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| 1 | Incidental gallbladder cancer during laparoscopic cholecystectomy:Managing an unexpected finding显示文摘AIM:To evaluate the impact of incidental gallbladder cancer on surgical experience.METHODS:Between 1998 and 2008 all cases of cholecystectomy at two divisions of general surgery,one university based and one at a public hospital,were retrospectively reviewed.Gallbladder pathology was diagnosed by history,physical examination,and laboratory and imaging studies [ultrasonography and computed tomography(CT)].Patients with gallbladder cancer(GBC) were further analyzed for demographic data,and type of operation,surgical morbidity and mortality,histopathological classification,and survival.Incidental GBC was compared with suspected or preoperatively diagnosed GBC.The primary endpoint was diseasefree survival(DFS).The secondary endpoint was the difference in DFS between patients previously treated with laparoscopic cholecystectomy and those who had oncological resection as first intervention.RESULTS:Nineteen patients(11 women and eight men) were found to have GBC.The male to female ratio was 1:1.4 and the mean age was 68 years(range:45-82 years).Preoperative diagnosis was made in 10 cases,and eight were diagnosed postoperatively.One was suspected intraoperatively and confirmed by frozen sections.The ratio between incidental and nonincidental cases was 9/19.The tumor node metastasis stage was:pTis(1),pT1a(2),pT1b(4),pT2(6),pT3(4),pT4(2);five cases with stageⅠa(T1 a-b);two with stageⅠb(T2 N0);one with stage Ⅱa(T3 N0);six with stage Ⅱb(T1-T3 N1);two with stage Ⅲ(T4 Nx Nx);and one with stage Ⅳ(Tx Nx Mx).Eighty-eight percent of the incidental cases were discovered at an early stage(≤Ⅱ).Preoperative diagnosis of the 19 patients with GBC was:GBC with liver invasion diagnosed by preoperative CT(nine cases),gallbladder abscess perforated into hepatic parenchyma and involving the transversal mesocolon and hepatic hilum(one case),porcelain gallbladder(one case),gallbladder adenoma(one case),and chronic cholelithiasis(eight cases).Every case,except one,with a T1b or more advanced invasion underwent Ⅳb + Ⅴ wedge liver resection and pericholedochic/hepatoduodenal lymphadenectomy.One patient with stage T1b GBC refused further surgery.Cases with Tis and T1a involvement were treated with cholecystectomy alone.One incidental case was diagnosed by intraoperative frozen section and treated with cholecystectomy alone.Six of the nine patients with incidental diagnosis reached 5-year DFS.One patient reached 38 mo survival despite a port-site recurrence 2 years after original surgery.Cases with non incidental diagnosis were more locally advanced and only two patients experienced 5-year DFS.CONCLUSION:Laparoscopic cholecystectomy does not affect survival if implemented properly.Reoperation should have two objectives:R0 resection and clearance of the lymph nodes. | Andrea Cavallaro Gaetano Piccolo Vincenzo Panebianco Emanuele Lo Menzo Massimiliano Berretta Antonio Zanghì Maria Di Vita Alessandro Cappellani | 2012 | World Journal of Gastroenterology2012，18，30： | 33 |
| 2 | Diffusion-weighted MRI in a liver protocol: Its role in focal lesion detection显示文摘AIM: To evaluate the role of diffusion-weighted imaging (DWI) in the detection of focal liver lesions (FLLs), using a conventional magnetic resonance imaging (MRI) protocol. METHODS: Fifty-two patients (22 males, average age 55.6 years, range: 25-82 years), studied using a 1.5 Tesla magnetic resonance scanner, were retrospectively analyzed; detection of FLLs was evaluated by considering the number of lesions observed with the following sequences: (1) respiratory-triggered diffusion-weighted single-shot echo-planar (DW SS-EP) sequences; (2) fat-suppressed fast spin-echo (fs-FSE) T2 weighted sequences; (3) steady-state free precession (SSFP) images; and (4) dynamic triphasic gadolinium-enhanced images, acquired with three-dimensional fast spoiled gradient-echo (3D FSPGR). Two radiologists independently reviewed the images: they were blinded to their respective reports. DW SS-EP sequences were compared to fs-FSE, SSFP and dynamic gadolinium-enhanced acquisitions using a t -test. Pairs were compared for the detection of: (1) all FLLs; (2) benign FLLs; (3) malignant FLLs; (4) metastases; and (5) hepatocellular carcinoma (HCC). RESULTS: Interobserver agreement was very good (weighted = 0.926, CI = 0.880-0.971); on the consensus reading, 277 FLLs were detected. In the comparison with fs-FSE, DW SS-EP sequences had a significantly higher score in the detection of all FLLs, benign FLLs, malignant FLLs and metastases; no statistical difference was observed in the detection of hepatocellular carcinoma (HCCs). In the comparison with SSFP sequences, DW SS-EP had significantly higher scores (P < 0.05) in the detection of all lesions, benign lesions, malignant lesions, metastases and HCC. All FLLs were better detected by dynamic 3D FSGR enhanced acquisition, with P = 0.0023 for reader 1 and P = 0.0086 for reader 2 in the comparison with DW SS-EP sequences; with reference to benign FLLs, DW SS-EP showed lower values than 3D FSPGR enhanced acquisition (P < 0.05). No statistical differences were observed in the detection of malignant lesions and metastases; considering HCCs, a very slight difference was reported by reader 1 (P = 0.049), whereas no difference was found by reader 2 (P = 0.06). CONCLUSION: In lesion detection, DWI had higher scores than T2 sequences; considering malignant FLLs, no statistical difference was observed between DWI and dynamic gadolinium images. | Stefano Palmucci Letizia Antonella Mauro Martina Messina Brunella Russo Giovanni Failla Pietro Milone Massimiliano Berretta Giovanni Carlo Ettorre | 2012 | World Journal of Radiology2012，4，7： | 11 |
