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| 1 | 满足欧4标准的发动机及其排放控制技术显示文摘北美、日本和欧洲这些交通运输高度发达的国家已经引用越来越严的排放法规。在国际化形势下,其他新兴市场对排放和燃油质量的控制也日益严格。发动机管理与排放控制系统相结合可以满足越来越严的法规。讨论了几种发动机排放控制系统的实例以及开发排放控制系统组合的方法。还对某些原设备制造商宣称能在不用NOx后处理的情况下达到美国2010重型车排放法规和欧5重型车排放法规的观点进行了探讨。 | Kumar S V | 2009 | 国外内燃机2009，41，1： | 15 |
| 2 | The role and significance of Magnesium in modern day research-A review显示文摘Magnesium is one of the largely available elements in the earth’s crust. It has a low structural density with high specific strength. This unique material property has forced an increase in the use of magnesium and its alloys in various applications pertaining to industrial sector,automobiles, aerospace and biomedical. Since magnesium is a highly reactive metal, it is prone to higher rate of corrosion as compared to its counterparts. Thus, it is essential to analyze the corrosion behavior of magnesium and its alloys in its applications. An appropriate process is to be followed in the design and development of magnesium alloys which overcome the limitations of magnesium and enhance the desired material properties in accordance to their applications. This review paper summarizes the importance of magnesium and its material properties. The influence of various alloying elements on the mechanical properties of magnesium is reviewed. The broad classification of Mg alloys and their behavioral trends are detailed. The corrosion behavior of magnesium and the influence of corrosion products on the material characteristics of magnesium, in aqueous medium, are discussed. The manufacturing techniques of magnesium alloys along with the secondary techniques are also covered. The various applications and the limitations of magnesium in these applications are covered. A complete section is dedicated towards detailing the recent trends of magnesium(Mg) alloys, i.e., the biodegradable nature and applications of Mg alloys. The influence of biocorrosion on Mg alloys and techniques to overcome it have been deliberated. This paper provides a thorough review on recent developments of magnesium with respect to engineering applications. | S V Satya Prasad S B Prasad Kartikey Verma Raghvendra Kumar Mishra Vikas Kumar Subhash Singh | 2022 | Journal of Magnesium and Alloys2022，10，1： | 11 |
| 3 | Pharmacognostic study and anti-inflammatory activity of Callistemon lanceolatus leaf显示文摘Objective:To study detail pharmacognosy and anti-inflammatory activity of Callistemon lanceolatus(C.lanceolatus) leaf.Methods:Leaf sample was studied by organoleptic, macroscopical,microscopical,phytochemical and other WHO recommended methods for standardizations.The methanolic leaf extract of the plant was also screened for antiinflammatory activity on carrageenan-induced paw edema in rat at doses of 200 and 400 mg/kg, orally.The detail pharmacognostic study of the C.lanceolatus leaf was carried out to lay down the standards which could be useful in future experimental studies.Results:C.lanceolatus methanolic leaf extract showed significant(P<0.0S) anti-inflammatory activity at doses of 200 mg/kg and 400 mg/kg.This significant anti-inflammatory of C.lanceolatus methanolic leaf extract at the dose of 400 mg/kg was comparable with diclofenac sodium.Conchuioiis:The pharmacognostic profile of the C.lanceolatus leaf is helpful in standardization for quality,purity and sample identification.The methanolic extract at a dose of 400 mg/kg shows a significant activity in comparison with the standard drug diclofenac sodium(50 mg/kg). | Kumar S Kumar V Prakash OM | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，3： | 10 |
