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| 1 | Total mesorectal excision for mid and low rectal cancer: laparoscopic vs robotic surgery显示文摘AIM: To compare the short- and long-term outcomes of laparoscopic and robotic surgery for middle and low rectal cancer.METHODS: This is a retrospective study on a prospectively collected database containing 111 patients who underwent minimally invasive rectal resection with total mesorectal excision(TME) with curative intent between January 2008 and December 2014(robot, n = 53; laparoscopy, n = 58). The patients all had a diagnosis of middle and low rectal adenocarcinoma with stage?Ⅰ-Ⅲ disease. The median follow-up period was 37.4 mo. Perioperative results, morbidity a pathological data were evaluated and compared. The 3-year overall survival and disease-free survival rates were calculated and compared.RESULTS: Patients were comparable in terms of preoperative and demographic parameters. The median surgery time was 192 min for laparoscopic TME(L-TME) and 342 min for robotic TME(R-TME)(P < 0.001). There were no differences found in the rates of conversion to open surgery and morbidity. Thepatients who underwent laparoscopic surgery stayed in the hospital two days longer than the robotic group patients(8 d for L-TME and 6 d for R-TME, P < 0.001). The pathologic evaluation showed a higher number of harvested lymph nodes in the robotic group(18 for R-TME, 11 for L-TME, P < 0.001) and a shorter distal resection margin for laparoscopic patients(1.5 cm for L-TME, 2.5 cm for R-TME, P < 0.001). The three-year overall survival and disease-free survival rates were similar between groups.CONCLUSION: Both L-TME and R-TME achieved acceptable clinical and oncologic outcomes. The robotic technique showed some advantages in rectal surgery that should be validated by further studies. | Francesco Feroci Andrea Vannucchi Paolo Pietro Bianchi Stefano Cantafio Alessia Garzi Giampaolo Formisano Marco Scatizzi | 2016 | World Journal of Gastroenterology2016，22，13： | 22 |
| 2 | Efficacy of a therapeutic strategy for eradication of Helicobacter pylori infection显示文摘AIM: To determine the efficacy of our therapeutic strategy for Helicobacter pylori (H. pylori) eradication and to identify predictive factors for successful eradication. METHODS: From April 2006 to June 2010, we retrospectively assessed 2428 consecutive patients (1025 men, 1403 women; mean age 55 years, age range 18-92 years) with gastric histology positive for H. pylori infection referred to our unit for 13-C urea breath test(UBT), after first-line therapy with proton pump inhibitor (PPI) b.i.d. + amoxicillin 1 g b.i.d. + clarithromycin 500 mg b.i.d. for 7 d. Patients who were still positive to UBT were recommended a second-line therapy (PPI b.i.d. + amoxicillin 1 g b.i.d. + tinidazole 500 mg b.i.d. for 14 d). Third choice treatment was empirical with PPI b.i.d. + amoxicillin 1 g b.i.d. + levofloxacin 250 mg b.i.d. for 14 d. RESULTS: Out of 614 patients, still H. pylori-positive after first-line therapy, only 326 and 19 patients respectively rechecked their H. pylori status by UBT after the suggested second and third-line regimens. 'Per protocol' eradication rates for first, second and thirdline therapy were 74.7% (95% CI: 72.7%-76.4%), 85.3% (95% CI: 81.1%-89.1%) and 89.5% (95% CI: 74.9%-103%) respectively. The overall percentage of patients with H. pylori eradicated after two treatments was 97.8% (95% CI: 97.1%-98.4%), vs 99.9% (95% CI: 99.8%-100%) after three treatments. The study found that eradication therapy was most effective in patients with ulcer disease (P < 0.05, P = 0.028), especially in those with duodenal ulcer. Smoking habits did not significantly affect the eradication rate. CONCLUSION: First-line therapy with amoxicillin and clarithromycin produces an H. pylori eradication rate comparable or superior to other studies and secondline treatment can still be triple therapy with amoxicillin and tinidazole. | Giuliana Sereni Francesco Azzolini Lorenzo Camellini Debora Formisano Francesco Decembrino Veronica Iori Cristiana Tioli Maurizio Cavina Francesco Di Mario Giuliano Bedogni Romano Sassatelli | 2012 | World Journal of Gastroenterology2012，18，33： | 4 |
