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| 1 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 2 | A randomized controlled clinical trial on the treatment of Thymosin-a1 versus interferon-α in patients with hepatitis B显示文摘INTRODUCTIONChronic hepatitis B virus (HBV) infection is a serious problem because of its world wide distribution and possible adverse sequelae ,such as cirrhosis and hepatocellular carcinoma .The World Health Organization estimates that HBV has infected mord than 350 million people worldwide ,and up to 20% of them will become chromic carricrs and will be at significant risk for cirrhosis and HCC .The ultimate goal of the therapy for chronic hepatitis B is to prevent progression to cirrhosis and to prevent development of HCC. | Jing You Lin Zhuang Bao Zhang Tang Wei Bo Yang Su Ying Ding Wu Li Rong Xue Wu Hong Li Zhang Yan Mei Zhang Shao Ming Yan Lu Zhang ~1Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China ~2Departrnent of Hepatology,Kunming Third Municipal People’s Hospital,Kunming 650041,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 48 |
| 3 | Relationship between hepatitis B virus DNA levels and liver histology in patients with chronic hepatitis B显示文摘瞄准:与长期的肝炎 B (CHB ) 在病人学习在肝炎 B (HBV ) DNA 层次和肝组织学之间的关系并且决定肝炎 B e 的流行和特征抗原(HBeAg )negative 病人。方法:有 CHB 的 213 个病人的一个总数被学习,并且浆液 HBV DNA 层次被 COBAS Amplicor HBV 监视器测量测试。所有病人根据 HBeAg 地位被划分成二个组。在浆液 HBV DNA 层次和肝损坏(肝组织学和生物化学) 之间的关联被探索。结果:有比 105 copies/mL 高的浆液 HBV DNA 层次的 213 个病人,(83.6%) 178 是 HBeAg 积极,(16.4%) 35 是 HBeAg 否定。浆液 HBV DNA 层次没在否定的 HBeAg 或 HBeAg 被相关到肝疾病的年龄, CHB 的历史,组织学的等级和阶段积极病人。在 HBV DNA 和丙氨酸 aminotransferanse (中高音) 的浆液层次之间没有关联,在 HBeAg 积极病人的 aspartate aminotrans-ferase (著名计算机生产厂商) 。在 HBeAg 否定病人,当浆液 DNA 层次与中高音相关时,在 HBV DNA 和著名计算机生产厂商的浆液层次之间没有关联(r = 0.351, P = 0.042 ) 。肝疾病的等级(G) 与中高音和著名计算机生产厂商相关(P <
0.05, r = 0.205, 0.327 分别地) 在 HBeAg 积极病人。在 HBeAg 否定病人,关联在中高音,著名计算机生产厂商和 G 之间被显示出(P <
0.01,并且 r = 0.862, 0.802 分别地) 。 HBeAg 否定病人更老( 35 +/- 9 年对 30 +/- 9 年, P <
0.05 )并且有 HBV 感染的更长的历史( 8 +/- 4 年对 6 +/- 4 年, P <
0.05 )并且更低的 HBV DNA 比 HBeAg 积极病人铺平( 8.4 +/- 1.7 木头 HBV DNA 对 9.8 +/- 1.3 木头 HBV DNA , P <
0.001 )。在在二个组之间的两性比率,中高音和著名计算机生产厂商层次和肝组织学没有有效差量。结论:浆液 HBV DNA 水平没与 HBV DNA 在 CHB 病人被相关到肝疾病的组织学的等级或舞台超过 105 copies/mL。比作 HBeAg 积极病人, HBeAg 否定病人更老并且有更低的 HBV DNA 水平和更长的 HBV 感染历史。在在二个组之间的两性比率,中高音和著名计算机生产厂商层次和肝组织学没有有效差量。 | Jie Shao Lai Wei Hao Wang Yan Sun Lan-Fang Zhang Jing Li Jian-Qiang Dong | 2007 | World Journal of Gastroenterology2007，13，14： | 35 |
| 4 | Millennial temperature reconstruction based on tree-ring widths of Qilian juniper from Wulan,Qinghai Province,China显示文摘The climate of the past 1000 years is an important context for evaluating the recent climate warming.However,there are few 1000-year-long climate reconstructions with annual resolution in the Qing-hai-Tibet Plateau.In this paper,a dendroclimatic analysis was conducted for the radial growth of Qilian juniper from the upper forest limit in Wulan,Qinghai Province.The results of correlation analysis between the tree-ring widths and the climate variables indicate that the growth of junipers at the upper forest limit is mainly limited by low temperatures of September,November and February of the pregrowth season,and July of the current growth season.There is no significant correlation between the tree-ring widths and precipitation.A mean temperature from the previous year's September to the current year's April was reconstructed for the Wulan area since A.D.1000.The reconstruction can explain 40.8% of the instrumental variance in the calibration period(1856―2002).The reconstruction shows that the 20th century is the warmest 100 years,and the 1990s is the warmest decade during the past 1000 years,while the coldest 100 years and decade occur at 1600―1699 and 1642―1651,respectively.The variations are verified well by the temperature reconstruction of the middle Qilian Mountain(QL) and the total organic carbon(TOC) in the Qinghai Lake sediments.The comparison of our reconstruction with the annual temperature reconstruction of extra-tropical Northern Hemisphere suggests that the climate of Wulan during the Medieval Warm Period is of obvious regional specialty,but there was a good response to the climate of hemispheric scales during the recent 400 years. | ZHU HaiFeng ZHENG YongHong SHAO XueMei LIU XiaoHong XU Yan LIANG ErYuan | 2008 | Chinese Science Bulletin2008，53，24： | 40 |
