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| 1 | Immune-mediated bile duct injury:The case of primary biliary cirrhosis显示文摘Autoimmune cholangitis would be the appropriate name to define the immune-mediated bile duct injury following the breakdown of tolerance to mitochondrial proteins and the appearance of serum autoantibodies and autoreactive T cells.Nevertheless,the conditionis universally named primary biliary cirrhosis(PBC).The disease etiology and pathogenesis remain largely unknown despite the proposed lines of evidence.One twin study and numerous epidemiology reportssuggest that both a susceptible genetic background and environmental factors determine disease onsetwhile a recent genome-wide association study proposed highly significant associations with several commongenetic polymorphisms in subgroups of patients.Specific infectious agents and chemicals may contribute to the disease onset and perpetuation in a geneticallysusceptible host,possibly through molecular mimicry.Importantly,several murine models have been proposed and include strains in which PBC is genetically determined or induced by immunization with chemicals and bacteria.From a pathogenetic standpoint,new exciting data have demonstrated the unique apoptotic features of bile duct cells that allow the mitochondrial autoantigens to be taken up in their intact form within apoptotic blebs.We are convinced that the application of the most recent molecular techniques will soon pro-vide developments in PBC etiology and pathogenesis with likely implications in diagnostics and therapeutics. | Carlo Selmi Andrea Affronti Laura Ferrari Pietro Invernizzi | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，4： | 6 |
| 2 | Are capecitabine and oxaliplatin (XELOX) suitable treatments for progressing low-grade and high-grade neuroendocrine tumours?显示文摘 | Emilio Bajetta Laura Catena Giuseppe Procopio Sara Dosso Ettore Bichisao Leonardo Ferrari Antonia Martinetti Marco Platania Elena Verzoni Barbara Formisano Roberto Bajetta | 2007 | Cancer Chemotherapy and Pharmacology2007，，： | 2 |
| 3 | Fetal DNA detection in maternal plasma throughout gestation显示文摘 | Silvia Galbiati Maddalena Smid Dania Gambini Augusto Ferrari Gabriella Restagno Elsa Viora Mario Campogrande Simona Bastonero Marco Pagliano Stefano Calza Maurizio Ferrari Laura Cremonesi | 2005 | Human Genetics (-)2005，，2： | 2 |
| 4 | Antibacterial,pro-angiogenic and pro-osteointegrative zein-bioactive glass/copper based coatings for implantable stainless steel aimed at bone healing显示文摘Stainless steel implants are suitable candidates for bone replacement due to their cytocompatibility and mechanical resistance,but they suffer from lack of bioactivity and are prone to bacterial infections.Accordingly,to overcome those limitations,in this study we developed by electrophoretic deposition(EPD),an innovative surface coating made of(i)zein,a natural fibroblast-friendly polymer,(ii)bioactive glass,a pro-osteogenic inorganic material and(iii)copper containing bioactive glass,an antibacterial and pro-angiogenic material.FESEM images confirmed that porous,uniform and free of cracks coatings were obtained by EPD;moreover,coatings were resistant to mechanical stress as demonstrated by the tape test,resulting in a 4B classification of adhesion to the substrate.The coatings were cytocompatible as indicated by metabolism evaluation of human fibroblasts,endothelial cells and mature or progenitor osteoblasts cultivated in direct contact with the specimens.They also maintained pro-osteogenic properties towards undifferentiated progenitor cells that expressed osteogenic genes after 15 days of direct cultivation.Copper conferred antibacterial properties as biofilm formation of the joint pathogens Staphylococcus aureus,Staphylococcus epidermidis and Escherichia coli was significantly reduced in comparison with copper-free coatings(p<0.05).Moreover,this anti-infective activity resulted as targeted towards bacteria while the cells viability was preserved when cells and bacteria were cultivated in the same environment by a co-culture assay.Finally,copper ability to recruit blood vessels and to inhibit bacterial infection was confirmed in vivo where the growth of S.aureus biofilm was inhibited and the formation of new(<50μm diameter spread)blood vessels was observed. | Laura Ramos Rivera Andrea Cochis Sarah Biser Elena Canciani Sara Ferraris Lia Rimondini Aldo R.Boccaccini | 2021 | Bioactive Materials2021，6，5： | 2 |
