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| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | mm Wave communications for 5G: implementation challenges and advances显示文摘The requirement of the fifth generation(5 G) wireless communication for high throughput motivates the wireless industry to use the mm Wave(millimeter wave) communications for its wide bandwidth advantage. To compensate the heavy path loss and increase the communications capacity, phased array beamforming and massive multiple-input multiple-output(MIMO) techniques are employed at both the user equipment(UE) and base stations(BS). Considering the commercial requirements, 5 G mm Wave large array systems should be implemented in an energy-and cost-efficient way with a small form factor. To address above issues and realize a reliable communications link, taking into account the particular characteristics of5 G mm Wave systems, this paper firstly examines the design challenges and trade-offs in system implementations, then some of the design strategies are summarized. At last, recent advance in RF front-end circuits and receiver sub-systems is then highlighted. | Lianming LI Dongming WANG Xiaokang NIU Yuan CHAI Linhui CHEN Long HE Xu WU Fuchun ZHENG Tiejun CUI Xiaohu YOU | 2018 | Science China(Information Sciences)2018，61，2： | 19 |
| 3 | Controlled synthesis of single cobalt atom catalysts via a facile one-pot pyrolysis for efficient oxygen reduction and hydrogen evolution reactions显示文摘Metal-nitrogen doped carbon catalysts(M-N/C) with abundantly accessible M-Nxsites, particularly single metal atom M-N/C(SAM-N/C), have been developed as a substitute for expensive Pt-based catalysts.These catalysts are used to increase the efficiency of otherwise sluggish oxygen reduction reactions(ORR) and hydrogen evolution reactions(HER). However, although the agglomerated metal nanoparticles are usually easy to form, they are very difficult to remove due to the protective surface-coating carbon layers, a factor that significantly hampers SAM-N/C fabrication. Herein, we report a one-step pyrolysis approach to successfully fabricate single cobalt atom Co-N/C(SACo-N/C) by using a Co2+-SCN-coordination compound as the metal precursor. Thanks to the decomposition of Co2+-SCN-compound at lower temperature than that of carbon layer deposition, Co-rich particles grow up to larger ones before carbon layers formation. Even though encapsulated by the carbon layers, it is difficult for the large Co-rich particle to be completely sealed. And thus, it makes the Co atoms possible to escape from incomplete carbon layer, to coordinate with nitrogen atoms, and to form SACo-N/C catalysts. This SACo-N/C exhibits excellent performances for both ORR(half-wave potential of 0.878 V) and HER(overpotential at 10 mA/cm2 of178 m V), and is thus a potential replacement for Pt-based catalysts. When SACo-N/C is integrated into a Zn-O2 battery, battery with high open-circuit voltage(1.536 V) has high peak power density(266 mW/cm2)and large gravimetric energy density(755 mA h/gZn) at current densities of 100 mA/cm2. Thus, we believe that this strategy may offer a new direction for the effective generation of SAM-N/C catalysts. | Yao Wang Linhui Chen Zhanxin Mao Lishan Peng Rui Xiang Xianyi Tang Jianghai Deng Zidong Wei Qiang Liao | 2019 | Science Bulletin2019，64，15： | 10 |
| 4 | Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death显示文摘 | Lifeng Yuan Linhui Zhai Lili Qian De Huang Yi Ding Handan Xiang Xiaojing Liu J. Will Thompson Juan Liu Yong-Han He Xiao-Qiong Chen Jing Hu Qing-Peng Kong Minjia Tan Xiao-Fan Wang | 2018 | Cell Research2018，28，6： | 7 |