| 4 | Influence of heat treatment on the machinability and corrosion behavior of AZ91 Mg alloy显示文摘In the present study,AZ91 Mg alloy was heat treated at 410℃ for 6,12 and 24 h to investigate the influence of heat treatment on machinability and corrosion behavior.The effect of soaking time on the amount and distribution of Mg 17 Al 12(β-phase)was analyzed under the optical microscope.Microhardness measurements demonstrated the increased hardness with increased heat treatment soaking time,which can be attributed to the solid solution strengthening.The influence of super saturatedα-grains on reducing the cutting force(F z)with respect to increased cutting speed was observed as prominent.The corrosion behavior of the heat treated specimens was studied by conducting electrochemical tests.Surprisingly,corrosion rate of heat treated samples was observed as increased compared with the base material.From the results,it is evident that the machinability of AZ91 Mg alloy can be improved by producing super saturatedα-grains through heat treatment but at the cost of losing corrosion resistance. | Swetha Chowdary V Ravikumar Dumpala Anand Kumar S Kondaiah VV Ratna Sunil B | 2018 | Journal of Magnesium and Alloys2018，6，1： | 7 |
| 5 | Analysis on Critical Success Factors for Agile Manufacturing Evaluation in Original Equipment Manufacturing Industry-An AHP Approach显示文摘Manufacturing industries are facing challenges in the implementation of agile manufacturing in their products and processes.Agility is widely accepted as a new competitive concept in the manufacturing sector in fulfilling varying customer demand. Thus,evaluation of agile manufacturing in industries has become a necessity. The success of an organisation depends on its ability to manage finding the critical success factors and give them special and continued attention in order to bring about high performance. This paper proposes a set of critical success factors(CSFs) for evaluating agile manufacturing considered appropriate for the manufacturing sector.The analytical hierarchy process(AHP) method is applied for prioritizing the success factors, by summarizing the opinions of experts. It is believed that the proposed CSFs enable and assist manufacturing industries to achieve a higher performance in agile manufacturing so as to increase competitiveness. | C Ajay Guru Dev V S Senthil Kumar | 2016 | Chinese Journal of Mechanical Engineering2016，29，5： | 7 |
| 6 | 临床表现罕见的流行性角结膜炎1例:腺病毒角结膜上皮炎(英文)显示文摘腺病毒角结膜炎,由腺病毒血清型8,19,37引起。腺病毒结膜炎典型的体征包括耳前淋巴结病变,结膜充血水肿,结膜下出血,结膜滤泡。腺病毒角结膜炎角膜受累情况各不相同,多数患者有弥散的轻微的浅层角膜炎,局部隆起的点状上皮损害,随后形成上皮下混浊。我们报道一例罕见的腺病毒角结膜上皮炎,为临床表现特殊的流行性角结膜炎(EKC),并回顾相关特殊病例文献。患者,男,35岁,患腺病毒结膜炎,临床表现罕见,表现为角结膜上皮炎形式,这种病例文献未见报道。经过保守治疗患者痊愈。角结膜上皮炎可以是临床表现特殊的腺病毒角结膜炎。 | Sudesh Kumar Arya Badri Prasad Badhu Ritu Amatya V G Ramachandran Poonam Lavaju | 2009 | 国际眼科杂志2009，9，8： | 4 |
| 7 | Hepatoprotective activity of Hepax-A polyherbal formulation显示文摘Objective:To evaluate the hepatoprotective potential of Hepax,a polyherbal formulation,against three experimentally induced hepatotoxicity models in rats.Methods:Hepatoprotective activity of Hepax was studied against three experimentally induced hepatotoxicity models,namely, carbon tetrachloride(CCl_4),paracetamol and thiocetamide induced hepatotoxicity in rats. Results:Administration of hepatotoxins(CCl_4,paracetamol and thiocetamide) showed significant morphological,biochemical and histological deteriorations in the liver of experimental animals. Pretreatment with Hepax had significant protection against hepatic damage by maintaining the morphological parameters(liver weight and liver weight to organ weight ratio) within normal range and normalizing the elevated levels of biochemical parameters(SGPT,SCOT,ALP and total bilirubin),which were evidently showed in histopathological study.Conclusions:The Hepax has highly significant hepatoprotective effect at 100 and 200 mg/kg,p.o.on the liver of all the three experimental animal models. | VC Devaraj B Gopala Krishna GL Viswanatha Jagadish V Kamath Sanjay Kumar | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 4 |