| 3 | 急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。 | 刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR | 2016 | 中华高血压杂志2016，24，8： | 4 |
| 4 | Prognostic and predictive response factors in colorectal cancer patients:Between hope and reality显示文摘Colorectal cancer(CRC) represents one of the most commonly diagnosed cancers worldwide.It is the second leading cause of cancer death in Western Countries.In the last decade the survival of patients with metastatic CRC has improved dramatically.Due to the advent of new drugs(irinotecan and oxaliplatin) and target therapies(i.e.,bevacizumab,cetuximab and panitumab),the median overall survival has risen from about 12 mo in the mid nineties to 30 mo recently.Many questions needing of right collocations and more clearness still exist regarding the prognostic factors and the predictive factors of response to therapy.Despite advances in dosing and scheduling of chemotherapy in both adjuvant and advanced settings,and a greater emphasis on early detection,the outlook still remains poor for most patients.Molecular analyses have shown that the natural history of all CRCs is not the same.Individual patients with same stage tumours may have different long term prognosis and response to therapy.In addition,some prognostic variables are likely to be more important than others.Here we review the role of prognostic factors and predictive factors according to the recently published English literature. | Chiara De Divitiis Guglielmo Nasti Massimo Montano Rossella Fisichella Rosario Vincenzo Iaffaioli Massimiliano Berretta | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 5 | Uterine tumors resembling ovarian sex cord tumors: a case report of conservative management in young women显示文摘 | Berretta R Patrelli TS Fadda GM | 2009 | Int J Gyneeol Cancer2009，19，4： | 1 |
| 6 | Leiomyosarcoma of the parotid gland in an HIV-positive patient:therapeutic ap-proach,clinical course and review of the literature显示文摘 | Berretta M Zanet E Taibi R | 2009 | J Che-mother2009，21，2： | 1 |
| 7 | CA 125 serum values in surgi- cally treated endometriosis patientsand its relationships with anatomic sites of endometriosis and pregnancy rate显示文摘 | Patrelli TS Berretta R Gizzo S | 2011 | Fertil Steril2011，95，1： | 1 |
| 8 | GABAergic interneurons : implications for understanding schizophrenia and bipolar disorder 显示文摘 | Benes FM Berretta S | 2001 | Neuropsychopharmacology2001，25，1： | 1 |
| 9 | Storm water pollution in the urban environment of Genoa, Italy 显示文摘 | Gnecco I Berretta C Lanza L G | 2005 | Atmospheric Research2005，77，124： | 1 |
| 10 | Endovascular treatment for type B dissection in Marian syndrome: is it worthwhile? 显示文摘 | Pacini D Parolari A Berretta P | 2013 | Ann Thorac Surg2013，95，2： | 1 |
| 11 | GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder显示文摘 | Banes FM Berretta S | 2001 | Neuropsychopharmacology2001，25，1： | 1 |
| 12 | GABAergic interneurons: implications for understandingschizophrenia and bipolar disorder 显示文摘 | Benes FM Berretta S | 2001 | Neuropsychopharmacology2001，25，1： | 1 |
| 13 | AIDS-related Kaposi,s sarcoma:state of the art and therapeutic strategies显示文摘 | Martellotta F Berretta M Vaccher E | 2009 | Curr HIV Res2009，7，6： | 1 |
| 14 | Retzius' space haematoma after spontaneous delivery: a case report 显示文摘 | Stefania Fieni Roberto Berretta Carla Merisio | 2005 | ACTA BIOMED2005，76，3： | 1 |
| 15 | Reduced sarcoplasmic reticulum Ca2 + load mediates impaired contrac- tile reserve in right ventrieular pressure overload 显示文摘 | Quaile M P Rossman E I Berretta R M | 2007 | J Mol Cell Cardiol2007，43，5： | 1 |
| 16 | Genotyping Isolates of the Entomopathogenic Fungus Beauveria bassiana by RAPD with Fluorescent Labels显示文摘 | Berretta M F Lecuona R E Zandomeni R O | | 0，，02： | 1 |
| 17 | Storm water pollution in the urban environment of Genoa, Italy 显示文摘 | Gnecco I Berretta C Lanza L G | 2005 | Atmospheric Research2005，77，14： | 1 |
| 18 | Differential effect of carbaba mazepine and oxcarbazepine on excitatory synaptic transmision in rat hip pocampus显示文摘 | Giustizieri M Armogida M Berretta N | 2008 | Synapse2008，62，10： | 1 |
| 19 | Hippocampus versusentorhinal cortex decoupling by an NR2 subunit-specific block ofNMDA receptors in a rat in vitro model of temporal lobe epilepsy显示文摘 | Berretta N Ledonne A Mango D | 2012 | Epilepsia2012，53，5： | 1 |
| 20 | The complexity of aging: Cancer risk among elderly People and infectious risk amongthose with Cancer 显示文摘 | Pinzone MR Berretta M Doerr HW | 2013 | Anticancer Agents Med Chem2013，13，9： | 1 |
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