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| 1 | Cilostazol for secondary stroke prevention:systematic review and meta-analysis显示文摘Background Stroke is one of the leading causes of death worldwide.Cilostazol,an antiplatelet and phosphodiesterase 3 inhibitor,has not been clearly established for ischaemic stroke use.We aim to determine the efficacy and safety of cilostazol for secondary stroke prevention.Methods MEDLINE,EMBASE,Cochrane Library,Web of Science and ClinicalTrials.gov were searched from inception to 25 September 2020,for randomised trials comparing the efficacy and safety of cilostazol monotherapy or dual therapy with another antiplatelet regimen or placebo,in patients with ischaemic stroke.Version 2 of the Cochrane risk-of-bias tool for randomised trials(RoB 2)was used to assess study quality.This meta-analysis was reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)statement.Results Eighteen randomised trials comprising 11429 participants were included in this meta-analysis.Most trials possessed low risk of bias and were of low heterogeneity.Cilostazol significantly reduced the rate of ischaemic stroke recurrence(risk ratio,RR=0.69,95%CI 0.58 to 0.81),any stroke recurrence(RR=0.64,95%CI 0.54 to 0.74)and major adverse cardiovascular events(RR=0.67,95%CI 0.56 to 0.81).Cilostazol did not significantly decrease mortality(RR=0.90,95%CI 0.64 to 1.25)or increase the rate of good functional outcome(Modified Rankin Scale score of 0–1;RR=1.07,95%CI 0.95 to 1.19).Cilostazol demonstrated favourable safety profile,significantly reducing the risk of intracranial haemorrhage(RR=0.46,95%CI 0.31 to 0.68)and major haemorrhagic events(RR=0.49,95%CI 0.34 to 0.70).Conclusions Cilostazol demonstrated superior efficacy and safety profiles compared with traditional antiplatelet regimens such as aspirin and clopidogrel for secondary stroke prevention but does not appear to affect functional outcomes.Future randomised trials can be conducted outside East Asia,or compare cilostazol with a wider range of antiplatelet agents. | Choon Han Tan Andrew GR Wu Ching-Hui Sia Aloysius ST Leow Bernard PL Chan Vijay Kumar Sharma Leonard LL Yeo Benjamin YQ Tan | 2021 | Stroke & Vascular Neurology2021，6，3： | 2 |
| 2 | NT-3 gene delivery elicitsgrowth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection显示文摘 | Tuszynski MH Grill R Leonard LL | 2003 | Exp Neurol2003，181，1： | 1 |
| 3 | A Method for Quantifying Vulnerability, Applied to the Agricultural System of the YaquiValley, Mexico 显示文摘 | Amy LL David B L Leonard S S | 2003 | Global Environmental Change2003，13，： | 1 |
| 4 | Increased saltsensi- tivity in endothelial nitric oxide synthase-knockout mice显示文摘 | Leonard AM Chafe LL Montani JP | 2006 | Am J Hypertens2006，19，12： | 1 |
| 5 | Preoperative and postoperative endotoxemia in children with congenital heart disease显示文摘 | Lequier LL Nikaidoh H Leonard SR | 2000 | Chest2000，117，： | 1 |
| 6 | Long-term outcome in chil- dren treated for craniopharyngioma with and without radio- therapy显示文摘 | Lin LL E1 Naqa I Leonard JR | 2008 | J Neurosurg Pediatr2008，1，2： | 1 |
| 7 | Long-term outcome in children treated for craniopharyngioma with and without radiotherapy 显示文摘 | Lin LL ElNaqa I Leonard JR | 2008 | J Neurosurg Pediatr2008，1，2： | 1 |
| 8 | Vibrating characteristics of fruits as related to in-transit injury显示文摘 | O'Brien M Claypool LL Leonard SJ | 1965 | Transactions of the ASAE1965，8，2： | 1 |
| 9 | Preoperative and postoperative endotoxemia in children with eongenital heart disease显示文摘 | Nikaidoh H Leonard SR | 2000 | Chest2000，117，6： | 1 |
| 10 | Long-term outcomein children treated for craniopharyngioma with and withoutradiotherapy 显示文摘 | Lin LL E1 Naqa I Leonard JR | 2008 | J Neurosurg Pediatr2008，1，2： | 1 |
| 11 | Current concepts and techniques in pterygium treatment显示文摘 | Leonard PK Ang Jocelyn LL Chua Donald TH Tan | 2007 | Current Opinion in Ophthalmology2007，，4： | 1 |
| 12 | Secondary metabolites in floral nectar reduce parasite infections in bumblebees 显示文摘 | Richardson LL Adler l_S Leonard AS | 2015 | P Roy Soe B Biol Sci2015，282，： | 1 |
| 13 | Work motivalion: The in- corporation of self- concept - based processes 显示文摘 | NH Leonard LL Beauvais RW Scholl | 1999 | Human Relations1999，52，8： | 1 |
| 14 | Preoperative and postoperative endotoxemia in children with congenital heart disease显示文摘 | Lequier LL Nikaidoh H Leonard SR | 2000 | Chest2000，117，： | 1 |
| 15 | Extravascular Doppler measurement of cardiac output in infants and children after operations for congenital heart disease显示文摘 | Lequier LL Leonard SR Nikaidoh H | 1999 | J Thorac Cardiovasc Surg1999，117，6： | 1 |
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