| 5 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 6 | Stable Carbon Isotopic Compositions of Methylated-MTTC in Crude Oils from Saline Lacustrine Depositional Environment:Source Implications显示文摘显著地高的丰富的 methyl-MethylTrimethylTridecylChromans (MTTC ) 从 Jizhong 消沉和 Jianghan 盆在原油在芳香的烃部分被检测了。这些混合物的分发被 methyl-MTTC 和 dimethyl-MTTC 系列统治,它在早阶段显示亢奋的盐的 depositional 环境的 diagenetic 产品并且显示出 methylation 的低度。显著地高的丰富的 methyl-MTTC 的出现主要取决于好保藏条件与一强烈减少,亢奋盐并且水列 depositional 环境和随后的非集中的 diagenetic 转变。稳定的碳在二件样品的 methyl-MTTCs 和 dimethyl-MTTCs 的同位素的作文与稳定的碳远不同 C_(30 ) 的同位素的作文惊讶明显的细菌生物的续生说的格子(多达 4.11 ‰和 5.75 ‰,分别地) 。这显然证明 methyl-MTTC 和 dimethyl-MTTCs 不能具有细菌起源,它与关于非光合的细菌产品或可能的重做细菌的产品的以前的观点不同。相反,稳定的碳在二件样品的 methyl-MTTC 和 dimethyl-MTTCs 的同位素的作文类似于一样的标记碳的 n 链烷的(显示他们分享一样的来源起源的 nC_(27 )-nC_(28)-nC(29)), 。特别在从 Zhao61 好、稳定的碳的原油,同位素的作文也类似于有 aaa-20R 异构体的一样的标记碳的 steranes 的(主要不到 0.4 ‰) 。在盐的湖上的以前的研究的结果的考虑生态的沉积,作者认为在盐的湖沉积的 methyl-MTTC 和 dimethyl-MTTCs 应该具有海藻的生物的续生说起源。 | LU Hong HOU Linhui CHEN Tengshui PENG Ping' an SHENG Guoying | 2007 | Acta Geologica Sinica(English Edition)2007，81，6： | 3 |
| 7 | Primary User Adversarial Attacks on Deep Learning-Based Spectrum Sensing and the Defense Method显示文摘The spectrum sensing model based on deep learning has achieved satisfying detection per-formence,but its robustness has not been verified.In this paper,we propose primary user adversarial attack(PUAA)to verify the robustness of the deep learning based spectrum sensing model.PUAA adds a care-fully manufactured perturbation to the benign primary user signal,which greatly reduces the probability of detection of the spectrum sensing model.We design three PUAA methods in black box scenario.In or-der to defend against PUAA,we propose a defense method based on autoencoder named DeepFilter.We apply the long short-term memory network and the convolutional neural network together to DeepFilter,so that it can extract the temporal and local features of the input signal at the same time to achieve effective defense.Extensive experiments are conducted to eval-uate the attack effect of the designed PUAA method and the defense effect of DeepFilter.Results show that the three PUAA methods designed can greatly reduce the probability of detection of the deep learning-based spectrum sensing model.In addition,the experimen-tal results of the defense effect of DeepFilter show that DeepFilter can effectively defend against PUAA with-out affecting the detection performance of the model. | Shilian Zheng Linhui Ye Xuanye Wang Jinyin Chen Huaji Zhou Caiyi Lou Zhijin Zhao Xiaoniu Yang | 2021 | China Communications2021，18，12： | 3 |
| 8 | Design of 60GHz RF Transceiver in CMOS:Challenges and Recent Advances显示文摘With more than 40 years Moore scaling, the speed of CMOS transistors is around 100 GHz. Such fact makes it possible to realize mm-wave circuits in CMOS. However, with the target of achieving broadband and power-efficient operation, 60 GHz CMOS RF transceiver faces severe challenges. After reviewing the technology issues, regarding the 60 GHz applications, this paper discusses design challenges both from the system and the building block levels, and also presents some simulated or measured circuits results. | LI Lianming NIU Xiaokang CHEN Linhui CHAI Yuan ZHANG Tao SHI Jun WANG Aili LUO Ying HE Long CHENG Depeng LIU Nan CUI Tiejun YOU Xiaohu | 2014 | China Communications2014，11，6： | 2 |
| 9 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 10 | An Optimizable Circuit Structure for High-Efficiency Wireless Power Transfer显示文摘 | Chen Linhui Liu Shuo Zhou Yongchun | 2013 | IEEE Transactions on Industrial Electronics2013，60，1： | 1 |