| 5 | Exotic origin of the Chinese continental shelf: new insights into the tectonic evolution of the western Pacific and eastern China since the Mesozoic显示文摘The effect of paleo-Pacific subduction on the geological evolution of the western Pacific and continental China is likely complex. Nevertheless, our analysis of the distribution of Mesozoic granitoids in the eastern continental China in space and time has led us to an interesting conclusion: The basement of the continental shelf beneath East and South China Seas may actually be of exotic origin geologically unrelated to the continental lithosphere of eastern China. By accepting the notion that the Jurassic–Cretaceous granitoids in the region are genetically associated with western Pacific subduction and the concept that subduction may cease to continue only if the trench is being jammed, then the termination of the granitoidmagmatism throughout the vast region at *88 ± 2 Ma manifests the likelihood of ‘‘sudden'', or shortly beforehand(*100 Ma), trench jam of the Mesozoic western Pacific subduction. Trench jam happens if the incoming‘‘plate'' or portion of the plate contains a sizeable mass that is too buoyant to subduct. The best candidate for such a buoyant and unsubductable mass is either an oceanic plateau or a micro-continent. We hypothesize that the basement of the Chinese continental shelf represents such an exotic, buoyant and unsubductable mass, rather than seaward extension of the continental lithosphere of eastern China. The locus of the jammed trench(i.e., the suture) is predictably located on the shelf in the vicinity of, and parallel to, the arc-curved coastal line of the southeast continental China. It is not straightforward to locate the locus in the northern section of the East China Sea shelf because of the more recent(\20 Ma) tectonic re-organization associated with the opening of the Sea of Japan. We predict that the trench jam at *100 Ma led to the re-orientation of the Pacific plate motion in the course of NNW direction as inferred from the age-progressive Emperor Seamount Chain of Hawaiian hotspot origin(its oldest unsubdued Meiji and Detroit seamounts are *82 Ma),making the boundary between the Pacific plate and the newly accreted plate of eastern Asia a transform fault at the location east of the continental shelf of exotic origin. This explains the apparent *40 Myr magmatic gap from *88to *50 Ma prior to present-day western Pacific subduction initiation. We propose that basement penetration drilling on well-chosen sites is needed to test the hypothesis in order to reveal the true nature of the Chinese continental shelf basement. This testing becomes critical and cannot longer be neglected in order to genuinely understand the tectonic evolution of the western Pacific and its effect on the geology of eastern China since the Mesozoic, includingthe cratonic lithosphere thinning, related magmatism/mineralization, and the mechanism of the subsequent South China Sea opening, while also offering novel perspectives on aspects of the plate tectonics theory. We also suggest the importance of future plate tectonic reconstruction of the western Pacific to consider the nature and histories of the Chinese continental shelf of exotic origin as well as the probable transform plate boundary from *100 to*50 Ma. Effort is needed to reveal the true nature and origin of the *88 ± 2 Ma granitic gneisses in Taiwan and the 110–88 Ma granitoids on the Hainan Island. | Yaoling Niu Yi Liu Qiqi Xue Fengli Shao Shuo Chen Meng Duan Pengyuan Guo Hongmei Gong Yan Hu Zhenxing Hu Juanjuan Kong Jiyong Li Jinju Liu Pu Sun Wenli Sun Lei Ye Yuanyuan Xiao Yu Zhang | 2015 | Science Bulletin2015，60，18： | 32 |