| 3 | Nuclear imaging in detection and monitoring of cardiotoxicity显示文摘Cardiotoxicity as a result of cancer treatment is a novel and serious public health issue that has a significant impact on a cancer patient’s management and outcome.The coexistence of cancer and cardiac disease in the same patient is more common because of aging population and improvements in the efficacy of antitumor agents.Left ventricular dysfunction is the most typical manifestation and can lead to heart failure.Left ventricular ejection fraction measurement by echocardiography and multigated radionuclide angiography is the most common diagnostic approach to detect cardiac damage,but it identifies a late manifestation of myocardial injury.Early non-invasive imaging techniques are needed for the diagnosis and monitoringof cardiotoxic effects.Although echocardiography and cardiac magnetic resonance are the most commonly used imaging techniques for cardiotoxicity assessment,greater attention is focused on new nuclear cardiologic techniques,which can identify high-risk patients in the early stage and visualize the pathophysiologic process at the tissue level before clinical manifestation.The aim of this review is to summarize the role of nuclear imaging techniques in the non-invasive detection of myocardial damage related to antineoplastic therapy at the reversible stage,focusing on the current role and future perspectives of nuclear imaging techniques and molecular radiotracers in detection and monitoring of cardiotoxicity. | Carmen D’Amore Paola Gargiulo Stefania Paolillo Angela Maria Pellegrino Tiziana Formisano Antonio Mariniello Giuseppe DellaRatta Elisabetta Iardino Marianna D’Amato Lucia La Mura Irma Fabiani Flavia Fusco Pasquale Perrone Filardi | 2014 | World Journal of Radiology2014，6，7： | 2 |
| 4 | Are capecitabine and oxaliplatin (XELOX) suitable treatments for progressing low-grade and high-grade neuroendocrine tumours?显示文摘 | Emilio Bajetta Laura Catena Giuseppe Procopio Sara Dosso Ettore Bichisao Leonardo Ferrari Antonia Martinetti Marco Platania Elena Verzoni Barbara Formisano Roberto Bajetta | 2007 | Cancer Chemotherapy and Pharmacology2007，，： | 2 |
| 5 | Late motor recovery is influenced by muscle tone changes after stroke 显示文摘 | Formisano R Pantano P Buzzi MG | 2005 | Arch Phys Med Rehabil2005，86，2： | 1 |
| 6 | Aluminium foil : Innovation and outlooks显示文摘 | Formisano V | 1996 | Allum Leghe1996，8，84： | 1 |
| 7 | On ERPs detection in disorders of consciousness rehabilitation 显示文摘 | Risetti M Formisano R Toppi J | 2013 | Front Hum Neuro- sci2013，7，： | 1 |
| 8 | Detection of methane in the atmosphere of mars显示文摘 | Formisano V Atreya S Encrenaz T | 2004 | Science2004，306，： | 1 |
| 9 | Functional connectivity as revealed by spatial independent component analysis of fMRI measurements during rest显示文摘 | van de VEN V G FORMISANO E PRVULOVIC D | 2004 | Hum Brain Map2004，22，3： | 1 |
| 10 | Late motor recovery is influ- enced by muscle tone changes after stroke 显示文摘 | Formisano R Pantano P Buzzi MG | 2005 | Arch Phys Med Reha- bil2005，86，2： | 1 |
| 11 | Assessing cognitive and psychological patterns in post - traumatic headache following severe brain injury显示文摘 | Formisano R Buzzi MG Bivona U | 2002 | J Neurotraurna2002，19，： | 1 |
| 12 | Clinical predictors and neurop sychological outcome in severe traumatic brain injury patients显示文摘 | Formisano R Carlesimo G A Sabbadini M | 2004 | Acta Neurochir (Wien)2004，146，5： | 1 |
| 13 | Mapping directed influence over the brain using Granger causality and fMRI 显示文摘 | Roebroeck A Formisano E | 2005 | Neuroimage2005，25，1： | 1 |
| 14 | Late motorrecovery is influenced by muscle tone changes after stroke显示文摘 | FORMISANO R PANTANO P BUZZI M G | 2005 | Arch Phys Med Rehabil2005，86，2： | 1 |
| 15 | Exploring brain function with magnetic resonance imaging显示文摘 | Di Salle F Formisano E Linden DE | 1999 | Eur J Radiol1999，30，2： | 1 |
| 16 | PED/PEA-15:an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis显示文摘 | Condorelli G Vigliotta G Cafieri A Trencia A AndalòP Oriente F Miele C Caruso M Formisano P Beguinot F | 1999 | Oncogene1999，18，31： | 1 |
| 17 | Medium- term and long-term outcomes following placement of midurethral slings for stress urinary incontinence: a systematic review and meta analysis显示文摘 | Tommaselli GA Di Carlo C Formisano C | 2015 | Int Urogyneeol2015，26，9： | 1 |
| 18 | PED/PEA-15 interacts with the 67 kD laminin receptor and regulates cell adhesion, migra- tion, proliferation and apoptosis 显示文摘 | Formisano P Ragno P Pesapane A | 2012 | J Cell Mol Med2012，16，7： | 1 |
| 19 | Gastric cancer: surgical treatment and prognostic score显示文摘 | Guida F Formisano G Esposito D | 2008 | Minerva Chit2008，63，2： | 1 |
| 20 | Active music therapy inthe rehabilitation of severe brain injured patients during coma recovery显示文摘 | Vinicola V Penta F | 2001 | AnnIst Super Sanita2001，37，4： | 1 |
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