| 5 | Role of molecular imaging in the management of patients affected by inflammatory bowel disease:State-of-the-art显示文摘AIM To present the current state-of-the art of molecular imaging in the management of patients affected by inflammatory bowel disease(IBD).METHODS A systematic review of the literature was performed in order to find important original articles on the role of molecular imaging in the management of patients affected by IBD. The search was updated until February 2016 and limited to articles in English.RESULTS Fifty-five original articles were included in this review, highlighting the role of single photon emission tomography and positron emission tomography. CONCLUSION To date, molecular imaging represents a useful tool to detect active disease in IBD. However, the available data need to be validated in prospective multicenter studies on larger patient samples. | Federico Caobelli Laura Evangelista Natale Quartuccio Demetrio Familiari Corinna Altini Angelo Castello Mariapaola Cucinotta Rossella Di Dato Cristina Ferrari Aurora Kokomani Iashar Laghai Riccardo Laudicella Silvia Migliari Federica Orsini Salvatore Antonio Pignata Cristina Popescu Erinda Puta Martina Ricci Silvia Seghezzi Alessandro Sindoni Martina Sollini Letterio Sturiale Anna Svyridenka Vittoria Vergura Pierpaolo Alongi | 2016 | World Journal of Radiology2016，8，10： | 1 |
| 6 | Oxaliplapin and Capecitabine (XELOX) Based Chemotherapy in the Treatment of Metastatic Colorectal Cancer: The Right Choice in Elderly Patients显示文摘 | Massimiliano Berretta Giuseppe Aprile Guglielmo Nasti Martina Urbani Alessandra Bearz Stefania Lutrino Luisa Foltran Laura Ferrari Renato Talamini Francesco Fiorica Arben Lleshi Vincenzo Canzonieri Chiara Lestuzzi Eugenio Borsatti Rossella Fisichella Umbe | 2013 | Anti-Cancer Agents in Medicinal Chemistry2013，，9： | 1 |
| 7 | Study of potential toxic effects on rainbow trout hepatocytes of surface water treated with chlorine or alternative disinfectants显示文摘 | Michela Ferraris Enzo Chiesara Sonia Radice Anita Giovara Silvia Frigerio Roberta Fumagalli Laura Marabini | 2004 | Chemosphere2004，，1： | 1 |
| 8 | Apoptosis of Endothelial Cells Precedes Myocyte Cell Apoptosis in Ischemia/Reperfusion Injury显示文摘 | Tiziano Scarabelli Anastasis Stephanou Neil Rayment Evasio Pasini Laura Comini Salvatore Curello Roberto Ferrari Richard Knight David Latchman | 2001 | Circulation: Journal of the American Heart Association2001，，3： | 1 |
| 9 | Treatment of mild non-chemotherapy-induced iron deficiency anemia in cancer patients: Comparison between oral ferrous bisglycinate chelate and ferrous sulfate显示文摘 | Paola Ferrari Andrea Nicolini Maria Laura Manca Giuseppe Rossi Loretta Anselmi Massimo Conte Angelo Carpi Ferruccio Bonino | 2012 | Biomedicine & Pharmacotherapy2012，，6： | 1 |
| 10 | Vinorelbine: An active, non cross-resistant drug in advanced breast cancer. Results from a phase II study显示文摘 | Monica Terenziani Romano Demicheli Cristina Brambilla Laura Ferrari Angela Moliterni Milvia Zambetti Augusto Caraceni Cinzia Martini Gianni Bonadonna | 1996 | Breast Cancer Research and Treatment1996，，3： | 1 |
| 11 | Usefulness of single-balloon enteroscopy in pediatric Crohn’s disease显示文摘 | Giovanni Di Nardo Salvatore Oliva Marina Aloi Paolo Rossi Emanuele Casciani Gabriele Masselli Federica Ferrari Saverio Mallardo Laura Stronati Salvatore Cucchiara | 2012 | Gastrointestinal Endoscopy2012，，1： | 1 |
| 12 | Vinorelbine: An active, non cross-resistant drug in advanced breast cancer. Results from a phase II study显示文摘 | Monica Terenziani Romano Demicheli Cristina Brambilla Laura Ferrari Angela Moliterni Milvia Zambetti Augusto Caraceni Cinzia Martini Gianni Bonadonna | 1996 | Breast Cancer Research and Treatment1996，，3： | 1 |
| 13 | Circulating plasma DNA as diagnostic biomarker in non-small cell lung cancer显示文摘 | Massimiliano Paci Sally Maramotti Enrica Bellesia Debora Formisano Laura Albertazzi Tommaso Ricchetti Guglielmo Ferrari Valerio Annessi Daniela Lasagni Cristiano Carbonelli Salvatore De Franco Maria Brini Giorgio Sgarbi Renzo Lodi | 2008 | Lung Cancer2008，，1： | 1 |
| 14 | Evidence-based appraisal of the upfront treatment for unresectable metastatic colorectal cancer patients显示文摘Colorectal cancer(CRC)is a significant health problem,with around 1 million new cases and 500000 deaths every year worldwide.Over the last two decades,the use of novel therapies and more complex treatment strategies have contributed to progressively increase the median survival of patients with unresectable advanced CRC up to approximately 30 mo.The availability of additional therapeutic options,however,has created new challenges and generated more complicated treatment algorithms.Moreover,several clinically important points are still in debate in first-line,such as the optimal treatment intensity,the most appropriate maintenance strategy,the preferred biologic to be used upfront in patients with KRAS wild-type CRC,and the need for more detailed information on tumor biology.In this moving landscape,this review analyses why the firstline treatment decision is crucial and how the choicemay impact on further treatment lines.In addition,it focuses on results of major phaseⅢrandomized trials. | Giuseppe Aprile Stefania Eufemia Lutrino Laura Ferrari Mariaelena Casagrande Marta Bonotto Elena Ongaro Fabio Puglisi | 2013 | World Journal of Gastroenterology2013，19，46： | 0 |
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