| 6 | A comprehensive classification method for VOC emission sources to tackle air pollution based on VOC species reactivity and emission amounts显示文摘In China, volatile organic compound(VOC) control directives have been continuously released and implemented for important sources and regions to tackle air pollution. The corresponding control requirements were based on VOC emission amounts(EA), but never considered the significant differentiation of VOC species in terms of atmospheric chemical reactivity. This will adversely influence the effect of VOC reduction on air quality improvement. Therefore,this study attempted to develop a comprehensive classification method for typical VOC sources in the Beijing–Tianjin–Hebei region(BTH), by combining the VOC emission amounts with the chemical reactivities of VOC species. Firstly, we obtained the VOC chemical profiles by measuring 5 key sources in the BTH region and referencing another 10 key sources, and estimated the ozone formation potential(OFP) per ton VOC emission for these sources by using the maximum incremental reactivity(MIR) index as the characteristic of source reactivity(SR). Then, we applied the data normalization method to respectively convert EA and SR to normalized EA(NEA) and normalized SR(NSR) for various sources in the BTH region.Finally, the control index(CI) was calculated, and these sources were further classified into four grades based on the normalized CI(NCI). The study results showed that in the BTH region,furniture coating, automobile coating, and road vehicles are characterized by high NCI and need to be given more attention; however, the petro-chemical industry, which was designated as an important control source by air quality managers, has a lower NCI. | Guohao Li Wei Wei Xia Shao Lei Nie Hailin Wang Xiao Yan Rui Zhang | 2018 | Journal of Environmental Sciences2018，30，5： | 32 |
| 7 | Artemisinin analogue SM934 ameliorates DSS- induced mouse ulcerative colitis via suppressing neutrophils and macrophages显示文摘 | Yu-xi YAN Mei-juan SHAO Qing QI Yan-sheng XU Xiao-qian YANG Feng-hua ZHU Shi-jun HE Pei-lan HE Chun-lan FENG Yan-wei WU Heng LI Wei TANG Jian-ping ZUO | 2018 | Acta Pharmacologica Sinica2018，39，10： | 32 |
| 8 | Modification mechanism of cerium on the Al-18Si alloy显示文摘在不同扔的状态下面的高级低共熔体的 Al-Si 合金上的稀土元素铈(Ce ) 的效果被光显微镜和量的图象分析学习了。尺寸和在铸造物的主要的硅的数量随 melt 的增加的 Ce 的增加减少,这被发现。好 facetted 形状的从分叉的形状的同时主要的硅变化。尽管在铸造物的最容易溶解的硅上的修正也随 melt 的增加的 Ce 的增加改善,离开主要的硅的最容易溶解的硅上的修正的效果在到主要的硅的最容易溶解的硅结束上是比那更明显的。修正机制借助于扫描详细被分析电子显微镜与精力装备了 X 光检查和热力学分析的散分析,它在反应和反应平衡的标准吉布斯精力在变化上包括了分析。 | ZHANG Henghua DUAN Haili SHAO Guangjie XU Luoping YIN Junlin YAN Biao | 2006 | Rare Metals2006，25，1： | 23 |
| 9 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 10 | Studies on mechanism of Sialy Lewis-X antigen in liver metastases of human colorectal carcinoma显示文摘INTRODUCTIONSialyl Lewis-X antigen ,correlated with carcinoma, is a group of carbohydrate antigen containing oligosaccharide expressed of embryonic tisue and glycoproteins on cell surface of embryonic tissue[1].The SLeX antigen located on cell surface is synthesized principally by two enzymes ,al ,3fucosyltransfrease and a2, 3sialyctransferase.In adults ,SLeX antigen is expressed principally on the surfaces of granulocytic cells and some tumor cells . | Xiao Wei Li~1 Yan Qing Ding~1 Jun Jie Cai~1 Shao Qing Yang~2 Lian Bing An~3 Dong Fang Qiao~3 ~1Department of Pathology,Nanfang Hospital of the First Military Medical University,Guangzhou 510515,Guangdong Province,China ~2The Northern Hospital of PLA,Shenyang 110015,Liaoning Province,China ~3Department of Electronmicroscopy,First Military Medical University,Guangzhou 510515,Gangdong Province,ChinaDr.Xiao Wei Li graduated from the First Military Medical University with a MM degree in 1999.Physician in Charge of pathology,having 6 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 19 |
