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1610篇 您的检索式:作者名="McCulloch"
    题名 作者 年代 出处 被引量
1MoS2 as a long-life host material for potassium ion intercalation显示文摘进二维的分层的瞬间 2 的电气化学的钾离子置闰在基于钾的电池在阳极为潜在的应用第一次被学习。X 光检查衍射分析显示设置的钾加重,六角形的 K 0.4 在置闰过程期间形成的瞬间 2, 。尽管有 K +, 瞬间的尺寸, 2 在 200 个周期以后与 97.5% 的能力保留是为重复的钾离子置闰和 de 置闰的一位长寿主人。在 K x + 离子的散开系数 > 瞬间 2 基于 Randles-Sevcik 方程被计算。更高的 K + 置闰比率不仅在瞬间 2, 遇到了慢得多的 K + 散开率而且导致了瞬间 2 减小。这研究证明那金属 dichalcogenides 为新兴的 K 离子,击倒 2, 和 K-S 电池正在答应钾阳极材料。Xiaodi Ren Qiang Zhao William D. McCulloch Yiying Wu 2017Nano Research2017,10,4:26
2黄药子抗肿瘤活性组分筛选及作用分析显示文摘目的 :分析中药薯蓣科植物黄药子可能的抗肿瘤组分及其作用机制。方法 :将黄药子依次用石油醚、乙醇、水系统地提取 ,采用HepA肿瘤细胞株在小鼠进行体内筛选和研究 ,观察不同组分对肿瘤腹水生长及肿瘤细胞的各种变化 ,分析各组分抗肿瘤作用及特征。结果 :石油醚提取物抑制肿瘤腹水生长作用强于乙醇提取物 ,而水提取物有一定的促生长作用。石油醚提取物能显著延长小鼠存活期 ,低降肿瘤腹水生成量和肿瘤细胞存活率 ,用药后肿瘤细胞再次传代 ,肿瘤腹水的形成时间显著延长。结论 :黄药子石油醚提取物具有显著的抗肿瘤活性 ,且抗肿瘤作用与直接的细胞作用有关。喻泽兰 刘欣荣 Michael McCulloch 高锦 2004中国中药杂志2004,29,6:23
3Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes.Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han 2008World Journal of Gastroenterology2008,14,29:7
4The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases显示文摘在他们描述脱氧核糖核酸双螺旋,沃森和克里克的结构写了什么可以是在科学文学的最大的保守的陈述之一的精液的出版,也就是那“这没疏忽特定的配对我们立即要求了为遗传物质建议可能的拷贝机制。“半个世纪以后,我们更充分欣赏它是与精确性复制 60 亿核苷酸的巨大的挑战需要稳定地在许多代上维持人的染色体的。这挑战也许比大 50 年以前被认识到,因为随后的研究表明了染色体能被在脱氧核糖核酸而且由现在质问到复制的正常脱氧核糖核酸的各种各样的顺序主题产生潜在地细胞毒素、诱变的损害的一个大数字和变化的环境压力使动摇不仅。向染色体稳定性的许多决定因素的更好的理解,这章考察 undamaged 和损坏脱氧核糖核酸与被拷贝的忠实,与真核细胞的 B 家庭和 Y 家庭 DNA 的一个焦点,并且考虑这忠实怎么被完成。Scott D McCulloch Thomas A Kunkel 2008Cell Research2008,18,1:5
5外科创新技术/器械临床研究方法学——IDEAL框架与推荐系列文章之一:IDEAL框架与推荐介绍显示文摘外科技术和器械的快速创新是外科临床研究和实践的重要内容,其评价总体思路与药物干预类似,但具体方法学存在很大差异。2009年IDEAL协作网提出一套适用于外科创新干预的方法学框架—IDEAL框架,将外科创新技术发展分为5个阶段,涵盖从概念提出到推广应用的全生命周期。2019年,协作网更新IDEAL框架,在原有基础上增加临床前评价(Pre-IDEAL),梳理明确各阶段研究目的、核心问题和伦理依据。作为IDEAL框架和推荐系统的首篇文章,本文将详细介绍IDEAL推荐和框架的产生、发展、具体内容、应用推广现状,旨在促进该方法在国内外科临床研究领域的应用和传播。喻佳洁 陕飞 Peter McCulloch Allison Hirst 胡建昆 孙鑫 李幼平 刘伦旭 刘雪梅 董念国 陈寄梅 乔贵宾 李鹤成 2021中国胸心血管外科临床杂志2021,28,2:4
6Identification of stable normalization genes for quantitative real-time PCR in porcine articular cartilage显示文摘Background: Expression levels for genes of interest must be normalized with an appropriate reference, or housekeeping gene, to make accurate comparisons of quantitative real-time PCR results. The purpose of this study was to identify the most stable housekeeping genes in porcine articular cartilage subjected to a mechanical injury from a panel of 10 candidate genes. Results: Ten candidate housekeeping genes were evaluated in three different treatment groups of mechanically impacted porcine articular cartilage. The genes evaluated were: beta actin, beta-2-microglobulin, glyceraldehyde-3-phosphate dehydrogenase, hydroxymethylbilane synthase, hypoxanthine phosphoribosyl transferase, peptidylprolyl isomerase A (cyclophilin A), ribosomal protein L4, succinate dehydrogenase flavoprotein subunit A, TATA box binding protein, and tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein-zeta polypeptide. The stability of the genes was measured using geNorm, BestKeeper, and NormFinder software. The four most stable genes measured via geNorm were (most to least stable) succinate dehydrogenase flavoprotein, subunit A, peptidylprolyl isomerase A, glyceraldehyde-3-phosphate dehydrogenase, beta actin; the four most stable genes measured via BestKeeper were glyceraldehyde-3-phosphate dehydrogenase, peptidylprolyl isomerase A, beta actin, succinate dehydrogenase flavoprotein, subunit A; and the four most stable genes measured via NormFinder were peptidylprolyl isomerase A, succinate dehydrogenase flavoprotein, subunit A, glyceraldehyde-3-phosphate dehydrogenase, beta actin. Conclusions: BestKeeper, geNorm, and NormFinder all generated similar results for the most stable genes in porcine articular cartilage. The use of these appropriate reference genes will facilitate accurate gene expression studies of porcine articular cartilage and suggest appropriate housekeeping genes for articular cartilage studies in other species.Ryan S McCulloch Melissa S Ashwell Audrey T O'Nan Peter L Mente 2012Journal of Animal Science and Biotechnology2012,3,4:2