| 11 | Effects of Zr content on electrochemical performance of Ti/Sn-Ru-Co-ZrO_(x)electrodes显示文摘The low cell voltage during electrolytic Mn from the MnCl_(2) system can effectively reduce the power consumption.In this work,the Ti/Sn−Ru−Co−Zr modified anodes were obtained by using thermal decomposition oxidation.The physical parameters of coatings were observed by SEM(scanning electron microscope).Based on the electrochemical performance and SEM/XRD(X-ray diffraction)of the coatings,the influence of Zr on electrode performance was studied and analyzed.When the mole ratio of Sn−Ru−Co−Zr is 6:1:0.8:0.3,the cracks on the surface of coatings were the smallest,and the compactness was the best due to the excellent filling effect of ZrO_(2)nanoparticles.Moreover,the electrode prepared under this condition had the lowest mass transfer resistance and high chloride evolution activity in the 1mol%NH_(4)Cl and 1.5mol%HCl system.The service life of 3102 h was achieved according to the empirical formula of accelerated-life-test of the new type anode. | Linhui Chang Sheng Chen Xionghui Xie Buming Chen Haihong Qiao Hui Huang Zhongcheng Guo Ruidong Xu | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，12： | 1 |
| 12 | Maternal genetic history of ancient Tibetans over the past 4000 years显示文摘The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity.Here,we reconstruct a 4000-year maternal genetic history of Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet.The phylogeny of haplotypes M9a1a,M9a1b,D4g2,G2a’c,and D4i show that ancient Tibetans share the most recent common ancestor with ancient Middle and Upper Yellow River populations around the Early and Middle Holocene.In addition,the connections between Tibetans and Northeastern Asians vary over the past 4000 years,with a stronger matrilineal connection between the two during 4000 BPe3000 BP,and a weakened connection after 3000 BP,that are coincident with climate change,followed by a reinforced connection after the Tubo period(1400 BPe1100 BP).Besides,an over 4000-year matrilineal continuity is observed in some of the maternal lineages.We also find the maternal genetic structure of ancient Tibetans is correlated to the geography and interactions between ancient Tibetans and ancient Nepal and Pakistan populations.Overall,the maternal genetic history of Tibetans can be characterized as a long-term matrilineal continuity with frequent internal and external population interactions that are dynamically shaped by geography,climate changes,as well as historical events. | Ganyu Zhang Can Cui Shargan Wangdue Hongliang Lu Honghai Chen Lin Xi Wei He Haibing Yuan Tinley Tsring Zujun Chen Feng Yang Tashi Tsering Shuai Li Norbu Tashi Tsho Yang Yan Tong Xiaohong Wu Linhui Li Yuanhong He Peng Cao Qingyan Dai Feng Liu Xiaotian Feng Tianyi Wang Ruowei Yang Wanjing Ping Ming Zhang Xing Gao Yichen Liu Wenjun Wang Qiaomei Fu | 2023 | Journal of Genetics and Genomics2023，50，10： | 1 |
| 13 | An optimizable circuit structure for high-effi- ciency wireless power transfer显示文摘 | Chen Linhui | 2013 | IEEE Transactions on Industri- al Electronics2013，60，1： | 1 |