| 11 | Application of an acrylic vessel supported by a stainless-steel truss for the JUNO central detector显示文摘在 Daya 海湾实验的成功以后, Jiangmen 地下的中微子天文台(Jupiter 之妻) 被发射测量中微子团层次和摆动参数并且学习另外的中微子物理。它的中央察觉者从反应堆,地球,空气,和阳光被放为反中微子。中央察觉者的主要要求是液体闪烁器的 20 kt 的抑制,作为目标团,和 3% 精力分辨率。它关于有它的内部表面上的 PMT 的 75% 范围的 38.5 m 的一个球形状察觉者。因为它必须为物理测量的几种不同类型满足要求并且在它的结构和工程拥有可行性和可靠性,如此的一个巨大的察觉者的设计是大挑战,都在合理时间和费用。为 JUNO 中央察觉者的一种选择是超丙烯酸的球在水里沉没了防护背景。这份报纸为如此的一个丙烯酸的球建议一个结构的计划那被支持由一不锈钢捆绑,在土木工程由支持点的眼镜窗帘墙启发了。计划的初步的设计被有限元素(FE ) 用 ABAQUS 完成并且验证方法。FE 分析证明计划能在 5 ~ 10 MPa 的限制以内控制丙烯酸的球的压力水平,根据中央察觉者的设计目的需求。计划具有突出的全球稳定性并且在本地连接上允许各种各样的选择。我们证明计划可行性好并且应该是为中央察觉者的一种合理选择。 | WANG Yuan Qing ZONG Liang HENG Yue Kun WANG Zong Yi ZHOU Yan HOU Shao Jing QIN Zhong Hua MA Xiao Yan | 2014 | Science China(Technological Sciences)2014，57，12： | 19 |
| 12 | MONOCULM 3,an Ortholog of WUSCHEL in Rice,Is Required for Tiller Bud Formation显示文摘WUSCHEL(WUS)plays an essential role for the maintenance of meristem activity in dicots,but its function is still elusive in monocots.We isolated a new monoculm mutant,monoculm 3(moc3),in which a point mutation causes the premature termination of rice O.sativa WUS(Os WUS).Morphological observation revealed that the formation of tiller buds was disrupted in moc3.MOC3 was localized in the nuclear and could interact with TOPLESS-RELATED PROTEINS(TPRs).The expression of MOC3 was induced by cytokinins and defection of MOC3 affected the expression of several two-component cytokinin response regulators,Os RRs and ORRs.Our results suggest that MOC3 is required for the formation of axillary buds and has a complex relationship with cytokinins. | Zefu Lu Gaoneng Shao Jinsong Xiong Yongqing Jiao Jing Wang Guifu Liu Xiangbing Meng Yan Liang Guosheng Xiong Yonghong Wang Jiayang Li | 2015 | Journal of Genetics and Genomics2015，42，2： | 17 |
| 13 | Characteristics of structural loess strength and preliminary framework for joint strength formula显示文摘The strength of structural loess consists of the shear strength and tensile strength. In this study, the stress path, the failure envelope of principal stress(fK line), and the strength failure envelope of structurally intact loess and remolded loess were analyzed through three kinds of tests: the tensile strength test, the uniaxial compressive strength test, and the conventional triaxial shear strength test. Then, in order to describe the tensile strength and shear strength of structural loess comprehensively and reasonably, a joint strength formula for structural loess was established. This formula comprehensively considers tensile and shear properties. Studies have shown that the tensile strength exhibits a decreasing trend with increasing water content. When the water content is constant, the tensile strength of the structurally intact soil is greater than that of remolded soil. In the studies, no loss of the originally cured cohesion in the structurally intact soil samples was observed, given that the soil samples did not experience loading disturbance during the uniaxial compressive strength test, meaning there is a high initial structural strength. The results of the conventional triaxial shear strength test show that the water content is correlated with the strength of the structural loess. When the water content is low, the structural properties are strong, and when the water content is high, the structural properties are weak, which means that the water content and the ambient pressure have significant effects on the stress-strain relationship of structural loess. The established joint strength formula of structural loess effectively avoids overestimating the role of soil tensile strength in the traditional theory of Mohr-Coulomb strength. | Rong-jian LI Jun-ding LIU Rui YAN Wen ZHENG Sheng-jun SHAO | 2014 | Water Science and Engineering2014，7，3： | 17 |
