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| 1 | Metastatic type 1 gastric carcinoid:A real threat or just a myth?显示文摘AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were recorded.Patients’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and histopathologically.Patients were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also recorded.The evaluation of response to treatment was defined using established WHO criteria.RESULTS:We studied twenty consecutive patients with a mean age of 55.1 years.The mean follow-up period was 83 mo.Twelve patients had regional lymph node metastases and 8 patients had liver metastases.The primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean Ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the tumor.The disease was stable in all but 3 patients who had progressive liver disease.All patients remained alive during the follow-up period.CONCLUSION:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated Ki-67 index and high serum gastrin levels. | Simona Grozinsky-Glasberg Dimitrios Thomas Jonathan R Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia Reissman Gregory Kaltsas David J Gross | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | Concurrent infections of dengue viruses serotype 2 and 3 in patient with severe dengue from Jakarta, Indonesia显示文摘Objective: To describe the clinical manifestation of patient with severe dengue, to identify the serotypes and genotypes of dengue viruses(DENV) which concurrently infecting the patient, and to explore the possible relationship of severe dengue with the concurrent infection of DENV. Methods: Dengue diagnosis was performed using NS1 antigen detection and Ig G/Ig M ELISA. Standard clinical and laboratory examinations were performed to obtain the clinical and hematological data. DENV concurrent infections were detected and confirmed using RT-PCR and DENV Envelope gene sequencing. Phylogenetic analyses were performed to determine the genotypes of the viruses. Results: The patient was classified as having severe dengue characterized by severe plasma leakage, hemorrhage, and organ damage involving lung, liver, and kidney. Concurrent infection of DENV serotype 2 and 3 was observed. The infecting DENV-2 virus was grouped into Cosmopolitan genotype while DENV-3 virus was classified into Genotype Ⅰ. Both viruses were closely related to isolates that were endemic in Jakarta. Viremia measurement was conducted and revealed a significantly higher virus titer of DENV-3 compared to DENV-2. Conclusions: The occurrence of multi-serotype DENV infections was presented in a patient with severe clinical manifestation in Indonesia. The hyperendemicity of dengue in Indonesia may contribute to the DENV concurrent infections cases and may underlie the severity of the disease. | Soroy Lardo Yaldiera Utami Benediktus Yohan Seri MMU Tarigan Widayat Djoko Santoso Leonard Nainggolan R Tedjo Sasmono | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，2： | 3 |
| 4 | Circulating MicroRNA Is a Biomarker of Pediatric Crohn Disease显示文摘 | Adam M Zahm Meena Thayu Nicholas J Hand Amber Horner Mary B Leonard Joshua R Friedman | 2011 | Journal of Pediatric Gastroenterology and Nutrition2011，，1： | 3 |
| 5 | piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans显示文摘 | Alyson Ashe Alexandra Sapetschnig Eva-Maria Weick Jacinth Mitchell Marloes P. Bagijn Amy C. Cording Anna-Lisa Doebley Leonard D. Goldstein Nicolas J. Lehrbach Jérémie Le Pen Greta Pintacuda Aisa Sakaguchi Peter Sarkies Shawn Ahmed Eric A. Miska | 2012 | Cell2012，，1： | 2 |
| 6 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 7 | Modeling tetracycline antibiotic sorption to clays显示文摘 | Figueroa R A Leonard A MacKay A A | 2003 | Environmental Science & Technology2003，38，2： | 1 |
| 8 | Primary end urologic realignment of complete posterior urethral disruption显示文摘 | Healy CE Leonard DS Cahill R | 2007 | Ir Med J2007，100，6： | 1 |
| 9 | Interleukin-21:a modulator of lymphoid proliferation,apoptosis and differentiation显示文摘 | Leonard WJ Spolski R | 2005 | Nat Rev Immunol2005，5，9： | 1 |
| 10 | NT-3 gene delivery elicitsgrowth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection显示文摘 | Tuszynski MH Grill R Leonard LL | 2003 | Exp Neurol2003，181，1： | 1 |
| 11 | Mutagenicity,Carcinogenicity and Teratogenicity of Beryllium显示文摘 | Leonard A Lauwyers R | 1987 | Mutation Research1987，186，1： | 1 |
| 12 | Efects of temperature and light on virulence of Exserehilum turcicum on corn 显示文摘 | Thakur R P Leonard K J Leath S | 1989 | Phytopathology1989，，79： | 1 |
| 13 | IL-21 and T follicular helper cells显示文摘 | Spolski R Leonard WJ | 2010 | Int Immunol2010，22，1： | 1 |
| 14 | Patent duetus arteriosus and its treatment as risk factors for neonatal and neurodevelopmental morbidity显示文摘 | Chorne N Leonard C Piecueh R | 2007 | Pediatrics2007，119，： | 1 |
| 15 | Identification of a volatile component in soybeans that contributes to raw bean flavor显示文摘 | LEONARD R MATTICK DAVID B HAND | 1969 | Journal of Agricukural Food Chemistry1969，17，1： | 1 |
| 16 | Modeling tetracycline antibiotic sorotion to clays显示文摘 | Figueroa R A Leonard A MacKay A A | 2004 | Environ Sci Technol2004，38，2： | 1 |
| 17 | Comparison of MIDI sherlock system and pulsed-gel electrophoresis in characterizing strains of methicillin-resistant Staphylococcus aureus from a recent hospital outbreak显示文摘 | Leonard R B Mayer J Sasser M | 1995 | Journal of Clinical Microbiology1995，33，10： | 1 |
| 18 | The role ofp53 in silica-induced cellular and molecular responses asso-ciated with carcinogenesis显示文摘 | Gwinn M R Leonard S S Sargent L M | 2009 | J Toxicol Environ Health A2009，72，23： | 1 |
| 19 | Breast cancer in the elderly显示文摘 | Crivellari D Aapro M Leonard R | 2007 | J Clin Oncol2007，25，14： | 1 |
| 20 | Perceived Usefulness,Service Quality and Loyalty Incentives:Effects on Electronic Service Continuance显示文摘 | Naidoo R Leonard A | | 0，，03： | 1 |
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