|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dynamic changes in blood cytokine levels as clinical indicators in severe acute respiratory syndrome显示文摘Objective To investigate the dynamic changes observed in serum levels of interleukins (ILs), tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) in severe acute respiratory syndrome (SARS) patients.Methods Sixty-one cases of SARS with positive antibodies to SARS coronavirus (SARS-CoV) were classified into the following categories: initial stage (3-7 days), peak stage (8-14 days), and remission and recovery stage (15-27 days). Forty-four healthy individuals were used as controls. Serum levels of ILs, TNF-α and TGF-β1 were measured in all subjects. Serum antibodies to SARS-CoV were detected only in SARS cases. Results The mean concentration of serum IL-6 in SARS patients did not differ from that in the control group in initial and peak stages, but became significantly higher in remission and recovery stage compared with the control group, initial and peak stages (P<0.01). The mean concentration of serum IL-8 in SARS patients did not differ from that of the control group in initial stage, but was significantly higher than control group in peak stage and remission and recovery stage (P<0.05). And it was more significantly higher in remission and recovery stage than in peak stage (P<0.01). The mean concentrations of IL-16 and TNF-α in SARS patients were higher than those of the control group for every length of the clinical courses investigated, and were especially high in remission and recovery stage (P<0.01). SARS patients experienced higher concentration of serum IL-13 compared with the controls in initial stage (P<0.01), but returned to normal levels in peak stage and in remission and recovery stage. The mean concentration of serum IL-18 in SARS patients was significantly lower than that of the control group during all clinical courses (P<0.05). The mean concentration of serum TGF-β1 in SARS patients was higher than that of the control group during all clinical courses. Although TGF-β1 in serum decreased in remission and recovery stage in SARS patients, the average was still higher than that of the control group (P<0.01).Conclusions Most proinflammatory cytokines and TGF-β1 were elevated during the early phase of SARS, which may be associated with lung infiltration and proliferation. Concurrently, the mean concentration of serum IL-13 decreased gradually, and the mean concentration of serum IL-18 level in SARS patients was lower than that of the control group during all the courses of SARS, suggesting that the immune state of the patients with SARS was obviously abnormal. Observing the dynamic changes in blood cytokine levels can provide a scientific basis to assess pathogenesis and efficacy of clinical treatment of SARS. | PangBS WangZ ZhangLM TongZH XuLL HuangXX GuoWJ ZhuM WangC LiXW HeZP LiHX ZhaoFJ | 2003 | Chinese Medical Journal2003，，9： | 12 |
| 2 | TWO MODIFICATORY K-ε TURBULENCE MODELS FOR TURBULENT SWIRLING FLOWS显示文摘Since the standard K ε model used to predict the strongly swirling flow leads to a large deviation from experimental results, it is necessary to introduce modification to the standard K ε model. Based on the algebraic Reynolds stress model and Bradshaw’s turbulent length scale modification conception, we present two modified K ε models. To investigate the behaviour of the modified turbulence models, they are used to predict two representative turbulent swirling flows. The computational results, after compared with the experimental data, show that the modified K ε models substantially improve the prediction of the standard K ε model for the turbulent swirling flows. | WangZe LiuWei-ming | 2003 | Journal of Hydrodynamics2003，15，2： | 11 |
| 3 | Piezoelectric nanogenerators based on zinc oxide nanowire arrays显示文摘 | WangZ L Song J H | 2006 | Science2006，312，5771： | 1 |
| 4 | Production of hydrogen from catalytic steam reforming of bio-oil using C12A17-O-based catalysts显示文摘 | WANGZ PANY DONGT ZHUX KANT YUANL TORIMOTOY SADAKATAM LIQ | 2007 | Appl Catal A2007，320，： | 1 |
| 5 | Atest of the generality of leaf trait relationships on the Tibetan Plateau 显示文摘 | HE JS WANGZ H WANGXP | 2006 | New Phytologist2006，170，4： | 1 |
| 6 | MicroRNA -451 func- tions as a tumor suppressor in human non - small cell hlng cancer by targeting ras - related protein 14 (RAB14) 显示文摘 | WANG R WANGZ X YANGJ S | 2011 | Oncogene2011，30，23： | 1 |
| 7 | 显示文摘 | 王泽(Wangz) 林伟刚(LinWG) 宋文立(SongwL) 姚建中(YaoJZ) 鲁长波(LuCB) 都林(DuL) | | 化学进展0，，： | 1 |
| 8 | MicroRNAsandatrialfibrillation:new fundamentals显示文摘 | WangZ LuY YangB | 2011 | Cardiovasc Res2011，89，4： | 1 |
| 9 | Distribution and plant avail-ability of heavy metals in different particle -size fractions of soil显示文摘 | Qian J Shan X Q WangZ | 1996 | Science of the Total Environment1996，187，2： | 1 |
| 10 | MappingChina’ s mangroves based on an object-oriented classification of Landsatimagery显示文摘 | JIAM WANGZ LIL SONGK RENC LIUB MAO D | 2013 | Wetlands2013，34，2： | 1 |
| 11 | Anti-inflammatorymechanismofω-3Polyunsaturatedfattyacids[J]显示文摘 | FUZM WANGZ | | 医药导报0，，： | 1 |
| 12 | Correlation of Electronic' Structures and Crystal Structures with Photocatalystic Properties of Undoped, N-Doped and l-Doped TiO2 显示文摘 | Long M C CaiW M WangZ P | 2006 | Journal of Chemistry and Physics Letters2006，，420： | 1 |
| 13 | 查看详情显示文摘 | Wang W N Ma X X Wu Q H Wang C Zang X H WangZ | | 0，，17： | 1 |
| 14 | GeneralizedspatialGgradientGbaseddigitalimagecorrelationfordisGplacementandshapemeasGurementwithsubpixelaccuracy显示文摘 | PanB WangZ XieH | 2009 | JournalofStrainAnalyGsisforEngineeringDesign2009，44，8： | 1 |
| 15 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
| 16 | An Approach to multiattribute decision making with interval-valued intuitionistie fuzzy assessments and ineomplete weights显示文摘 | Wangz J Li K W Wang W Z | 2009 | Information Science2009，179，17： | 1 |
| 17 | Foxm1 mediatesresistancetoherceptinandpaclitaxel显示文摘 | CarrJR Park HJ WangZ etal | 2010 | CancerRes2010，70，12： | 1 |
| 18 | Rapamycin inhibits pre-B acute lymphoblastic leukemia cells by downregulating DNA and RNA polymerases显示文摘 | WangZ XuF YuanN | 2014 | Leuk Res2014，8，8： | 1 |
| 19 | A novel time domain current detection algorithm for shunt active power filters显示文摘 | LIHY ZHUO F WANGZ A | 2005 | IEEE Trans on Power Syst2005，20，2： | 1 |
| 20 | 查看详情显示文摘 | QianS WangZ LeeY | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员