| 14 | A Deep Learning Approach for Fault Diagnosis of Induction Motors in Manufacturing显示文摘Extracting features from original signals is a key procedure for traditional fault diagnosis of induction motors, as it directly influences the performance of fault recognition. However, high quality features need expert knowledge and human intervention. In this paper,a deep learning approach based on deep belief networks(DBN) is developed to learn features from frequency distribution of vibration signals with the purpose of characterizing working status of induction motors. It combines feature extraction procedure with classification task together to achieve automated and intelligent fault diagnosis. The DBN model is built by stacking multiple-units of restricted Boltzmann machine(RBM), and is trained using layer-bylayer pre-training algorithm. Compared with traditional diagnostic approaches where feature extraction is needed,the presented approach has the ability of learning hierarchical representations, which are suitable for fault classification, directly from frequency distribution of the measurement data. The structure of the DBN model is investigated as the scale and depth of the DBN architecture directly affect its classification performance. Experimental study conducted on a machine fault simulator verifies the effectiveness of the deep learning approach for fault diagnosis of induction motors. This research proposes an intelligent diagnosis method for induction motor which utilizes deep learning model to automatically learn features from sensor data and realize working status recognition. | Si-Yu Shao Wen-Jun Sun Ru-Qiang Yan Peng Wang Robert X Gao | 2017 | Chinese Journal of Mechanical Engineering2017，30，6： | 17 |
| 15 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 16 | Recent advances in g-CN-based heterojunction photocatalysts显示文摘Semiconductor heterojunction photocatalysts have received much concern due to their great application prospect in solar energy utilization and conversion.Rational construction of heterostructure with two or more semiconductor materials can integrate the advantages of multi-components to simultaneously improve the photo-induced charges separation,extend visible light absorption range and retain the high redox ability of photocatalysts.Recently,constructing of g-C3 N4-based heterostructure has become a hot focus due to the multiple merits of g-C3 N4,such as facile synthesis,high stability,unique optical and electronic characteristics.This review tries to give a comprehensive introduction and provide the possible tendency in design and fabrication of g-C3 N4-based heterojunction photocatalysts,especially in rational synthesis of type-II heterojunction,direct Z-scheme heterojunction,new type of S-scheme heterojunction,p-n heterojunction and Schottky heterojunction.Furthermore,the special charges transfer mechanisms of g-C3 N4-based heterojunctions are discussed and their potential applications in photocatalytic water splitting,photo-degradation of contaminants and photo-reduction of CO2 into fuels are also summarized.Finally,we attempt to propose some crucial issues based on the current research,which should be further investigated and resolved in this interesting research area. | Yunfeng Li Minghua Zhou Bei Cheng Yan Shao | 2020 | Journal of Materials Science & Technology2020，56，21： | 16 |
| 17 | Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes:A Population-based Prospective Cohort Study of Inner Mongolians in China显示文摘This prospective study was designed to examine the combined influence of insulin resistance(IR)and inflammatory biomarker levels on type 2 diabetes mellitus(T2DM)among 1,903Inner Mongolians.During follow-up,205(10.77%)participants developed T2DM,and the incidence | QIU Qiao Yan ZHANG Bei Lei ZHANG Ming Zhi WU Jia Hui ZHOU Jing Wen LIANG Zhu ZHANG Yong Hong ZHANG Shao Yan | 2018 | Biomedical and Environmental Sciences2018，31，4： | 15 |
