剂的制造的一个安全资源为家畜喂添加剂。从 M. 的活跃成分 ? cordata 被知道包括 benzylisoquinoline 碱(偏爱) 象 sanguinarine (圣) 和 chelerythrine (CHE ) 那样的 ?,而是他们的新陈代谢的小径还得在这非模型植物被学习。在 M. 的圣和 CHE 的活跃生合成 ? cordata 被喂 13标记 C 的酷氨酸。为了增加,推进卓见,我们 de novo 定序 M 的整个染色体。cordata,第一从 Papaveraceae 家庭被定序。M.? 盖住 378 Mb 的 cordata 染色体与 43.5%being 编码 22,328 预言的编码蛋白质的基因 transposable 元素。作为基础 eudicot 的一个成员, M.? cordata 染色体缺乏 ? 发生在几乎所有 eudicots 的 paleohexaploidy 事件。从 genomics 数据, 16 的一个完全的集合 ? 新陈代谢 ? 为圣和 CHE 生合成的基因被检索,并且 14 项他们的生物化学的活动被验证。这些 genomics 和新陈代谢的数据在 M. 显示出保存 BIA 新陈代谢的小径 ? cordata 并且由庄稼改进或微生物引起的小径重建为圣和 CHE 的未来生产提供知识基础。 | Xiubin Liu Yisong Liu Peng Huang Yongshuo Ma Zhixing Qing Qi Tang Huifen Cao Pi Cheng Yajie Zheng Zejun Yuan Yuan Zhou Jinfeng Liu Zhaoshan Tang Yixiu Zhuo Yancong Zhang Linlan Yu Jialu Huang Peng Yang Qiong Peng dinbo Zhang Wenkai Jiang Zhonghua Zhang Kui Lin Dae-Kyun Ro Xiaoya Chen Xingyao Xiong Yi Shang Sanwen Huang Jianguo Zeng | 2017 | Molecular Plant2017，10，7： | 19 |
| 11 | Application of autocorrelation method on ionospheric short--term forecasting in China显示文摘Adopting the autocorrelation method in the ionospheric short-term forecasting, we put for- ward a simple and practical forecasting method― the sectional autocorrelation method, that is, for pre- dictions of one hour to four hours ahead the auto- correlation coefficient of RDF with the “iteration” method is selected, for prediction of more than four hours ahead, the autocorrelation coefficient of f0F2 with the “at once” method is used. The prediction precisions have been quantitatively estimated based on the data from Chongqing and Guangzhou Ionos- onde Stations. It is shown that the method is much improved for the predictions of one hour to four hours ahead. For the predictions of more than four hours ahead the prediction error reaches a saturation value, which is still lower than that of the “median” method. This new method could also be applied to the short-term forecasting of other ionospheric parame- ters. | LIU Ruiyuan LIU Shunlin XU Zhonghua WU Jian WANG Xianyi ZHANG Beichen HU Hongqiao | 2006 | Chinese Science Bulletin2006，51，3： | 17 |
| 12 | Aggregated spatial distributions of species in a subtropical karst forest,southwestern China显示文摘Aims spatial distribution patterns of species reflect not only the ecological processes but also the habitat features that are related to species distribution.in karst topography,species distribution patterns provide more specific information about their environments.The objectives of this study are as follows:(i)to analyse and explain the spatial distribution patterns of conspecific trees in an old-growth subtropical karst forest;(ii)to investigate pattern changes at different spatial scales;(iii)to test the spatial pattern similarity(or dissimilarity)between trees at different abundances,diameter at breast height classes,canopy layers and different functional groups(shade tolerance and seed dispersal mode);(iv)to examine whether habitat heterogeneity has an