| 14 | Variation of peroxidase isoenzyme and biofilm of Phanerochaete chrysosporium in continuous membrane bioreactor for Reactive Brilliant Red X3-B treatment显示文摘The inuence of a Reactive Brilliant Red X-3B (RBR X-3B) dye on the peroxidase isoenzyme of Phanerochaete chrysosporium was determined, and the biofilm structure in a white rot fungal continuous membrane bioreactor (MBR) was also investigated by scanning electron microscope (SEM). The variation of peroxidase isoenzyme and the decolorization rate in the continuous MBR were evaluated. The results showed that the 100 mg/L RBR X-3B could stimulate the production of the peroxidase isoenzyme in the shaking-ask culture. In addition, two new peroxidase isoenzyme bands with relative mobility (Rf) value of 0.27 and 0.28 appeared, but the activity was lower than the blank control of 11 d. In the continuous MBR, the system worked stably during the first 60 d, the main peroxidase isoenzyme bands existed and three new bands with Rf value of 0.10, 0.27, and 0.28 appeared. Meanwhile, the biofilm grew well and the average decolorization rate could reach 90.6%. But the bands of peroxidase isoenzyme decreased rapidly at day 65, only two bands with Rf value 0.24 and 0.26 existed, and the decolorization rate decreased to 78.3%. Therefore, 5 bottles of P. chrysosporium mycelial pellet were added into the MBR, and then the activity of the peroxidase isoenzyme and the decolorization rate had a slight recovery. Finally, the decolorization rate finally decreased to 75.2%. These results contribute to a comprehensive understanding of the variation of peroxidase isoenzyme and biofilm in continuous MBR by white rot fungi. | GAO Shang, CHEN Cheng, TAO Fang, HUANG Minsheng, MA Lihua, WANG Zhonghua, WU Linhui School of Resource and Environment Science, East China Normal University, Shanghai 200062, China. | 2009 | Journal of Environmental Sciences2009，21，7： | 1 |
| 15 | Silencing of CXCR4 by RNA interference inhibits cell growth and metastasisin human renal cancer cells显示文摘 | Linhui Wang Ting Huang Wei Chen Xiaofeng Gao Tie Zhou Zhenjie Wu Yinghao Sun | 2012 | Oncology Reports2012，，6： | 1 |
| 16 | MicroRNA-26a acts as a tumor suppressor inhibiting gallbladder cancercell proliferation by directly targeting HMGA2显示文摘 | Huading Zhou Weijie Guo Yingjun Zhao Yifei Wang Ruopeng Zha Jie Ding Linhui Liang Jun Hu Hao Shen Zongyou Chen Baobing Yin Baojin Ma | 2014 | International Journal of Oncology2014，，6： | 1 |
| 17 | An optimisable circuit structure for high-efficiency wireless power transfer显示文摘 | Linhui Chen Shuo Liu Yongchun Zhou | 2013 | IEEE Transactions on Industrial Electronics2013，60，1： | 1 |
| 18 | The path to 5G:mmWave aspects显示文摘The wide spectrum and propagation characteristics over the air give mmWave communication unique advantages as well as design challenges for 5G applications.To increase the system speed,capacity,and coverage,there is a need for innovation in the RF system architecture,circuit,antenna,and package in terms of implementation opportunities and constraints.The discuss mmWave spectrum characteristics,circuits,RF system architecture,and their implementation issues are discussed.Moreover,the transmitter key components,i.e.,the receiver,antenna,and packaging are reviewed. | LI Lianming NIU Xiaokang CHAI Yuan CHEN Linhui ZHANG Tao CHENG Depeng XIA Haiyang WANG Jiangzhou CUI Tiejun YOU Xiaohu | 2016 | Journal of Communications and Information Networks2016，1，2： | 1 |
| 19 | Analysis of HK-2 cells exposed to oxalate and calcium oxalate crystals: proteomic insights into the molecular mechanisms of renal injury and stone formation显示文摘 | Shushang Chen Xiaofeng Gao Yinghao Sun Chuanliang Xu Linhui Wang Tie Zhou | 2010 | Urological Research2010，，1： | 1 |
| 20 | An optimizable circuit structure for high-efficiency wireless power transfer显示文摘 | Chen Linhui Liu Shuo Zhou Yongchun | 2013 | IEEE Transactions on Industrial Electronics2013，60，1： | 1 |
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