| 18 | Applications of urinary proteomics in biomarker discovery显示文摘Urine is an important source of biomarkers.This article reviews current advances,major challenges,and future prospects in the field of urinary proteomics.Because the practical clinical problem is to distinguish diseases with similar symptoms,merely comparing samples from patients of a particular disease to those of healthy individuals is inadequate for finding biomarkers with sufficient diagnostic power.In addition,the variation of expression levels of urinary proteins among healthy individuals and individuals under different physiological conditions adds to the difficulty in identifying biomarkers.We propose that establishing the natural variation in urinary protein expression among a healthy population can serve as a reference to help identify protein abundance changes that are caused by disease,not by individual variations or physiological changes.We also discuss that comparing protein expression levels between urine and plasma may reveal the physiological function of the kidney and that may facilitate biomarker discovery.Finally,we propose that establishing a data-sharing platform for data collection and integrating results from all urinary biomarker studies will help promote the development of urinary proteomics. | SHAO Chen WANG Yan GAO YouHe | 2011 | Science China(Life Sciences)2011，54，5： | 15 |
| 19 | Tiller Bud Formation Regulators MOC1 and MOC3 Cooperatively Promote Tiller Bud Outgrowth by Activating F0N1 Expression in Rice显示文摘Tillering in rice is one of the most important agronomic traits.Rice tiller development can be divided into two main processes: the formation of the axillary bud and its subsequent outgrowth.Several genes critical for bud formation in rice have been identified by genetic studies;however,their molecular functions and relationships are still largely unknown.Here,we report that MONOCULM 1 (MOC1) and MONOCULM 3/ TILLERS ABSENT 1/STERILE AND REDUCED TILLERING 1 (MOC3/TAB1/SRT1),two vital regulators for tiller formation in rice,physically interact to regulate tiller bud outgrowth through upregulating the expression of FLORAL ORGAN NUMBER 1 (FON1),the homolog of CLAVATA1 in rice.We found that M0C3 is able to directly bind the promoter ofFONI and subsequently activate FON1 expression.MOC1 functions as a coactivator of MOC3,whereas it could not directly bind the FON1 promoter,and further activated FON1 expression in the presence of MOC3.Accordingly,FON1 is highly expressed at axillary meristems and shows remarkably decreased expression levels in mod and moc3 mutants.Loss-of-function mutants of FON1 exhibit normal bud formation but defective bud outgrowth and reduced tiller number.Collectively,these results shed light on a joint transcriptional regulatory mechanim by MOC1 and MOC3,and establish a new framework for the control of tiller bud formation and outgrowth. | Gaoneng Shao Zefu Lu Jinsong Xiong Bing Wang Yanhui Jing Xiangbing Meng Guifu Liu Haiyan Ma Yan Liang Fan Chen Yonghong Wang Jiayang Li Hong Yu | 2019 | Molecular Plant2019，12，8： | 15 |
| 20 | Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload显示文摘Abnormally increased levels of iron in the brain trigger cascade amplification in Alzheimer's disease patients,resulting in neuronal death.This study investigated whether components extracted from the Chinese herbs epimedium herb,milkvetch root and kudzuvine root could relieve the abnormal expression of iron metabolism-related protein in Alzheimer's disease patients.An APPswe/PS1ΔE9 double transgenic mouse model of Alzheimer's disease was used.The intragastric administration of compounds from epimedium herb,milkvetch root and kudzuvine root improved pathological alterations such as neuronal edema,increased the number of neurons,downregulated divalent metal transporter 1 expression,upregulated ferroportin 1 expression,and inhibited iron overload in the cerebral cortex of mice with Alzheimer's disease.These compounds reduced iron overload-induced impairment of the central nervous system,indicating a new strategy for developing novel drugs for the treatment of Alzheimer's disease. | Xian-hui Dong Jiang-tao Bai Wei-na Kong Xiao-ping He Peng Yan Tie-mei Shao Wen-guo Yu Xi-qing Chai Yan-hua Wu Cong Liu | 2015 | Neural Regeneration Research2015，10，5： | 14 |
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