important effect on the species spatial distribution.Methods The spatial distributions of woody species with≥20 individuals in a 1-ha subtropical karst forest plot at maolan in southwestern China were quantified using the relative neighbourhood densityΩbased on the average density of conspecific species in a circular neigh-bourhood around each species.Important Findingsaggregated distribution is the dominant pattern in the karst forest,but the ratio of aggregated species in total species number decreases with an increase in spatial scale.less abundant species are more aggregated than most abundant species.aggregation is weaker in larger diameter classes,which is consistent with the prediction of self-thinning.seed dispersal mode influences spatial patterns,with species dispersed by animals being less aggregated than those dispersed by wind and gravity.other species functional traits(e.g.shade tolerance)also influence the species spatial distributions.moreover,differences among species habitat associations,e.g.with rocky outcrops,play a significant role in species spatial distributions.These results indicate that habitat heterogeneity,seed dispersal limitation and self-thinning primarily contribute to the species spatial distributions in this subtropical karst forest. | Zhonghua Zhang Gang Hu Jiedong Zhu Jian Ni | 2013 | Journal of Plant Ecology2013，6，2： | 17 |
| 13 | Comparison and significance of specific and non-specific cellular immunity in patients with chronic hepatitis B caused by infection with genotypes B or C of hepatitis B virus显示文摘The present study was designed to investigate possible relationships between the genotypes of hepatitis B virus(HBV) and the HBV-specific cytotoxic T lymphocyte(CTL) responses.HBV genotypes,HBV specific CTL HBV DNA and other markers of HBV infection were determined in 138 patients with chronic hepatitis B.The results showed that the patients infected with genotype C(n=62) had a significantly lower HBV-specific CTL response than those who were infected with HBV genotype B(P<0.01).HBV DNA titer was higher in patients infected with HBV genotype C than in those infected with HBV geno-type B(P<0.01).Both alanine aminotransferase(ALT) and total bilirubin(TBIL) were higher in HBV genotype C infected patients than in those infected with genotype B(P<0.01 and <0.05,respectively).These results suggest that compared with CHB patients infected with HBV genotype B,the higher HBV DNA level and more severe liver damages in the patients infected with genotype C of HBV may be associated with genotype C of the virus. | GU XiBing,YANG XiaoJuan,WANG Dong,HUA Zhong,WU HangYuan,CHEN HaoKun,XU YueQin & LU ZhongHua Wuxi Hospital for Infectious Diseases,Wuxi 214005,China | 2009 | Science China(Life Sciences)2009，52，8： | 16 |