7Self-assembled V2O5 interconnected microspheres produced in a fish-water electrolyte medium as a high- performance lithium-ion-battery cathode显示文摘V 2 由极端长的 nanobelts 组成的 O 5 被采用与退火相结合的一个常规阳极化过程以一个环境友好方法综合。因为它不要求任何另外的化学药品或试剂,合成过程简单、便宜。商业鱼水被用作电解质媒介第一次阳极化钒陪衬。电子显微镜学调查表明每条带与在他们之间的空间由众多的 nanofibers 组成。因此,这新奇 nanostructure 在电气化学的操作期间表明许多突出的特征。这结构阻止活跃材料的自我聚集并且充分由维持在活跃材料,传导性的添加剂,和电解质之间的一个大有效接触区域利用活跃材料的优点,它是为大多数 nanomaterials 的关键挑战。电极与 227 mAhub 的一个稳定的分泌物能力展出有希望的电气化学的性能 > 49 -based synergistic tri 形式的治疗根除了异种皮移植肿瘤和没有复发被观察在以内一 9 月列在后面起来。而且,钨元素的强壮的 X 光检查变细能力(Z = 74, 4.438 厘米 2????  ??  ?? 佦 ? 畳 ?? 猯扵 ̄??Md Mokhlesur Rahman Abu Z. Sadek Irin Sultana Mateti Srikanth Xiujuan J. Dai Matthew R. Field Dougal G. McCulloch Sri Balaji Ponraj Ying Chen 2015Nano Research2015,8,11:2
8Filamin A regulates cell spreading and survival via β1 integrins显示文摘Hugh Kim Anita Sengupta Michael Glogauer Christopher A. McCulloch 2007Experimental Cell Research2007,,4:2
9Increasing diabetes self-management education in community settings显示文摘Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch 2002American Journal of Preventive Medicine2002,,4:2
10Posttraumatic Stress Disorder in Aware Patients from the B-Aware Trial显示文摘Kate Leslie Matthew T. V. Chan Paul S. Myles Andrew Forbes Timothy J. McCulloch 2010Anesthesia & Analgesia2010,,3:2
11Dissolved oxygen prediction in prawn ponds from a group of one step predictors显示文摘In this paper we have presented a novel approach to predict dissolved oxygen in prawn ponds.It is necessary to maintain dissolved oxygen above a certain level in the ponds for expected growth and survival of the prawns.An accurate prediction of dissolved oxygen can assist farmers to take necessary measures to maintain dissolved oxygen levels ideal for prawn growth.Existing approaches to dissolved oxygen prediction performs well on short term,however incurs high error on long term prediction.We propose a new approach where a group of predictors are developed where each model predicts a certain time stamps ahead.Each predictor is trained on sampled data so that it predicts a step ahead prediction only,however,the sampling process decides on the actual number of time stamp ahead prediction.Since step ahead predictor acts like a short term predictor,it incurs small error even at higher time stamp ahead prediction.Experimental results demonstrate that the proposed approach achieves significantly lower error on long term prediction compared to other existing approaches.Ashfaqur Rahman Joel Dabrowski John McCulloch 2020Information Processing in Agriculture2020,7,2:2
12Tissue engineering:a new paradigm for periodontal regeneration based on molecular and cell biology显示文摘Bartold PM Mcculloch CAG Narayanan AS 2000Periodontology2000,2000,24:2
13Adaptive Bayesian Wavelet Shrinkage显示文摘CHIPMAN HA KOLACZYK ED MCCULLOCH RE 1997Journal of the American Statistics Association1997,92,12:1
14The structure and annealing properties of multilayer carbon films 显示文摘McCulloch D G Xiao X L Peng J L 2005Surf Coating Techol2005,198,:1
15Perioperative complication and risk faction in the surgical treatment of obstructive sleep apnea syndrome 显示文摘Esclamado RM Glenn MG Mcculloch TM 1989Laryngoscope1989,99,11:1
16Dance Band on the Titanic: Biomechanical Signaling in Cardiac Hypertrophy显示文摘Mark A. Sussman Andrew McCulloch Thomas K. Borg 2002Circulation Research: Journal of the American Heart Association2002,,10:1
17Preindustrial to moderninterdecadal variability in coral reef pH显示文摘Pelejero C Calvo E McCulloch M T Marshall J F Gagan M K Lough J M Opdyke B N 2005Science2005,309,5744:1
18Emmetropisation following pretemn birth显示文摘Saunders K J McCulloch DL Shepherd A J 2002Br J Ophthalmol2002,86,9:1
19High-precision U-series dating of corals from Western Australia and implications for the timing and duration of the Last Interglacial显示文摘Stirling C H East T M McCulloch M T 1995Earth and Planetary Science Letters1995,,135:1
20A Logical calculus of the ideas immanent in nervous activity 显示文摘McCulloch W S Pitts W 1943Bulletin of Mathematical Biophysics1943,10,5:1
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