| 8 | Evaluating the effectiveness of marine actinobacterial extract and its mediated titanium dioxide nanoparticles in the degradation of azo dyes显示文摘Aim of the present study was to synthesize titanium dioxide nanoparticles(TiO2 NPs) from marine actinobacteria and to develop an eco-friendly azo-dye degradation method. A total of five actinobacterial isolates were isolated from Chennai marine sediments, Tamilnadu, India and analyzed for the synthesis of TiO2 NPs using titanium hydroxide. Among these, the isolate PSV 3 showed positive results for the synthesis of TiO2 NPs, which was confirmed by UV analysis. Further characterization of the synthesized TiO2 NPs was done using XRD, AFM and FT-IR analysis. Actinobacterial crude extract and synthesized TiO2 NPs was found efficient in degrading azo dye such as Acid Red 79(AR-79) and Acid Red 80(AR-80). Degradation percentage was found to be 81% for AR-79, 83% for AR-80 using actinobacterial crude extract and 84% for AR-79, 85% for AR-80 using TiO2 NPs. Immobilized actinobacterial cells showed 88% for AR-79 and 81% for AR-80, dye degrading capacity. Degraded components were characterized by FT-IR and GC-MS analysis. The phytotoxicity test with 500 μg/mL of untreated dye showed remarkable phenotypic as well as cellular damage to Tagetes erecta plant. Comparatively no such damage was observed on plants by degraded dye components. In biotoxicity assay, treated dyes showed less toxic effect as compared to the untreated dyes. | S Priyaragini S Veena D Swetha L Karthik G Kumar K V Bhaskara Rao | 2014 | Journal of Environmental Sciences2014，26，4： | 4 |
| 9 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 10 | Antidiabetic and hypolipidemic activities of Kigelia pinnata flowers extract in streptozotocin induced diabetic rats显示文摘Objective:To evaluate antidiabetic and hypolipidemic activities of Kigelia pinnata rnethanolic(lowers extract in slreplozolocin(STZ) induced diabetic W islar rat.Methods.Rats were made diabetic by a single dose of STZ at 60 mg/kg body weight i.p.The blood glucose level was checked before and 72 h after STZ injection to confirm the development ot diabetes.The flower extract and glibenclamide were administered orally at the doses of 250 and 500 mg/kg body weight for 21 days.Results:Daily oral treatment with the extract and standard drug for 21 days significantly reduced blood glucose,serum cholesterol and triglycerides levels.High density lipoprotein-cholesterol level was found to be improved(P<0.01) as compared to diabetic control group.Conclusions:It is concluded that Kigellia pinnata flowers extract have significant antidiabetic and hypolipidemic effect. | Kumar S Kumar V Prakash OM | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，7： | 4 |
| 11 | Antidiabetic and anti-lipemic effects of Cassia siamea leaves extract in streptozotocin induced diabetic rats显示文摘Objective:To investigate the antidiabetic and anti-lipemic effects of Cassia siamea methanolic leaves extract.Methods:The antidiabetic study was performed by measuring blood glucose level with elegance glucometer at weekly intervals i.e.0,7,14 and 21 in normal and streptozotocin induced diabetic rats.Total cholesterol,triglyceride and HDL-cholesterol were determined in normal and streptozotocin induces diabetic rats by autoanalyser.Glibenclamide was used as a reference drug at a dose of 10 mg/kg.Results:After the oral administration of extracts at doses of 250 mg/kg and 500 mg/kg for three weeks,blood glucose levels and body weights were significantly improved(P<0.01).Daily oral treatment with the extract also resulted in significantly reduction of serum cholesterol and triglycerides.HDL-cholesterol level was found to be improved to(P<0.01).Conclusions:The Cassia siamea leaf extract is useful in controlling blood glucose level as well as improving lipid metabolism and body weight in rats with induced diabetes. | S Kumar V Kumar Om Prakash | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，11： | 3 |
| 12 | 家蚕来源肠球菌DNA多态性的RAPD分析显示文摘运用随机扩增多态性DNA(randomamplifiedpolymorphicDNA,RAPD)技术,对从家蚕消化道中分离的表现为生理生化特性多样性的14个肠球菌分离菌株和3个标准菌株进行了DNA多态性研究。应用筛选的8条随机引物,共扩增出625个位点,其中997%为多态性位点,表明供试菌株具有丰富的DNA多态性。对扩增结果进行聚类分析,供试菌株分为Entfaecalis、Entfaecium、Entcasseliflavus、Entavium等4个类群,与其数值鉴定结果呈相同趋势。 | 王彦文 鲁兴萌 牟志美 V Shyam Kumar | 2005 | 蚕业科学2005，31，1： | 3 |
| 13 | Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing. | Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann | 2022 | Bone Research2022，10，3： | 2 |