| 14 | An ACC Oxidase Gene Essential for Cucumber Carpel Development显示文摘在植物的性决心产生便于 outcrossing 并且提高基因差异的单性的花。在黄瓜和甜瓜,乙烯支持心皮开发并且逮捕雄蕊开发。五性决心基因被识别了,包括四个编码在乙烯生合成催化限制率的步骤的 1-aminocyclopropane-1-carboxylate (ACC ) synthase,和抄写因素基因在甜瓜对应于孟德尔的地点 gynoecious 并且是女性的一个否定管理者的 CmWIP1。ACC oxidase (ACO ) 把 ACC 变换成乙烯;然而,它留下逃犯在黄瓜染色体的基因为性决心是它 ACO 并且怎么批评的 CmWIP1 镇压女花的开发。在这研究,我们在 ACO 基因发现了那个变化, CsACO2,在忍受仅仅男的花的黄瓜授与 androecy。变化破坏 CsACO2 的酶的活动,导致从射击尖端的 50% 更少的乙烯排放。CsACO2 在心皮 primordia 被表示,它的表示为性决心在关键阶段在女花与 CsACS11 的重叠了,大概提供为合适的 CsACS2 要求的足够的乙烯表示。CmACO3, CsACO2 的 ortholog,在心皮区域显示出一个类似的表示模式,建议 CsACO2/CmACO3 的保存功能。我们表明了那 CsWIP1, CmWIP1 的 ortholog,能直接绑 CsACO2 的倡导者并且镇压它的表示。一起拿,我们建议由 WIP1 抄写因素和 ACO 组成的一个大概保存的规章的模块在黄瓜和甜瓜控制单性的花开发。 | Huiming Chen Jinjing Sun Shuai Li Qingzhi Cui Huimin Zhang Fengjiao Xin Huaisong Wang Tao Lin Dongli Gao Shenhao Wang Xia Li Donghui Wang Zhonghua Zhang Zhihong Xu Sanwen Huang | 2016 | Molecular Plant2016，9，9： | 16 |
| 15 | Post-translational regulation of inflammasomes显示文摘在对微生物引起的感染的有免疫力的保护的 Inflammasomes 戏必需品角色。然而,过多的发炎在各种各样的人的疾病被含有,包括 autoinflammatory 症候群,糖尿病,多重硬化,心血管的混乱和 neurodegenerative 疾病。因此,当限制并行的织物损坏时, inflammasome 活动的精确规定为足够的有免疫力的保护是批评的。在这评论,我们集中于调整 NLRP3, NLRP1, NLRC4, AIM2 和 IFI16 inflammasomes 的激活的 translational 以后修正(PTM ) 的新兴的角色。我们预计 PTM 的这些类型将在另外的类型和更少的描绘得好的 inflammasomes 被识别。因为这些高度多样、万用的 PTM 响应感染和织物损坏塑造不同煽动性的回答,指向酶在这些包含了 PTM 将无疑在各种各样的 pathophysiological 条件下面为 inflammasome 活动的精确调整提供机会。 | Jie Yang Zhonghua Liu Tsan Sam Xiao | 2017 | Cellular & Molecular Immunology2017，14，1： | 15 |
| 16 | Oxidized low-density lipoprotein activates adipophilin through ERK1/2 signal pathway in RAW264.7 cells显示文摘它被报导了那氧化低密度的脂蛋白(Ox-LDL ) 能增加 adipophilin 的表示。然而,详细机制充分没被理解。这研究的目的是在 adipophilin 表示和细胞内部的类脂化合物微滴累积上调查 Ox-LDL 的机制。一个鼠标像巨噬细胞的房间线, RAW264.7,全部被使用,并且 Ox-LDL 以一种剂量依赖者方式导致了 adipophilin 表示,这被发现。而且, Ox-LDL 导致了 peroxisome 激活 proliferator 的受体 --(PPAR ) 表示和 PPAR 特定的禁止者 T0070907 没废除 Ox-LDL-induced adipophilin 表示,而是特定的收缩筋 GW1929。而且, Ox-LDL 导致了 ERK1/2 的 phosphorylation,并且由 PD98059 的 ERK1/2-specific 抑制压制了 Ox-LDL-induced PPAR 和 adipophilin 表示。结果显示出那 ERK1/2 或 PPAR 特定的抑制减少了细胞内部的类脂化合物微滴的数量。同时, PPAR 特定的收缩筋增加了细胞内部的类脂化合物微滴。这些结果建议 Ox-LDL-induced 经由 ERK1/2 激活在 adipophilin 水平增加是在 RAW264.7 房间导致细胞内部的类脂化合物微滴的更大的数量的机制之一,它显示 adipophilin 涉及动脉粥样硬化患者前进。 | Qingnan Liu Zhibing Dai Zhiqiang Liu Xiaohui Liu Chaoke Tang Zuo Wang Guanghui Yi Lushan Liu Zhisheng Jiang Yongzong Yang Zhonghua Yuan | 2010 | Acta Biochimica et Biophysica Sinica2010，42，9： | 13 |
| 17 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 18 | Aspartic acid in the hippocampus:a biomarker for postoperative cognitive dysfunction显示文摘This study established an aged rat model of cognitive dysfunction using anesthesia with 2% isoflurane and 80% oxygen for 2 hours. Twenty-four hours later, Y-maze test results showed that isoflurane significantly impaired cognitive function in aged rats. Gas chromatography-mass spectrometry results showed that isoflurane also significantly increased the levels of N,N-diethylacetamide, n-ethylacetamide, aspartic acid, malic acid and arabinonic acid in the hippocampus of isoflurane-treated rats. Moreover, aspartic acid, N,N-diethylacetamide, n-ethylacetamide