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| 1 | 米非司酮基于糖皮质激素受体调节糖尿病大鼠高血糖的作用机制显示文摘目的观察米非司酮(MIF)对2型糖尿病大鼠血浆中促肾上腺皮质激素释放激素(CRH)、促肾上腺皮质激素(ACTH)、皮质酮(CORT)、胰岛素(INS)、醛甾酮(ALD)的水平和海马组织中糖皮质激素受体(GR)mRNA表达的影响,探讨MIF对2型糖尿病高血糖的调节作用及其可能机制。方法采用高脂饲料加小剂量链脲佐菌素(30 mg·kg^-1)腹腔注射诱导2型糖尿病模型。随机分为正常对照组、模型对照组、阳性对照组(给予二甲双胍200 mg·kg^-1·d^-1)、米非司酮小剂量组(10 mg·kg^-1·d^-1)、米非司酮中剂量组(25 mg·kg^-1·d^-1)、米非司酮大剂量组(50 mg·kg^-1·d^-1),正常对照组和模型对照组给予纯化水。每周测定大鼠空腹血糖,给药5周后断头处死,计算脏器指数,测定血浆中CRH、ACTH、CORT、INS、ALD水平,采用实时荧光定量PCR技术测定大鼠海马组织中GR mRNA的表达。结果与正常对照组比较,模型对照组大鼠体质量明显降低(P〈0.01),空腹血糖升高(P〈0.01),脏器指数增加(P〈0.05),CRH、ACTH、CORT、INS、ALD水平升高;糖尿病大鼠海马组织中GRmRNA的表达降低(P〈0.01)。与模型对照组比较,米非司酮中剂量组和大剂量组给药14 d体质量有所增加(P〈0.01);给药第1~4周,米非司酮中剂量组空腹血糖水平有所降低,且在第4周差异有统计学意义(P〈0.05);米非司酮中剂量组和大剂量组肾指数减小(P〈0.01或P〈0.05);米非司酮小剂量组CRH、ACTH、CORT增加,ALD降低,米非司酮中和大剂量组CRH、ACTH、CORT、ALD降低,INS升高,但均差异无统计学意义(P〉0.05)。米非司酮小剂量组、中剂量组、大剂量组GR mRNA的相对表达均有所增加(均P〈0.01)。结论 MIF对2型糖尿病的高血糖有缓解作用,其机制可能与MIF基于GR拮抗调节HPA轴功能有关。 | 王晓丽 周珺 李茂星 邱建国 贾正平 张汝学 | 2014 | 医药导报2014，33，10： | 0 |
| 2 | Barringtonia acutangula improves the biochemical parameters in diabetic rats显示文摘AIM: This study was aimed at evaluating the anti-diabetic activity of the ethanol and aqueous extracts of the leaf material of Barringtonia acutangula in a diabetic animal model. METHODS: The ethanolic and aqueous extracts(250 and 500 mg kg 1body weight) of the leaves of B. acutangula were assessed for antidiabetic activity in a streptozotocin(STZ)-induced diabetes animal model following 21 days of treatment. Glibenclamide(0.6 mg kg 1p.o.) was used as a positive control. The hematological parameters, such as blood glucose level, urea, creatinin, cholesterol, HDL-C, and LDL-C levels were examined. RESULTS: An acute toxicity study(5 000 mg kg 1, p.o.) did not produce any symptoms of toxicity. Significant reductions in blood glucose level, and serum total cholesterol and triglyceride levels were noted in animals treated with the extract. The high density lipoprotein-cholesterol(HDLC) level was found to increase as compared with the diabetic control group. CONCLUSION: These results suggest that the leaf aqueous and ethanolic extracts of B. acutangula have anti-diabetic effects. The aqueous extract of B. acutangula produced a similar effect when compared with the ethanol extract. It is proposed that consumption of B. acutangula in some form like tea may help the management of diabetes. | Marslin Gregory Vinoth Kumar Megraj Khandelwal Revina Ann Mary V.K.Kalaichelvan V.Palanivel | 2014 | Chinese Journal of Natural Medicines2014，12，2： | 0 |
| 3 | Antidiabetic and antidiarrhoeal potentials of ethanolic extracts of aerial parts of Cynodon dactylon Pers显示文摘Objective: To explore the antidiabetic and the antidiarrhoeal effects of ethanolic extracts of Cynodon dactylon Pers. aerial parts(EECA) in Wistar rats.Methods: To assess the antidiabetic activity of EECA, oral glucose tolerance test(OGTT) model and alloxan induced diabetic test(AIDT) model were performed. The EECA was used at the doses of 2 g/kg, 1 g/kg and 500 mg/kg body weight in OGTT model and 1.5 g/kg was used for AIDT model. Castor oil-induced diarrhoeal model and gastrointestinal motility test with barium sulphate milk model were performed for evaluating the antidiarrhoeal effects at doses of 1 g/kg, 750 mg/kg respectively.Results: The dose 2 g/kg in OGTT and 1.5 g/kg in AIDT model blood glucose levels decreased significantly(P < 0.01) in Wistar rats that showed antidiabetic effect of EECA. After administration of EECA at the dose of 1 g/kg, the extract showed significant(P < 0.05) antidiarrhoeal activity in castor oil-induced diarrhoeal model. The results were also significant(P < 0.01) in barium sulphate milk model for the same dose by using above mentioned animals.Conclusions: It is concluded that EECA contains both antidiabetic and the antidiarrhoeal properties. | Md.Saidur Rahman Rasheda Akter Santosh Mazumdar Faridul Islam Nusrat Jahan Mouri Nemai Chandra Nandi Abu Syeed | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，8： | 0 |
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