| 14 | Methanolic extract of Momordica cymbalaria enhances glucose uptake in L6 myotubes in vitro by up-regulating PPAR-γ and GLUT-4显示文摘The present study was undertaken to evaluate the influence of the methanolic fruit extract of Momordica cymbalaria(MFMC) on PPARγ(Peroxisome Proliferator Activated Receptor gamma) and GLUT-4(Glucose transporter-4) with respect to glucose transport. Various concentrations of MFMC ranging from 62.5 to 500 μg·mL-1 were evaluated for glucose uptake activity in vitro using L6 myotubes, rosiglitazone was used as a reference standard. The MFMC showed significant and dose-dependent increase in glucose uptake at the tested concentrations, further, the glucose uptake activity of MFMC(500 μg·mL-1) was comparable with rosigilitazone. Furthermore, MFMC has shown up-regulation of GLUT-4 and PPARγ gene expressions in L6 myotubes. In addition, the MFMC when incubated along with cycloheximide(CHX), which is a protein synthesis inhibitor, has shown complete blockade of glucose uptake. This indicates that new protein synthesis is required for increased GLUT-4 translocation. In conclusion, these findings suggest that MFMC is enhancing the glucose uptake significantly and dose dependently through the enhanced expression of PPARγ and GLUT-4 in vitro. | Puttanarasaiah Mahesh Kumar Marikunte V Venkataranganna Kirangadur Manjunath Gollapalle L Viswanatha Godavarthi Ashok | 2014 | Chinese Journal of Natural Medicines2014，12，12： | 2 |
| 15 | Design and discovery of materials guided by theory and computation显示文摘Computational materials science and engineering has emerged as an interdisciplinary subfield spanning materials science and engineering,condensed matter physics,chemistry,mechanics and engineering in general.Modern materials research often requires a close integration of computation and experiments in order to fundamentally understand the materials structures and properties and their relation to synthesis and processing.A number of computational methods and tools at different spatiotemporal scales are now well established,ranging from electronic structure calculations based on density functional theory,1,2 atomic molecular dynamics3,4 and Monte Carlo techniques,5 phase-field method6–9 to continuum macroscopic approaches.Over the last few years,computational materials activities have been steadily moving from technique development and purely computational studies of materials towards discovering and designing new materials guided by computation,machine learning and data mining or by a closely tied combination of computational predictions and experimental validation.This movement is being further accelerated by the recent initiatives by various government agencies in the United States,Europe,China and other countries to pursue the materials genome initiative,10 integrated computational materials engineering11–13 as well as the‘Big Data’initiative. | Long-Qing Chen Li-Dong Chen Sergei V Kalinin Gerhard Klimeck Sanat K Kumar Jörg Neugebauer Ichiro Terasaki | 2015 | npj Computational Materials2015，，1： | 2 |
| 16 | Phytoextraction:the use of plants to remove heavy metals from soils显示文摘 | NADAN KUMAR P B A DUSHENKOV V MOTTO H | 1995 | Environ Sci Technol1995，29，5： | 2 |
| 17 | Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial显示文摘 | Edward B Garon Tudor-Eliade Ciuleanu Oscar Arrieta Kumar Prabhash Konstantinos N Syrigos Tuncay Goksel Keunchil Park Vera Gorbunova Ruben Dario Kowalyszyn Joanna Pikiel Grzegorz Czyzewicz Sergey V Orlov Conrad R Lewanski Michael Thomas Paolo Bidoli Shaker | 2014 | The Lancet2014，，： | 2 |
| 18 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 19 | Objectively determined 10-day African rainfall estimates created for famine early warning systems显示文摘 | Herman A V B Kumar P A Arkin | 1997 | Int J Remote Sens1997，18，： | 2 |
| 20 | Percutaneous ureterolitholapaxy: the best bet to clear large bulk impacted upper ureteral calculi显示文摘 | Kumar V Ahlawat R Banjeree GK | 1996 | Arch Esp Urol1996，49，： | 2 |
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