and malic acid concentration was positively correlated with the degree of cognitive dysfunction in the isoflurane-treated rats. It is evident that hippocampal metabolite changes are involved in the formation of cognitive dysfunction after isoflurane anesthesia. To further verify these results, this study cultured hippocampal neurons in vitro, which were then treated with aspartic acid(100 μmol/L). Results suggested that aspartic acid concentration in the hippocampus may be a biomarker for predicting the occurrence and disease progress of cognitive dysfunction. | Rong Hu Dong Huang Jianbin Tong Qin Liao Zhonghua Hu Wen Ouyang | 2014 | Neural Regeneration Research2014，9，2： | 12 |
| 19 | GBSS-BINDING PROTEIN,encoding a CBM48 domain-containing protein,affects rice quality and yield^∞显示文摘The percentage of amylose in the endosperm of rice(Oryza sativa)largely determines grain cooking and eating qualities.Granule-bound starch synthase I(GBSSI)and GBSSII are responsible for amylose biosynthesis in the endosperm and leaf,respectively.Here,we identified OsGBP,a rice GBSS-binding protein that interacted with GBSSI and GBSSII in vitro and in vivo.The total starch and amylose contents in osgbp mutants were significantly lower than those of wild type in leaves and grains,resulting in reduced grain weight and quality.The carbohydrate-binding module 48(CBM48)domain present in the C-terminus of OsGBP is crucial for OsGBP binding to starch.In the osgbp mutant,the extent of GBSSI and GBSSII binding to starch in the leaf and endospermwas significantly lower than wild type.Our data suggest that OsGBP plays an important role in leaf and endosperm starch biosynthesis by mediating the binding of GBSS proteins to developing starch granules.This elucidation of the function of OsGBP enhances our understanding of the molecular basis of starch biosyn-thesis in rice and contributes information that can be potentially used for the genetic improvement of yield and grain quality. | Wei Wang Xiangjin Wei Guiai Jiao Wenqiang Chen Yawen Wu Zhonghua Sheng Shikai Hu Lihong Xie Jiayu Wang Shaoqing Tang Peisong Hu | 2020 | Journal of Integrative Plant Biology2020，62，7： | 12 |
| 20 | A Preconditioned Multigrid Method for Efficient Simulation of Three-dimensional Compressible and Incompressible Flows显示文摘为了为翅膀和建筑群的数字优化图案开发一个有效、柔韧的空气动力学的分析方法,配置,矩阵 preconditioning 的联合和 multigrid 方法被介绍并且调查。三维的海军司烧方程的时间衍生物是由原来为二维的低马赫数字被设计的 Choi-Merkle preconditioning 矩阵的 preconditioned 粘滞流动。对的扩展三维粘滞流动被实现,并且为接近音速的流动改进集中的一个方法被建议。空间 discretizaition 被采用一个有限卷的以房间为中心的计划并且使用中央差别执行。前进基于一个明确的 Runge-Kutta 计划的时间由詹姆森求婚了。一个有效船边交货 multigrid 方法被用来加速集中到不变的答案。粘滞在 ONERA M6 翅膀和 M100 翅膀上的流动数字地被模仿,马赫数字从 0.010 ~ 0.839 。在 DLR-F4 翅膀身体配置上的 inviscid 流动也被计算 preliminarily 为复杂配置检验介绍方法的表演。计算结果与试验性的数据相比,好同意被完成。介绍方法为可压缩、不可压缩的流动有效、柔韧并且为翅膀和复杂配置的空气动力学的优化图案是很吸引人的,这被显示出。 | Han Zhonghua He Fei Song Wenping Qiao Zhide | 2007 | Chinese Journal of Aeronautics2007，20，4： | 12 |
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